| Entry |
|
|---|
| Name |
adenosylcobinamide-phosphate synthase;
CbiB |
|---|
| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
 |
|---|
| Sysname |
adenosylcobyric acid:(R)-1-aminopropan-2-yl phosphate ligase
(ADP-forming) |
|---|
| Reaction(IUBMB) |
(1) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate =
ADP + phosphate + adenosylcobinamide phosphate [RN:R06529];
(2) ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP +
phosphate + adenosylcobinamide [RN:R07302] |
|---|
| Reaction(KEGG) |
R06529 R07302
 |
|---|
| Substrate |
ATP [CPD:C00002];
adenosylcobyric acid [CPD:C06507];
(R)-1-aminopropan-2-yl phosphate [CPD:C04122];
(R)-1-aminopropan-2-ol [CPD:C03194] |
|---|
| Product |
ADP [CPD:C00008];
phosphate [CPD:C00009];
adenosylcobinamide phosphate;
adenosylcobinamide |
|---|
| Comment |
One of the substrates for this reaction, (R)-1-aminopropan-2-yl
phosphate, is produced by CobD (EC 4.1.1.81, threonine-phosphate
decarboxylase). |
|---|
| Pathway |
PATH: ec00860 Porphyrin and chlorophyll metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K02227 adenosylcobinamide-phosphate synthase CobD |
|---|
| Genes |
STY: STY2239(cobD)
STT: t0839(cobD)
SPT: SPA0837(cobD)
SEK: SSPA0782(cobD)
SPQ: SPAB_01071(cobD)
SEI: SPC_1681(cobD)
SEC: SC2042(cobD)
SEH: SeHA_C2256(cobD)
SEE: SNSL254_A2210(cobD)
SEW: SeSA_A2203(cobD)
SEA: SeAg_B2156(cobD)
SED: SeD_A2369(cobD)
SEG: SG2060(cobD)
SET: SEN2032(cobD)
SES: SARI_00854(cobD)
STM: STM2034(cobD)
YEN: YE2724(cobD)
PLU: plu2998(cobD)
PAY: PAU_01602(cobD)
KPN: KPN_03199(cobD)
KPE: KPK_0917(cobD)
KPU: KP1_4465
CKO: CKO_00804(cobD)
EIC: NT01EI_2192
ETR: ETAE_2003(cbiB)
XCC: XCC3062(cobD)
XCB: XC_1096(cobD)
XCA: xccb100_1132(cobD)
XCV: XCV3319(cobD)
XAC: XAC3190(cobD)
VCH: VC2380
VCO: VC0395_A1958
VCM: VCM66_2303
VCJ: VCD_001971
VVU: VV1_0559
VVY: VV0634
VPA: VP0478
VHA: VIBHAR_00922
VSP: VS_0467 VS_2669
VEX: VEA_004472
VFI: VF_2129
VFM: VFMJ11_2237
VSA: VSAL_I2566
PPR: PBPRA0537
PAE: PA1275(cobD)
PAU: PA14_47730(cobD)
PAP: PSPA7_4115(cobD)
PAG: PLES_40371(cobD)
PPU: PP_1675(cobD)
PPF: Pput_4044(cobD)
PPG: PputGB1_1274(cobD)
PPW: PputW619_1234(cobD)
PST: PSPTO_1711(cobD)
PSB: Psyr_3678(cobD)
PSP: PSPPH_3699(cobD)
PFL: PFL_4428(cobD)
PFO: Pfl01_1644(cobD)
PFS: PFLU4488
PEN: PSEEN1381(cobD)
PMY: Pmen_1753(cobD)
PSA: PST_1295(cobD)
CJA: CJA_3769(cobD)
AVN: Avin_33100(cobD)
SON: SO_1321
