KEGG   ENZYME: 5.99.1.4Help
Entry
EC 5.99.1.4                 Enzyme                                 

Name
2-hydroxychromene-2-carboxylate isomerase;
HCCA isomerase;
2HC2CA isomerase;
2-hydroxychromene-2-carboxylic acid isomerase
Class
Isomerases;
Other isomerases;
Sole sub-subclass for isomerases that do not belong in the other subclasses
BRITE hierarchy
Sysname
2-hydroxy-2H-chromene-2-carboxylate---(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate isomerase
Reaction(IUBMB)
2-hydroxy-2H-chromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate [RN:R05137]
Reaction(KEGG)
Substrate
2-hydroxy-2H-chromene-2-carboxylate [CPD:C06204]
Product
(3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate [CPD:C06203]
Comment
This enzyme is involved in naphthalene degradation.
History
EC 5.99.1.4 created 2010
Pathway
Naphthalene degradation
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K14584  
2-hydroxychromene-2-carboxylate isomerase
Genes
PPI: 
ND062(nahD)
PSC: 
ALT: 
PNA: 
Taxonomy
Reference
1  [PMID:9722670]
  Authors
Ohmoto T, Kinoshita T, Moriyoshi K, Sakai K, Hamada N, Ohe T
  Title
Purification and some properties of 2-hydroxychromene-2-carboxylate isomerase from naphthalenesulfonate-assimilating Pseudomonas sp. TA-2.
  Journal
J. Biochem. 124 (1998) 591-7.
Reference
2  [PMID:16804169]
  Authors
Keck A, Conradt D, Mahler A, Stolz A, Mattes R, Klein J
  Title
Identification and functional analysis of the genes for naphthalenesulfonate catabolism by Sphingomonas xenophaga BN6.
  Journal
Microbiology. 152 (2006) 1929-40.
  Organism
Sphingobium xenophagum
  Sequence
[up:Q9X9Q7]
Reference
3  [PMID:8002605]
  Authors
Eaton RW
  Title
Organization and evolution of naphthalene catabolic pathways: sequence of the DNA encoding 2-hydroxychromene-2-carboxylate isomerase and trans-o-hydroxybenzylidenepyruvate hydratase-aldolase from the NAH7 plasmid.
  Journal
J. Bacteriol. 176 (1994) 7757-62.
  Organism
Pseudomonas putida
  Sequence
[up:Q51948]
Reference
4  [PMID:17508726]
  Authors
Thompson LC, Ladner JE, Codreanu SG, Harp J, Gilliland GL, Armstrong RN
  Title
2-Hydroxychromene-2-carboxylic acid isomerase: a kappa class glutathione transferase from Pseudomonas putida.
  Journal
Biochemistry. 46 (2007) 6710-22.
  Organism
Pseudomonas putida
  Sequence
[up:Q51948]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
UM-BBD (Biocatalysis/Biodegradation Database): 
BRENDA, the Enzyme Database: 

DBGET integrated database retrieval system