| Entry |
|
|---|
| Name |
tetrahydrofolate synthase;
folylpolyglutamate synthase;
folate polyglutamate synthetase;
formyltetrahydropteroyldiglutamate synthetase;
N10-formyltetrahydropteroyldiglutamate synthetase;
folylpoly-gamma-glutamate synthase;
folylpolyglutamyl synthetase;
folylpoly(gamma-glutamate) synthase;
folylpolyglutamate synthetase;
folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase;
FPGS;
tetrahydrofolylpolyglutamate synthase;
tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming);
tetrahydropteroyl-[gamma-Glu]n:L-glutamate gamma-ligase
(ADP-forming) |
|---|
| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
 |
|---|
| Sysname |
tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase
(ADP-forming) |
|---|
| Reaction(IUBMB) |
ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate = ADP + phosphate
+ tetrahydropteroyl-[gamma-Glu]n+1 [RN:R04241] |
|---|
| Reaction(KEGG) |
R04241 > R00942;
(other) R01654 R02237 R05197
 |
|---|
| Substrate |
ATP [CPD:C00002];
tetrahydropteroyl-[gamma-Glu]n [CPD:C03541];
L-glutamate [CPD:C00025] |
|---|
| Product |
ADP [CPD:C00008];
phosphate [CPD:C00009];
tetrahydropteroyl-[gamma-Glu]n+1 [CPD:C03541] |
|---|
| Comment |
In some bacteria, a single protein catalyses both this activity and
that of EC 6.3.2.12, dihydrofolate synthase [3], the combined
activity of which leads to the formation of the coenzyme
polyglutamated tetrahydropteroate (H4PteGlun), i.e. various
tetrahydrofolates (H4folate). In contrast, the activities are
located on separate proteins in most eukaryotes studied to date [4].
In Arabidopsis thaliana, this enzyme is present as distinct isoforms
in the mitochondria, the cytosol and the chloroplast. Each isoform
is encoded by a separate gene, a situation that is unique among
eukaryotes [4]. As the affinity of folate-dependent enzymes
increases markedly with the number of glutamic residues, the
tetrahydropteroyl polyglutamates are the preferred coenzymes of C1
metabolism. (reviewed in [5]). The enzymes from different sources
(particularly eukaryotes versus prokaryotes) have different
substrate specificities with regard to one-carbon substituents and
the number of glutamate residues present on the tetrahydrofolates. |
|---|
| Pathway |
PATH: ec00790 Folate biosynthesis
PATH: ec01061 Biosynthesis of phenylpropanoids
