| Entry |
|
|---|
| Name |
butyrate---CoA ligase;
butyryl-CoA synthetase;
fatty acid thiokinase (medium chain);
acyl-activating enzyme;
fatty acid elongase;
fatty acid activating enzyme;
fatty acyl coenzyme A synthetase;
medium chain acyl-CoA synthetase;
butyryl-coenzyme A synthetase;
L-(+)-3-hydroxybutyryl CoA ligase;
short-chain acyl-CoA synthetase |
|---|
| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
 |
|---|
| Sysname |
butanoate:CoA ligase (AMP-forming) |
|---|
| Reaction(IUBMB) |
ATP + an acid + CoA = AMP + diphosphate + an acyl-CoA [RN:R00389] |
|---|
| Reaction(KEGG) |
R00389 > R01176
 |
|---|
| Substrate |
ATP [CPD:C00002];
acid [CPD:C00174];
CoA [CPD:C00010] |
|---|
| Product |
AMP [CPD:C00020];
diphosphate [CPD:C00013];
acyl-CoA [CPD:C00040] |
|---|
| Comment |
Acts on acids from C4 to C11 and on the corresponding 3-hydroxy- and
2,3- or 3,4-unsaturated acids. |
|---|
| Pathway |
PATH: ec00650 Butanoate metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01896 medium-chain acyl-CoA synthetase |
|---|
| Genes |
HSA: 116285(ACSM1) 123876(ACSM2A) 341392(ACSM4) 54988(ACSM5)
6296(ACSM3)
PTR: 451813(ACSM4) 467918(ACSM2B) 741782(ACSM5) 742192(ACSM3)
MCC: 696124 696498 722167
MMU: 117147(Acsm1) 20216(Acsm3) 233799(Acsm2) 233801(Acsm4)
272428(Acsm5)
RNO: 246263(Acsm2) 24763(Acsm3) 353317(Acsm4) 361637(Acsm5)
CFA: 479821 479822(ACSM2A) 608888(ACSM3) 609009(ACSM5)
BTA: 282576(ACSM1) 512227(ACSM2A) 533798(ACSM3) 785935(ACSM5)
ECB: 100057758 100068270 100068289 100068672 100068752(ACSM4)
100147266
MDO: 100026263 100026277 100026355
OAA: 100077223 100089732
GGA: 426999(ACSM3)
TGU: 100226082 100231857
XLA: 444799
DRE: 100002035
BFO: BRAFLDRAFT_275193
HMG: 100203680
BFU: BC1G_04784
DAL: Dalk_0007
SWI: Swit_4371
HMO: HM1_0898
 |
|---|
| Structures |
PDB: 2VZE 2WD9 3B7W 3C5E 3DAY 3EQ6 3GPC |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:13084616]
MAHLER HR, WAKIL SJ, BOCK RM.
Studies on fatty acid oxidation. I. Enzymatic activation of fatty
acids.
J. Biol. Chem. 204 (1953) 453-68.
Bos taurus [GN:bta], Sus scofa [GN:ssc], Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:14285249]
MASSARO EJ, LENNARZ WJ.
THE PARTIAL PURIFICATION AND CHARACTERIZATION OF A BACTERIAL FATTY
ACYL COENZYME A SYNTHETASE.
Biochemistry. 4 (1965) 85-90.
Bacillus megaterium |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:14253428]
WEBSTER LT Jr, GEROWIN LD, RAKITA L.
PURIFICATION AND CHARACTERISTICS OF A BUTYRYL COENZYME A SYNTHETASE
FROM BOVINE HEART MITOCHONDRIA.
J. Biol. Chem. 240 (1965) 29-33.
Bos taurus [GN:bta] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.2.1.2
IUBMB Enzyme Nomenclature: 6.2.1.2
ExPASy - ENZYME nomenclature database: 6.2.1.2
BRENDA, the Enzyme Database: 6.2.1.2
CAS: 9080-51-7 |
|---|
