| Entry |
|
|---|
| Name |
methylcrotonoyl-CoA carboxylase;
methylcrotonyl coenzyme A carboxylase;
beta-methylcrotonyl coenzyme A carboxylase;
beta-methylcrotonyl CoA carboxylase;
methylcrotonyl-CoA carboxylase |
|---|
| Class |
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified
to date)
 |
|---|
| Sysname |
3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) |
|---|
| Reaction(IUBMB) |
ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate +
3-methylglutaconyl-CoA [RN:R04138] |
|---|
| Reaction(KEGG) |
R04138
 |
|---|
| Substrate |
ATP [CPD:C00002];
3-methylcrotonoyl-CoA [CPD:C03069];
HCO3- [CPD:C00288] |
|---|
| Product |
ADP [CPD:C00008];
phosphate [CPD:C00009];
3-methylglutaconyl-CoA [CPD:C03231] |
|---|
| Cofactor |
Biotin [CPD:C00120] |
|---|
| Comment |
A biotinyl-protein. |
|---|
| Pathway |
PATH: ec00280 Valine, leucine and isoleucine degradation
PATH: ec01100 Metabolic pathways |
|---|
| Orthology |
KO: K01967 3-methylcrotonyl-CoA carboxylase
KO: K01968 3-methylcrotonyl-CoA carboxylase alpha subunit
KO: K01969 3-methylcrotonyl-CoA carboxylase beta subunit |
|---|
| Genes |
HSA: 56922(MCCC1) 64087(MCCC2)
PTR: 460872(MCCC1) 461823(MCCC2)
MCC: 701211(MCCC2) 708258
MMU: 72039(Mccc1) 78038(Mccc2)
RNO: 294972(Mccc1) 361884(Mccc2)
CFA: 478091(MCCC2) 478645(MCCC1)
BTA: 513504(MCCC1)
ECB: 100058574 100073301
MDO: 100011617 100016006
OAA: 100073515
GGA: 424962(MCCC1) 427395(MCCC2)
TGU: 100221068
XLA: 100037195 444497
XTR: 448313(mccc1) 595048(mccc2)
DRE: 405863(mccc2) 559969 777632 792190
CIN: 100178704
SPU: 579180
DME: Dmel_CG2118 Dmel_CG3267
DPO: Dpse_GA15253
DAN: Dana_GF23246
DER: Dere_GG11849
DPE: Dper_GL24188
DSE: Dsec_GM16413
DSI: Dsim_GD16261
DYA: Dyak_GE23296
DGR: Dgri_GH14119
DMO: Dmoj_GI10647
AGA: AgaP_AGAP010228
AAG: AaeL_AAEL010288 AaeL_AAEL010296
CQU: CpipJ_CPIJ003841
AME: 410554 413233
NVI: 100117061
TCA: 657963
API: 100165961
ISC: IscW_ISCW016937
CEL: F32B6.2
CBR: CBG03464
NVE: NEMVE_v1g204823
TAD: TRIADDRAFT_18834
ATH: AT4G34030(MCCB)
POP: POPTR_559591
RCU: RCOM_0646250
VVI: 100251183
OSA: 4345605(Os08g0424200) 4352741(Os12g0605800)
SBI: SORBI_08g020810(SORBIDRAFT_08g020810)
ZMA: 100280665
PPP: PHYPADRAFT_176782
CME: CMT071C CMT073C
YLI: YALI0B14619g
NCR: NCU00591 NCU02127
PAN: PODANSg4006
MGR: MGG_02541 MGG_10320
FGR: FG08688.1
ANI: AN4687.2 AN4690.2
AFM: AFUA_5G08910 AFUA_5G08940
AOR: AO090020000492 AO090020000495
ANG: An07g04270 An07g04300
AFV: AFLA_099250
PCS: Pc21g01060
NFI: NFIA_078400
CIM: CIMG_06726
URE: UREG_03732
SSL: SS1G_11418
BFU: BC1G_08870
CNE: CNC01910
CNB: CNBC5340
LBC: LACBIDRAFT_243007(MCCA)
UMA: UM02822.1
MBR: MONBRDRAFT_21541
DDI: DDB_0230065(mccA) DDB_0234167(mccB)
TET: TTHERM_00502240
PTM: GSPATT00001876001
TBR: Tb11.02.4480
