KEGG   ENZYME: 6.2.1.12Help
Entry
EC 6.2.1.12                 Enzyme                                 

Name
4-coumarate---CoA ligase;
4-coumaroyl-CoA synthetase;
p-coumaroyl CoA ligase;
p-coumaryl coenzyme A synthetase;
p-coumaryl-CoA synthetase;
p-coumaryl-CoA ligase;
feruloyl CoA ligase;
hydroxycinnamoyl CoA synthetase;
4-coumarate:coenzyme A ligase;
caffeolyl coenzyme A synthetase;
p-hydroxycinnamoyl coenzyme A synthetase;
feruloyl coenzyme A synthetase;
sinapoyl coenzyme A synthetase;
4-coumaryl-CoA synthetase;
hydroxycinnamate:CoA ligase;
p-coumaryl-CoA ligase;
p-hydroxycinnamic acid:CoA ligase;
4CL
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
4-coumarate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA [RN:R01616]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
4-coumarate [CPD:C00811];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
4-coumaroyl-CoA [CPD:C00223]
History
EC 6.2.1.12 created 1976
Pathway
Ubiquinone and other terpenoid-quinone biosynthesis
Phenylalanine metabolism
Phenylpropanoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Orthology
K01904  
4-coumarate--CoA ligase
Genes
CEL: 
TSP: 
ATH: 
ALY: 
CRB: 
EUS: 
BRP: 
CIT: 
CIC: 
TCC: 
GMX: 
PVU: 
MTR: 
CAM: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
CSV: 
CMO: 
RCU: 
POP: 
POPTR_0001s07400g(POPTRDRAFT_639764) POPTR_0001s13900g(POPTRDRAFT_548019) POPTR_0003s09880g(POPTRDRAFT_349958A) POPTR_0003s17130g POPTR_0003s18720g(POPTRDRAFT_758231) POPTR_0004s10170g(POPTRDRAFT_831184) POPTR_0006s18490g POPTR_0006s18510g POPTR_0017s13880g POPTR_0018s10210g(POPTRDRAFT_262277) POPTR_0019s07600g(POPTRDRAFT_665396)
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0177600-01(Os02g0177600) Os02t0697400-01(Os02g0697400) Os03t0152400-01(Os03g0152400) Os04t0310800-01(Os04g0310800) Os06t0656500-01(Os06g0656500) Os08t0143300-00(Os08g0143300) Os08t0245200-01(Os08g0245200) Os08t0448000-01(Os08g0448000) Os10t0578950-00(Os10g0578950)
OBR: 
BDI: 
SBI: 
SORBI_0011s012850(SORBIDRAFT_0011s012850) SORBI_01g016420(SORBIDRAFT_01g016420) SORBI_01g027820(SORBIDRAFT_01g027820) SORBI_03g000610(SORBIDRAFT_03g000610) SORBI_04g005210(SORBIDRAFT_04g005210) SORBI_04g031010(SORBIDRAFT_04g031010) SORBI_06g016630(SORBIDRAFT_06g016630) SORBI_07g007810(SORBIDRAFT_07g007810) SORBI_07g022040(SORBIDRAFT_07g022040) SORBI_10g026130(SORBIDRAFT_10g026130)
ZMA: 
SITA: 
PDA: 
MUS: 
ATR: 
s00019p00213640(AMTR_s00019p00213640) s00025p00217510(AMTR_s00025p00217510) s00025p00217630(AMTR_s00025p00217630) s00048p00101790(AMTR_s00048p00101790) s00048p00141400(AMTR_s00048p00141400) s00076p00189570(AMTR_s00076p00189570)
SMO: 
PPP: 
AFM: 
PFJ: 
BCOM: 
DPP: 
HHA: 
SIL: 
SPO0801(fadD)
RDE: 
RHA: 
 » show all
Taxonomy
Reference
1  [PMID:4364250]
  Authors
Gross GG, Zenk MH.
  Title
Isolation and properties of hydroxycinnamate: CoA ligase from lignifying tissue of Forsythia.
  Journal
Eur. J. Biochem. 42 (1974) 453-9.
Reference
2  [PMID:4699252]
  Authors
Lindl T, Kreuzaler F, Hahlbrock K.
  Title
Synthesis of p-coumaroyl coenzyme a with a partially purified p-coumarate:CoA ligase from cell suspension cultures of soybean (Glycine max).
  Journal
Biochim. Biophys. Acta. 302 (1973) 457-64.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37332-51-7

DBGET integrated database retrieval system