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01930 folylpolyglutamate synthase
KO: K11754 dihydrofolate synthase / folylpolyglutamate synthase |
|---|
| Genes |
HSA: 2356(FPGS)
MCC: 699587(FPGS)
MMU: 14287(Fpgs)
RNO: 687266(Fpgs)
CFA: 609176(FPGS)
BTA: 505809(FPGS)
ECB: 100070426
MDO: 100011859
TGU: 100223385
DRE: 406746(fpgs)
SPU: 592205
DME: Dmel_CG2543 Dmel_CG31773
DPO: Dpse_GA15391
CEL: F25B5.6
ATH: AT5G41480(GLA1)
OSA: 4331360(Os03g0111100)
OLU: OSTLU_16744
CME: CMQ033C
SCE: YKL132C(RMA1) YMR113W(FOL3) YOR241W(MET7)
AGO: AGOS_ACR134W AGOS_AEL310C
DHA: DEHA0F09449g DEHA0F23221g
PIC: PICST_47181(FOL3) PICST_71737
CGR: CAGL0J03762g CAGL0K03553g
YLI: YALI0A10032g YALI0E24497g
SPO: SPAC227.09 SPBC1709.17
NCR: NCU00892 NCU01337
MGR: MGG_06002 MGG_11267
ANI: AN3840.2 AN4384.2
AFM: AFUA_4G06740 AFUA_4G08060 AFUA_6G09440 AFUA_8G04160
AOR: AO090009000308 AO090023000763 AO090023000912
ANG: An02g02950 An04g01120 An04g02490
CNE: CNC04840 CNH02620
PFA: PF13_0140
TAN: TA20775
TPV: TP01_0440
TET: TTHERM_01332110
TBR: Tb10.6k15.3140
TCR: 509715.70 510105.80
LMA: LmjF36.2610
ECO: b2315(folC)
ECJ: JW2312(folC)
ECD: ECDH10B_2477(folC)
EBW: BWG_2089(folC)
ECE: Z3577(folC)
ECS: ECs3199
ECF: ECH74115_3455(folC)
ETW: ECSP_3190(folC)
ECG: E2348C_2455(folC)
ECC: c2860(folC)
ECI: UTI89_C2600(folC)
ECP: ECP_2354
ECV: APECO1_4249(folC)
ECW: EcE24377A_2609(folC)
ECX: EcHS_A2466(folC)
ECM: EcSMS35_2471(folC)
ECY: ECSE_2624
ECL: EcolC_1337
ECK: EC55989_2559(folC)
ECQ: ECED1_2779(folC)
ECR: ECIAI1_2392(folC)
ECT: ECIAI39_2464(folC)
ECZ: ECS88_2462(folC)
EUM: ECUMN_2655(folC)
ELF: LF82_0723(folC)
EBL: B21_02200(folC)
EBD: ECBD_1344
EBR: ECB_02240(folC)
EFE: EFER_0848(folC)
STY: STY2596(folC)
STT: t0499(folC)
SPT: SPA0499(folC)
SEK: SSPA0463
SPQ: SPAB_00605
SEI: SPC_1340(folC)
SEC: SC2367(folC)
SEH: SeHA_C2607(folC)
SEE: SNSL254_A2553(folC)
SEW: SeSA_A2595
SEA: SeAg_B2507(folC)
SED: SeD_A2716(folC)
SEG: SG2395(folC)
SET: SEN2347(folC)
SES: SARI_00534
STM: STM2365(folC)
YPE: YPO2769(folC)
YPK: y1602(folC)
YPM: YP_2395(folC)
YPA: YPA_2075
YPN: YPN_2178
YPG: YpAngola_A0358(folC)
YPP: YPDSF_1992
YPS: YPTB2615(folC)
YPI: YpsIP31758_1423(folC)
YPY: YPK_1532
YPB: YPTS_2710
YEN: YE1312(dedC)
SFL: SF2391(folC)
SFX: S2526(folC)
SFV: SFV_2384(folC)
SSN: SSON_2373(folC)
SBO: SBO_2352(folC)
SBC: SbBS512_E2693(folC)
SDY: SDY_2514(folC)
ECA: ECA3055(folC)
