KEGG   ENZYME: 6.3.1.5Help
Entry
EC 6.3.1.5                  Enzyme                                 
Name NAD+ synthase;
NAD synthetase;
NAD synthase;
nicotinamide adenine dinucleotide synthetase;
diphosphopyridine nucleotide synthetase
Class Ligases;
Forming carbon-nitrogen bonds;
Acid-D-ammonia (or amine) ligases (amide synthases)
BRITE hierarchy
Sysname deamido-NAD+:ammonia ligase (AMP-forming)
Reaction(IUBMB) ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+ [RN:R00189]
Reaction(KEGG) R00189
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Substrate ATP [CPD:C00002];
deamido-NAD+ [CPD:C00857];
NH3 [CPD:C00014]
Product AMP [CPD:C00020];
diphosphate [CPD:C00013];
NAD+ [CPD:C00003]
Comment L-Glutamine also acts, more slowly, as amido-donor [cf. EC 6.3.5.1].
Pathway PATH: ec00760  Nicotinate and nicotinamide metabolism
PATH: ec00910  Nitrogen metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01916  NAD+ synthase
Genes ECO: b1740(nadE)
ECJ: JW1729(nadE)
EBW: BWG_1553(nadE)
ECE: Z2770(nadE)
ECS: ECs2446(nadE)
ECF: ECH74115_2458(nadE)
ECC: c2139(nadE)
ECI: UTI89_C1934(nadE)
ECP: ECP_1686(nadE)
ECV: APECO1_809(nadE)
ECW: EcE24377A_1961(nadE)
ECX: EcHS_A1822(nadE)
ECM: EcSMS35_1451(nadE)
EBL: B21_01697(nadE)
EBD: ECBD_1905
EBR: ECB_01709(nadE)
STY: STY1803(nadE)
STT: t1189(nadE)
SPT: SPA1534(nadE)
SPQ: SPAB_02031(nadE)
SEI: SPC_2420(nadE)
SEC: SC1331(nadE)
SEH: SeHA_C1439(nadE)
SEE: SNSL254_A1424(nadE)
SEW: SeSA_A1407(nadE)
SEA: SeAg_B1861(nadE)
SED: SeD_A2034(nadE)
STM: STM1310(nadE)
SFL: SF1486(nadE)
SFX: S1603(nadE)
SFV: SFV_1480(nadE)
SSN: SSON_1418(nadE)
SBO: SBO_1350(nadE)
SBC: SbBS512_E1984(nadE)
SDY: SDY_1540(nadE)
ECA: ECA2412(nadE)
PCT: PC1_1898
ETA: ETA_18510(nadE)
PLU: plu3310(nadE)
BUC: BU174(nadE)
BAS: BUsg168(nadE)
WBR: WGLp342(nadE)
SGL: SG1866(nadE)
ENT: Ent638_1704(nadE)
ESA: ESA_02148(nadE)
KPN: KPN_01228(nadE)
KPE: KPK_3214(nadE)
KPU: KP1_2260(nadE)
CKO: CKO_01765(nadE)
DDA: Dd703_2044
DZE: Dd1591_1960
MSU: MS1888(nadE)
ASU: Asuc_0640
XCC: XCC3091(nadE)
XCB: XC_1067(nadE)
XAC: XAC3220(nadE)
XOO: XOO1595(nadE)
XOM: XOO_1479(nadE)
VCH: VCA0207(nadE)
VCO: VC0395_1021(nadE)
VVU: VV2_1599(nadE)
