KEGG   ENZYME: 6.2.1.13Help
Entry
EC 6.2.1.13                 Enzyme                                 
Name acetate---CoA ligase (ADP-forming);
acetyl-CoA synthetase (ADP-forming);
acetyl coenzyme A synthetase (adenosine diphosphate-forming);
acetate thiokinase
Class Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname acetate:CoA ligase (ADP-forming)
Reaction(IUBMB) ATP + acetate + CoA = ADP + phosphate + acetyl-CoA [RN:R00229]
Reaction(KEGG) R00229;
(other) R00920
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Substrate ATP [CPD:C00002];
acetate [CPD:C00033];
CoA [CPD:C00010]
Product ADP [CPD:C00008];
phosphate [CPD:C00009];
acetyl-CoA [CPD:C00024]
Comment Also acts on propanoate and, very slowly, on butanoate.
Pathway PATH: ec00620  Pyruvate metabolism
PATH: ec00640  Propanoate metabolism
Orthology KO: K01905  acetyl-CoA synthetase (ADP-forming)
Genes BMA: BMAA0367
BMV: BMASAVP1_1554
BML: BMA10229_1742
BMN: BMA10247_A0404
BPS: BPSS2130
BPM: BURPS1710b_A1237
BPL: BURPS1106A_A2882
BPD: BURPS668_A2999
BTE: BTH_II2206
BPE: BP0661
BBR: BB4797
VEI: Veis_3495
SAT: SYN_00647 SYN_02607 SYN_02878
BBT: BBta_7760
CHY: CHY_0264
MMP: MMP0253(acd)
PFU: PF1540 PF1787
RCI: RCIX1773(acdB) RCIX1774(acdA)
Taxonomy
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:13076]
Reeves RE, Warren LG, Susskind B, Lo HS.
An energy-conserving pyruvate-to-acetate pathway in Entamoeba
histolytica. Pyruvate synthase and a new acetate thiokinase.
J. Biol. Chem. 252 (1977) 726-31.
Entamoeba histolytica [GN:ehi]
Other DBs ExplorEnz - The Enzyme Database: 6.2.1.13
IUBMB Enzyme Nomenclature: 6.2.1.13
ExPASy - ENZYME nomenclature database: 6.2.1.13
BRENDA, the Enzyme Database: 6.2.1.13
CAS: 62009-85-2
DBGET integrated database retrieval system