KEGG   ENZYME: 5.4.99.39Help
Entry
EC 5.4.99.39                Enzyme                                 

Name
beta-amyrin synthase;
2,3-oxidosqualene beta-amyrin cyclase;
AsbAS1;
BPY;
EtAS;
GgbAS1;
LjAMY1;
MtAMY1;
PNY;
BgbAS
Class
Isomerases;
Intramolecular transferases;
Transferring other groups
BRITE hierarchy
Sysname
(3S)-2,3-epoxy-2,3-dihydrosqualene mutase (cyclizing, beta-amyrin-forming)
Reaction(IUBMB)
(3S)-2,3-epoxy-2,3-dihydrosqualene = beta-amyrin [RN:R06469]
Reaction(KEGG)
Substrate
(3S)-2,3-epoxy-2,3-dihydrosqualene [CPD:C01054]
Product
beta-amyrin [CPD:C08616]
Comment
Some organism possess a monofunctional beta-amyrin synthase [3,4,6-11], other have a multifunctional enzyme that also catalyses the synthesis of alpha-amyrin (EC 5.4.99.40) [5] or lupeol (EC 5.4.99.41) [6].
History
EC 5.4.99.39 created 2011
Pathway
Sesquiterpenoid and triterpenoid biosynthesis
Biosynthesis of secondary metabolites
Orthology
K15813  
beta-amyrin synthase
K15815  
lupeol synthase 2
Genes
ATH: 
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
CSV: 
CMO: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
 » show all
Taxonomy
Reference
1
  Authors
Abe, I, Ebizuka, Y., Seo, S. and Sankawa, U.
  Title
Purification of squalene-2,3-epoxide cyclases from cell suspension cultures of Rabdosia japonica Hara.
  Journal
FEBS Lett. 249 (1989) 100-104.
Reference
2
  Authors
Abe, I., Sankawa, U. and Ebizuka, Y.
  Title
Purification of 2,3-oxdosqualene:beta-amyrin cyclase from pea seedlings.
  Journal
Chem. Pharm. Bull. 37 (1989) 536.
Reference
3  [PMID:9746369]
  Authors
Kushiro T, Shibuya M, Ebizuka Y
  Title
Beta-amyrin synthase--cloning of oxidosqualene cyclase that catalyzes the formation of the most popular triterpene among higher plants.
  Journal
Eur. J. Biochem. 256 (1998) 238-44.
  Sequence
[up:O82140]
Reference
4  [PMID:11510484]
  Authors
Hayashi H, Huang P, Kirakosyan A, Inoue K, Hiraoka N, Ikeshiro Y, Kushiro T, Shibuya M, Ebizuka Y
  Title
Cloning and characterization of a cDNA encoding beta-amyrin synthase involved in  glycyrrhizin and soyasaponin biosyntheses in licorice.
  Journal
Biol. Pharm. Bull. 24 (2001) 912-6.
  Sequence
[up:Q9MB42]
Reference
5  [PMID:11247608]
  Authors
Husselstein-Muller T, Schaller H, Benveniste P
  Title
Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana.
  Journal
Plant. Mol. Biol. 45 (2001) 75-92.
  Sequence
Reference
6  [PMID:12683345]
  Authors
Iturbe-Ormaetxe I, Haralampidis K, Papadopoulou K, Osbourn AE
  Title
Molecular cloning and characterization of triterpene synthases from Medicago truncatula and Lotus japonicus.
  Journal
Plant. Mol. Biol. 51 (2003) 731-43.
Reference
7  [PMID:12736505]
  Authors
Zhang H, Shibuya M, Yokota S, Ebizuka Y
  Title
Oxidosqualene cyclases from cell suspension cultures of Betula platyphylla var. japonica: molecular evolution of oxidosqualene cyclases in higher plants.
  Journal
Biol. Pharm. Bull. 26 (2003) 642-50.
  Sequence
[up:Q8W3Z1]
Reference
8  [PMID:15256745]
  Authors
Hayashi H, Huang P, Takada S, Obinata M, Inoue K, Shibuya M, Ebizuka Y
  Title
Differential expression of three oxidosqualene cyclase mRNAs in Glycyrrhiza glabra.
  Journal
Biol. Pharm. Bull. 27 (2004) 1086-92.
  Sequence
[up:Q9MB42]
Reference
9  [PMID:16005035]
  Authors
Kajikawa M, Yamato KT, Fukuzawa H, Sakai Y, Uchida H, Ohyama K
  Title
Cloning and characterization of a cDNA encoding beta-amyrin synthase from petroleum plant Euphorbia tirucalli L.
  Journal
Phytochemistry. 66 (2005) 1759-66.
Reference
10 [PMID:17803686]
  Authors
Basyuni M, Oku H, Tsujimoto E, Kinjo K, Baba S, Takara K
  Title
Triterpene synthases from the Okinawan mangrove tribe, Rhizophoraceae.
  Journal
FEBS. J. 274 (2007) 5028-42.
  Sequence
[up:A8CDT2]
Reference
11 [PMID:19420748]
  Authors
Liu Y, Cai Y, Zhao Z, Wang J, Li J, Xin W, Xia G, Xiang F
  Title
Cloning and Functional Analysis of a beta-amyrin synthase gene associated with oleanolic acid biosynthesis in Gentiana straminea MAXIM.
  Journal
Biol. Pharm. Bull. 32 (2009) 818-24.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 

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