| Entry |
|
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| Name |
D-alanine---poly(phosphoribitol) ligase;
D-alanyl-poly(phosphoribitol) synthetase;
D-alanine: membrane acceptor ligase;
D-alanine-D-alanyl carrier protein ligase;
D-alanine-membrane acceptor ligase;
D-alanine-activating enzyme |
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| Class |
Ligases;
Forming carbon-oxygen bonds;
Ligases forming aminoacyl-tRNA and related compounds
 |
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| Sysname |
D-alanine:poly(phosphoribitol) ligase (AMP-forming) |
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| Reaction(IUBMB) |
ATP + D-alanine + poly(ribitol phosphate) = AMP + diphosphate +
O-D-alanyl-poly(ribitol phosphate) [RN:R02718] |
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| Reaction(KEGG) |
R02718
 |
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| Substrate |
ATP [CPD:C00002];
D-alanine [CPD:C00133];
poly(ribitol phosphate) [CPD:C00653] |
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| Product |
AMP [CPD:C00020];
diphosphate [CPD:C00013];
O-D-alanyl-poly(ribitol phosphate) [CPD:C04260] |
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| Comment |
A thioester bond is formed transiently between D-alanine and the
sulfhydryl group of the 4'-phosphopantetheine prosthetic group of
D-alanyl carrier protein during the activation of the alanine.
Involved in the synthesis of teichoic acids. |
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| Pathway |
PATH: ec00473 D-Alanine metabolism |
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| Orthology |
KO: K03367 D-alanine-poly(phosphoribitol) ligase |
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| Genes |
ECP: ECP_1976
ECA: ECA3128(dltA)
PCT: PC1_2910
PWA: Pecwa_1365
PLU: plu4384(dltA)
CKO: CKO_00863
DDA: Dd703_0940
DDC: Dd586_3221
DZE: Dd1591_0952
TTU: TERTU_4300
LPF: lpl2156
LPP: lpp2183
LPC: LPC_1698
BPM: BURPS1710b_0819
BPL: BURPS1106A_0656(acpP)
BPD: BURPS668_0642(acpP)
BUR: Bcep18194_A4786
BPE: BP2987(dltA)
BPA: BPP3907(dltA)
BBR: BB4380(dltA)
BAV: BAV2987(dltA)
DAC: Daci_2937
ABU: Abu_1280(dltA) Abu_1284(dltC)
HBA: Hbal_2323
BSU: BSU38500(dltA) BSU38520(dltC)
BAN: BA1387(dltC) BA1389(dltA)
BAR: GBAA1387(dltC) GBAA1389(dltA)
BAA: BA_1913 BA_1915
BAT: BAS1285 BAS1287
BAH: BAMEG_3204(dltA) BAMEG_3206(dltC)
BAI: BAA_1456(dltC) BAA_1458(dltA)
BCE: BC1370 BC1372
BCA: BCE_1485(dltC) BCE_1487(dltA)
BCZ: BCZK1259(dltC) BCZK1261(dltA) pE33L466_0443(dltC)
BCR: BCAH187_A1528(dltC) BCAH187_A1530(dltA)
BCB: BCB4264_A1422(dltC) BCB4264_A1424(dltA)
BCU: BCAH820_1459(dltC) BCAH820_1461(dltA)
BCG: BCG9842_B3920(dltA) BCG9842_B3922(dltC)
BCQ: BCQ_1443(dltC) BCQ_1445(dltA)
BCX: BCA_1424(dltC) BCA_1426(dltA)
BCY: Bcer98_1090 Bcer98_1092
BTK: BT9727_1257(dltC) BT9727_1259(dltA)
BTL: BALH_1229 BALH_1231(dltA)
BWE: BcerKBAB4_1292 BcerKBAB4_1294
BLI: BL03932(dltC) BL03934(dltA)
