KEGG   ENZYME: 6.2.1.12Help
Entry
EC 6.2.1.12                 Enzyme                                 
Name
4-coumarate---CoA ligase;
4-coumaroyl-CoA synthetase;
p-coumaroyl CoA ligase;
p-coumaryl coenzyme A synthetase;
p-coumaryl-CoA synthetase;
p-coumaryl-CoA ligase;
feruloyl CoA ligase;
hydroxycinnamoyl CoA synthetase;
4-coumarate:coenzyme A ligase;
caffeolyl coenzyme A synthetase;
p-hydroxycinnamoyl coenzyme A synthetase;
feruloyl coenzyme A synthetase;
sinapoyl coenzyme A synthetase;
4-coumaryl-CoA synthetase;
hydroxycinnamate:CoA ligase;
p-coumaryl-CoA ligase;
p-hydroxycinnamic acid:CoA ligase;
4CL
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-coumarate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-coumarate [CPD:C00811];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-coumaroyl-CoA [CPD:C00223]
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Phenylalanine metabolism
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01904  
4-coumarate--CoA ligase
Genes
CEL: 
ATH: 
AT1G51680(4CL1) AT1G62940(ACOS5) AT1G65060(4CL3) AT3G21230(4CL5) AT3G21240(4CL2) AT4G05160
ALY: 
GMX: 
MTR: 
RCU: 
POP: 
POPTR_548019(ACLL14) POPTR_639764(Ptr4CL3) POPTR_665396(Ptr4CL4) POPTR_827715(4CL1) POPTR_831184(Ptr4CL8) POPTR_837028(Ptr4CL6)
VVI: 
OSA: 
BDI: 
SBI: 
SORBI_01g016420(SORBIDRAFT_01g016420) SORBI_03g000610(SORBIDRAFT_03g000610) SORBI_04g005210(SORBIDRAFT_04g005210) SORBI_04g031010(SORBIDRAFT_04g031010) SORBI_10g026130(SORBIDRAFT_10g026130)
ZMA: 
100191850 100283944 542166(pco063262)
SMO: 
SELMODRAFT_115483 SELMODRAFT_116986 SELMODRAFT_446445 SELMODRAFT_450526(4CL1-1) SELMODRAFT_450546(4CL1-2)
PPP: 
PHYPADRAFT_104959 PHYPADRAFT_113172 PHYPADRAFT_140413 PHYPADRAFT_209184 PHYPADRAFT_81614 PHYPADRAFT_89614
AFM: 
AFUA_1G13110
HHA: 
Hhal_1819
REH: 
H16_B0714
RPA: 
RPA4421
SIL: 
SPO0801(fadD)
RDE: 
RD1_1868
RHA: 
RHA1_ro08971
 » show all
Taxonomy
Reference
1  [PMID:4364250]
  Authors
Gross GG, Zenk MH.
  Title
Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia.
  Journal
Eur. J. Biochem. 42 (1974) 453-9.
  Organism
Forsythia suspensa
Reference
2  [PMID:4699252]
  Authors
Lindl T, Kreuzaler F, Hahlbrock K.
  Title
Synthesis of p-coumaroyl coenzyme a with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max).
  Journal
Biochim. Biophys. Acta. 302 (1973) 457-64.
  Organism
Glycine max
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37332-51-7
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