VVY: VVA0410(nadE)
VPA: VPA0412(nadE)
VFI: VF_A0602(nadE)
VFM: VFMJ11_A0612(nadE)
PPR: PBPRB0911(nadE)
PAE: PA4920(nadE)
PAU: PA14_64980(nadE)
PPU: PP_4869(nadE)
PPF: Pput_4747(nadE)
PST: PSPTO_4922(nadE)
PSB: Psyr_0594(nadE)
PSP: PSPPH_0587(nadE)
PFL: PFL_0593(nadE) PFL_2468(nadE)
PFO: Pfl01_0547(nadE)
PEN: PSEEN4920(nadE)
PMY: Pmen_1410(nadE)
PSA: PST_1831(nadE)
SON: SO_2021(nadE)
SDN: Sden_1432(nadE)
SFR: Sfri_1542(nadE)
SAZ: Sama_1552(nadE)
SBL: Sbal_2543(nadE)
SLO: Shew_1464(nadE)
SPC: Sputcn32_2294(nadE)
SSE: Ssed_1802(nadE) Ssed_2324
SPL: Spea_1758(nadE)
SHE: Shewmr4_2246(nadE)
SHM: Shewmr7_2318(nadE)
SHN: Shewana3_2438(nadE)
SHW: Sputw3181_1714(nadE)
ILO: IL1186(nadE)
CPS: CPS_3918(nadE)
PHA: PSHAa0075(nadE)
PAT: Patl_3163(nadE)
PIN: Ping_3205(nadE)
FTU: FTT_1259(nadE)
FTF: FTF1259(nadE)
FTW: FTW_0685(nadE)
FTL: FTL_0685
FTH: FTH_0687(nadE)
FTA: FTA_0724(nadE)
FTM: FTM_1107(nadE)
FTN: FTN_1278(nadE)
FPH: Fphi_1406
TGR: Tgr7_2382
DNO: DNO_0197(nadE)
BCI: BCI_0288(nadE)
NMA: NMA1576
NME: NMB1364
NMC: NMC1299(nadE)
NMN: NMCC_1275(nadE)
NMI: NMO_1200(nadE)
NGO: NGO0654
NGK: NGK_1255
BMA: BMAA0760(nadE)
BMV: BMASAVP1_0588(nadE)
BML: BMA10229_0698(nadE)
BMN: BMA10247_A1653(nadE)
BPS: BPSS1482(nadE)
BPM: BURPS1710b_A0515(nadE)
BPL: BURPS1106A_A2006(nadE)
BPD: BURPS668_A2101(nadE)
BTE: BTH_II0886(nadE)
BVI: Bcep1808_3530(nadE)
BUR: Bcep18194_B0372(nadE)
BCN: Bcen_3089(nadE)
BCH: Bcen2424_5278(nadE)
BAM: Bamb_4638(nadE)
BXE: Bxe_B1989(nadE) Bxe_C0163(nadE)
AAV: Aave_0975
DAR: Daro_1290(nadE)
MFA: Mfla_1886
HPY: HP0329
HPJ: jhp0312(nadE)
HPA: HPAG1_0333
HPS: HPSH_01710
HPG: HPG27_311
HPP: HPP12_0327(nadE)
HHE: HH1008(nadE)
HAC: Hac_0991(nadE)
WSU: WS0206(nadE)
TDN: Suden_0851
CJE: Cj0810(nadE)
CJR: CJE0901(nadE)
CJJ: CJJ81176_0831(nadE)
CJU: C8J_0761(nadE)
CJD: JJD26997_1200(nadE)
CFF: CFF8240_1078(nadE)
CCV: CCV52592_0125(nadE)
CHA: CHAB381_1025(nadE)
CLA: Cla_0900(nadE)
ABU: Abu_1250(nadE)
NAM: NAMH_0616(nadE)
GSU: GSU0652(nadE)
GME: Gmet_2862(nadE)
GUR: Gura_3754(nadE)
GLO: Glov_2228
GBM: Gbem_1083(nadE) Gbem_3421
GEO: Geob_1496 Geob_2949
GEM: GM21_3482
PPD: Ppro_2868(nadE)
DDE: Dde_2091
DOL: Dole_0568
