| Entry |
|
|---|
| Name |
lanosterol synthase;
2,3-epoxysqualene lanosterol cyclase;
squalene-2,3-oxide-lanosterol cyclase;
lanosterol 2,3-oxidosqualene cyclase;
squalene 2,3-epoxide:lanosterol cyclase;
2,3-oxidosqualene sterol cyclase;
oxidosqualene cyclase;
2,3-oxidosqualene cyclase;
2,3-oxidosqualene-lanosterol cyclase;
oxidosqualene-lanosterol cyclase;
squalene epoxidase-cyclase |
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| Class |
Isomerases;
Intramolecular transferases;
Transferring other groups
 |
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| Sysname |
(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming) |
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| Reaction(IUBMB) |
(S)-2,3-epoxysqualene = lanosterol [RN:R03199] |
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| Reaction(KEGG) |
R03199
 |
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| Substrate |
(S)-2,3-epoxysqualene [CPD:C01054] |
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| Product |
lanosterol [CPD:C01724] |
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| Inhibitor |
29-MOS [CPD:C05373] |
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| Pathway |
PATH: ec00100 Steroid biosynthesis
PATH: ec01066 Biosynthesis of alkaloids derived from terpenoid and
polyketide
PATH: ec01100 Metabolic pathways |
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| Orthology |
KO: K01852 lanosterol synthase |
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| Genes |
HSA: 4047(LSS)
PTR: 474058(LSS)
MCC: 709227(LSS)
MMU: 16987(Lss)
RNO: 81681(Lss)
CFA: 491611
BTA: 615906(LSS)
ECB: 100055292
MDO: 100026255
OAA: 100083602
GGA: 424037(LSS)
XTR: 733925(lss)
DRE: 795400(lss)
TAD: TRIADDRAFT_22852
ATH: AT3G45130(LAS1)
POP: POPTR_832441
RCU: RCOM_0588620
SBI: SORBI_04g003190(SORBIDRAFT_04g003190)
SORBI_04g003200(SORBIDRAFT_04g003200)
ZMA: 100285643
SCE: YHR072W(ERG7)
AGO: AGOS_AGR351W
KLA: KLLA0B10175g
LTH: KLTH0H14850g
DHA: DEHA0C06501g
PIC: PICST_77382(ERG7)
PPA: PAS_chr2-1_0391
VPO: Kpol_339p12
LEL: LELG_00573
ZRO: ZYRO0D10164g
CAL: CaO19.1570(ERG7)
CTP: CTRG_01395
CDU: CD36_17130(ERG7)
CGR: CAGL0J10824g
YLI: YALI0F04378g
SPO: SPAC13G7.01c(erg7)
NCR: NCU01119
PAN: PODANSg8579
MGR: MGG_11702
FGR: FG05950.1
AFM: AFUA_4G14770 AFUA_5G04080
AOR: AO090102000611
ANG: An07g06150 An09g06490
AFV: AFLA_006860 AFLA_102160
PCS: Pc22g14100
NFI: NFIA_038030 NFIA_101360 NFIA_104210
CIM: CIMG_02792 CIMG_06646
URE: UREG_03791
SSL: SS1G_01528
BFU: BC1G_05572
CNE: CND02520 CND02590
CNB: CNBD3820
LBC: LACBIDRAFT_185468
MPR: MPER_02146 MPER_03149
MGL: MGL_1532
MBR: MONBRDRAFT_18210
TBR: Tb927.7.5230
LIF: LinJ06.0670
LBZ: LbrM06_V2.0650
PTI: PHATR_645
TPS: THAPSDRAFT_277(CAS1)
 |
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| Structures |
PDB: 1W6J 1W6K |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:6027261]
Dean PD, Ortiz de Montellano PR, Bloch K, Corey EJ.
A soluble 2,3-oxidosqualene sterol cyclase.
J. Biol. Chem. 242 (1967) 3014-5.
Rattus norvegicus [GN:rno] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 5.4.99.7
IUBMB Enzyme Nomenclature: 5.4.99.7
ExPASy - ENZYME nomenclature database: 5.4.99.7
BRENDA, the Enzyme Database: 5.4.99.7
CAS: 9032-71-7 |
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