SDN: Sden_2802
SFR: Sfri_2967
SAZ: Sama_0854
SBM: Shew185_1219
SBN: Sbal195_1252
SBP: Sbal223_3138
SLO: Shew_1026
SPC: Sputcn32_1133
SSE: Ssed_1114 Ssed_2089
SPL: Spea_1000
SHE: Shewmr4_2875
SHM: Shewmr7_2957
SHN: Shewana3_3053
SHW: Sputw3181_3031
SHL: Shal_1050
SWD: Swoo_1216
SWP: swp_3831
CPS: CPS_1143 CPS_4742
PHA: PSHAa0546
PAT: Patl_0517 Patl_1131
MAQ: Maqu_0271(cobD)
AMC: MADE_01626
TTU: TERTU_3323(cobD)
MCA: MCA2287(cobD)
AEH: Mlg_2818
HHA: Hhal_1857
HCH: HCH_06462(cobD)
ABO: ABO_2377(cobD)
MMW: Mmwyl1_3677
ASA: ASA_2654(cbiB)
TAU: Tola_1680
CVI: CV_1002 CV_1575(cobD)
LHK: LHK_02548
RSO: RSc0938(cobD) RSc2392(cobD)
RPI: Rpic_0809 Rpic_2658(cobD)
RPF: Rpic12D_0880 Rpic12D_2200
REU: Reut_A0663(cobD) Reut_A0903
REH: H16_A2713 H16_A2963(cobD)
RME: Rmet_2578 Rmet_2780(cobD)
CTI: RALTA_A2204 RALTA_A2437(cobD)
BMA: BMA0396 BMA0695(cobD)
BMV: BMASAVP1_A2318(cobD) BMASAVP1_A2539
BML: BMA10229_A0912 BMA10229_A2969(cobD)
BMN: BMA10247_0235 BMA10247_1630(cobD)
BPS: BPSL0985(cobD) BPSL2485
BPM: BURPS1710b_1198(cobD) BURPS1710b_2962(cobD)
BPL: BURPS1106A_1043(cobD) BURPS1106A_2912
BPD: BURPS668_1037(cobD) BURPS668_2852
BPR: GBP346_A1036(cobD) GBP346_A3032
BTE: BTH_I0842(cobD) BTH_I1666
BVI: Bcep1808_0994 Bcep1808_2532(cobD)
BUR: Bcep18194_A4188 Bcep18194_A5779(cobD)
BCN: Bcen_1837(cobD)
BCH: Bcen2424_1074 Bcen2424_2448(cobD)
BCM: Bcenmc03_1033 Bcenmc03_2453(cobD)
BCJ: BCAL2658(cobD) BCAL2923
BAM: Bamb_2496(cobD)
BAC: BamMC406_0954 BamMC406_2364(cobD)
BMU: Bmul_0846(cobD) Bmul_2229
BMJ: BMULJ_01010(cobD) BMULJ_02412(cobD)
BXE: Bxe_A1011 Bxe_A3494(cobD)
BPH: Bphy_0774 Bphy_2205(cobD)
BPY: Bphyt_1003(cobD) Bphyt_2972
BGL: bglu_1g09080 bglu_1g28140
PNE: Pnec_1279
RFR: Rfer_1407 Rfer_2616
POL: Bpro_1695 Bpro_2762
PNA: Pnap_1466 Pnap_2148
AAV: Aave_1545 Aave_1889
AJS: Ajs_3180 Ajs_3350
VEI: Veis_0320
DAC: Daci_2804 Daci_5340
DIA: Dtpsy_2533 Dtpsy_2698
VAP: Vapar_1478 Vapar_2555
CTT: CtCNB1_0902 CtCNB1_1850
MPT: Mpe_A1109 Mpe_B0516(cbiB)
HAR: HEAR0628 HEAR0967
MMS: mma_0596(cobD1) mma_1098(cobD2)
LCH: Lcho_0686
NMU: Nmul_A1994
EBA: ebA2136(cobD) ebA5199(cbiB)
AZO: azo3518(cobD)
DAR: Daro_0140(cobD) Daro_3023
TBD: Tbd_1044 Tbd_2716(cobD)
MFA: Mfla_0102(cobD) Mfla_2432
MMB: Mmol_0268
MEI: Msip34_0141 Msip34_2603
APP: CAP2UW1_1383
GSU: GSU2990(cobD)
GME: Gmet_0486
GUR: Gura_0042
GLO: Glov_3553
GBM: Gbem_3538
GEO: Geob_0039
GEM: GM21_3604
PCA: Pcar_0483
