KEGG   ENZYME: 6.4.1.1Help
Entry
EC 6.4.1.1                  Enzyme                                 
Name pyruvate carboxylase;
pyruvic carboxylase
Class Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified
to date)
BRITE hierarchy
Sysname pyruvate:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB) ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate [RN:R00344]
Reaction(KEGG) R00344
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Substrate ATP [CPD:C00002];
pyruvate [CPD:C00022];
HCO3- [CPD:C00288]
Product ADP [CPD:C00008];
phosphate [CPD:C00009];
oxaloacetate [CPD:C00036]
Cofactor Acetyl-CoA [CPD:C00024];
Manganese [CPD:C00034];
Zinc [CPD:C00038];
Biotin [CPD:C00120]
Comment A biotinyl-protein containing manganese (animal tissues) or zinc
(yeast). The animal enzyme requires acetyl-CoA.
Pathway PATH: ec00020  Citrate cycle (TCA cycle)
PATH: ec00620  Pyruvate metabolism
PATH: ec01100  Metabolic pathways
Orthology KO: K01959  pyruvate carboxylase subunit A
KO: K01960  pyruvate carboxylase subunit B
Genes HSA: 5091(PC)
MCC: 713103(PC)
MMU: 18563(Pcx)
RNO: 25104(Pc)
CFA: 483704(PC)
BTA: 338471(PC)
SSC: 397630(PC)
ECB: 100052853(PC)
MDO: 100015028
GGA: 374263(PCX)
XLA: 398811(MGC68971)
DRE: 58068(pc)
CIN: 100181512
DME: Dmel_CG1516
DPO: Dpse_GA13539
DAN: Dana_GF13141
DER: Dere_GG25254
DPE: Dper_GL10237
DSE: Dsec_GM24372
DSI: Dsim_GD10045
DYA: Dyak_GE21984
DGR: Dgri_GH20214
DMO: Dmoj_GI20741
AGA: AgaP_AGAP004742
AAG: AaeL_AAEL009691
CQU: CpipJ_CPIJ002514
AME: 725182
NVI: 100115516
TCA: 662701
API: 100162105
CEL: D2023.2(pyc-1)
CBR: CBG23262
SMM: Smp_141360
NVE: NEMVE_v1g178585
HMG: 100200393
TAD: TRIADDRAFT_30016
CRE: CHLREDRAFT_112730(PYC1)
OLU: OSTLU_32964
SCE: YBR218C(PYC2) YGL062W(PYC1)
AGO: AGOS_AAR162C
KLA: KLLA0C05764g
LTH: KLTH0H06600g
DHA: DEHA0C10208g
PIC: PICST_90975(PYC1)
PPA: PAS_chr2-2_0024
VPO: Kpol_461p4
LEL: LELG_04434
ZRO: ZYRO0C04818g
CAL: CaO19.789(PYC2)
CTP: CTRG_00259
CDU: CD36_43660
CGR: CAGL0F06941g CAGL0K06787g
YLI: YALI0C24101g
SPO: SPBC17G9.11c(pyr1)
NCR: NCU02505
PAN: PODANSg10109
MGR: MGG_07756
FGR: FG07075.1
ANI: AN4462.2
AFM: AFUA_4G07710
AOR: AO090023000801
ANG: An04g02090(pyc)
AFV: AFLA_112120
PCS: Pc13g07230
NFI: NFIA_108470
CIM: CIMG_09573
URE: UREG_04749
SSL: SS1G_12839
BFU: BC1G_05327
CNE: CNF00650
CNB: CNBF4030
LBC: LACBIDRAFT_185474(PYC)
MPR: MPER_09591
UMA: UM01054.1
MGL: MGL_2649
MBR: MONBRDRAFT_10371
EHI: EHI_082530
TGO: TGME49_084190
PTI: PHATRDRAFT_30519(PYC1) PHATRDRAFT_49339(PYC2)