PCT: PC1_2797
PWA: Pecwa_1468
ETA: ETA_11740(folC)
PLU: plu3170(folC)
PAY: PAU_01454(folC)
BUC: BU167(folC)
BAS: BUsg161(folC)
BAB: bbp157(folC)
BAP: BUAP5A_165(folC)
BAU: BUAPTUC7_166(folC)
WBR: WGLp311(folC)
SGL: SG1616
ENT: Ent638_2864
ESA: ESA_00901
CTU: Ctu_29430(folC)
KPN: KPN_02705(folC)
KPE: KPK_1439(folC)
KPU: KP1_3953(folC)
CKO: CKO_00471
SPE: Spro_3331
PMR: PMI1786(folC)
EIC: NT01EI_2717
BFL: Bfl494(folC)
BPN: BPEN_510(folC)
HDE: HDEF_0785(folC)
DDA: Dd703_2573
DZE: Dd1591_1371
HIN: HI1261(folC)
HIT: NTHI1903(folC)
HDU: HD1465(folC)
HAP: HAPS_0399(folC)
HSO: HS_0880(folC)
HSM: HSM_1359
PMU: PM0635(folC)
MSU: MS1173(folC)
APL: APL_0632(folC)
APJ: APJL_0627(folC)
APA: APP7_0677
ASU: Asuc_1382
AAP: NT05HA_0733
AAT: D11S_1290
XFA: XF1946
XFT: PD0854
XFM: Xfasm12_1026
XFN: XfasM23_0902
XCC: XCC0950(folC)
XCB: XC_3285
XCA: xccb100_3402
XCV: XCV1058(folC)
XAC: XAC1029(folC)
XOO: XOO3679(folC)
XOM: XOO_3475
XOP: PXO_02507
SML: Smlt0964(folC)
SMT: Smal_0809
VCH: VC1001
VCO: VC0395_A0522(folC)
VCM: VCM66_0957(folC)
VCJ: VCD_003337
VVU: VV1_1994
VVY: VV2422
VPA: VP2188
VHA: VIBHAR_03098
VSP: VS_0905
VEX: VEA_002876
VFI: VF_1694(folC)
VFM: VFMJ11_1819
VSA: VSAL_I1077(folC)
PPR: PBPRA2651
PAE: PA3111(folC)
PAU: PA14_23880(folC)
PAP: PSPA7_2022(folC)
PAG: PLES_19491(folC)
PPU: PP_1997(folC)
PPF: Pput_3764
PPG: PputGB1_1531
PPW: PputW619_1558
PST: PSPTO_3814(folC)
PSB: Psyr_1665
PSP: PSPPH_1659(folC)
PFL: PFL_2074(folC)
PFO: Pfl01_1899
PFS: PFLU4186
PEN: PSEEN1692(folC)
PMY: Pmen_2714
PSA: PST_1781(folC)
CJA: CJA_1754(folC)
AVN: Avin_34180(folC)
PAR: Psyc_0435(folC)
PCR: Pcryo_0470
PRW: PsycPRwf_0758
ACI: ACIAD0644(folC)
ABM: ABSDF0575(folC)
ABY: ABAYE0615(folC)
ABN: AB57_3371(folC)
SON: SO_3067(folC)
SDN: Sden_1487
SFR: Sfri_1396
SAZ: Sama_2149
SBL: Sbal_2741
SBM: Shew185_2758
SBN: Sbal195_2835
SBP: Sbal223_1618
SLO: Shew_2305
SPC: Sputcn32_2440
SSE: Ssed_1653
SPL: Spea_1618
SHE: Shewmr4_1427
SHM: Shewmr7_1492
SHN: Shewana3_1480
SHW: Sputw3181_1568
SHL: Shal_2640
SWD: Swoo_2983
SWP: swp_3115
ILO: IL1015(folC)
CPS: CPS_3801(folC)
PHA: PSHAa2073(folC)
PAT: Patl_1606
SDE: Sde_2076
MAQ: Maqu_1555
AMC: MADE_01207
PIN: Ping_1968
TTU: TERTU_2492(folC)
CBU: CBU_0894(folC)
CBS: COXBURSA331_A1053(folC)
CBD: CBUD_0958(folC)
CBG: CbuG_1108(folC)
CBC: CbuK_0759(folC)
LPN: lpg1342(folC)
LPF: lpl1295(folC)
