| Entry |
|
|---|
| Name |
6-carboxyhexanoate---CoA ligase;
6-carboxyhexanoyl-CoA synthetase;
pimelyl-CoA synthetase |
|---|
| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
 |
|---|
| Sysname |
6-carboxyhexanoate:CoA ligase (AMP-forming) |
|---|
| Reaction(IUBMB) |
ATP + 6-carboxyhexanoate + CoA = AMP + diphosphate +
6-carboxyhexanoyl-CoA [RN:R03209] |
|---|
| Reaction(KEGG) |
R03209
 |
|---|
| Substrate |
ATP [CPD:C00002];
6-carboxyhexanoate [CPD:C02656];
CoA [CPD:C00010] |
|---|
| Product |
AMP [CPD:C00020];
diphosphate [CPD:C00013];
6-carboxyhexanoyl-CoA [CPD:C01063] |
|---|
| Pathway |
PATH: ec00780 Biotin metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01906 6-carboxyhexanoate--CoA ligase |
|---|
| Genes |
REH: H16_B0928 H16_B1438
BXE: Bxe_C0568
PCA: Pcar_1666(bioW)
BJA: blr3446
BBT: BBta_5094
BSU: BSU30240(bioW)
BLI: BL02411(bioW)
BLD: BLi00766(bioW)
BAY: RBAM_018290(bioW)
SAU: SA2211
SAV: SAV2423
SAW: SAHV_2407
SAM: MW2346
SAR: SAR2513
SAS: SAS2314
SAC: SACOL2424(bioW)
SAB: SAB2304c
SAA: SAUSA300_2369
SAX: USA300HOU_2407(bioW)
SAO: SAOUHSC_02712
SAJ: SaurJH9_2449
SAH: SaurJH1_2497
SAE: NWMN_2322(bioW)
SEP: SE0182
SER: SERP2393(bioW)
CDI: DIP1381
SEN: SACE_5038
TTH: TTC1711
AAE: aq_1659(bioW)
HYA: HY04AAS1_0813
SUL: SYO3AOP1_1703
SAF: SULAZ_1395(bioW)
PMX: PERMA_1854(bioW)
TYE: THEYE_A0810(bioW)
MJA: MJ1297
MMP: MMP1575(bioW)
MMQ: MmarC5_0001
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4623286]
Izumi Y, Morita H, Sato K, Tani Y, Ogata K.
Synthesis of biotin-vitamers from pimelic acid and coenzyme A by
cell-free extracts of various bacteria.
Biochim. Biophys. Acta. 264 (1972) 210-3.
Bacillus megaterium, Bacillus sphaericus |
|---|
Reference
Authors
Title
Journal
|
2
Izumi, Y., Morita, H., Tani, Y. and Ogata, K.
The pimelyl-CoA synthetase responsible for the first step in biotin
biosynthesis by microorganisms.
Agric. Biol. Chem. 38 (1974) 2257-2262. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.2.1.14
IUBMB Enzyme Nomenclature: 6.2.1.14
ExPASy - ENZYME nomenclature database: 6.2.1.14
BRENDA, the Enzyme Database: 6.2.1.14
CAS: 55467-50-0 |
|---|