TCR: 504835.20 506773.40 508799.170
LMA: LmjF11.0590 LmjF31.3130
LIF: LinJ31.3880
LBZ: LbrM31_V2.3570
PTI: PHATR_843
XCC: XCC0244(accC) XCC0245(accD)
XCB: XC_0254 XC_0255
XCA: xccb100_0266(mccA)
XCV: XCV0271(accC)
XAC: XAC0263(accC) XAC0264(accD)
XOO: XOO4377(accC) XOO4378(accD)
XOM: XOO_4121 XOO_4122
XOP: PXO_03803
SML: Smlt0237
SMT: Smal_0196
VVU: VV2_0497
VVY: VVA1047
VPA: VPA0617 VPA1126 VPA1128
VEX: VEA_000380
PPR: PBPRB1115 PBPRB1116
PAE: PA2891(atuF)
PAU: PA14_26670
PAP: PSPA7_2263 PSPA7_3277
PAG: PLES_21731(atuF) PLES_33111(liuD)
PPF: Pput_1774
PPG: PputGB1_3665
PPW: PputW619_1809
PFL: PFL_4199
PFO: Pfl01_3659 Pfl01_3950
PFS: PFLU3892 PFLU4397
PEN: PSEEN3389
PMY: Pmen_2694
PSA: PST_3216
AVN: Avin_49520(accC)
PAR: Psyc_0311
PCR: Pcryo_0342
PRW: PsycPRwf_2064
ACB: A1S_3005
ABM: ABSDF2868
ABY: ABAYE0483
ABC: ACICU_01408 ACICU_03204
ABN: AB57_1598 AB57_3456
ABB: ABBFA_000511 ABBFA_002121
SON: SO_1894 SO_1896(pccB-1)
SDN: Sden_2248
SFR: Sfri_2730
SAZ: Sama_1359
SBL: Sbal_2831
SBM: Shew185_2849
SBN: Sbal195_2976
SBP: Sbal223_1527
SLO: Shew_2573
SPC: Sputcn32_1716
SSE: Ssed_1455
SPL: Spea_2800
SHE: Shewmr4_2325
SHM: Shewmr7_2397
SHN: Shewana3_1669
SHW: Sputw3181_2309
SHL: Shal_2905
SWD: Swoo_3226
SWP: swp_3445
ILO: IL0875 IL0877
CPS: CPS_1600(mccA) CPS_1602(mccB)
PHA: PSHAa1449 PSHAa1451
PAT: Patl_0319 Patl_2928
MAQ: Maqu_2125 Maqu_2807
AMC: MADE_02415
CBU: CBU_0975 CBU_0977
CBS: COXBURSA331_A0962
CBD: CBUD_1070
CBG: CbuG_1028
CBC: CbuK_0862
HCH: HCH_03946 HCH_05752
ABO: ABO_0986(accA) ABO_1237(fabG)
AHA: AHA_2075 AHA_2077
ASA: ASA_1909(mccA) ASA_1911(mccB)
KKO: Kkor_1056
RSO: RSc0265
RPI: Rpic_0108 Rpic_0116
RPF: Rpic12D_0115 Rpic12D_0123
REU: Reut_A0151 Reut_A1463 Reut_B4460
REH: H16_A1974
RME: Rmet_0608 Rmet_1724
CTI: RALTA_A0127 RALTA_A1550
BMA: BMAA0805
BMV: BMASAVP1_0539
BML: BMA10229_0651
BMN: BMA10247_A1605
BPS: BPSS1445
BPM: BURPS1710b_A0468(accA)
BPL: BURPS1106A_A1956
BPD: BURPS668_A2053
BTE: BTH_II0950
BVI: Bcep1808_3492
BUR: Bcep18194_B0426
BCN: Bcen_3130
BCH: Bcen2424_5237
BCM: Bcenmc03_5035
BCJ: BCAM2430
BAM: Bamb_4585
BAC: BamMC406_5118
BMU: Bmul_3469
BMJ: BMULJ_05047
BXE: Bxe_A2760 Bxe_B0963
BPH: Bphy_3559
BPY: Bphyt_4689
BGL: bglu_2g11270
BPE: BP0448(accB) BP0449(accA)
BPA: BPP4362(accB) BPP4363(accA)
BBR: BB4948(accB) BB4949(accA)
BPT: Bpet0055(accA1)
BAV: BAV3372
RFR: Rfer_2815 Rfer_3830
POL: Bpro_4157 Bpro_5266
PNA: Pnap_0475
AAV: Aave_4351
AJS: Ajs_3759
VEI: Veis_0847 Veis_2415
DAC: Daci_5970
DIA: Dtpsy_3040
VAP: Vapar_0326 Vapar_4719
CTT: CtCNB1_0507 CtCNB1_1721
MPT: Mpe_A3356
LCH: Lcho_2116
EBA: ebA4659
DAR: Daro_0089
TMZ: Tmz1t_0751
APP: CAP2UW1_4326
GME: Gmet_3292
BBA: Bd3580(mccB)
ACP: A2cp1_0279
AFW: Anae109_0279
ANK: AnaeK_0268
MXA: MXAN_0082(accC)
SCL: sce4836(accC2)