BLD: BLi04080(dltA) BLi04082(dltC)
BAY: RBAM_035710(dltA) RBAM_035730(dltC)
BPU: BPUM_2477(dltC) BPUM_2479(dltA)
SAU: SA0793(dltA) SA0795(dltC)
SAV: SAV0932(dltA) SAV0934(dltC)
SAW: SAHV_0927(dltA) SAHV_0929(dltC)
SAM: MW0814(dltA) MW0816(dltC)
SAR: SAR0894(dltA) SAR0896(dltC)
SAS: SAS0802 SAS0804
SAC: SACOL0935(dltA) SACOL0937(dltC)
SAB: SAB0798(dltA) SAB0800(dltC)
SAA: SAUSA300_0835(dltA) SAUSA300_0837(dltC)
SAX: USA300HOU_0893(dltA) USA300HOU_0895(dltC)
SAO: SAOUHSC_00869 SAOUHSC_00871
SAJ: SaurJH9_0932 SaurJH9_0934
SAH: SaurJH1_0951 SaurJH1_0953
SAE: NWMN_0803(dltA) NWMN_0805(dltC)
SAD: SAAV_0893(dltA) SAAV_0895(dltC)
SEP: SE0624 SE0626
SER: SERP0518(dltA) SERP0520(dltC)
SHA: SH2019(dltC) SH2021(dltA)
SSP: SSP1841 SSP1843
SCA: Sca_0534(dltA) Sca_0536(dltC)
LMO: lmo0972(dltC) lmo0974(dltA)
LMF: LMOf2365_0992(dltC) LMOf2365_0994(dltA)
LMH: LMHCC_1649(dltA) LMHCC_1651(dltC)
LMC: Lm4b_00992(dltC) Lm4b_00994(dltA)
LIN: lin0971(dltC) lin0973(dltA)
LWE: lwe0954(dltC) lwe0956(dltA)
LSP: Bsph_0472 Bsph_0474
MCL: MCCL_0560(dltA)
PJD: Pjdr2_3261
LLA: L90005(dltC) L91510(dltA)
LLK: LLKF_1324(dltC) LLKF_1326(dltA)
LLC: LACR_1372 LACR_1374
LLM: llmg_1219(dltA) llmg_1221(dltC)
SPY: SPy_1310(dltC) SPy_1312(dltA)
SPZ: M5005_Spy_1071 M5005_Spy_1073(dltA)
SPM: spyM18_1322 spyM18_1324(dltA)
SPG: SpyM3_0992(dltC) SpyM3_0994(dltA)
SPS: SPs0864 SPs0866
SPH: MGAS10270_Spy1127 MGAS10270_Spy1129(dltA)
SPI: MGAS10750_Spy1164 MGAS10750_Spy1166(dltA)
SPJ: MGAS2096_Spy1070 MGAS2096_Spy1073(dltA)
SPK: MGAS9429_Spy1113 MGAS9429_Spy1115(dltA)
SPF: SpyM50792(dltA) SpyM50794(dltC)
SPA: M6_Spy1041 M6_Spy1043
SPB: M28_Spy1052 M28_Spy1054(dltA)
SOZ: Spy49_1035c(dltC) Spy49_1037c(dltA)
SPN: SP_2174 SP_2176
SPD: SPD_2003(dltC) SPD_2005(dltA)
SPR: spr1980(dltC) spr1982(dltA)
SPW: SPCG_2142(dltC) SPCG_2144(dltA)
SPX: SPG_2116(dltC) SPG_2118(dltA)
SNE: SPN23F_22070(dltC) SPN23F_22090(dltA)
SPV: SPH_2370(dltC) SPH_2372(dltA)
SNM: SP70585_2301(dltC) SP70585_2304(dltA)
SJJ: SPJ_2202(dltC) SPJ_2204(dltA)
SPP: SPP_2226(dltC) SPP_2228(dltA)
SNT: SPT_2189(dltC) SPT_2191(dltA)
SAG: SAG1788(dltC) SAG1790(dltA)
SAN: gbs1831 gbs1833
SAK: SAK_1810(dltC) SAK_1812(dltA)
SMU: SMU.1689(dltC) SMU.1691(dltA)
STC: str0761(dltA) str0763(dltC)
STL: stu0761(dltA) stu0763(dltC)
STE: STER_0802 STER_0804
SSA: SSA_2332(dltC) SSA_2334(dltA)
SSU: SSU05_0638 SSU05_0640
SSV: SSU98_0638 SSU98_0640
SSB: SSUBM407_1226(dltC) SSUBM407_1228(dltA)
SSI: SSU0596(dltA) SSU0598(dltC)
SSS: SSUSC84_0569(dltA) SSUSC84_0571(dltC)
SGO: SGO_0054(dltA) SGO_0056(dltC)
SEQ: SZO_06940 SZO_06960
SEZ: Sez_1269(dltC) Sez_1271(dltA)
SEU: SEQ_1451 SEQ_1453
SUB: SUB1147(dltC) SUB1149(dltA)
SDS: SDEG_1307(dltC) SDEG_1309(dltA)
LPL: lp_1406(dltC2) lp_2017(dltC1) lp_2019(dltA)
LPJ: JDM1_1176(dltC2) JDM1_1685(dltC1) JDM1_1687(dltA)
LJO: LJ1782 LJ1784
LJF: FI9785_1732(dltC) FI9785_1734(dltA)
LAC: LBA1924(dltC) LBA1926(dltA)
LSA: LSA0395(dltA) LSA0397(dltC)