ADE: Adeh_2788(nadE)
ACP: A2cp1_2957
AFW: Anae109_1248(nadE)
ANK: AnaeK_2865(nadE)
NSE: NSE_0097(nadE)
PUB: SAR11_1149(nadE)
MLO: mll0818(nadE) mll6744(nadE)
MES: Meso_1463(nadE) Meso_2881(nadE)
SME: SM_b20649(nadE) SMc00161(nadE)
SMD: Smed_4337(nadE)
RET: RHE_CH01195(nadE)
RLE: RL1332(nadE)
BMF: BAB1_1033(nadE)
BMB: BruAb1_1020(nadE)
BMS: BR1015(nadE)
BOV: BOV_0981(nadE)
BJA: blr3780(nadE)
BBT: BBta_3495
RPA: RPA1986(nadE)
RPB: RPB_3381(nadE)
RPC: RPC_2082(nadE)
RPD: RPD_2060(nadE)
RPE: RPE_0579(nadE) RPE_1993(nadE)
NWI: Nwi_1225(nadE)
NHA: Nham_1485(nadE)
BHE: BH06450(nadE)
BQU: BQ06780(nadE)
SIT: TM1040_2278(nadE)
RSP: RSP_2333(nadE)
RSH: Rsph17029_1008(nadE)
RSQ: Rsph17025_1593(nadE)
JAN: Jann_3346(nadE)
PDE: Pden_0853(nadE)
DSH: Dshi_0601(nadE)
MMR: Mmar10_0982
ZMO: ZMO0899
NAR: Saro_0970(nadE)
SAL: Sala_2943(nadE)
ACR: Acry_1986(nadE)
RRU: Rru_A0687(nadE)
BSU: BSU03130(nadE)
BHA: BH2285(nadE)
BAN: BA1998(nadE)
BAR: GBAA1998(nadE)
BAA: BA_2498
BAT: BAS1855(nadE)
BCE: BC1994(nadE)
BCA: BCE_2075(nadE)
BCZ: BCZK1810(nadE)
BCR: BCAH187_A2095(nadE)
BCB: BCB4264_A2000(nadE)
BCU: BCAH820_2031(nadE)
BTK: BT9727_1826(nadE)
BTL: BALH_1767(nadE)
BLI: BL01706(nadE)
BLD: BLi00370(nadE)
BCL: ABC2151(nadE)
OIH: OB0387(nadE)
GKA: GK2596
GTN: GTNG_2526
GWC: GWCH70_2526
AFL: Aflv_0707(nadE)
SAU: SA1728(nadE)
SAV: SAV1912(nadE)
SAM: MW1853(nadE)
SAR: SAR2005(nadE)
SAS: SAS1836(nadE)
SAC: SACOL1974(nadE)
SAB: SAB1849c(nadE)
SAA: SAUSA300_1893(nadE)
SAX: USA300HOU_1914(nadE)
SAO: SAOUHSC_02132(nadE)
SAJ: SaurJH9_1968(nadE)
SAH: SaurJH1_2002(nadE)
SAE: NWMN_1850(nadE)
SEP: SE1596(nadE)
SER: SERP1449(nadE)
SHA: SH1040(nadE)
SSP: SSP0879(nadE)
LMO: lmo1093(nadE)
LMF: LMOf2365_1107(nadE)
LMH: LMHCC_1540(nadE)
LIN: lin1078(nadE)
LWE: lwe1068(nadE)
LSP: Bsph_0188(nadE)
ESI: Exig_2023(nadE)
AAC: Aaci_2118
LLA: L0203(nadE)
LLC: LACR_1204(nadE)
LLM: llmg_1470(nadE)
SPY: SPy_1652(nadE)
SPZ: M5005_Spy_1357(nadE)
SPM: spyM18_1663(nadE)
SPG: SpyM3_1392(nadE)
SPS: SPs0470(nadE)
SPH: MGAS10270_Spy1474(nadE)
SPI: MGAS10750_Spy1466(nadE)
SPJ: MGAS2096_Spy1379(nadE)
SPK: MGAS9429_Spy1353(nadE)
SPF: SpyM50434(nadE)
SPA: M6_Spy1403(nadE)
SPB: M28_Spy1398(nadE)
