KEGG   ENZYME: 6.3.4.10Help
Entry
EC 6.3.4.10                 Enzyme                                 
Name
biotin---[propionyl-CoA-carboxylase (ATP-hydrolysing)] ligase;
biotin-[propionyl-CoA-carboxylase (ATP-hydrolysing)] synthetase;
biotin-propionyl coenzyme A carboxylase synthetase;
propionyl coenzyme A holocarboxylase synthetase
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
biotin:apo-[propanoyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming)
Reaction(IUBMB)
ATP + biotin + apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] = AMP + diphosphate + [propionyl-CoA:carbon-dioxide ligase (ADP-forming)] [RN:R04582]
Reaction(KEGG)
R04582;
(other) R01074 R05145
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Substrate
ATP [CPD:C00002];
biotin [CPD:C00120];
apo-[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04763]
Product
AMP [CPD:C00020];
diphosphate [CPD:C00013];
[propionyl-CoA:carbon-dioxide ligase (ADP-forming)] [CPD:C04727]
Pathway
Biotin metabolism
Metabolic pathways
Orthology
K01942  
biotin--protein ligase
Genes
HSA: 
3141(HLCS)
PTR: 
473989(HLCS)
PPS: 
100985942(HLCS)
GGO: 
101135438(HLCS)
PON: 
100457062(HLCS)
MCC: 
694733(HLCS)
MMU: 
110948(Hlcs)
RNO: 
288240(Hlcs)
CFA: 
478412(HLCS)
AML: 
100464483(HLCS)
FCA: 
101100992(HLCS)
BTA: 
534247(HLCS)
SSC: 
100515056(HLCS)
ECB: 
100061132(HLCS)
MDO: 
100012694(HLCS)
SHR: 
100914711(HLCS)
OAA: 
100081454 100087267
GGA: 
418516(HLCS)
MGP: 
100544537
TGU: 
100229815
ACS: 
100562676(hlcs)
XTR: 
100492512(hlcs)
DRE: 
337784(hlcs)
TRU: 
101061285
OLA: 
101169801
CIN: 
100179742
SPU: 
577740
DME: 
Dmel_CG14670(Hcs)
DPO: 
Dpse_GA26365
DAN: 
Dana_GF17255
DER: 
Dere_GG12849
DPE: 
Dper_GL21666
DSE: 
Dsec_GM10811
DSI: 
Dsim_GD19789
DWI: 
Dwil_GK11222
DYA: 
Dyak_GE25471
DGR: 
Dgri_GH18598
DMO: 
Dmoj_GI23080
DVI: 
Dvir_GJ22700
AGA: 
AgaP_AGAP001481
AAG: 
AaeL_AAEL009340
CQU: 
CpipJ_CPIJ007072
AME: 
411759(Hcs)
NVI: 
100120765(NV16350)
TCA: 
100141937
API: 
100166501
PHU: 
Phum_PHUM492490
ISC: 
IscW_ISCW015948
BMY: 
Bm1_15240
SMM: 
Smp_153150
NVE: 
NEMVE_v1g105387
TAD: 
TRIADDRAFT_31020
AQU: 
100632425
CRE: 
CHLREDRAFT_151096(BPL1) CHLREDRAFT_169728
SCE: 
YDL141W(BPL1)
AGO: 
AGOS_ADR085W
ERC: 
Ecym_8066
KLA: 
KLLA0F05049g
LTH: 
KLTH0H02024g
PPA: 
PAS_chr3_0569
VPO: 
Kpol_1019p23
ZRO: 
ZYRO0F05940g
CGR: 
CAGL0I03806g
NCS: 
NCAS_0A13910(NCAS0A13910)
NDI: 
NDAI_0A02120(NDAI0A02120)
TPF: 
TPHA_0A03060(TPHA0A03060)
TBL: 
TBLA_0F02180(TBLA0F02180)
TDL: 
TDEL_0C02310(TDEL0C02310)
KAF: 
KAFR_0B01050(KAFR0B01050)
DHA: 
DEHA2A13750g
PIC: 
PICST_69676(BPL1)
PGU: 
PGUG_01114
LEL: 
LELG_05238
CAL: 
CaO19.7645(BPL1)
CTP: 
CTRG_05783
CDU: 
CD36_35420
COT: 
CORT_0D00250
YLI: 
YALI0E30591g
CLU: 
CLUG_02270
NCR: 
NCU05516
SMP: 
SMAC_00725
PAN: 
PODANSg2869
TTT: 
THITE_2110501
MTM: 
MYCTH_2119403
MGR: 
MGG_00436
FGR: 
FG08329.1
NHE: 
NECHADRAFT_36078
VAL: 
VDBG_09198
SSL: 
SS1G_04467
BFU: 
BC1G_00456
ANI: 
AN6055.2
NFI: 
NFIA_085040
AFM: 
AFUA_2G09550
AOR: 
AOR_1_1208054(AO090011000708)
AFV: 
AFLA_045250
ACT: 
ACLA_081340
CIM: 
CIMG_07858
CPW: 
CPC735_041520
PBL: 
PAAG_06513
URE: 
UREG_02182
ABE: 
ARB_05148
TVE: 
TRV_07820
AJE: 
HCAG_08683
PNO: 
SNOG_08427
PTE: 
PTT_11266
ZTR: 
MYCGRDRAFT_67807
TML: 
GSTUM_00004427001
SPO: 
SPBC30D10.07c
CNE: 
CNC00800
CNB: 
CNBC6470
CGI: 
CGB_C1330W
LBC: 
LACBIDRAFT_317063
CCI: 
CC1G_15548
SCM: 
SCHCODRAFT_256476
UMA: 
UM03839.1
MGL: 
MGL_0053
PGR: 
PGTG_14205
DPP: 
DICPUDRAFT_18614
 » show all
Taxonomy
Reference
1  [PMID:14284697]
  Authors
SIEGEL L, FOOTE JL, COON MJ.
  Title
THE ENZYMATIC SYNTHESIS OF PROPIONYL COENZYME A HOLOCARBOXYLASE FROM D-BIOTINYL 5'-ADENYLATE AND THE APOCARBOXYLASE.
  Journal
J. Biol. Chem. 240 (1965) 1025-31.
  Organism
Oryctolagus cuniculus
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
37318-67-5
DBGET integrated database retrieval system