KEGG   ENZYME: 6.2.1.2Help
Entry
EC 6.2.1.2                  Enzyme                                 

Name butyrate---CoA ligase;
butyryl-CoA synthetase;
fatty acid thiokinase (medium chain);
acyl-activating enzyme;
fatty acid elongase;
fatty acid activating enzyme;
fatty acyl coenzyme A synthetase;
medium chain acyl-CoA synthetase;
butyryl-coenzyme A synthetase;
L-(+)-3-hydroxybutyryl CoA ligase;
short-chain acyl-CoA synthetase
Class Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname butanoate:CoA ligase (AMP-forming)
Reaction(IUBMB) ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Reaction(KEGG) R00389 > R01176
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Substrate ATP [CPD:C00002];
acid [CPD:C00174];
CoA [CPD:C00010]
Product AMP [CPD:C00020];
diphosphate [CPD:C00013];
acyl-CoA [CPD:C00040]
Comment Acts on acids from C4 to C11 and on the corresponding 3-hydroxy- and
2,3- or 3,4-unsaturated acids.
Pathway PATH: ec00650  Butanoate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01896  medium-chain acyl-CoA synthetase
Genes HSA: 116285(ACSM1) 123876(ACSM2A) 341392(ACSM4) 54988(ACSM5)
     6296(ACSM3)
PTR: 451813(ACSM4) 467918(ACSM2B) 741782(ACSM5) 742192(ACSM3)
MCC: 696124 696498 722167
MMU: 117147(Acsm1) 20216(Acsm3) 233799(Acsm2) 233801(Acsm4)
     272428(Acsm5)
RNO: 246263(Acsm2) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5)
CFA: 479821 479822(ACSM2A) 608888(ACSM3) 609009(ACSM5)
BTA: 282576(ACSM1) 512227(ACSM2A) 533798(ACSM3) 785935(ACSM5)
ECB: 100057758 100068270 100068289 100068672 100068752(ACSM4)
     100147266
MDO: 100026263 100026277 100026355
OAA: 100077223 100089732
GGA: 426999(ACSM3)
TGU: 100226082 100231857
XLA: 444799
DRE: 100002035
BFO: BRAFLDRAFT_275193
HMG: 100203680
BFU: BC1G_04784
DAL: Dalk_0007
SWI: Swit_4371
HMO: HM1_0898
Taxonomy
Structures PDB: 2VZE  2WD9  3B7W  3C5E  3DAY  3EQ6  3GPC  
Reference
  Authors
  Title

  Journal
  Organism
1  [PMID:13084616]
MAHLER HR, WAKIL SJ, BOCK RM.
Studies on fatty acid oxidation. I. Enzymatic activation of fatty
acids.
J. Biol. Chem. 204 (1953) 453-68.
Bos taurus [GN:bta], Sus scofa [GN:ssc], Rattus norvegicus [GN:rno]
Reference
  Authors
  Title

  Journal
  Organism
2  [PMID:14285249]
MASSARO EJ, LENNARZ WJ.
THE PARTIAL PURIFICATION AND CHARACTERIZATION OF A BACTERIAL FATTY
ACYL COENZYME A SYNTHETASE.
Biochemistry. 4 (1965) 85-90.
Bacillus megaterium
Reference
  Authors
  Title

  Journal
  Organism
3  [PMID:14253428]
WEBSTER LT Jr, GEROWIN LD, RAKITA L.
PURIFICATION AND CHARACTERISTICS OF A BUTYRYL COENZYME A SYNTHETASE
FROM BOVINE HEART MITOCHONDRIA.
J. Biol. Chem. 240 (1965) 29-33.
Bos taurus [GN:bta]
Other DBs ExplorEnz - The Enzyme Database: 6.2.1.2
IUBMB Enzyme Nomenclature: 6.2.1.2
ExPASy - ENZYME nomenclature database: 6.2.1.2
BRENDA, the Enzyme Database: 6.2.1.2
CAS: 9080-51-7

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