SOZ: Spy49_1281c(nadE)
SPN: SP_1420(nadE)
SPD: SPD_1250(nadE)
SPR: spr1276(nadE)
SPW: SPCG_1407(nadE)
SPX: SPG_1360(nadE)
SPV: SPH_1550(nadE)
SPP: SPP_1438(nadE)
SNT: SPT_0854(nadE)
SAG: SAG0296(nadE)
SAN: gbs0286(nadE)
SAK: SAK_0368(nadE)
SMU: SMU.465(nadE)
STC: str0227(nadE)
STL: stu0227(nadE)
STE: STER_0274(nadE)
SSA: SSA_1863(nadE)
SSU: SSU05_1673(nadE)
SSV: SSU98_1684(nadE)
SGO: SGO_0583(nadE)
SEZ: Sez_1573(nadE)
LPL: lp_0566(nadE)
LJO: LJ1733(nadE)
LAC: LBA0522(nadE)
LSA: LSA1569(nadE)
LSL: LSL_1260(nadE)
LDB: Ldb0455(nadE)
LBU: LBUL_0405(nadE)
LBR: LVIS_0544(nadE)
LCA: LSEI_1804(nadE)
LCB: LCABL_20240(nadE)
LGA: LGAS_1527(nadE)
LRE: Lreu_0285(nadE)
PPE: PEPE_1524(nadE)
EFA: EF2625(nadE)
OOE: OEOE_0008(nadE)
LME: LEUM_1541(nadE)
CDF: CD0794(nadE)
AMT: Amet_2234
AOE: Clos_1779
SWO: Swol_1437
DSY: DSY0788(nadE)
DHD: Dhaf_0798
DRM: Dred_1657
DAU: Daud_1366
FMA: FMG_0894
CHY: CHY_1526(nadE)
CPO: COPRO5265_0809(nadE)
NTH: Nther_1801
HOR: Hore_19030
MGE: MG_383
MPN: MPN562(outB)
MPU: MYPU_6230(nadE)
MPE: MYPE1940(nadE)
MMY: MSC_0440(nadE)
MMO: MMOB1920(nadE)
MHY: mhp471(nadE)
MHJ: MHJ_0470(nadE)
MHP: MHP7448_0473(nadE)
MCP: MCAP_0531
MAA: MAG_6600(nadE)
MAT: MARTH_orf282(nadE)
MCO: MCJ_006050(nadE)
UUR: UU460(nadE)
UPA: UPA3_0479(nadE)
UUE: UUR10_0504(nadE)
MFL: Mfl521
MAB: MAB_3419(nadE)
CGL: NCgl2446(nadE)
CGB: cg2792(nadE)
CGT: cgR_2441(nadE)
CEF: CE2428(nadE)
CDI: DIP1873(nadE)
CJK: jk0474(nadE)
NFA: nfa43120(nadE)
RHA: RHA1_ro06432(nadE)
SCO: SCO0506(nadE)
TWH: TWT405(nadE)
TWS: TW365(nadE)
LXX: Lxx12860(nadE)
CMI: CMM_1443(nadE)
CMS: CMS_1539(nadE)
ART: Arth_0494(nadE)
AAU: AAur_0519(nadE)
RSA: RSal33209_3070(nadE)
KRH: KRH_01690(nadE)
ABA: Acid345_2524
SUS: Acid_0621 Acid_7496
GFO: GFO_2783(nadE)
FJO: Fjoh_1792
FPS: FP2070(nadE)
FBA: FIC_01788
COC: Coch_0918
FNU: FN1202(nadE)
LBA: Lebu_1784
SYN: slr1691(nadE)
SYC: syc1399_d(nadE)
SYF: Synpcc7942_0105(nadE)
SYD: Syncc9605_2180
SYG: sync_2294(nadE)
TEL: tlr1180(nadE)
ANA: alr2485(nadE)
AVA: Ava_0417(nadE)
PMB: A9601_16481(nadE)
PMC: P9515_16251(nadE)
PMG: P9301_16361(nadE)
TER: Tery_1984(nadE)
CTE: CT0560(nadE)
CPC: Cpar_0584
CCH: Cag_1279(nadE)
CPH: Cpha266_0810(nadE)
