| Entry |
|
|---|
| Name |
benzoate---CoA ligase;
benzoate---coenzyme A ligase;
benzoyl-coenzyme A synthetase;
benzoyl CoA synthetase (AMP forming) |
|---|
| Class |
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
 |
|---|
| Sysname |
benzoate:CoA ligase (AMP-forming) |
|---|
| Reaction(IUBMB) |
ATP + benzoate + CoA = AMP + diphosphate + benzoyl-CoA [RN:R01422] |
|---|
| Reaction(KEGG) |
R01422
 |
|---|
| Substrate |
ATP [CPD:C00002];
benzoate [CPD:C00180];
CoA [CPD:C00010] |
|---|
| Product |
AMP [CPD:C00020];
diphosphate [CPD:C00013];
benzoyl-CoA [CPD:C00512] |
|---|
| Comment |
Also acts on 2-, 3- and 4-fluorobenzoate, but only very slowly on
the corresponding chlorobenzoates. |
|---|
| Pathway |
PATH: ec00632 Benzoate degradation via CoA ligation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K04110 benzoate-CoA ligase |
|---|
| Genes |
REU: Reut_A1327
REH: H16_A1412 H16_B1918
RME: Rmet_1224
BXE: Bxe_A1419 Bxe_C0896
RFR: Rfer_0216
POL: Bpro_1624 Bpro_2983
PNA: Pnap_2948
VEI: Veis_0730
EBA: ebA2757(bclA) ebA5301(bclA)
GME: Gmet_2143
SAT: SYN_02896 SYN_02898
BBT: BBta_6637(badA)
RPA: RPA0661(badA)
RPC: RPC_1025
RPD: RPD_1534
RPE: RPE_0592 RPE_0604
SIL: SPO3697(badA-1) SPOA0401(badA-2)
SWI: Swit_0829
 |
|---|
| Structures |
PDB: 2V7B |
|---|
Reference
Authors
Title
Journal
|
1
Hutber, G.N. and Ribbons, D.W.
Involvement of coenzyme-A esters in the metabolism of benzoate and
cyclohexanecarboxylate by Rhodopseudomonas palustris.
J. Gen. Microbiol. 129 (1983) 2413-2420. |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:2857161]
Schennen U, Braun K, Knackmuss HJ.
Anaerobic degradation of 2-fluorobenzoate by benzoate-degrading,
denitrifying bacteria.
J. Bacteriol. 161 (1985) 321-5.
Pseudomonas sp. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.2.1.25
IUBMB Enzyme Nomenclature: 6.2.1.25
ExPASy - ENZYME nomenclature database: 6.2.1.25
UM-BBD (Biocatalysis/Biodegradation Database): 6.2.1.25
BRENDA, the Enzyme Database: 6.2.1.25
CAS: 95329-17-2 |
|---|