PPD: Ppro_0870
DVU: DVU2237
DVL: Dvul_1005
DVM: DvMF_0833
DDE: Dde_1529
DDS: Ddes_2140
DMA: DMR_17050(cobD)
DSA: Desal_1613
DBA: Dbac_2886
DPS: DP1949
DOL: Dole_1233
DAL: Dalk_0457
DAT: HRM2_45650(cbiB)
SCL: sce0211(cobD)
SFU: Sfum_1738
MLO: mlr1304
SME: SMc04279(cobD)
SMD: Smed_1743(cobD)
ATU: Atu2809(cobD)
ATC: AGR_C_5095(cobD)
ARA: Arad_2783(cobD)
AVI: Avi_2621(cobD)
RET: RHE_CH02481(cobD)
REC: RHECIAT_CH0002584(cobD)
RLE: RL2821(cobD)
RLT: Rleg2_2121(cobD)
RLG: Rleg_2363
RHI: NGR_c18120(cobD)
BME: BMEI0707(cobD)
BMF: BAB1_1314(cobD)
BMB: BruAb1_1295(cobD)
BMC: BAbS19_I12270(cobD)
BMS: BR1294(cobD)
BMT: BSUIS_A1344(cobD)
BOV: BOV_1256(cobD)
BCS: BCAN_A1317(cobD)
BMR: BMI_I1307(cobD)
OAN: Oant_1891(cobD)
BJA: blr3257(cobD)
BRA: BRADO4914
BBT: BBta_3137
RPA: RPA0719(cobD)
RPB: RPB_0735
RPC: RPC_3744
RPD: RPD_0633
RPE: RPE_2239
RPT: Rpal_0790
XAU: Xaut_3779
AZC: AZC_2259
MEX: Mext_4724
MEA: Mex_1p5175(cobD)
MDI: METDI5777(cobD)
MRD: Mrad2831_1475
MET: M446_4869
MPO: Mpop_5263
MCH: Mchl_5191 Mchl_5724
MNO: Mnod_1854
BID: Bind_0388
MSL: Msil_3273
HCI: HCDSEM_015(cobD)
CAK: Caul_2741
SIL: SPO3225(cobD)
SIT: TM1040_2585(cobD)
RSP: RSP_0430(cobD)
RSH: Rsph17029_2087
RSQ: Rsph17025_2355
RSK: RSKD131_1766
JAN: Jann_0370(cobD)
RDE: RD1_1330(cobD)
PDE: Pden_3631
DSH: Dshi_0165(cobD)
HNE: HNE_1519(cobD)
HBA: Hbal_2160
NAR: Saro_0324
GBE: GbCGDNIH1_0653
GDI: GDI_0655(cobD)
GDJ: Gdia_1351
APT: APA01_22450(cobD)
RRU: Rru_A3382
RCE: RC1_0322(cobD) RC1_2367(cobD)
MAG: amb0293
MGM: Mmc1_1424
BHA: BH1588(cobD)
GKA: GK2263(cobD)
GTN: GTNG_2196(cobD)
GWC: GWCH70_2209
GYM: GYMC10_5188
GYC: GYMC61_0419
AFL: Aflv_1044(cobD)
LMO: lmo1192(cobD)
LMF: LMOf2365_1201(cobD)
LMH: LMHCC_1459(cobD)
LMC: Lm4b_01196
LIN: lin1155(cobD)
LWE: lwe1149(cobD)
LSP: Bsph_2442(cobD)
BBE: BBR47_12440(cbiB)
PJD: Pjdr2_3350
SSA: SSA_0464
LRE: Lreu_1721
LRF: LAR_1609
CAC: CAC0582(cobD)
CPE: CPE1039(cobD)
CPF: CPF_1294(cobD)
CPR: CPR_1113(cobD)
CTC: CTC00721(cobD)
CNO: NT01CX_2082(cobD)
CTH: Cthe_3150
CDF: CD3433(cbiB)
CDC: CD196_3209(cbiB)
CDL: CDR20291_3255(cbiB)
CBO: CBO0915(cobD)
CBA: CLB_0955(cobD)
CBH: CLC_0969(cobD)
CBY: CLM_1062(cobD)
CBL: CLK_0352(cobD)
CBK: CLL_A2919(cobD)
CBB: CLD_3645(cobD)
CBI: CLJ_B0965(cobD)
CBT: CLH_2662(cobD)
CBF: CLI_1001(cobD)
CBE: Cbei_1268(cobD)
CKL: CKL_2910(cobD)
CKR: CKR_2580
CPY: Cphy_1110
CCE: Ccel_1286
AMT: Amet_3615
AOE: Clos_2212
