KEGG   ENZYME: 6.2.1.2Help
Entry
EC 6.2.1.2                  Enzyme                                 

Name
butyrate---CoA ligase;
butyryl-CoA synthetase;
fatty acid thiokinase (medium chain);
acyl-activating enzyme;
fatty acid elongase;
fatty acid activating enzyme;
fatty acyl coenzyme A synthetase;
medium chain acyl-CoA synthetase;
butyryl-coenzyme A synthetase;
L-(+)-3-hydroxybutyryl CoA ligase;
short-chain acyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
butanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
carboxylate [CPD:C00060];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
acyl-CoA [CPD:C00040]
Comment
Acts on acids from C4 to C11 and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids.
History
EC 6.2.1.2 created 1961, modified 2011
Pathway
Butanoate metabolism
Metabolic pathways
Orthology
K01896  
medium-chain acyl-CoA synthetase
Genes
HSA: 
116285(ACSM1) 123876(ACSM2A) 341392(ACSM4) 348158(ACSM2B) 54988(ACSM5) 6296(ACSM3)
PTR: 
101058263(ACSM1) 451813(ACSM4) 467918(ACSM2B) 741782(ACSM5) 742192(ACSM3)
PPS: 
100972336(ACSM1) 100984659(ACSM5) 100992481(ACSM4) 100994660(ACSM2A) 100994985(ACSM2B) 100995253(ACSM3)
GGO: 
PON: 
100171624(ACSM3) 100442712(ACSM2B) 100444065(ACSM1) 100452655(ACSM5) 100459933(ACSM4)
NLE: 
100584025(ACSM5) 100599336(ACSM3) 100600564(ACSM1) 100601481(ACSM2B) 100604255(ACSM4) 101176597
MCC: 
696124(ACSM5) 696244(ACSM2B) 696498(ACSM1) 696622(ACSM3) 722167(ACSM4)
MCF: 
102120589(ACSM5) 102121480(ACSM2B) 102123380(ACSM1) 102126505(ACSM3) 102142462(ACSM4)
CJC: 
100385629(ACSM5) 100385986(ACSM2B) 100386695(ACSM3) 100390897(ACSM4)
MMU: 
117147(Acsm1) 20216(Acsm3) 233799(Acsm2) 233801(Acsm4) 272428(Acsm5)
RNO: 
246263(Acsm2a) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5) 361638(Acsm1)
CGE: 
HGL: 
101698533(Acsm4) 101703873(Acsm3) 101711830(Acsm5) 101712192(Acsm2a) 101712893
TUP: 
102475928(ACSM4) 102478447(ACSM3) 102480423(ACSM1) 102480846(ACSM5)
CFA: 
479821(ACSM4) 479822(ACSM2A) 608888(ACSM3) 609009(ACSM5)
AML: 
UMR: 
FCA: 
101082455(ACSM3) 101083228(ACSM4) 101083474 101092980(ACSM5)
PTG: 
102954003 102954285(ACSM5) 102957684(ACSM4) 102968571(ACSM3)
BTA: 
100298888(ACSM5) 100299006(ACSM4) 282576(ACSM1) 512227(ACSM2B) 533798(ACSM3)
BOM: 
102269733(ACSM3) 102270868(ACSM4) 102271152 102271620(ACSM2B) 102273415(ACSM5)
PHD: 
102330040(ACSM3) 102331138(ACSM4) 102331492 102332061(ACSM2B) 102332418(ACSM5)
CHX: 
102180366(ACSM5) 102181180(ACSM2B) 102182274 102183382(ACSM4) 102185052(ACSM3)
OAS: 
101112785(ACSM5) 101120131(ACSM2B) 101120375 101120794(ACSM4) 101121307(ACSM3)
SSC: 
100510957(ACSM2B) 100511318(ACSM5) 100512220(ACSM3) 100512595(ACSM4)
CFR: 
102504377(ACSM5) 102504633(ACSM2B) 102504896 102505166(ACSM4) 102505419(ACSM3)
BACU: 
LVE: 
ECB: 
MYB: 
MYD: 
PALE: 
102878400(ACSM3)
MDO: 
SHR: 
OAA: 
GGA: 
426991(ACSM4) 426992(ACSM5) 426999(ACSM3)
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
XLA: 
444799(acsm3)
XTR: 
100491087(acsm3)
DRE: 
100002035(acsm3)
LCM: 
102348417(ACSM3)
CMK: 
103188271(acsm3)
BFO: 
SPU: 
LGI: 
NVE: 
HMG: 
DAL: 
SWI: 
DKU: 
DRU: 
DGI: 
HMO: 
 » show all
Taxonomy
Reference
1  [PMID:13084616]
  Authors
MAHLER HR, WAKIL SJ, BOCK RM.
  Title
Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids.
  Journal
J. Biol. Chem. 204 (1953) 453-68.
Reference
2  [PMID:14285249]
  Authors
MASSARO EJ, LENNARZ WJ.
  Title
THE PARTIAL PURIFICATION AND CHARACTERIZATION OF A BACTERIAL FATTY ACYL COENZYME A SYNTHETASE.
  Journal
Biochemistry. 4 (1965) 85-90.
Reference
3  [PMID:14253428]
  Authors
WEBSTER LT Jr, GEROWIN LD, RAKITA L.
  Title
PURIFICATION AND CHARACTERISTICS OF A BUTYRYL COENZYME A SYNTHETASE FROM BOVINE HEART MITOCHONDRIA.
  Journal
J. Biol. Chem. 240 (1965) 29-33.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9080-51-7

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