LSL: LSL_0890 LSL_0892
LDB: Ldb2146(dltC) Ldb2148(dltA)
LBU: LBUL_1983 LBUL_1985
LBR: LVIS_1324 LVIS_1326
LCA: LSEI_0794 LSEI_0796
LCB: LCABL_08550(dltA) LCABL_08570(dltC)
LGA: LGAS_1816 LGAS_1818
LRE: Lreu_0250 Lreu_0252
LRF: LAR_0241 LAR_0243
LHE: lhv_2058 lhv_2060
LFE: LAF_0061 LAF_0063
LRH: LGG_00777(dltA) LGG_00779(dltC)
LRL: LC705_00772(dltA) LC705_00774(dltC)
PPE: PEPE_1588 PEPE_1590
EFA: EF2747(dltC) EF2749
OOE: OEOE_0287
LME: LEUM_1815 LEUM_1817
LCI: LCK_01237(dltC) LCK_01239
CDF: CD2851(dltC) CD2853(dltA)
CDC: CD196_2695(dltC) CD196_2697(dltA)
CDL: CDR20291_2742(dltC) CDR20291_2744(dltA)
CBO: CBO2589
CBA: CLB_2530
CBH: CLC_2461
CBY: CLM_2896
CBL: CLK_1974
CBK: CLL_A0687 CLL_A0689(dltC)
CBB: CLD_1976
CBI: CLJ_B2819
CBT: CLH_0648 CLH_0650(dltC)
CBF: CLI_2652
CBE: Cbei_1091 Cbei_4330 Cbei_4332
DSY: DSY0221 DSY0223
DHD: Dhaf_0165 Dhaf_0167
EEL: EUBELI_00116
ERE: EUBREC_2665 EUBREC_2666
RHA: RHA1_ro00144
ELE: Elen_1791 Elen_1793 Elen_2184
GAU: GAU_0575
PMH: P9215_14821
 |
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| Structures |
PDB: 3DHV 3E7W 3E7X 3FCC 3FCE 3L8C |
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Reference
Authors
Title
Journal
Organism
|
1 [PMID:13795638]
BADDILEY J, NEUHAUS FC.
The enzymic activation of D-alanine.
Biochem. J. 75 (1960) 579-87.
Lactobacillus casei [GN:lca], Bacillus subtilis [GN:bsu],
Lactobacillus arabinosus, Staphylococcus aureus |
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Reference
Authors
Title
Journal
Organism
|
2 [PMID:4399593]
Reusch VM Jr, Neuhaus FC.
D-Alanine: membrane acceptor ligase from Lactobacillus casei.
J. Biol. Chem. 246 (1971) 6136-43.
Lactobacillus casei [GN:lca] |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
3 [PMID:7797557]
Perego M, Glaser P, Minutello A, Strauch MA, Leopold K, Fischer W.
Incorporation of D-alanine into lipoteichoic acid and wall teichoic
acid in Bacillus subtilis. Identification of genes and regulation.
J. Biol. Chem. 270 (1995) 15598-606.
Bacillus subtilis [GN:bsu]
BSU: BSU38500 BSU38520 |
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Reference
Authors
Title
Journal
Organism
|
4 [PMID:8300523]
Heaton MP, Neuhaus FC.
Role of the D-alanyl carrier protein in the biosynthesis of
D-alanyl-lipoteichoic acid.
J. Bacteriol. 176 (1994) 681-90.
Lactobacillus casei [GN:lca] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:8682792]
Debabov DV, Heaton MP, Zhang Q, Stewart KD, Lambalot RH, Neuhaus FC.
The D-Alanyl carrier protein in Lactobacillus casei: cloning,
sequencing, and expression of dltC.
J. Bacteriol. 178 (1996) 3869-76.
Lactobacillus casei [GN:lca] |
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| Other DBs |
ExplorEnz - The Enzyme Database: 6.1.1.13
IUBMB Enzyme Nomenclature: 6.1.1.13
ExPASy - ENZYME nomenclature database: 6.1.1.13
BRENDA, the Enzyme Database: 6.1.1.13
CAS: 9023-65-8 |
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