TPS: THAPSDRAFT_269908
PAE: PA1400 PA5435 PA5436
PAU: PA14_71740(accC)
PAP: PSPA7_6224(accC1)
PPU: PP_5347(accC-2)
PPF: Pput_5256
PPG: PputGB1_5396
PPW: PputW619_5125
PST: PSPTO_5511
PSB: Psyr_5061
PSP: PSPPH_5143
PFL: PFL_3029 PFL_6158(accC)
PFO: Pfl01_5640
PEN: PSEEN5496(accC-2)
PMY: Pmen_3842 Pmen_4478 Pmen_4479
PSA: PST_0186(accC-2)
SLO: Shew_2867
LPN: lpg0466 lpg2664
LPF: lpl2591
LPP: lpp2718
LPC: LPC_0475(accC)
HHA: Hhal_0402
HCH: HCH_06705(accC2)
CSA: Csal_1555
MMW: Mmwyl1_3926
REU: Reut_A2997 Reut_B3892 Reut_B4717
REH: H16_A1251(pyc) H16_A2142(accA2)
RME: Rmet_1638 Rmet_4069
CTI: RALTA_A1205
BUR: Bcep18194_C7328
BAM: Bamb_5754
BAC: BamMC406_5521
BXE: Bxe_C0325
BPA: BPP0604
BBR: BB0610
VEI: Veis_4187
TBD: Tbd_1555
MFA: Mfla_1511
HHE: HH1849
WSU: WS1289(pycA)
TDN: Suden_1259
CJE: Cj0933c(pycB) Cj1037c(pycA)
CJU: C8J_0974(pycA)
CFF: CFF8240_1293
CCV: CCV52592_0964
CHA: CHAB381_1620
ABU: Abu_0176(pycB1) Abu_0605(accC2) Abu_1226(pycB2)
GSU: GSU2428(pyc)
GME: Gmet_0816
GUR: Gura_2907
GLO: Glov_2549
GBM: Gbem_0273
GEO: Geob_3494
GEM: GM21_0258
PCA: Pcar_1957(pyc)
PPD: Ppro_1336
DVU: DVU1834
DVL: Dvul_1015 Dvul_1328
DVM: DvMF_0417
DDE: Dde_1541 Dde_2081
DDS: Ddes_1553
DMA: DMR_28100
DBA: Dbac_0873 Dbac_2160
DRT: Dret_0690 Dret_2308
BBA: Bd3578
DPS: DP0686
DAL: Dalk_3023
ADE: Adeh_3015
ACP: A2cp1_3215
AFW: Anae109_2995
ANK: AnaeK_3114
MXA: MXAN_3881(pyc)
SAT: SYN_01040 SYN_01041
MLO: mll3969
MES: Meso_3329
PLA: Plav_2692
SME: SMc03895(pyc)
SMD: Smed_3139
ATU: Atu2726(pycA)
ATC: AGR_C_4940
ARA: Arad_4718(pyc)
AVI: Avi_4375(pycA)
RET: RHE_CH04002(pyc)
REC: RHECIAT_CH0004290(pyc)
RLE: RL4638
RLT: Rleg2_3839
RLG: Rleg_4167
RHI: NGR_c32860
BME: BMEI0266
BMF: BAB1_1791(pyc)
BMB: BruAb1_1764(pyc)
BMC: BAbS19_I16740
BMS: BR1781(pyc)
BMT: BSUIS_B1257(pyc)
BOV: BOV_1716(pyc)
BCS: BCAN_A1819
BMR: BMI_I1799(pyc)
OAN: Oant_1119 Oant_4597
BJA: bll7292
RPA: RPA1450
RPB: RPB_0228
RPC: RPC_3200
RPD: RPD_0602
RPE: RPE_0635
MSL: Msil_1360
CCR: CC_3214
CAK: Caul_4464
SIL: SPO1171(pyc)
SIT: TM1040_2028
RSP: RSP_2090(pycA)
RSH: Rsph17029_0765
RSQ: Rsph17025_0677
RSK: RSKD131_0398
JAN: Jann_2781
RDE: RD1_3376(pyc)
PDE: Pden_4144
DSH: Dshi_2485
MMR: Mmar10_1142
ACR: Acry_2669
RRU: Rru_A1121 Rru_A2317
MAG: amb0239
BSU: BSU14860(pycA)
BHA: BH2625(pycA)
BAN: BA4157(pyc)
BAR: GBAA4157(pyc)
BAA: BA_4626
BAT: BAS3859
BAH: BAMEG_4200(pyc)
BAI: BAA_4182(pyc)
BCE: BC3947
BCA: BCE_3994(pyc)
BCZ: BCZK3707(pyc)
BCR: BCAH187_A4065(pyc)
BCB: BCB4264_A4050(pyc)