CPB: Cphamn1_1813
CLI: Clim_0524
PVI: Cvib_1211(nadE)
PLT: Plut_0564(nadE)
PPH: Ppha_0857
PAA: Paes_0701
CTS: Ctha_1765
RRS: RoseRS_3650(nadE)
RCA: Rcas_0488
DRA: DR_A0201(nadE)
DGE: Dgeo_1327(nadE)
TTH: TTC1538
TTJ: TTHA1900
TMA: TM0645
TPT: Tpet_0284
TLE: Tlet_1607
TRQ: TRQ2_0283
TNA: CTN_0012
TME: Tmel_0086
TAF: THA_303(nadE1)
FNO: Fnod_0878
KOL: Kole_1677
MJA: MJ1352
MFE: Mefer_0664
MVU: Metvu_1076
MMP: MMP1349
MMQ: MmarC5_0229
MMX: MmarC6_1324
MMZ: MmarC7_0594
MAE: Maeo_0662
MVN: Mevan_0660
MAC: MA1030(nadE) MA3526(nadE) MA3715(nadE)
MBA: Mbar_A0269(nadE) Mbar_A2320(nadE)
MMA: MM_0446(nadE) MM_0612(nadE)
MBU: Mbur_1809(nadE)
MHU: Mhun_2601
MLA: Mlab_1353
MBN: Mboo_2324
MPL: Mpal_1197
MTH: MTH1510
MST: Msp_0170(nadE)
MSI: Msm_1171
MKA: MK1418(nadE)
AFU: AF1000(nadE)
HAL: VNG2031G(nadE)
HMA: pNG7227(nadE2) rrnAC2486(nadE1)
HWA: HQ1091A(nadE)
NPH: NP0054A(nadE_2) NP3828A(nadE_1)
HLA: Hlac_0090
HUT: Huta_1352
TAC: Ta0899(nadE)
TVO: TVN1017(nadE)
PTO: PTO0986(nadE)
PHO: PH0182(nadE)
PAB: PAB2244(nadE)
PFU: PF0098(nadE)
TKO: TK1798(nadE)
TGA: TGAM_0073(nadE)
TSI: TSIB_1759
RCI: RCIX358(nadE)
APE: APE_1958.1(nadE)
SMR: Smar_1310
IHO: Igni_1391
HBU: Hbut_0932
SSO: SSO2172(nadE)
STO: ST2159
SAI: Saci_0009(nadE)
SIS: LS215_2954
SIA: M1425_2789
SIM: M1627_2841
SID: M164_2770
SIY: YG5714_2969
SIN: YN1551_3159
MSE: Msed_0716
PAI: PAE1219
PIS: Pisl_1302 Pisl_1454
PCL: Pcal_0793
PAS: Pars_0310 Pars_1020
CMA: Cmaq_1108
TNE: Tneu_0248 Tneu_0526
TPE: Tpen_1044 Tpen_1444
NMR: Nmar_0966
KCR: Kcr_0978
Taxonomy
Structures PDB: 1WXE  1WXF  1WXG  1WXH  1WXI  1XNG  1XNH  2E18  2PZ8  2PZA  
     2PZB  3FIU  3HMQ  
Reference
  Authors
  Title


  Journal
  Organism
 1  [PMID:4290215]
Spencer RL, Preiss J.
Biosynthesis of diphosphopyridine nucleotide. The purification and
the properties of diphospyridine nucleotide synthetase from
Escherichia coli b.
J. Biol. Chem. 242 (1967) 385-92.
Escherichia coli [GN:eco]
Other DBs ExplorEnz - The Enzyme Database: 6.3.1.5
IUBMB Enzyme Nomenclature: 6.3.1.5
ExPASy - ENZYME nomenclature database: 6.3.1.5
BRENDA, the Enzyme Database: 6.3.1.5
CAS: 9032-69-3
DBGET integrated database retrieval system