KEGG   ENZYME: 6.3.4.16Help
Entry
EC 6.3.4.16                 Enzyme                                 

Name
carbamoyl-phosphate synthase (ammonia);
carbon-dioxide---ammonia ligase;
carbamoylphosphate synthase;
carbamylphosphate synthetase;
carbamoylphosphate synthase (ammonia);
carbamoylphosphate synthetase;
carbamylphosphate synthetase I
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
Reaction(IUBMB)
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate [RN:R00149]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
NH3 [CPD:C00014];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
carbamoyl phosphate [CPD:C00169]
History
EC 6.3.4.16 created 1965 as EC 2.7.2.5, transferred 1978 to EC 6.3.4.16
Pathway
Alanine, aspartate and glutamate metabolism
Arginine and proline metabolism
Nitrogen metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01948  
carbamoyl-phosphate synthase (ammonia)
Genes
HSA: 
1373(CPS1)
PTR: 
738670(CPS1)
PPS: 
100984596(CPS1)
GGO: 
101130709(CPS1)
PON: 
100442727(CPS1)
NLE: 
100596216(CPS1)
MCC: 
711806(CPS1)
MCF: 
102139369(CPS1)
CJC: 
100402602(CPS1)
MMU: 
227231(Cps1)
RNO: 
497840(Cps1)
CGE: 
100760467(Cps1)
NGI: 
103744467(Cps1)
HGL: 
101696508(Cps1)
OCU: 
100303765(CPS1)
TUP: 
102491899(CPS1)
CFA: 
488506(CPS1)
AML: 
100466842(CPS1)
UMR: 
103659822(CPS1)
FCA: 
101099824(CPS1)
PTG: 
102968283(CPS1)
BTA: 
510506(CPS1)
BOM: 
102267831(CPS1)
PHD: 
102342950(CPS1)
CHX: 
102179612(CPS1)
OAS: 
101107584(CPS1)
SSC: 
100157716(CPS1)
CFR: 
BACU: 
103003987(CPS1)
LVE: 
103079188(CPS1)
ECB: 
100050116(CPS1)
MYB: 
102262103(CPS1)
MYD: 
102756563(CPS1)
PALE: 
102895317(CPS1)
MDO: 
100015090(CPS1)
SHR: 
100929825(CPS1)
OAA: 
100077228(CPS1)
GGA: 
428994(CPS1)
MGP: 
APLA: 
101797791(CPS1)
TGU: 
100221389(CPS1)
FAB: 
101816308(CPS1)
PHI: 
102105821(CPS1)
FPG: 
101910440(CPS1)
FCH: 
102046837(CPS1)
CLV: 
102091543(CPS1)
ASN: 
102386005(CPS1)
AMJ: 
102564082(CPS1)
PSS: 
102462440(CPS1)
CMY: 
102943091(CPS1)
ACS: 
100562333(cps1)
PBI: 
103061484(CPS1)
XLA: 
733340(cps1)
XTR: 
100158506(cps1)
DRE: 
555623(cps1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102363877(CPS1)
CMK: 
103182939(cps1)
BFO: 
SPU: 
LGI: 
PTI: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:14213379]
  Authors
FAHIEN LA, COHEN PP.
  Title
A KINETIC STUDY OF CARBAMYL PHOSPHATE SYNTHETASE.
  Journal
J. Biol. Chem. 239 (1964) 1925-34.
Reference
2  [PMID:13790558]
  Authors
JONES ME, SPECTOR L.
  Title
The pathway of carbonate in the biosynthesis of carbamyl phosphate.
  Journal
J. Biol. Chem. 235 (1960) 2897-901.
Reference
3  [PMID:13563449]
  Authors
METZENBERG RL, MARSHALL M, COHEN PP.
  Title
Purification of carbamyl phosphate synthetase from frog liver.
  Journal
J. Biol. Chem. 233 (1958) 102-5.
Reference
4
  Authors
Marshall, M., Metzenberg, R.L. and Cohen, P.P.
  Title
Physical and kinetic properties of carbamyl phosphate synthetase from frog liver.
  Journal
J. Biol. Chem. 236 (1961) 2229-2237.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-23-7

DBGET integrated database retrieval system