KEGG   ENZYME: 6.2.1.2Help
Entry
EC 6.2.1.2                  Enzyme                                 
Name
butyrate---CoA ligase;
butyryl-CoA synthetase;
fatty acid thiokinase (medium chain);
acyl-activating enzyme;
fatty acid elongase;
fatty acid activating enzyme;
fatty acyl coenzyme A synthetase;
medium chain acyl-CoA synthetase;
butyryl-coenzyme A synthetase;
L-(+)-3-hydroxybutyryl CoA ligase;
short-chain acyl-CoA synthetase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
BRITE hierarchy
Sysname
butanoate:CoA ligase (AMP-forming)
Reaction(IUBMB)
ATP + a carboxylate + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
carboxylate [CPD:C00060];
CoA [CPD:C00010]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
acyl-CoA [CPD:C00040]
Comment
Acts on acids from C4 to C11 and on the corresponding 3-hydroxy- and 2,3- or 3,4-unsaturated acids.
Pathway
Butanoate metabolism
Metabolic pathways
Orthology
K01896  
medium-chain acyl-CoA synthetase
Genes
HSA: 
116285(ACSM1) 123876(ACSM2A) 341392(ACSM4) 348158(ACSM2B) 54988(ACSM5) 6296(ACSM3)
PTR: 
101058263(ACSM1) 451813(ACSM4) 467918(ACSM2B) 741782(ACSM5) 742192(ACSM3)
PPS: 
100992481(ACSM4) 100994985(ACSM2B) 100995253(ACSM3)
GGO: 
101148413(ACSM5) 101149339(ACSM4) 101149481 101151788(ACSM3)
PON: 
100171624(ACSM3) 100442712(ACSM2B) 100444065(ACSM1) 100452655(ACSM5) 100459933(ACSM4)
MCC: 
696124(ACSM5) 696244(ACSM2B) 696498(ACSM1) 696622(ACSM3) 722167(ACSM4)
MMU: 
117147(Acsm1) 20216(Acsm3) 233799(Acsm2) 233801(Acsm4) 272428(Acsm5)
RNO: 
246263(Acsm2a) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5)
CFA: 
479822(ACSM2A) 608888(ACSM3) 609009(ACSM5)
AML: 
FCA: 
101082455(ACSM3) 101083228 101083474 101092980(ACSM5)
BTA: 
100298888(ACSM5) 100299006(ACSM4) 282576(ACSM1) 512227(ACSM2A) 533798(ACSM3)
SSC: 
100510957(ACSM2B) 100511318(ACSM5) 100512220 100512595(ACSM4)
ECB: 
100057758 100068270 100068289 100068672(ACSM3) 100068752(ACSM4) 100147266(ACSM5)
MDO: 
100026263(ACSM5) 100026277(ACSM2A) 100026355 100619197
SHR: 
100927836(ACSM5) 100932504(ACSM2A) 100932766 100933025 100933288(ACSM3)
OAA: 
100076750 100077223 100089732(ACSM5)
GGA: 
426991(ACSM4) 426992(ACSM5) 426999(ACSM3)
MGP: 
100540035(ACSM3) 100540188 100540655
TGU: 
100226082 100231857
ACS: 
100561854 100562048 100563167(acsm5)
XLA: 
444799(acsm3)
XTR: 
100491087
DRE: 
100002035(acsm3)
BFO: 
BRAFLDRAFT_275193
SPU: 
100891330 756659
NVE: 
NEMVE_v1g182669
HMG: 
100203680
DAL: 
Dalk_0007
SWI: 
Swit_4371
DKU: 
Desku_1227
DRU: 
Desru_1970
HMO: 
HM1_0898
 » show all
Taxonomy
Reference
1  [PMID:13084616]
  Authors
MAHLER HR, WAKIL SJ, BOCK RM.
  Title
Studies on fatty acid oxidation. I. Enzymatic activation of fatty acids.
  Journal
J. Biol. Chem. 204 (1953) 453-68.
  Organism
Bos taurus [GN:bta], Sus scofa [GN:ssc], Rattus norvegicus [GN:rno]
Reference
2  [PMID:14285249]
  Authors
MASSARO EJ, LENNARZ WJ.
  Title
THE PARTIAL PURIFICATION AND CHARACTERIZATION OF A BACTERIAL FATTY ACYL COENZYME A SYNTHETASE.
  Journal
Biochemistry. 4 (1965) 85-90.
  Organism
Bacillus megaterium
Reference
3  [PMID:14253428]
  Authors
WEBSTER LT Jr, GEROWIN LD, RAKITA L.
  Title
PURIFICATION AND CHARACTERISTICS OF A BUTYRYL COENZYME A SYNTHETASE FROM BOVINE HEART MITOCHONDRIA.
  Journal
J. Biol. Chem. 240 (1965) 29-33.
  Organism
Bos taurus [GN:bta]
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9080-51-7
DBGET integrated database retrieval system