| Entry |
|
|---|
| Name |
asparagine synthase (glutamine-hydrolysing);
asparagine synthetase (glutamine-hydrolysing);
glutamine-dependent asparagine synthetase;
asparagine synthetase B;
AS;
AS-B |
|---|
| Class |
Ligases;
Forming carbon-nitrogen bonds;
Carbon-nitrogen ligases with glutamine as amido-N-donor
 |
|---|
| Sysname |
L-aspartate:L-glutamine amido-ligase (AMP-forming) |
|---|
| Reaction(IUBMB) |
(1) ATP + L-aspartate + L-glutamine + H2O = AMP + diphosphate +
L-asparagine + L-glutamate [RN:R00578];
(2) (1a) L-glutamine + H2O = L-glutamate + NH3 [RN:R00256];
(3) (1b) ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine
[RN:R00483] |
|---|
| Reaction(KEGG) |
R00256 R00483 R00578
 |
|---|
| Substrate |
ATP [CPD:C00002];
L-aspartate [CPD:C00049];
L-glutamine [CPD:C00064];
H2O [CPD:C00001];
NH3 [CPD:C00014] |
|---|
| Product |
AMP [CPD:C00020];
diphosphate [CPD:C00013];
L-asparagine [CPD:C00152];
L-glutamate [CPD:C00025];
NH3 [CPD:C00014] |
|---|
| Comment |
The enzyme from Escherichia coli has two active sites [4] that are
connected by an intramolecular ammonia tunnel [6,7]. The enzyme
catalyses three distinct chemical reactions: glutamine hydrolysis to
yield ammonia takes place in the N-terminal domain. The C-terminal
active site mediates both the synthesis of a beta-aspartyl-AMP
intermediate and its subsequent reaction with ammonia. The ammonia
released is channeled to the other active site to yield asparagine
[7]. |
|---|
| Pathway |
PATH: ec00250 Alanine, aspartate and glutamate metabolism
PATH: ec00910 Nitrogen metabolism
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01953 asparagine synthase (glutamine-hydrolysing) |
|---|
| Genes |
HSA: 440(ASNS)
PTR: 463556(ASNS)
MCC: 697232(ASNS)
MMU: 27053(Asns)
RNO: 25612(Asns)
CFA: 475240(ASNS)
BTA: 514209(ASNS)
ECB: 100063632
MDO: 100027701
GGA: 420574(ASNS)
TGU: 100224891
XTR: 448254(asns)
DRE: 394138(asns)
CIN: 100185185
SPU: 575946
DME: Dmel_CG33486(asparagine-synthetase)
DPO: Dpse_GA29320
DAN: Dana_GF24297
DER: Dere_GG16161
DPE: Dper_GL15046
DSE: Dsec_GM22343
DSI: Dsim_GD14936
DYA: Dyak_GE19730
DGR: Dgri_GH14963 Dgri_GH14964
DMO: Dmoj_GI13124 Dmoj_GI13125
AGA: AgaP_AGAP003833
AAG: AaeL_AAEL007557 AaeL_AAEL015631
CQU: CpipJ_CPIJ007938
AME: 724480
NVI: 100113652
TCA: 100141713
API: 100160265
CEL: F25G6.6(nrs-2) M02D8.4
CBR: CBG01494 CBG15441
NVE: NEMVE_v1g156799 NEMVE_v1g163815 NEMVE_v1g222375
HMG: 100215424
TAD: TRIADDRAFT_34900
ATH: AT3G47340(ASN1) AT5G10240(ASN3) AT5G65010(ASN2)
POP: POPTR_207428 POPTR_722643
RCU: RCOM_0212760 RCOM_0479760
VVI: 100240866 100241610
OSA: 4332506(Os03g0291500) 4340706(Os06g0265000)
SBI: SORBI_10g009590(SORBIDRAFT_10g009590)
