KEGG   ENZYME: 5.5.1.9Help
Entry
EC 5.5.1.9                  Enzyme                                 
Name
cycloeucalenol cycloisomerase;
cycloeucalenol---obtusifoliol isomerase
Class
Isomerases;
Intramolecular lyases;
Intramolecular lyases (only sub-subclass identified to date)
BRITE hierarchy
Sysname
cycloeucalenol lyase (cyclopropane-decyclizing)
Reaction(IUBMB)
cycloeucalenol = obtusifoliol [RN:R03775]
Reaction(KEGG)
Substrate
cycloeucalenol [CPD:C02141]
Product
obtusifoliol [CPD:C01943]
Comment
Opens the cyclopropane ring of a number of related 4alpha-methyl-9beta-19-cyclosterols, but not those with a 4beta-methyl group, with formation of an 8(9) double bond. Involved in the synthesis of plant sterols.
Pathway
Steroid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K08246  
cycloeucalenol cycloisomerase
Genes
AQU: 
ATH: 
AT5G50375(CPI1)
ALY: 
GMX: 
MTR: 
CSV: 
RCU: 
POP: 
VVI: 
BDI: 
SBI: 
SORBI_09g002170(SORBIDRAFT_09g002170)
ZMA: 
100283632
SMO: 
SELMODRAFT_135190
PPP: 
PHYPADRAFT_206696
CRE: 
CHLREDRAFT_193038(CPI1)
VCN: 
VOLCADRAFT_109265
OLU: 
OSTLU_6401
OTA: 
Ot04g04910
PAN: 
PODANSg6085
FGR: 
FG06622.1
NGR: 
NAEGRDRAFT_81142
DDI: 
DDB_G0268970
PTI: 
PHATRDRAFT_49447
TPS: 
THAPSDRAFT_7708
 » show all
Taxonomy
Reference
1  [PMID:4369016]
  Authors
Heintz R, Benveniste P.
  Title
Plant sterol metabolism. Enzymatic cleavage of the 9beta, 19beta-cyclopropane ring of cyclopropyl sterols in bramble tissue cultures.
  Journal
J. Biol. Chem. 249 (1974) 4267-74.
  Organism
Rubus fruticosus
Reference
2
  Authors
Rahier, A., Schmitt, P. and Benveniste, P.
  Title
7-oxo-24xi(28)-dihydrocycloeucalenol, a potent inhibitor of plant sterol biosynthesis.
  Journal
Phytochemistry 21 (1982) 1969-1974.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
60496-19-7
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