LPP: lpp1296(folC)
LPC: LPC_0758(folC)
MCA: MCA2492(folC)
FTU: FTT_0371c(folC)
FTF: FTF0371c(folC)
FTW: FTW_1705(folC)
FTL: FTL_1308
FTH: FTH_1280(folC)
FTA: FTA_1383
FTM: FTM_0293(folC)
FTN: FTN_0273(folC)
TCX: Tcr_0806
NOC: Noc_1023
AEH: Mlg_1239
HHA: Hhal_1801
TGR: Tgr7_1256
HNA: Hneap_1156
HCH: HCH_02439(folC)
CSA: Csal_1264
ABO: ABO_1458(folC)
MMW: Mmwyl1_2045
AHA: AHA_2678(folC)
ASA: ASA_2529(folC)
TAU: Tola_1567
DNO: DNO_0404(folC)
AFE: Lferr_1724
AFR: AFE_2066(folC)
BCI: BCI_0366(folC)
RMA: Rmag_0999
VOK: COSY_0895(folC)
KKO: Kkor_1483
NMA: NMA0896
NME: NMB0693(folC)
NMC: NMC0644(folC)
NMN: NMCC_0652(folC)
NMI: NMO_0585(folC)
NGO: NGO0266
NGK: NGK_0409
CVI: CV_2518(folC)
LHK: LHK_02114(folC)
RSO: RSc1979(folC)
RPI: Rpic_2133
RPF: Rpic12D_1809
REU: Reut_A2302
REH: H16_A2610(folC)
RME: Rmet_2463
CTI: RALTA_A2108(folC)
BMA: BMAA1717(folC)
BMV: BMASAVP1_1653(folC)
BML: BMA10229_1862(folC)
BMN: BMA10247_A0533(folC)
BPS: BPSS1695(folC)
BPM: BURPS1710b_A0765(folC)
BPL: BURPS1106A_A2303(folC)
BPD: BURPS668_A2441(folC)
BTE: BTH_II0683
BVI: Bcep1808_4466
BUR: Bcep18194_B2121
BCN: Bcen_4405
BCH: Bcen2424_3962
BCM: Bcenmc03_3566
BCJ: BCAM0995(folC)
BAM: Bamb_3352
BAC: BamMC406_3857
BMU: Bmul_4618
BMJ: BMULJ_03893(folC)
BXE: Bxe_B2877
BPH: Bphy_4378
BPY: Bphyt_6838
BGL: bglu_2g08460
PNU: Pnuc_0775
PNE: Pnec_1046
BPE: BP1412(folC)
BPA: BPP1519(folC)
BBR: BB2597(folC)
BPT: Bpet2161(folC)
BAV: BAV1725(dedC)
RFR: Rfer_2686
POL: Bpro_1604
PNA: Pnap_1089
AAV: Aave_1860
AJS: Ajs_2739
VEI: Veis_3374
DAC: Daci_4772
DIA: Dtpsy_2229
VAP: Vapar_3762
MPT: Mpe_A2154 Mpe_A3265
HAR: HEAR1226(folC)
MMS: mma_2161(folC)
LCH: Lcho_1685
NEU: NE0696(folC)
NET: Neut_1155
NMU: Nmul_A1909
EBA: ebA4777(folC)
AZO: azo1050(folC)
DAR: Daro_0873
TBD: Tbd_1911
MFA: Mfla_1695
MMB: Mmol_0983
MEI: Msip34_1543
APP: CAP2UW1_1233
HPY: HP1545
HPJ: jhp1454(folC)
HPA: HPAG1_1494
HPS: HPSH_08060
HPG: HPG27_1483(folC)
HPP: HPP12_1539(folC)
HPB: HELPY_1548(folC)
HHE: HH0462(folC)
HAC: Hac_0295(folC)
WSU: WS1242(folC)
TDN: Suden_1569
CJE: Cj1088c(folC)
CJR: CJE1231(folC)
CJJ: CJJ81176_1106(folC)
CJU: C8J_1029(folC)
CJD: JJD26997_0635(folC)
CFF: CFF8240_0734(folC)
CCV: CCV52592_0713
CHA: CHAB381_0471
CLA: Cla_1042(folC)
ABU: Abu_0404(folC)
NIS: NIS_1462(folC)
SUN: SUN_2042(folC)
GSU: GSU2368(folC)
GME: Gmet_2475
GUR: Gura_3277
GLO: Glov_1236
GBM: Gbem_3348