ZMA: 100192349(AsnS2) 100192350(AsnS3) 542435(asn1)
PPP: PHYPADRAFT_173106 PHYPADRAFT_180723 PHYPADRAFT_226188
CRE: CHLREDRAFT_140252 CHLREDRAFT_186302
OLU: OSTLU_45116
CME: CMM145C
SCE: YGR124W(ASN2) YPR145W(ASN1)
AGO: AGOS_AFR303W
KLA: KLLA0B10868g
LTH: KLTH0F14630g
DHA: DEHA0B09944g
PIC: PICST_83540(ASN1)
PPA: PAS_chr3_0675
VPO: Kpol_480p19
LEL: LELG_02563
ZRO: ZYRO0B04136g
CAL: CaO19.198(ASN1) CaO19.7828(ASN1)
CTP: CTRG_01919
CDU: CD36_23240
CGR: CAGL0I10648g
YLI: YALI0A13387g
SPO: SPBC119.10
NCR: NCU04303
PAN: PODANSg1125 PODANSg8830
MGR: MGG_00969 MGG_08450
FGR: FG09934.1 FG11396.1
ANI: AN4401.2 AN8754.2
AFM: AFUA_4G06900
AOR: AO090023000896 AO090103000353 AO090103000354 AO090120000180
ANG: An04g01340 An12g07660
AFV: AFLA_008780 AFLA_091700 AFLA_113050
PCS: Pc21g12620 Pc22g17940
NFI: NFIA_109340
CIM: CIMG_04121
URE: UREG_05561
SSL: SS1G_10649
BFU: BC1G_04186
CNE: CNH00920
CNB: CNBL0870
LBC: LACBIDRAFT_188009
MPR: MPER_07359 MPER_11110 MPER_11630
UMA: UM00311.1
MGL: MGL_0551
DDI: DDB_0230140(asnA) DDB_0230142(asnB)
PFA: MAL3P3.14
PFH: PFHG_01093
PYO: PY02906
PCB: PC000916.01.0
PBE: PB000521.01.0
PKN: PKH_083070
PVX: PVX_119585
TGO: TGME49_053430
TET: TTHERM_00052420
PTM: GSPATT00000284001 GSPATT00000832001 GSPATT00008656001
PTI: PHATRDRAFT_18337
TPS: THAPSDRAFT_268718(ANS1)
ECO: b0674(asnB)
ECJ: JW0660(asnB)
ECD: ECDH10B_0739(asnB)
EBW: BWG_0534(asnB)
ECE: Z0821(asnB)
ECS: ECs0704(asnB)
ECF: ECH74115_0764(asnB)
ETW: ECSP_0721(asnB)
ECG: E2348C_0556(asnB)
ECC: c0749(asnB)
ECI: UTI89_C0668(asnB)
ECP: ECP_0686(asnB)
ECV: APECO1_1398(asnB)
ECW: EcE24377A_0699(asnB)
ECX: EcHS_A0717(asnB)
ECM: EcSMS35_0693(asnB)
ECY: ECSE_0734(asnB)
ECL: EcolC_2982(asnB)
ECK: EC55989_0660(asnB)
ECQ: ECED1_0655(asnB)
ECR: ECIAI1_0651(asnB)
ECT: ECIAI39_0631(asnB)
ECZ: ECS88_0699(asnB)
EUM: ECUMN_0759(asnB)
ELF: LF82_0166(asnB)
EBL: B21_00622(asnB)
EBD: ECBD_2988
EBR: ECB_00631(asnB)
EOH: ECO103_0670(asnB)
EOI: ECO111_0693(asnB)
EOJ: ECO26_0738(asnB)
EFE: EFER_2435(asnB)
STY: STY0718(asnB)
STT: t2195(asnB)
SEK: SSPA1921a(asnB)
SPQ: SPAB_02863(asnB)
SEI: SPC_0689(asnB)
SEC: SC0701(asnB)
SEH: SeHA_C0799(asnB)
SEE: SNSL254_A0739(asnB)
SEW: SeSA_A0835(asnB)
SEA: SeAg_B0727(asnB)
SED: SeD_A0786(asnB)
SEG: SG0677(asnB)
SET: SEN0644(asnB)
SES: SARI_02262(asnB)
STM: STM0680(asnB)
YPE: YPO2623(asnB)
YPK: y1198(asnB)
YPM: YP_1090(asnB)
YPA: YPA_2474(asnB)
YPN: YPN_1109(asnB)
YPG: YpAngola_A0334(asnB)
YPP: YPDSF_2630(asnB)
YPS: YPTB1115(asnB)
YPI: YpsIP31758_2913(asnB)
YPY: YPK_3001(asnB)
YPB: YPTS_1173(asnB)
YEN: YE2983(asnB)
SFL: SF0619(asnB)
SFX: S0630(asnB)
SFV: SFV_0657(asnB)
SSN: SSON_0627(asnB)
SBO: SBO_0536(asnB)
SBC: SbBS512_E0577(asnB)
SDY: SDY_0608(asnB)
ECA: ECA1323(asnB)