HOH: Hoch_1857
MLO: mll6011 mll6012 mll7727 mll7731
MES: Meso_0918 Meso_0930
PLA: Plav_2788
SME: SM_b21122(mccA) SM_b21124(mccB)
SMD: Smed_4535
ATU: Atu3478(mccB) Atu3479(mccA)
ATC: AGR_L_2704 AGR_L_2706
ARA: Arad_1376
AVI: Avi_7691(accC)
RET: RHE_PC00062(mccB)
RLE: pRL100294(mccc1)
RLT: Rleg2_4376
RLG: Rleg_6512
RHI: NGR_b11630(mccB)
BME: BMEI1924 BMEI1925
BMF: BAB1_0018 BAB1_0019
BMB: BruAb1_0018 BruAb1_0019
BMC: BAbS19_I00150
BMS: BR0018 BR0019
BMT: BSUIS_A0019
BCS: BCAN_A0018
BMR: BMI_I18
OAN: Oant_0039
BJA: blr0986(mccB) blr0987(mccA) blr4420(mccB) blr4421(mccA)
BRA: BRADO3680
BBT: BBta_4048
RPC: RPC_2781
RPD: RPD_2535
RPE: RPE_2255 RPE_2911
RPT: Rpal_2436 Rpal_2809
XAU: Xaut_1855
AZC: AZC_4593
MET: M446_2316
MNO: Mnod_0291
MSL: Msil_3434
CCS: CCNA_02250
CAK: Caul_1876 Caul_3151
PZU: PHZ_c3025(bccA)
SIL: SPO0579 SPO2789(mccA) SPO2790(mccB)
SIT: TM1040_0738
RSP: RSP_2508(mccB) RSP_2509(mccA)
RSH: Rsph17029_1171
RSQ: Rsph17025_2010
RSK: RSKD131_0824
JAN: Jann_1147
RDE: RD1_3297(mccA) RD1_3298(mccB)
DSH: Dshi_1301(mccA)
HBA: Hbal_1602
NAR: Saro_1642
SWI: Swit_2163
ACR: Acry_1514
RRU: Rru_A1941
RCE: RC1_0381(mccA) RC1_3531
MAG: amb0674
FRA: Francci3_1527 Francci3_1528
NML: Namu_1728
CAI: Caci_0164 Caci_3760
RXY: Rxyl_1702
LIL: LA2736(accC2)
LIC: LIC11277(accC)
LBF: LBF_0538
RRS: RoseRS_0434
RCA: Rcas_0979
CAU: Caur_2832
CAG: Cagg_1133
CHL: Chy400_3068
HAU: Haur_2628
 |
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| Structures |
PDB: 2EJM |
|---|
Reference
Authors
Title
Journal
|
1 [PMID:14457200]
KNAPPE J, SCHLEGEL HG, LYNEN F.
[On the biochemical function of biotin. I. The participation of
beta-methyl-crotonyl-carboxylase in the formation of
beta-hydroxy-beta-methyl-glutaryl-CoA from
beta-hydroxy-isovaleryl-CoA.]
Biochem. Z. 335 (1961) 101-22. |
|---|
Reference
Authors
Title
Journal
|
2 [PMID:14467590]
LYNEN F, KNAPPE J, LORCH E, JUETTING G, RINGELMANN E, LACHANCE JP.
[On the biochemical function of biotin. II. Purification and mode of
action of beta-methyl-crotonyl-carboxylase.]
Biochem. Z. 335 (1961) 123-67. |
|---|
Reference
Authors
Title
Journal
Organism
|
3 [PMID:13741692]
RILLING HC, COON MJ.
The enzymatic isomerization of alpha-methylvinylacetyl coenzyme A
and the specificity of a bacterial alpha-methylcrotonyl coenzyme A
carboxylase.
J. Biol. Chem. 235 (1960) 3087-92.
Bos taurus [GN:bta] |
|---|
Reference
Authors
Title
Journal
|
4
Vagelos, P.
Regulation of fatty acid biosynthesis.
Curr. Top. Cell. Regul. 4 (1971) 119-166. |
|---|
| Other DBs |
ExplorEnz - The Enzyme Database: 6.4.1.4
IUBMB Enzyme Nomenclature: 6.4.1.4
ExPASy - ENZYME nomenclature database: 6.4.1.4
BRENDA, the Enzyme Database: 6.4.1.4
CAS: 9023-95-4 |
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