BCU: BCAH820_3962(pyc)
BCG: BCG9842_B1190(pyc)
BCQ: BCQ_3735(pyc)
BCX: BCA_4052(pyc)
BCY: Bcer98_2649
BTK: BT9727_3690(pyc)
BTL: BALH_3575
BWE: BcerKBAB4_3773
BLI: BL02976(pycA)
BLD: BLi01703(pycA)
BCL: ABC2395(pycA)
BAY: RBAM_014720(pycA)
BPU: BPUM_1377(pycA)
OIH: OB1430(pycA)
GKA: GK1079
GTN: GTNG_0944
GWC: GWCH70_0980
GYC: GYMC61_1852
AFL: Aflv_1871(pycA)
SAU: SA0963(pycA)
SAV: SAV1114(pycA)
SAW: SAHV_1106(pycA)
SAM: MW0997(pycA)
SAR: SAR1088
SAS: SAS1049
SAC: SACOL1123(pyc)
SAB: SAB0979
SAA: SAUSA300_1014(pyc)
SAX: USA300HOU_1052(pycA)
SAO: SAOUHSC_01064
SAJ: SaurJH9_1174
SAH: SaurJH1_1196
SAE: NWMN_0979(pycA)
SAD: SAAV_1080
SEP: SE0813
SER: SERP0704(pyc)
SHA: SH1838(pycA)
SSP: SSP1675
SCA: Sca_0740(pyc)
LMO: lmo1072(pycA)
LMF: LMOf2365_1089(pyc)
LMH: LMHCC_1558(pyc)
LMC: Lm4b_01088(pycA)
LIN: lin1060
LWE: lwe1050(pycA)
LSP: Bsph_1392
ESI: Exig_1992
EAT: EAT1b_2805
MCL: MCCL_0729
BBE: BBR47_40960(pycA)
LLA: L63652(pycA)
LLK: LLKF_0645(pycA)
LLC: LACR_0696
LLM: llmg_0634(pycA)
LPL: lp_2136(pycA)
LPJ: JDM1_1792(pycA)
LSL: LSL_0658(pycA)
LCA: LSEI_1315
LCB: LCABL_15450(pycA)
LRH: LGG_01329(pycA)
LRL: LC705_01343(pycA)
PPE: PEPE_0246
EFA: EF2456(pycA)
CAC: CAC2660(pykA)
CTC: CTC02224
CNO: NT01CX_0659
CDF: CD0021(pyc)
CDC: CD196_0022(pyc)
CDL: CDR20291_0010(pyc)
CBO: CBO3312
CBA: CLB_3368(pyc)
CBH: CLC_3254(pyc)
CBY: CLM_3746(pyc)
CBL: CLK_2728(pyc)
CBK: CLL_A1699(pyc)
CBB: CLD_1211(pyc)
CBI: CLJ_B3593(pyc)
CBT: CLH_1897(pyc)
CBF: CLI_3482(pyc)
CBE: Cbei_4960
CKL: CKL_0447(pyc)
CKR: CKR_0392
AMT: Amet_0579
STH: STH2182
SWO: Swol_0519
VPR: Vpar_0752
FMA: FMG_1572
MTU: Rv2967c(pca)
MTC: MT3045(pca)
MRA: MRA_2995(pca)
MTF: TBFG_12982
MTB: TBMG_01003(TBMG_01003.1)
MBO: Mb2991c(pca)
MBB: BCG_2988c(pca)
MBT: JTY_2983(pca)
MPA: MAP0294c(pca) MAP2873c
MAV: MAV_0342(pyc) MAV_3657
MSM: MSMEG_2412(pyc) MSMEG_6648(pyc)
MUL: MUL_1992(pca)
MVA: Mvan_2165
MGI: Mflv_1882 Mflv_4198
MAB: MAB_3267c
MMC: Mmcs_1943 Mmcs_4307
MKM: Mkms_1989 Mkms_4393
MJL: Mjls_1923 Mjls_4687
MMI: MMAR_1749(pca)
CGL: NCgl0659(cgl0689)
CGB: cg0791(pyc)
CGT: cgR_0809
CEF: CE0709(pyc)
CDI: DIP0646(pyc)
CAR: cauri_0550(pyc)
CKP: ckrop_0286(pyc)
NFA: nfa26940 nfa41910
RHA: RHA1_ro02782 RHA1_ro06517(pycA)
RER: RER_24250(pyc)
ROP: ROP_05140(pyc) ROP_65680(pyc)
GBR: Gbro_1816
SCO: SCO0546(pyc)
TWH: TWT630(pca)
TWS: TW647(pyc)
LXX: Lxx15470(pycA)
CMI: CMM_1880(pycA)
CMS: CMS_1351(pyc)
ART: Arth_1546
AAU: AAur_1686(pyc) AAur_pTC10073(pyc)
ACH: Achl_1547
RSA: RSal33209_2522
KRH: KRH_15040(pyc)
