KEGG   ENZYME: 6.3.4.16Help
Entry
EC 6.3.4.16                 Enzyme                                 

Name
carbamoyl-phosphate synthase (ammonia);
carbon-dioxide---ammonia ligase;
carbamoylphosphate synthase;
carbamylphosphate synthetase;
carbamoylphosphate synthase (ammonia);
carbamoylphosphate synthetase;
carbamylphosphate synthetase I
Class
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
BRITE hierarchy
Sysname
carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)
Reaction(IUBMB)
2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate [RN:R00149]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
NH3 [CPD:C00014];
CO2 [CPD:C00011];
H2O [CPD:C00001]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
carbamoyl phosphate [CPD:C00169]
Pathway
Alanine, aspartate and glutamate metabolism
Arginine and proline metabolism
Nitrogen metabolism
Metabolic pathways
Microbial metabolism in diverse environments
Orthology
K01948  
carbamoyl-phosphate synthase (ammonia)
Genes
HSA: 
1373(CPS1)
PTR: 
738670(CPS1)
PPS: 
100984596(CPS1)
GGO: 
101130709(CPS1)
PON: 
100442727(CPS1)
MCC: 
711806(CPS1)
MCF: 
102139369(CPS1)
MMU: 
227231(Cps1)
RNO: 
497840(Cps1)
CGE: 
100760467(Cps1)
HGL: 
101696508(Cps1)
TUP: 
102491899(CPS1)
CFA: 
488506(CPS1)
AML: 
100466842(CPS1)
FCA: 
101099824(CPS1)
BTA: 
510506(CPS1)
BOM: 
102267831(CPS1)
PHD: 
102342950(CPS1)
CHX: 
102179612(CPS1)
SSC: 
100157716(CPS1)
CFR: 
ECB: 
100050116(CPS1)
MYB: 
102262103(CPS1)
MDO: 
SHR: 
100929825(CPS1)
OAA: 
GGA: 
428994(CPS1)
MGP: 
TGU: 
100221389(CPS1)
FAB: 
101816308(CPS1)
PHI: 
102105821(CPS1)
APLA: 
101797791(CPS1)
FPG: 
101910440(CPS1)
FCH: 
102046837(CPS1)
CLV: 
102091543(CPS1)
ASN: 
102386005(CPS1)
PSS: 
102462440(CPS1)
ACS: 
XLA: 
733340(cps1)
XTR: 
100158506(cps1)
DRE: 
555623(cps1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102363877(CPS1)
BFO: 
SPU: 
PTI: 
TPS: 
PIF: 
 » show all
Taxonomy
Reference
1  [PMID:14213379]
  Authors
FAHIEN LA, COHEN PP.
  Title
A KINETIC STUDY OF CARBAMYL PHOSPHATE SYNTHETASE.
  Journal
J. Biol. Chem. 239 (1964) 1925-34.
  Organism
frog
Reference
2  [PMID:13790558]
  Authors
JONES ME, SPECTOR L.
  Title
The pathway of carbonate in the biosynthesis of carbamyl phosphate.
  Journal
J. Biol. Chem. 235 (1960) 2897-901.
  Organism
frog
Reference
3  [PMID:13563449]
  Authors
METZENBERG RL, MARSHALL M, COHEN PP.
  Title
Purification of carbamyl phosphate synthetase from frog liver.
  Journal
J. Biol. Chem. 233 (1958) 102-5.
  Organism
frog
Reference
4
  Authors
Marshall, M., Metzenberg, R.L. and Cohen, P.P.
  Title
Physical and kinetic properties of carbamyl phosphate synthetase from frog liver.
  Journal
J. Biol. Chem. 236 (1961) 2229-2237.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9026-23-7

DBGET integrated database retrieval system