GEO: Geob_1868
PCA: Pcar_0738(folC)
PPD: Ppro_1160
DVU: DVU2882(folC)
DVL: Dvul_0483
DVM: DvMF_1310
LIP: LI0131(folC)
DPS: DP2878
DAL: Dalk_0204
DAT: HRM2_17030(folC)
ADE: Adeh_1258
ACP: A2cp1_2698
AFW: Anae109_2510
ANK: AnaeK_2605
MXA: MXAN_2705(folC)
SCL: sce5787(folC)
SAT: SYN_01606
SFU: Sfum_1671
RPR: RP536
RTY: RT0524(folC)
RCO: RC0779(folC)
RFE: RF_0740(folC)
RRJ: RrIowa_0812
RBE: RBE_1202(folC)
OTS: OTBS_0584(folC)
WOL: WD1052(folC)
WRI: WRi_010890(folC)
AMA: AM699(folC)
AMF: AMF_522(folC)
APH: APH_0747(folC)
ERU: Erum3680(folC)
ERW: ERWE_CDS_03790(folC)
ERG: ERGA_CDS_03740(folC)
ECN: Ecaj_0353
ECH: ECH_0702(folC)
NSE: NSE_0715(folC)
PUB: SAR11_0485(folC)
MLO: mlr5076
MES: Meso_0662
PLA: Plav_0140
SME: SMc02763(folC)
SMD: Smed_3240
ATU: Atu0021(folC)
ATC: AGR_C_35(folC)
RET: RHE_CH00024(folC)
REC: RHECIAT_CH0000025(folC)
RLE: RL0024(folC)
RHI: NGR_c33810(folC)
BME: BMEI2021
BMF: BAB1_2108(folC)
BMB: BruAb1_2081(folC)
BMC: BAbS19_I19710
BMS: BR2106(folC)
BMT: BSUIS_A1946(folC)
BOV: BOV_2022(folC)
BCS: BCAN_A2150(folC)
BMR: BMI_I2128(folC)
OAN: Oant_0814
BJA: blr0748(folC)
BRA: BRADO0088
BBT: BBta_0094
RPA: RPA0072(folC)
RPB: RPB_0564 RPB_0632
RPC: RPC_0389
RPD: RPD_0200
RPE: RPE_0113 RPE_0457
NWI: Nwi_0052
NHA: Nham_0060
BHE: BH00330(folC)
BQU: BQ00310(folC)
BBK: BARBAKC583_1352(folC)
BTR: Btr_0034(folC)
XAU: Xaut_1697
AZC: AZC_1025
MEX: Mext_4444
MDI: METDI5480(folC)
MCH: Mchl_4908
CCR: CC_3541
CCS: CCNA_03655
CAK: Caul_4979
SIL: SPO3818(folC)
SIT: TM1040_2675
RSP: RSP_0930(folC)
RSH: Rsph17029_2589
RSQ: Rsph17025_2985
JAN: Jann_0059
RDE: RD1_0327(folC)
PDE: Pden_1988
DSH: Dshi_0132(folC)
MMR: Mmar10_0088
HNE: HNE_3472
ZMO: ZMO0582
NAR: Saro_1299
SAL: Sala_1061
SWI: Swit_2729
ELI: ELI_07605
GOX: GOX1205
GBE: GbCGDNIH1_2012
ACR: Acry_0844
GDI: GDI_1252(folC)
RRU: Rru_A3431
RCE: RC1_2834(folC)
MAG: amb4014
MGM: Mmc1_2329
BSU: BSU28080(folC)
BHA: BH3037(folC)
BAN: BA4689(folC)
BAR: GBAA4689(folC)
BAA: BA_5128
BAT: BAS4354
BCE: BC4464
BCA: BCE_4548(folC)
BCZ: BCZK4201(folC)
BCR: BCAH187_A4590(folC)
BCB: BCB4264_A4575(folC)
BCU: BCAH820_4544(folC)
BCG: BCG9842_B0659(folC)
BCQ: BCQ_4244(folC)
BCY: Bcer98_3173
BTK: BT9727_4190(folC)
BTL: BALH_4050(folC)
BWE: BcerKBAB4_4302
BLI: BL00632(folC)
BLD: BLi02937(folC)
BCL: ABC2620(folC)
BAY: RBAM_025130(folC)
BPU: BPUM_2448(folC)
OIH: OB2058(folC)
GKA: GK2637