STH: STH1927
VPR: Vpar_0907
DSY: DSY4061(cobD)
DHD: Dhaf_1305
DRM: Dred_2704
DAE: Dtox_3092
PTH: PTH_1312(cbiB)
DAU: Daud_1847
HMO: HM1_2398(cbiB)
EEL: EUBELI_20175
ERE: EUBREC_1920
TTE: TTE0377(cbiB)
TEX: Teth514_0301
TPD: Teth39_1899
CHY: CHY_0770(cobD)
MTA: Moth_1099
ADG: Adeg_1468
NTH: Nther_0940
MTU: Rv2236c(cobD)
MTC: MT2295(cobD)
MRA: MRA_2255(cobD)
MTF: TBFG_12265(cobD)
MTB: TBMG_01744(TBMG_01744.1)
MBO: Mb2260c(cobD)
MBB: BCG_2253c(cobD)
MBT: JTY_2247(cobD)
MPA: MAP1987c(cobD)
MAV: MAV_2205(cobD)
MSM: MSMEG_4310(cobD)
MUL: MUL_1317(cobD)
MVA: Mvan_3624(cobD)
MGI: Mflv_2886(cobD)
MAB: MAB_1898
MMC: Mmcs_3349(cobD)
MJL: Mjls_3360(cobD)
MMI: MMAR_3311(cobD)
CEF: CE2140
CDI: DIP1685
CKP: ckrop_0678(cobD)
NFA: nfa16270(cobD)
RHA: RHA1_ro01188(cobD)
RER: RER_36650(cobD)
ROP: ROP_09130(cobD)
GBR: Gbro_3102
SCO: SCO1847(cobD)
SMA: SAV_6417(cobD)
SGR: SGR_5645(cobD)
PAC: PPA0418
NCA: Noca_2885
TFU: Tfu_2224(cobD)
TCU: Tcur_1287
SRO: Sros_7401
FRA: Francci3_2604(cobD)
FRE: Franean1_4864(cobD)
FAL: FRAAL2886(cobD)
NML: Namu_0174
SEN: SACE_1574(cobD)
SVI: Svir_06900 Svir_17720
AMI: Amir_0872
STP: Strop_3555(cobD)
SAQ: Sare_3929(cobD)
CAI: Caci_6127
RXY: Rxyl_0649
AFO: Afer_0538
SHI: Shel_21170
TDE: TDE2389(cobD)
LIL: LB150(cobD)
LIC: LIC20120(cobD)
LBJ: LBJ_4192(cobD)
LBL: LBL_4207(cobD)
BHY: BHWA1_01354(cbiB)
BFR: BF2489
BFS: BF2522
BVU: BVU_3117
PGI: PG1159(cbiB)
PGN: PGN_1258
PDI: BDI_3959
DFE: Dfer_5371
CPI: Cpin_4469
FNU: FN0975
LBA: Lebu_0042
STR: Sterm_1019
AMU: Amuc_1682
GAU: GAU_0492(cobD)
TAI: Taci_0555
SYN: slr1925(cobD)
SYW: SYNW1651(cobD)
SYC: syc0115_d(cobD)
SYF: Synpcc7942_1441(cobD)
SYD: Syncc9605_0838
SYE: Syncc9902_1551
SYG: sync_0724(cobD-1)
SYR: SynRCC307_0593(cobD)
SYX: SynWH7803_1766(cobD)
CYA: CYA_0424(cobD-1)
CYB: CYB_2498(cobD-2)
TEL: tlr2377(cobD)
MAR: MAE_35170(cobD)
CYT: cce_0450(cbiB)
CYP: PCC8801_3805
CYC: PCC7424_1441
CYN: Cyan7425_0418
CYH: Cyan8802_3857
GVI: gvip340(cobD)
ANA: alr2082(cobD)
NPU: Npun_F2898(cobD)
AVA: Ava_3127(cobD)
PMA: Pro1390(cbiB)
PMM: PMM1316(cobD)
PMT: PMT0312(cobD)
PMN: PMN2A_0882
PMI: PMT9312_1413
PMB: A9601_15151(cbiB)
PMC: P9515_14771(cbiB)
PMF: P9303_20061(cbiB)
PMG: P9301_15021(cbiB)
PMH: P9215_15451(cbiB)
PMJ: P9211_13641(cbiB)
PME: NATL1_17371(cbiB)
TER: Tery_1861(cobD)
AMR: AM1_3326(cbiB)
CTE: CT0940(cobD)
CPC: Cpar_1179(cobD)
CCH: Cag_0757(cobD)
CPH: Cpha266_1119(cobD)
