KEGG   ENZYME: 6.2.1.13Help
Entry
EC 6.2.1.13                 Enzyme                                 

Name
acetate---CoA ligase (ADP-forming);
acetyl-CoA synthetase (ADP-forming);
acetyl coenzyme A synthetase (adenosine diphosphate-forming);
acetate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
acetate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + acetate + CoA = ADP + phosphate + acetyl-CoA [RN:R00229]
Reaction(KEGG)
R00229;
(other) R00920
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Substrate
ATP [CPD:C00002];
acetate [CPD:C00033];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
acetyl-CoA [CPD:C00024]
Comment
Also acts on propanoate and, very slowly, on butanoate.
History
EC 6.2.1.13 created 1978
Pathway
Glycolysis / Gluconeogenesis
Pyruvate metabolism
Propanoate metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01905  
acetyl-CoA synthetase (ADP-forming)
Genes
BMA: 
BMV: 
BML: 
BMN: 
BMAL: 
BPS: 
BPM: 
BPL: 
BPD: 
BPSE: 
BPSM: 
BPSU: 
BPSD: 
BPZ: 
BPQ: 
BPK: 
BTE: 
BTQ: 
BTJ: 
BTZ: 
BTD: 
BOK: 
BGL: 
BGD: 
BPE: 
BPER: 
BPAR: 
BBR: 
BBM: 
BBH: 
VEI: 
DTO: 
DTI: 
TMO: 
FAA: 
DKU: 
CHY: 
MMP: 
MMP0253(acd)
MPD: 
MCP_0448(acdB)
MEZ: 
Mtc_1390(acdB) Mtc_1391(acdA)
RCI: 
RCIX1773(acdB) RCIX1774(acdA)
HLR: 
PHO: 
PAB: 
PAB0203(sucC-like) PAB1937
PFU: 
PFI: 
PYN: 
PYA: 
PYS: 
TKO: 
TON: 
TGA: 
TGAM_1201(acdA-5) TGAM_1288(acdB-2)
TSI: 
TBA: 
THE: 
THA: 
THM: 
TLT: 
THS: 
TNU: 
PPAC: 
SMR: 
SHC: 
DKA: 
DMU: 
DFD: 
TAG: 
IAG: 
THG: 
HBU: 
PFM: 
PAI: 
PIS: 
PCL: 
PAS: 
PYR: 
POG: 
TNE: 
CMA: 
TUZ: 
TTN: 
VDI: 
VMO: 
TPE: 
THB: 
FFO: 
KCR: 
 » show all
Taxonomy
Reference
1  [PMID:13076]
  Authors
Reeves RE, Warren LG, Susskind B, Lo HS.
  Title
An energy-conserving pyruvate-to-acetate pathway in Entamoeba histolytica. Pyruvate synthase and a new acetate thiokinase.
  Journal
J. Biol. Chem. 252 (1977) 726-31.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
62009-85-2

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