PCT: PC1_1200
PWA: Pecwa_3131
ETA: ETA_23350(asnB)
PLU: plu2770
PAY: PAU_02262(wbmC) PAU_04336(wbfR)
WBR: WGLp587(asnB)
SGL: SG0813(asnB)
ENT: Ent638_1189(asnB)
ESA: ESA_02665(asnB)
CTU: Ctu_12880(asnB)
KPN: KPN_00695(asnB)
KPE: KPK_3878(asnB)
KPU: KP1_1645(asnB)
CKO: CKO_02490(asnB)
SPE: Spro_0346 Spro_1222(asnB)
EIC: NT01EI_2913
ETR: ETAE_2623(asnB)
HDE: HDEF_2098(asnB)
DDA: Dd703_1111
DDC: Dd586_1156
DZE: Dd1591_2945
XFA: XF0118(asnB)
XFT: PD0089(asnB)
XFM: Xfasm12_0096(asnB)
XFN: XfasM23_0082(asnB)
XCC: XCC1388(asnB) XCC1432(wbpS)
XCB: XC_2806 XC_2848(asnB)
XCA: xccb100_2866(asnB2) xccb100_2908(asnB)
XCV: XCV1490(asnB) XCV1533(asnB2) XCV1549
XAC: XAC0051(asnB) XAC0059(asn) XAC1433(asnB) XAC1475
XOO: XOO1523 XOO1990(asnB)
XOM: XOO_1412 XOO_1881(asnB)
XOP: PXO_01146(asnB) PXO_04798(asnB)
SML: Smlt0598 Smlt1520(asnB) Smlt3206
SMT: Smal_0474 Smal_1280(asnB) Smal_2639
VCH: VC0991(asnB)
VCO: VC0395_A0512(asnB)
VCM: VCM66_0947(asnB)
VCJ: VCD_003347
VVU: VV1_0183(asnB)
VVY: VV1007(asnB)
VPA: VP0826(asnB)
VHA: VIBHAR_01332(asnB)
VSP: VS_2264(asnB)
VEX: VEA_004132
VFI: VF_0804(asnB)
VFM: VFMJ11_0842(asnB)
VSA: VSAL_I0827(asnB)
PPR: PBPRA1027(asnB)
PAE: PA0051(phzH) PA2084 PA3459
PAU: PA14_00640(phzH) PA14_19370(asnB) PA14_37560(asnB)
PAP: PSPA7_1668(asnB)
PAG: PLES_00521(phzH) PLES_16011 PLES_19131 PLES_32371 PLES_53841
PPU: PP_1750(asnB)
PPF: Pput_3964
PPG: PputGB1_1342
PPW: PputW619_1300 PputW619_2683
PST: PSPTO_1633(asnB)
PSB: Psyr_3747 Psyr_4315
PSP: PSPPH_1509(asnB)
PFL: PFL_4333
PFO: Pfl01_4100
PFS: PFLU2452 PFLU4320
PEN: PSEEN1469 PSEEN2476 PSEEN5526
PMY: Pmen_2955
PSA: PST_1440(asnB)
AVN: Avin_34960(asnB)
PAR: Psyc_0665(asnB) Psyc_0668(wbpS)
PCR: Pcryo_0622
PRW: PsycPRwf_0241
SON: SO_2767(asnB) SO_3175(asnB-2)
SDN: Sden_2075(asnB) Sden_3533 Sden_3771
SFR: Sfri_1602(asnB)
SAZ: Sama_2101(asnB)
SBL: Sbal_1731(asnB)
SBM: Shew185_1726(asnB)
SBN: Sbal195_1769(asnB)
SBP: Sbal223_2558(asnB)
SLO: Shew_1509(asnB) Shew_3038
SPC: Sputcn32_1592(asnB)
SSE: Ssed_1838(asnB)
SPL: Spea_2583(asnB)
SHE: Shewmr4_2384(asnB)
SHM: Shewmr7_2456(asnB)
SHN: Shewana3_2549(asnB)
SHW: Sputw3181_2430(asnB)
SHL: Shal_1673(asnB)
SWD: Swoo_2749(asnB)
SWP: swp_1809(asnB)
ILO: IL1526(asnB)
CPS: CPS_0587 CPS_2794(asnB)
PHA: PSHAa1440(asnB)
PAT: Patl_1194 Patl_2955(asnB)
SDE: Sde_0146
MAQ: Maqu_1636
AMC: MADE_01303 MADE_02722(asnB)
PIN: Ping_1104(asnB) Ping_2657
TTU: TERTU_4301(asnB)
CBU: CBU_0831(asnB-1) CBU_0840(asnB-2)
CBS: COXBURSA331_A1110(asnB1) COXBURSA331_A1119(asnB2)
CBD: CBUD_0896(asnB2) CBUD_0905(asnB1)
CBG: CbuG_1161(asnB1) CbuG_1170(asnB2)
CBC: CbuK_0699(asnB1.1) CbuK_0708(asnB1.2)
LPN: lpg2949(wbmI)
LPC: LPC_3262(wbmI)
MCA: MCA0472 MCA0542 MCA2127