GTN: GTNG_2566
GWC: GWCH70_2572
AFL: Aflv_0615(folC)
SAU: SA1487(folC)
SAV: SAV1662(folC)
SAW: SAHV_1649(folC)
SAM: MW1606(folC)
SAR: SAR1742(folC)
SAS: SAS1591
SAC: SACOL1709(folC)
SAB: SAB1523c(folC)
SAA: SAUSA300_1610(folC)
SAX: USA300HOU_1654(folC)
SAO: SAOUHSC_01766
SAJ: SaurJH9_1720
SAH: SaurJH1_1754
SAE: NWMN_1557(folC)
SEP: SE1338
SER: SERP1227(folC)
SHA: SH1264(folC)
SSP: SSP1102
LMO: lmo1551(folC)
LMF: LMOf2365_1572(folC)
LMH: LMHCC_1018
LMC: Lm4b_01562(folC)
LIN: lin1586
LWE: lwe1564(folC)
ESI: Exig_2132
EAT: EAT1b_2652
BBE: BBR47_18250(folC)
LLA: L0177(folC)
LLC: LACR_1278
LLM: llmg_1334(folC)
SPY: SPy_0814(folC.2) SPy_1096(folC.1)
SPZ: M5005_Spy_0628(folC.2) M5005_Spy_0820(folC.1)
SPM: spyM18_0876(folC) spyM18_1058(folC)
SPG: SpyM3_0547(folC.2) SpyM3_0758(folC.1)
SPS: SPs0958 SPs1307
SPH: MGAS10270_Spy0684(folC2) MGAS10270_Spy0936(folC1)
SPI: MGAS10750_Spy0716(folC2) MGAS10750_Spy0971(folC1)
SPJ: MGAS2096_Spy0693(folC2) MGAS2096_Spy0894(folC1)
SPK: MGAS9429_Spy0683(folC2) MGAS9429_Spy0939(folC1)
SPF: SpyM50968(folC1) SpyM51179(folC2)
SPA: M6_Spy0645 M6_Spy0818
SPB: M28_Spy0608(folC.2) M28_Spy0797(folC.1)
SOZ: Spy49_0851(folC1)
SAG: SAG1117(folC)
SAN: gbs1184
SAK: SAK_1202(folC)
SMU: SMU.839(fol) SMU.967(folC)
STC: str0409(folC1) str1546(folC2)
STL: stu0409(folC1) stu1546(folC2)
STE: STER_0448 STER_1504
SSA: SSA_0198 SSA_2237
SSU: SSU05_0056
SSV: SSU98_0056
SGO: SGO_2039
SUB: SUB0812(folC1)
LPL: lp_2321(folC1) lp_3296(folC2)
LJO: LJ0959
LAC: LBA0795(folC)
LSA: LSA0850(folC1) LSA1099(folC2)
LSL: LSL_1071(folC)
LDB: Ldb0248(folC2) Ldb0728(folC1)
LBU: LBUL_0210 LBUL_0660
LBR: LVIS_1252
LCA: LSEI_1252
LGA: LGAS_1218
LRE: Lreu_0510 Lreu_1277
LRF: LAR_0496
LFE: LAF_1338
PPE: PEPE_1290
EFA: EF2928
OOE: OEOE_1391
LCI: LCK_00966(folC2)
CAC: CAC2398(folC)
CPE: CPE1918(folC)
CPF: CPF_2174(folC)
CPR: CPR_1885(folC)
CTC: CTC02301
CNO: NT01CX_1729
CTH: Cthe_1384
CDF: CD3253(folC)
CBO: CBO3163(folC)
CBA: CLB_3198(folC)
CBH: CLC_3072(folC)
CBL: CLK_2559(folC)
CBK: CLL_A2503
CBB: CLD_1373(folC)
CBT: CLH_2272
CBF: CLI_3227(folC)
CBE: Cbei_1784
CKL: CKL_3218(folC)
CKR: CKR_2851
CPY: Cphy_2764
CCE: Ccel_1447
AMT: Amet_1403
AOE: Clos_2028
STH: STH367
SWO: Swol_1648
ATE: Athe_1490
DSY: DSY3187
DHD: Dhaf_4360
DRM: Dred_2552
PTH: PTH_0813(folC)
DAU: Daud_1472
FMA: FMG_1087
EEL: EUBELI_01612
TTE: TTE0783(folC)
