| Entry |
|
|---|
| Name |
carbamoyl-phosphate synthase (ammonia);
carbon-dioxide---ammonia ligase;
carbamoylphosphate synthase;
carbamylphosphate synthetase;
carbamoylphosphate synthase (ammonia);
carbamoylphosphate synthetase;
carbamylphosphate synthetase I |
|---|
| Class |
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
 |
|---|
| Sysname |
carbon-dioxide:ammonia ligase (ADP-forming,
carbamate-phosphorylating) |
|---|
| Reaction(IUBMB) |
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate
[RN:R00149] |
|---|
| Reaction(KEGG) |
R00149
 |
|---|
| Substrate |
ATP [CPD:C00002];
NH3 [CPD:C00014];
CO2 [CPD:C00011];
H2O [CPD:C00001] |
|---|
| Product |
ADP [CPD:C00008];
phosphate [CPD:C00009];
carbamoyl phosphate [CPD:C00169] |
|---|
| Effector |
N-Acetyl-L-glutamate [CPD:C00624] |
|---|
| Pathway |
PATH: ec00250 Alanine, aspartate and glutamate metabolism
PATH: ec00330 Arginine and proline metabolism
PATH: ec00910 Nitrogen metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01948 carbamoyl-phosphate synthase (ammonia) |
|---|
| Genes |
HSA: 1373(CPS1)
PTR: 738670(CPS1)
MCC: 711806
MMU: 227231(Cps1)
RNO: 497840(Cps1)
CFA: 488506(CPS1)
BTA: 510506(CPS1)
SSC: 100156131
ECB: 100050116(CPS1)
MDO: 100015090
GGA: 428994(CPS1)
TGU: 100221389
XLA: 733340
DRE: 555623(DKEY-225D17.3)
SPU: 584369
 |
|---|
| Structures |
PDB: 2YVQ |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:14213379]
FAHIEN LA, COHEN PP.
A KINETIC STUDY OF CARBAMYL PHOSPHATE SYNTHETASE.
J. Biol. Chem. 239 (1964) 1925-34.
frog |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:13790558]
JONES ME, SPECTOR L.
The pathway of carbonate in the biosynthesis of carbamyl phosphate.
J. Biol. Chem. 235 (1960) 2897-901.
frog |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13563449]
METZENBERG RL, MARSHALL M, COHEN PP.
Purification of carbamyl phosphate synthetase from frog liver.
J. Biol. Chem. 233 (1958) 102-5.
frog |
|---|
Reference
Authors
Title
Journal
|
4
Marshall, M., Metzenberg, R.L. and Cohen, P.P.
Physical and kinetic properties of carbamyl phosphate synthetase
from frog liver.
J. Biol. Chem. 236 (1961) 2229-2237. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.3.4.16
IUBMB Enzyme Nomenclature: 6.3.4.16
ExPASy - ENZYME nomenclature database: 6.3.4.16
BRENDA, the Enzyme Database: 6.3.4.16
CAS: 9026-23-7 |
|---|