FTU: FTT_1456c(wbtH)
FTF: FTF1456c(wbtH)
FTW: FTW_0419(wbtH)
FTL: FTL_0600
FTH: FTH_0600(asnB)
FTA: FTA_0634(wbtH)
FTM: FTM_1490(wbtH)
FTN: FTN_0935(asnB) FTN_1421(wbtH)
FPH: Fphi_1471
TCX: Tcr_0595
NOC: Noc_0777 Noc_1965 Noc_1975 Noc_2478
AEH: Mlg_0134 Mlg_0138 Mlg_2339
HHA: Hhal_1512
TGR: Tgr7_0185 Tgr7_2360 Tgr7_2387 Tgr7_2461
HNA: Hneap_0742
HCH: HCH_01655(asnB1) HCH_02383(asnB2) HCH_02398(asnB3)
HCH_02399(asnB4) HCH_06054
AHA: AHA_2657(asnB)
ASA: ASA_2510(asnB)
TAU: Tola_2208
AFR: AFE_1353(asnB)
RMA: Rmag_0373
VOK: COSY_0351(asnB)
KKO: Kkor_2050
CVI: CV_0797 CV_1713(asnB) CV_3959
LHK: LHK_02790 LHK_02791
REU: Reut_B5373
REH: H16_A3223
BMA: BMA0234 BMAA1158 BMAA1921(asnB)
BMV: BMASAVP1_0936(asnB) BMASAVP1_A2712
BML: BMA10229_0082(asnB-1) BMA10229_1222(asnB-2) BMA10229_A2366
BMN: BMA10247_2446 BMA10247_A1535(asnB-1) BMA10247_A2198(asnB-2)
BPS: BPSL0682 BPSS0163(asnO) BPSS0677
BPM: BURPS1710b_0900(asnB) BURPS1710b_A1682(asnB)
BURPS1710b_A2247(asnB)
BPL: BURPS1106A_0733 BURPS1106A_A0231(asnB) BURPS1106A_A0918(asnB)
BPD: BURPS668_0719 BURPS668_A0321(asnB) BURPS668_A1004(asnB)
BPR: GBP346_A0649(asnB_1)
BTE: BTH_II0232(asnB-1) BTH_II1749(asnB-2)
BVI: Bcep1808_5331
BUR: Bcep18194_B0858
BCN: Bcen_3523
BCH: Bcen2424_4843
BCM: Bcenmc03_5441 Bcenmc03_5645
BCJ: BCAM2044
BAM: Bamb_4217
BAC: BamMC406_4740
BMU: Bmul_3751
BMJ: BMULJ_04765(asnB)
BPE: BP3146
BPA: BPP0123 BPP0136(wbmI) BPP0142(wbmC) BPP0795
BBR: BB0123 BB0136(wbmI) BB0142(wbmC) BB0880
BPT: Bpet1328(asnB) Bpet4026(wbpS)
BAV: BAV0515(wbpS)
RFR: Rfer_0669 Rfer_0671 Rfer_0683 Rfer_3652
POL: Bpro_3988
PNA: Pnap_4494
AAV: Aave_0959 Aave_0961
VEI: Veis_4847
MPT: Mpe_A2724
LCH: Lcho_1389
NEU: NE1127(asnB) NE1795
NET: Neut_0901 Neut_1419 Neut_1735
NMU: Nmul_A2519 Nmul_A2668
EBA: ebA4263(asnB) ebA4265 ebA4285 ebA5271(asnB)
AZO: azo3247(asn) azo3271(asnB1) azo3273(asnB2)
DAR: Daro_1275 Daro_2408 Daro_2428
TBD: Tbd_0060 Tbd_0292 Tbd_0298
MMB: Mmol_0913
APP: CAP2UW1_1422 CAP2UW1_1424 CAP2UW1_1627
WSU: WS0042(wbpS) WS0046(glmS) WS2185(wbfR) WS2192(PAB1605)
TDN: Suden_0163 Suden_0186 Suden_0200
CFF: CFF8240_1611(asnB) CFF8240_1617(asnB)
CCO: CCC13826_0524(asnB) CCC13826_0536(asnB)
ABU: Abu_0045(asnB1) Abu_0668(asnB2) Abu_0678(asnB)
SDL: Sdel_2216
NIS: NIS_1441 NIS_1648
SUN: SUN_2082
NAM: NAMH_0676(asnB)
GSU: GSU1953(asnB)
GME: Gmet_2024 Gmet_2172
GUR: Gura_1346 Gura_1351
GLO: Glov_1501
GBM: Gbem_1081 Gbem_1615 Gbem_1778
GEO: Geob_2948
GEM: GM21_2469 GM21_3180
PPD: Ppro_0050 Ppro_2466 Ppro_2871
DVU: DVU3014 DVUA0073
DVL: Dvul_0358 Dvul_3035
DDE: Dde_1135 Dde_2891 Dde_3317 Dde_3677
DDS: Ddes_2055
DMA: DMR_00560 DMR_42760
DSA: Desal_1082 Desal_3603
LIP: LIB007(asnB)
DBA: Dbac_0125 Dbac_2388 Dbac_3261