TEX: Teth514_2209
TPD: Teth39_1528
CHY: CHY_0335(folC)
MTA: Moth_0533
CSC: Csac_2037
NTH: Nther_1110
HOR: Hore_14370
MMY: MSC_0942(folC)
MCP: MCAP_0775(folC)
POY: PAM007(folC)
MFL: Mfl060
MTU: Rv2447c(folC)
MTC: MT2523(folC)
MRA: MRA_2473(folC)
MBO: Mb2474c(folC)
MBB: BCG_2467c(folC)
MLE: ML1471(folC)
MPA: MAP2270c(folC)
MAV: MAV_1725
MUL: MUL_3718(folC)
MGI: Mflv_2631
CGL: NCgl2292(cgl2375)
CGB: cg2608(folC)
CGT: cgR_2257
CEF: CE2281
CDI: DIP1785
CJK: jk0551(folC)
NFA: nfa13490(folC)
RHA: RHA1_ro01317
SCO: SCO2614(fpgS)
SMA: SAV_5452(fpgS)
TWH: TWT476(folC)
TWS: TW288(fgs)
LXX: Lxx07980(folC)
ART: Arth_2397
AAU: AAur_2373(folC)
RSA: RSal33209_3257
PAC: PPA0821
TFU: Tfu_2190
FRA: Francci3_1208 Francci3_1209
FAL: FRAAL1913(folC) FRAAL1914
ACE: Acel_0742
KRA: Krad_3497
SEN: SACE_1387(folC)
BLO: BL1353(folC)
BAD: BAD_1088(folC)
RXY: Rxyl_1534
PCU: pc1626(folC)
TPA: TP0340
TDE: TDE1084
LIL: LA0637(folC)
LIC: LIC12950(folC)
LBJ: LBJ_2330(folC)
LBL: LBL_0778(folC)
ABA: Acid345_0119
BTH: BT_1335
BFR: BF2974
BFS: BF2850
PGI: PG0463(folC)
SRU: SRU_2420
CHU: CHU_1542(folC)
CPI: Cpin_3070
GFO: GFO_2899(folC)
FJO: Fjoh_0461
FPS: FP0541(folC)
FBA: FIC_00042
COC: Coch_1979
FNU: FN1014
OTE: Oter_3525
MIN: Minf_0385(folC)
AMU: Amuc_0918
RBA: RB6237(folC)
RSD: TGRD_491
SYN: sll1612(folC)
SYW: SYNW1635(folC)
SYC: syc0598_c(folC)
SYF: Synpcc7942_0944
SYD: Syncc9605_0857
SYE: Syncc9902_1535
SYG: sync_0743
SYR: SynRCC307_0610(folC)
SYX: SynWH7803_1748(folC)
SYP: SYNPCC7002_A0401(folC)
CYA: CYA_1353(folC)
CYB: CYB_1382(folC)
TEL: tlr0190(folC)
MAR: MAE_15990(folC)
CYT: cce_4130(folC)
CYP: PCC8801_0207
CYC: PCC7424_0544
CYN: Cyan7425_4359
GVI: gvip147(folC)
ANA: alr1026
NPU: Npun_F5003
AVA: Ava_3683
PMA: Pro1376(folC)
PMM: PMM1302(folC)
PMT: PMT0330(folC)
PMN: PMN2A_0868
PMI: PMT9312_1398
PMB: A9601_15011(folC)
PMC: P9515_14631(folC)
PMF: P9303_19851(folC)
PMG: P9301_14881(folC)
PMH: P9215_15311(folC)
PMJ: P9211_13501(folC)
PME: NATL1_17221(folC)
TER: Tery_1603
AMR: AM1_1737(folC)
CTE: CT0263(folC)
CCH: Cag_0458
CPH: Cpha266_0391
CPB: Cphamn1_0423
CLI: Clim_0322
PVI: Cvib_1538
PLT: Plut_1757
DET: DET0016
DEH: cbdb_A18(folC)
DEB: DehaBAV1_0015
RRS: RoseRS_4541
CAG: Cagg_3099
HAU: Haur_0603
TRO: trd_A0255
DRA: DR_0340 DR_2575(folC)
DGE: Dgeo_0083 Dgeo_0333
TTH: TTC0975 TTC1640
TTJ: TTHA0343 TTHA1340
AAE: aq_2045(folC)
SAF: SULAZ_1058