CPB: Cphamn1_1514(cobD)
CLI: Clim_1068(cobD)
PVI: Cvib_0816(cobD)
PLT: Plut_1138(cobD)
PPH: Ppha_1266(cobD)
PAA: Paes_1267(cobD)
CTS: Ctha_1273
DET: DET0654(cobD-2) DET0688(cobD-3) DET1138(cobD-4)
DEH: cbdb_A1067(cobD) cbdb_A638(cbiB)
DEB: DehaBAV1_0624 DehaBAV1_0967
DEV: DhcVS_592(cbiB) DhcVS_956(cobD)
RRS: RoseRS_0564
RCA: Rcas_0645
CAU: Caur_2573
CAG: Cagg_1272
CHL: Chy400_2782
HAU: Haur_1057
DRA: DR_B0010
DGE: Dgeo_2348
DDR: Deide_2p01700(cobD)
TTH: TT_P0019(cbiB)
TTJ: TTHB062
TLE: Tlet_1240
TME: Tmel_0859
TAF: THA_1041(cobD)
FNO: Fnod_1370
TYE: THEYE_A1176(cobD)
MJA: MJ1314(cobD)
MFE: Mefer_1420
MVU: Metvu_1201
MMP: MMP0951(cobD)
MMQ: MmarC5_0758(cobD)
MMX: MmarC6_1704(cobD)
MMZ: MmarC7_0198(cobD)
MAE: Maeo_0706(cobD)
MVN: Mevan_0238(cobD)
MAC: MA0941(cobD)
MBA: Mbar_A3454
MMA: MM_2059
MBU: Mbur_2090
MTP: Mthe_0295
MHU: Mhun_2321
MLA: Mlab_0061
MEM: Memar_0008
MBN: Mboo_0007
MPL: Mpal_2229
MPD: MCP_1953(cobD)
MTH: MTH1409(cobD)
MST: Msp_1588(cobD)
MSI: Msm_1266(cobD)
MKA: MK1516(cbiB)
AFU: AF1336(cobD)
HAL: VNG1578H
HSL: OE3253F(cbiB)
HMA: rrnAC1930
HWA: HQ1411A(cbiB)
NPH: NP5308A(cbiB)
HLA: Hlac_0232
HUT: Huta_2495
HMU: Hmuk_0144
TAC: Ta0076(cobD)
TVO: TVN0030(cobD)
PTO: PTO0811(cobD)
PHO: PH0376(cobD)
PAB: PAB0025(cobD)
PFU: PF0296(cobD)
TKO: TK0863(cobD)
TON: TON_0679(cobD)
TGA: TGAM_0544(cobD)
RCI: RCIX2654(cbiB)
APE: APE_2039.1(cobD)
SSO: SSO3235(cbiB)
STO: ST2342
SAI: Saci_0411(cobD)
SIS: LS215_2294
SIA: M1425_2131
SIM: M1627_2211
SID: M164_2135
SIY: YG5714_2258
SIN: YN1551_0658
MSE: Msed_0197
PAI: PAE0381
PIS: Pisl_1371
PCL: Pcal_1539(cobD)
CMA: Cmaq_0722(cobD)
TNE: Tneu_0282
NMR: Nmar_1583
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11939774]
Cheong CG, Bauer CB, Brushaber KR, Escalante-Semerena JC, Rayment I.
Three-dimensional structure of the L-threonine-O-3-phosphate
decarboxylase (CobD) enzyme from Salmonella enterica.
Biochemistry. 41 (2002) 4798-808.
Salmonella enterica |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:12195810]
Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC.
The biosynthesis of adenosylcobalamin (vitamin B12).
Nat. Prod. Rep. 19 (2002) 390-412.
Salmonella enterica |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.3.1.10
IUBMB Enzyme Nomenclature: 6.3.1.10
ExPASy - ENZYME nomenclature database: 6.3.1.10
BRENDA, the Enzyme Database: 6.3.1.10
CAS: 905988-16-1 |
|---|