MLU: Mlut_13810
JDE: Jden_1298
NCA: Noca_3513
FRA: Francci3_0317
FRE: Franean1_6501
FAL: FRAAL0680
NML: Namu_1877
SEN: SACE_6118(pyc)
SVI: Svir_09250
AMI: Amir_5973
RXY: Rxyl_2041
SUS: Acid_5645
BTH: BT_1697
BFR: BF2937
BFS: BF2820
SRU: SRU_0828(pycA)
GFO: GFO_2678(pyc)
OTE: Oter_0972
RBA: RB10592(pyc)
CPH: Cpha266_1063
CLI: Clim_1376
CTS: Ctha_2637
DEB: DehaBAV1_0250
RCA: Rcas_2954
DRA: DR_A0310
AAE: aq_1517(pycB) aq_1520(pycA)
SAF: SULAZ_0523
MJA: MJ1229 MJ1231
MMP: MMP0340(pycB) MMP0341(pycA)
MMQ: MmarC5_1333
MMX: MmarC6_0611
MMZ: MmarC7_1341 MmarC7_1342
MAE: Maeo_1005 Maeo_1006
MVN: Mevan_1350 Mevan_1351
MAC: MA0674(pycB) MA0675(pycA)
MBA: Mbar_A1586 Mbar_A1587
MMA: MM_1827 MM_1828
MBU: Mbur_2425 Mbur_2426
MTP: Mthe_0794 Mthe_1733
MHU: Mhun_3189 Mhun_3190
MLA: Mlab_0137 Mlab_0138
MEM: Memar_1642 Memar_1643
MBN: Mboo_1783 Mboo_1784
MTH: MTH1107 MTH1917
MST: Msp_0914(pycA) Msp_1173(pycB)
MSI: Msm_0765 Msm_0939
AFU: AF0220(acc) AF1252m(oadA)
HAL: VNG1532G(acc)
HMA: rrnB0263(accC1)
RCI: RCIX749(pycB) RCIX750(pycA)
SMR: Smar_0140 Smar_0341
SSO: SSO2466(accC)
STO: ST0593
SAI: Saci_0260(pycA)
SIS: LS215_0285
SIA: M1425_0254
SIM: M1627_0254
SID: M164_0272
SIY: YG5714_0257
SIN: YN1551_2862
MSE: Msed_0147
TPE: Tpen_0119
Taxonomy
Structures PDB: 1ULZ  2DZD  2QF7  3BG3  3BG9  
Reference
  Authors
  Title

  Journal
  Organism
 1  [PMID:5578910]
McClure WR, Lardy HA, Kneifel HP.
Rat liver pyruvate carboxylase. I. Preparation, properties, and
cation specificity.
J. Biol. Chem. 246 (1971) 3569-78.
Rattus norvegicus [GN:rno]
Reference
  Authors
  Title
  Journal
  Organism
 2  [PMID:5484476]
Scrutton MC, Young MR, Utter MF.
Pyruvate carboxylase from baker's yeast. The presence of bound zinc.
J. Biol. Chem. 245 (1970) 6220-7.
Saccharomyces cerevisiae [GN:sce]
Reference
  Authors
  Title

  Journal
  Organism
 3  [PMID:13750403]
SEUBERT W, REMBERGER U.
[Purification and mechanism of action of pyruvate carboxylase from
Pseudomonas citronellolis.]
Biochem. Z. 334 (1961) 401-14.
Pseudomonas citronellolis
Reference
  Authors
  Title
  Journal
  Organism
 4  [PMID:14063279]
UTTER MF, KEECH DB.
PYRUVATE CARBOXYLASE. I. NATURE OF THE REACTION.
J. Biol. Chem. 238 (1963) 2603-8.
Aspergillus niger　[GN:ang], Gallus gallus [GN:gga]
Other DBs ExplorEnz - The Enzyme Database: 6.4.1.1
IUBMB Enzyme Nomenclature: 6.4.1.1
ExPASy - ENZYME nomenclature database: 6.4.1.1
BRENDA, the Enzyme Database: 6.4.1.1
CAS: 9014-19-1
DBGET integrated database retrieval system