DPS: DP0033
DOL: Dole_1107(asnB) Dole_1462
DAT: HRM2_22820(asnB)
ADE: Adeh_2780 Adeh_2789
ACP: A2cp1_2956
AFW: Anae109_1247
ANK: AnaeK_2864
MXA: MXAN_0301
SCL: sce2064 sce3187(asnB1) sce3826(asnB2) sce4939(asnH)
sce8804(asnB3)
HOH: Hoch_5687
SAT: SYN_02666 SYN_02678
SFU: Sfum_0965
MLO: mll5256 mll6743 mlr5888 mlr6755
MES: Meso_2469 Meso_2884
PLA: Plav_0816
SME: SM_b20481(asnO) SM_b20652(asnB)
SMD: Smed_3642 Smed_4334
ARA: Arad_7631(asnB)
RET: RHE_CH00758(asnB)
RLE: pRL100163
RHI: NGR_b11900 NGR_b19210
OAN: Oant_2962
BJA: bll6010 blr6298(asnB)
BRA: BRADO0860 BRADO4822 BRADO5156
BBT: BBta_3705 BBta_5624 BBta_7206
RPB: RPB_1541 RPB_1548 RPB_2064
RPC: RPC_2050 RPC_3874
RPE: RPE_0582
RPT: Rpal_4592
OCA: OCAR_7488
AZC: AZC_1365
MEX: Mext_3554 Mext_4868
MEA: Mex_1p5325
MDI: METDI5926
MRD: Mrad2831_3188
MET: M446_2680
MPO: Mpop_5410
MCH: Mchl_5353
MNO: Mnod_0142 Mnod_6993 Mnod_7772
CAK: Caul_2241 Caul_5191
PZU: PHZ_c0612 PHZ_c2175
RSP: RSP_2557(asnB) RSP_7386
RSH: Rsph17029_1216
RSQ: Rsph17025_1965
RSK: RSKD131_0870
RDE: RD1_3849(asnO)
PDE: Pden_3554
NAR: Saro_2327 Saro_3241
SAL: Sala_1919
SWI: Swit_4039 Swit_4548
ELI: ELI_06815 ELI_12565
GOX: GOX1964
GBE: GbCGDNIH1_1983
ACR: Acry_0265
GDI: GDI_1468
GDJ: Gdia_2168
APT: APA01_17360
RRU: Rru_A0230 Rru_A0819 Rru_A0855 Rru_A1279 Rru_A1460 Rru_A1483
Rru_A1989 Rru_A2937 Rru_A3028 Rru_A3121
RCE: RC1_3544(asnB) RC1_3781(asnB) RC1_4027(asnB)
MAG: amb0042 amb0105 amb0119 amb1266 amb1462 amb4020
MGM: Mmc1_0216 Mmc1_0573 Mmc1_0596 Mmc1_3228
BSU: BSU10790(asnO) BSU30540(asnB) BSU39920(asnH)
BHA: BH1508
BAN: BA1157(asnO-1) BA1751(asnO-2) BA2251(asnO-3)
BAR: GBAA1157(asnO-1) GBAA1751(asnO-2) GBAA2251(asnO-3)
BAA: BA_1702 BA_2264 BA_2754
BAT: BAS1074 BAS1625 BAS2095
BAH: BAMEG_2345(asnO3) BAMEG_2836(asnO2) BAMEG_3425(asnO1)
BAI: BAA_1239(asnO1) BAA_1826(asnO2) BAA_2313(asnO3)
BCE: BC1152 BC1153 BC1697 BC2204
BCA: BCE_1259(asnO) BCE_1828(asnO) BCE_2280(asnO)
BCZ: BCZK1053(asnO) BCZK1577(asnO) BCZK2033(asnB)
BCR: BCAH187_A1310(asnO1) BCAH187_A1882(asnB) BCAH187_A2361(asnO3)
BCB: BCB4264_A1207(asnO1) BCB4264_A1767(asnO2) BCB4264_A2233(asnO3)
BCU: BCAH820_1234(asnO1) BCAH820_1802(asnO) BCAH820_2276(asnO3)
BCG: BCG9842_B3091(asnO3) BCG9842_B3575(asnO2) BCG9842_B4134(asnO1)
BCQ: BCQ_1214(asnO) BCQ_1770(asnO) BCQ_2188(asnB)
BCX: BCA_1196(asnO1) BCA_1764(asnO2) BCA_2334(asnO3)
BCY: Bcer98_0872 Bcer98_1407 Bcer98_1652
BTK: BT9727_1055(asnO) BT9727_1586(asnO) BT9727_2035(asnB)
BTL: BALH_1017 BALH_1539 BALH_2013
BWE: BcerKBAB4_1056 BcerKBAB4_1625 BcerKBAB4_2074 BcerKBAB4_3386
BLI: BL00002(asnB) BL01342(asnO)
BLD: BLi01174(asnO) BLi03195(asnB) BLi04033
BCL: ABC1768(asnO) ABC2580(asnB)
BAY: RBAM_010950(asnO) RBAM_027560(asnB)
