| Entry |
|
|---|
| Name |
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase;
L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase;
ACV synthetase;
L-alpha-aminoadipyl-cysteinyl-valine synthetase |
|---|
| Class |
Ligases;
Forming carbon-nitrogen bonds;
Acid-D-amino-acid ligases (peptide synthases)
 |
|---|
| Sysname |
L-2-aminohexanedioate:L-cysteine:L-valine ligase (AMP-forming,
valine-inverting) |
|---|
| Reaction(IUBMB) |
3 ATP + L-2-aminohexanedioate + L-cysteine + L-valine + H2O = 3 AMP
+ 3 diphosphate +
N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine [RN:R04870] |
|---|
| Reaction(KEGG) |
R04870
 |
|---|
| Substrate |
ATP [CPD:C00002];
L-2-aminohexanedioate [CPD:C00956];
L-cysteine [CPD:C00097];
L-valine [CPD:C00183];
H2O [CPD:C00001] |
|---|
| Product |
AMP [CPD:C00020];
diphosphate [CPD:C00013];
N-[L-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine [CPD:C05556] |
|---|
| Comment |
Requires Mg2+. The enzyme contains 4'-phosphopantetheine, which may
be involved in the mechanism of the reaction. Forms part of the
penicillin biosynthesis pathway (for pathway, click here). |
|---|
| Pathway |
PATH: ec00311 Penicillin and cephalosporin biosynthesis
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K12743 N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine
synthase |
|---|
| Genes |
ANI: AN2621.2
 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:11851475]
Byford MF, Baldwin JE, Shiau CY, Schofield CJ.
The Mechanism of ACV Synthetase.
Chem. Rev. 97 (1997) 2631-2650.
Cephalosporium acremonium |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:9355751]
Theilgaard HB, Kristiansen KN, Henriksen CM, Nielsen J.
Purification and characterization of
delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from
Penicillium chrysogenum.
Biochem. J. 327 ( Pt 1) (1997) 185-91.
Penicillium chrysogenum [GN:pcs] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.3.2.26
IUBMB Enzyme Nomenclature: 6.3.2.26
ExPASy - ENZYME nomenclature database: 6.3.2.26
BRENDA, the Enzyme Database: 6.3.2.26
CAS: 57219-73-5 |
|---|