TMA: TM0166
TPT: Tpet_0759
TRQ: TRQ2_0782
TME: Tmel_1568
DTH: DICTH_0596
DTU: Dtur_0758
TYE: THEYE_A0558
HAL: VNG0412G(folP)
HWA: HQ1767A(folCP)
NPH: NP1478A(folCP)
TAC: Ta0637
TVO: TVN0757
PTO: PTO1256
 |
|---|
| Structures |
PDB: 1FGS 1JBV 1JBW 2GC5 2GC6 2GCA 2GCB 2VOR 2VOS |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:6458762]
Cichowicz DJ, Foo SK, Shane B.
Folylpoly-gamma-glutamate synthesis by bacteria and mammalian cells.
Mol. Cell. Biochem. 39 (1981) 209-28.
Sus scofa [GN:ssc], Streptococcus faecalis, Lactobacillus casei
[GN:lca], Corynebacterium sp., Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7027025]
McGuire JJ, Bertino JR.
Enzymatic synthesis and function of folylpolyglutamates.
Mol. Cell. Biochem. 38 Spec No (1981) 19-48.
Neurospora crassa [GN:ncr] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:2985605]
Bognar AL, Osborne C, Shane B, Singer SC, Ferone R.
Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase.
Cloning and high expression of the Escherichia coli folC gene and
purification and properties of the gene product.
J. Biol. Chem. 260 (1985) 5625-30.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:11752472]
Ravanel S, Cherest H, Jabrin S, Grunwald D, Surdin-Kerjan Y, Douce
R, Rebeille F.
Tetrahydrofolate biosynthesis in plants: molecular and functional
characterization of dihydrofolate synthetase and three isoforms of
folylpolyglutamate synthetase in Arabidopsis thaliana.
Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 15360-5.
Arabidopsis thaliana [GN:ath] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:9190084]
Cossins EA, Chen L.
Folates and one-carbon metabolism in plants and fungi.
Phytochemistry. 45 (1997) 437-52.
Corynebacterium sp., Neurospora crassa [GN:ncr], Escherichia coli
[GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
Sequence
|
6 [PMID:10799479]
Cherest H, Thomas D, Surdin-Kerjan Y.
Polyglutamylation of folate coenzymes is necessary for methionine
biosynthesis and maintenance of intact mitochondrial genome in
Saccharomyces cerevisiae.
J. Biol. Chem. 275 (2000) 14056-63.
Saccharomyces cerevisiae [GN:sce]
SCE: YOR241W |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.3.2.17
IUBMB Enzyme Nomenclature: 6.3.2.17
ExPASy - ENZYME nomenclature database: 6.3.2.17
BRENDA, the Enzyme Database: 6.3.2.17
CAS: 63363-84-8 |
|---|