BPU: BPUM_1010(asnO) BPUM_2685(asnB)
OIH: OB2608
GKA: GK0700 GK0906(ansB)
GTN: GTNG_0607 GTNG_0790
GWC: GWCH70_0690 GWCH70_2776
GYM: GYMC10_1494
GYC: GYMC61_1505 GYMC61_1694
AFL: Aflv_1225(asnB) Aflv_2202(asnO)
LMO: lmo1663(ansB)
LMF: LMOf2365_1687(asnB)
LMH: LMHCC_0902(asnB)
LMC: Lm4b_01676(ansB)
LIN: lin1772
LWE: lwe1682(ansB)
LSP: Bsph_0019 Bsph_4225
BBE: BBR47_19980(asnB) BBR47_21760(asnO) BBR47_39830
PJD: Pjdr2_4456
AAC: Aaci_0101
LLA: L00396(asnB) L0095(asnH)
LLK: LLKF_0407(asnB) LLKF_2495(asnH)
LLC: LACR_0398(asnB) LACR_2533
LLM: llmg_0372(asnB) llmg_2506(asnH)
SPW: SPCG_0140
SNM: SP70585_1296
SSU: SSU05_0912
SSV: SSU98_0918
SSS: SSUSC84_0817
LPL: lp_0980(asnB1) lp_3085(asnB2)
LPJ: JDM1_0813(asnB1) JDM1_2460(asnB2)
LJO: LJ0135
LJF: FI9785_202(asnB)
LAC: LBA0158(asnH)
LSA: LSA0636(asnB)
LSL: LSL_0012(asnB)
LDB: Ldb0209(asnB1)
LBU: LBUL_0183
LBR: LVIS_1501
LCA: LSEI_2162
LCB: LCABL_23430(asnH)
LGA: LGAS_0135
LRE: Lreu_1938
LRF: LAR_1814
LHE: lhv_0164
LFE: LAF_0646(asnB) LAF_1836
LRH: LGG_02175(asnH)
LRL: LC705_02174(asnH)
PPE: PEPE_0659
CAC: CAC2243(asnB) CAC2249
CTH: Cthe_0556
CDF: CD0391 CD1632(asnB)
CDC: CD196_0376 CD196_1555(asnB)
CDL: CDR20291_0362 CDR20291_1530(asnB)
CBO: CBO2706
CBA: CLB_2647
CBH: CLC_2579
CBK: CLL_A1395(asnB) CLL_A2544(asnB)
CBI: CLJ_B2941
CBT: CLH_1324(asnB) CLH_2310(asnB)
CBE: Cbei_1034
CKL: CKL_1024(asnB) CKL_2310(asnB)
CKR: CKR_0928 CKR_2032
CPY: Cphy_2936
AMT: Amet_4405
STH: STH231 STH259(asnB)
SWO: Swol_0712
ATE: Athe_1539
DSY: DSY4329
DHD: Dhaf_0993
DRM: Dred_2812
DAE: Dtox_1034 Dtox_1627 Dtox_2340 Dtox_3272
PTH: PTH_0673(asnB)
DAU: Daud_0140
HMO: HM1_0486(asnB)
EEL: EUBELI_01276
ERE: EUBREC_0144
TTE: TTE0817(asnB)
TEX: Teth514_0461 Teth514_2106(asnB)
TPD: Teth39_1423(asnB) Teth39_1774
CHY: CHY_0104(asnB)
MTA: Moth_1299
CSC: Csac_2226
NTH: Nther_0444 Nther_0960 Nther_0961 Nther_1868
HOR: Hore_22410
POY: PAM594(asnB)
AYW: AYWB_130
MTU: Rv2201(asnB)
MTC: MT2257
MRA: MRA_2217(asnB)
MTF: TBFG_12229
MTB: TBMG_01780(TBMG_01780.1)
MBO: Mb2224(asnB)
MBB: BCG_2217(asnB)
MBT: JTY_2211(asnB)
MLE: ML0874(asnB)
MLB: MLBr_00874(asnB)
MPA: MAP1421(asnB_1) MAP1941(asnB_2)
MAV: MAV_2290(asnB) MAV_3055(asnB)
MSM: MSMEG_2594(asnB) MSMEG_4269(asnB)
MUL: MUL_3558(asnB)
MVA: Mvan_2276 Mvan_3565
MGI: Mflv_2948 Mflv_4066
MAB: MAB_1960c
MMC: Mmcs_2055 Mmcs_3299
MKM: Mkms_2101 Mkms_3361
MJL: Mjls_2038 Mjls_3310
MMI: MMAR_3245(asnB)
CGL: NCgl2116(cgl2196)
CGB: cg2410(ltsA)
CGT: cgR_2077
CEF: CE2088(ltsA)
CDI: DIP1630(asnB)
CJK: jk0714(asnB)
CUR: cur_1240
CAR: cauri_1702(ltsA)
CKP: ckrop_0707
NFA: nfa17070(asnB) nfa29020
RHA: RHA1_ro01138(asn1) RHA1_ro05010(asn2)
RER: RER_36030(ltsA)
ROP: ROP_08660(ltsA) ROP_50720(asnB)
