| Entry |
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| Name |
urea carboxylase;
urease (ATP-hydrolysing);
urea carboxylase (hydrolysing);
ATP---urea amidolyase;
urea amidolyase;
UALase;
UCA
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| Class |
Ligases;
Forming carbon-nitrogen bonds;
Other carbon-nitrogen ligases
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| Sysname |
urea:carbon-dioxide ligase (ADP-forming)
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| Reaction(IUBMB) |
ATP + urea + HCO3- = ADP + phosphate + urea-1-carboxylate [RN: R00774]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
A biotinyl-protein. The yeast enzyme (but not that from green algae) also catalyses the reaction of EC 3.5.1.54 allophanate hydrolase, thus bringing about the hydrolysis of urea to CO2 and NH3. Previously also listed as EC 3.5.1.45. The enzyme from the prokaryotic bacterium Oleomonas sagaranensis can also use acetamide and formamide as substrates [4].
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| Pathway |
| Arginine and proline metabolism | | Metabolic pathways |
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| Orthology |
| urea carboxylase | | urea carboxylase / allophanate hydrolase |
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| Genes |
SCE: | | AGO: | | KLA: | | LTH: | | PPA: | | VPO: | | ZRO: | | CGR: | | DHA: | | PIC: | | LEL: | | CAL: | | CTP: | | CDU: | | YLI: | | CLU: | | FGR: | | SEX: | | ECA: | | PCT: | | PCC: | | PWA: | | PEC: | | ETA: | | EBI: | | ENC: | | EEC: | | ENL: | | EAS: | | ESA: | | CSK: | | CSZ: | | CTU: | | KPE: | | KVA: | | KOX: | | SPE: | | SRR: | | SRS: | | SRA: | | SMAF: | | SMW: | | DDC: | | DDD: | | DZE: | | PAM: | | PLF: | | PAJ: | | PAQ: | | PVA: | | PAO: | | RAH: | | RAQ: | | RAA: | | EBF: | | XAC: | | XAO: | | XCI: | | PSD: | | PPUU: | | PST: | | PSB: | | PSP: | | PFO: | | PFE: | | PMY: | | PMK: | | PSZ: | | PSR: | | PSC: | | PSH: | | PBA: | | PFV: | | CJA: | | ACD: | | ABY: | | ABC: | | ABN: | | ABB: | | ABX: | | ABZ: | | ABR: | | ABD: | | ABH: | | ABAD: | | ACC: | | SAZ: | | SLO: | | SDE: | | MAD: | | MBS: | | TTU: | | TCX: | | HHA: | | TGR: | | HNA: | | ABO: | | ADI: | | MPC: | | TOL: | | TAU: | | REU: | | BMA: | | BMV: | | BML: | | BMN: | | BPS: | | BPM: | | BPL: | | BPD: | | BPZ: | | BPQ: | | BVI: | | BCN: | | BCH: | | BCM: | | BCJ: | | BMU: | | BMJ: | | BXE: | | BPH: | | BPY: | | BGL: | | BUG: | | BGE: | | BGD: | | BYI: | | BUK: | | BPX: | | BPT: | | AXY: | | PNA: | | VEI: | | HSE: | | THI: | | NEU: | | NET: | | NIT: | | NII: | | NMU: | | DAR: | | MEH: | | MEI: | | MEP: | | SLT: | | GCA: | | WSU: | | SKU: | | ARC: | | SCL: | | PLA: | | ARA: | | AVI: | | RET: | | REC: | | RLE: | | RLT: | | RLG: | | RTR: | | BBT: | | RPA: | | RPC: | | RPD: | | RPE: | | RPT: | | RPX: | | XAU: | | AZC: | | MEX: | | MEA: | | MDI: | | MCH: | | MPO: | | MSL: | | HMC: | | CCR: | | CCS: | | CAK: | | AEX: | | SIT: | | NAR: | | NPP: | | SJP: | | GOH: | | GBE: | | ACR: | | AMV: | | APT: | | APF: | | APU: | | APG: | | APQ: | | APX: | | APZ: | | AZL: | | BMD: | | BMH: | | BAG: | | PJD: | | PMS: | | PMQ: | | AAC: | | AAD: | | SGY: | | CLE: | | RIX: | | RIM: | | EHA: | | SAY: | | SAP: | | MSG: | | MSA: | | MMV: | | MMC: | | MKM: | | MJL: | | MJD: | | ASD: | | CEF: | | NCY: | | NBR: | | RHA: | | RER: | | ROP: | | REQ: | | GPO: | | GOR: | | SMA: | | SCB: | | SBH: | | SHY: | | SHO: | | KSK: | | CMI: | | CMS: | | CMC: | | ART: | | AAU: | | APN: | | ARR: | | CFL: | | FRI: | | KRA: | | AMD: | | AMN: | | AMM: | | ASE: | | CAI: | | ACM: | | GMA: | | SUS: | | CAA: | | SYNP: | | CYN: | | GLP: | | CMP: | | GVI: | | CALO: | | ONI: | |
» show all
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| Reference |
1 |
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| Authors |
Roon, R.J. and Levenberg, B. |
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| Title |
ATP-Urea amidolyase (ADP) (Candida utilis). |
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| Journal |
Methods Enzymol. 17A (1970) 317-324. |
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| Reference |
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| Authors |
Roon RJ, Levenberg B. |
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| Title |
Urea amidolyase. I. Properties of the enzyme from Candida utilis. |
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| Journal |
J. Biol. Chem. 247 (1972) 4107-13. |
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| Organism |
Candida utilis |
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| Reference |
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| Authors |
Sumrada RA, Cooper TG. |
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| Title |
Urea carboxylase and allophanate hydrolase are components of a multifunctional protein in yeast. |
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| Journal |
J. Biol. Chem. 257 (1982) 9119-27. |
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| Organism |
Candida utilis, Saccharomyces cerevisiae [GN: sce] |
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| Reference |
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| Authors |
Kanamori T, Kanou N, Atomi H, Imanaka T. |
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| Title |
Enzymatic characterization of a prokaryotic urea carboxylase. |
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| Journal |
J. Bacteriol. 186 (2004) 2532-9. |
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| Organism |
Oleomonas sagaranensis |
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| Sequence |
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| Other DBs |
ExplorEnz - The Enzyme Database: IUBMB Enzyme Nomenclature: ExPASy - ENZYME nomenclature database: BRENDA, the Enzyme Database: CAS: 9058-98-4 |
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