GBR: Gbro_3062 Gbro_3766
SCO: SCO0386(SCF62.12)
SMA: SAV_2197 SAV_259(asnH1) SAV_5689(asnH2)
SGR: SGR_6784
LXX: Lxx21710(asn)
RSA: RSal33209_2004 RSal33209_2934
BFA: Bfae_10450 Bfae_21010
XCE: Xcel_0090
TFU: Tfu_1145
SRO: Sros_3531 Sros_4169 Sros_6500
FRA: Francci3_2103 Francci3_2910 Francci3_2986
FRE: Franean1_2293
FAL: FRAAL4488 FRAAL4922 FRAAL5643(asnO)
NML: Namu_3256 Namu_4478 Namu_4484 Namu_5099
KRA: Krad_3398
SEN: SACE_1677(asn1) SACE_6091(asnB-1)
SVI: Svir_02110 Svir_10620
AMI: Amir_1366 Amir_3071 Amir_3327 Amir_3676
STP: Strop_0917 Strop_1632 Strop_2108 Strop_2541 Strop_3057
SAQ: Sare_0860 Sare_1618 Sare_2728 Sare_3283
CAI: Caci_4250 Caci_5966 Caci_6881 Caci_6999
BLN: Blon_0478
BAD: BAD_1077(asnH)
CCU: Ccur_11980
ELE: Elen_0644 Elen_1053 Elen_2121
ACA: ACP_1045(asnB1) ACP_1820(asnB2) ACP_3222
SUS: Acid_0272 Acid_4105 Acid_4624 Acid_5610
BTH: BT_0551(asnB)
BFR: BF2639(asnB)
BFS: BF2661(asnB)
BVU: BVU_4009(asnB)
PGI: PG1136
PGN: PGN_1234
PDI: BDI_0324(asnB)
APS: CFPG_314(asnB)
RMR: Rmar_0967 Rmar_2070 Rmar_2386
CHU: CHU_0058(asnB) CHU_3607(asnB) CHU_3693(asnB)
DFE: Dfer_4543
CPI: Cpin_3403 Cpin_3710 Cpin_4904
GFO: GFO_0573(asnB) GFO_1998(asnB) GFO_2750(asnB)
FJO: Fjoh_2251(asnB) Fjoh_2252(asnB)
FPS: FP0526(asnB) FP1997(asnB)
FBA: FIC_01692
RBI: RB2501_10447
AAS: Aasi_0901
STR: Sterm_0374
OTE: Oter_2956 Oter_3265 Oter_3376
GAU: GAU_0557(asnB)
RBA: RB12191 RB13303(asnB) RB4577(asnB)
SYW: SYNW2453(asnB)
SYD: Syncc9605_2633
SYE: Syncc9902_2260
SYG: sync_0178(asnB)
SYR: SynRCC307_0175 SynRCC307_1124(asnB)
TEL: tll0236
CYT: cce_4003(asnB)
CYC: PCC7424_2579 PCC7424_5791
CYN: Cyan7425_1026 Cyan7425_2952 Cyan7425_3874 Cyan7425_4960
NPU: Npun_F1373 Npun_R1853 Npun_R1857
PMA: Pro0058(asnB)
PMI: PMT9312_1324
PMH: P9215_14791 P9215_14831(asnB)
PME: NATL1_08651(asnB)
TER: Tery_2515 Tery_4278
AMR: AM1_1915(asnB) AM1_5764(asnB)
CPC: Cpar_1424
PVI: Cvib_0642
PLT: Plut_1852
PAA: Paes_0114
CTS: Ctha_0361 Ctha_2023 Ctha_2582
RRS: RoseRS_2044 RoseRS_2461(asnB) RoseRS_3649 RoseRS_4419
RoseRS_4439
RCA: Rcas_0489 Rcas_0764 Rcas_0793 Rcas_2336 Rcas_3021
CAG: Cagg_1962 Cagg_3428
HAU: Haur_3359 Haur_3584 Haur_3710 Haur_4005
DDR: Deide_20310(asnB)
TTH: TTC0282
HYA: HY04AAS1_1597
SAF: SULAZ_0349(asnB)
TRQ: TRQ2_0311
TME: Tmel_0508
KOL: Kole_1285
TYE: THEYE_A0484(asnB)
TTR: Tter_1153 Tter_2826 Tter_2829
MJA: MJ1056 MJ1116
MFE: Mefer_0302
MVU: Metvu_0164
MMP: MMP0918(asnB)
MMQ: MmarC5_0497 MmarC5_0725
MMX: MmarC6_1737
MMZ: MmarC7_0165
MAE: Maeo_0205
MVN: Mevan_0211
MAC: MA0051 MA1966(asn)
MBA: Mbar_A2257
MMA: MM_1351 MM_2805
MBU: Mbur_0465 Mbur_1580
MHU: Mhun_1015
MLA: Mlab_0834
MEM: Memar_0774 Memar_2057
MBN: Mboo_0855 Mboo_2442
MPL: Mpal_0838 Mpal_1295
MPD: MCP_2438
MTH: MTH414
MST: Msp_0490
MSI: Msm_0160
MKA: MK0103(asnB)
AFU: AF1439(asnB)
HAL: VNG0867G(asnA)
HSL: OE2278F(asnA)
HMA: rrnAC1359(asnB)
HWA: HQ1691A(asnB)
NPH: NP2978A(asn)
HLA: Hlac_0611
HUT: Huta_0732
HMU: Hmuk_1987
TAC: Ta0315
TVO: TVN0439
PTO: PTO1047
PHO: PH1102
PAB: PAB0750(asnB) PAB1605
PFU: PF0792 PF1071
TKO: TK0950
TON: TON_1083
TGA: TGAM_0001 TGAM_1938(asnB) TGAM_2143
TSI: TSIB_1407 TSIB_2023
RCI: RCIX1956(asnB-1) RCIX2428(asnB-2)
APE: APE_2041.1
IHO: Igni_0570
PAI: PAE0376
PIS: Pisl_1452
PCL: Pcal_1537
TNE: Tneu_0528
NMR: Nmar_0935 Nmar_1466
 |
|---|
| Structures |
PDB: 1CT9 |
|---|
Reference
Authors
Title
Journal
Organism
|
1 [PMID:4295091]
Patterson MK Jr, Orr GR.
Asparagine biosynthesis by the Novikoff Hepatoma isolation,
purification, property, and mechanism studies of the enzyme system.
J. Biol. Chem. 243 (1968) 376-80.
Rattus norvegicus [GN:rno] |
|---|
Reference
Authors
Title
Journal
Organism
|
2 [PMID:7907328]
Boehlein SK, Richards NG, Schuster SM.
Glutamine-dependent nitrogen transfer in Escherichia coli asparagine
synthetase B. Searching for the catalytic triad.
J. Biol. Chem. 269 (1994) 7450-7.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:9559053]
Richards NG, Schuster SM.
Mechanistic issues in asparagine synthetase catalysis.
Adv. Enzymol. Relat. Areas. Mol. Biol. 72 (1998) 145-98.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
4 [PMID:10587437]
Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden
HM, Rayment I.
Three-dimensional structure of Escherichia coli asparagine
synthetase B: a short journey from substrate to product.
Biochemistry. 38 (1999) 16146-57.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
5 [PMID:10852734]
Larsen TM, Boehlein SK, Schuster SM, Richards NG, Thoden JB, Holden
HM, Rayment I I.
Three-dimensional structure of escherichia coli asparagine
synthetase B: A short journey from substrate to product
Biochemistry. 39 (2000) 7330.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
6 [PMID:11395405]
Huang X, Holden HM, Raushel FM.
Channeling of substrates and intermediates in enzyme-catalyzed
reactions.
Annu. Rev. Biochem. 70 (2001) 149-80.
Escherichia coli [GN:eco] |
|---|
Reference
Authors
Title
Journal
Organism
|
7 [PMID:12706338]
Tesson AR, Soper TS, Ciustea M, Richards NG.
Revisiting the steady state kinetic mechanism of glutamine-dependent
asparagine synthetase from Escherichia coli.
Arch. Biochem. Biophys. 413 (2003) 23-31.
Escherichia coli [GN:eco] |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.3.5.4
IUBMB Enzyme Nomenclature: 6.3.5.4
ExPASy - ENZYME nomenclature database: 6.3.5.4
BRENDA, the Enzyme Database: 6.3.5.4
CAS: 37318-72-2 |
|---|
