KEGG   ENZYME: 6.4.1.4Help
Entry
EC 6.4.1.4                  Enzyme                                 
Name
methylcrotonoyl-CoA carboxylase;
methylcrotonyl coenzyme A carboxylase;
beta-methylcrotonyl coenzyme A carboxylase;
beta-methylcrotonyl CoA carboxylase;
methylcrotonyl-CoA carboxylase
Class
Ligases;
Forming carbon-carbon bonds;
Ligases that form carbon-carbon bonds (only sub-subclass identified to date)
BRITE hierarchy
Sysname
3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)
Reaction(IUBMB)
ATP + 3-methylcrotonoyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA [RN:R04138]
Reaction(KEGG)
Substrate
ATP [CPD:C00002];
3-methylcrotonoyl-CoA [CPD:C03069];
HCO3- [CPD:C00288]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
3-methylglutaconyl-CoA [CPD:C03231]
Comment
A biotinyl-protein.
Pathway
Valine, leucine and isoleucine degradation
Metabolic pathways
Orthology
K01968  
3-methylcrotonyl-CoA carboxylase alpha subunit
K01969  
3-methylcrotonyl-CoA carboxylase beta subunit
Genes
HSA: 
56922(MCCC1) 64087(MCCC2)
PTR: 
460872(MCCC1) 461823(MCCC2)
PPS: 
100967647(MCCC2) 100976898(MCCC1)
GGO: 
PON: 
100437483(MCCC1) 100461467(MCCC2)
MCC: 
701211(MCCC2) 708258
MMU: 
72039(Mccc1) 78038(Mccc2)
RNO: 
294972(Mccc1) 361884(Mccc2)
CFA: 
478091(MCCC2) 478645(MCCC1)
AML: 
FCA: 
101090589(MCCC2) 101096912(MCCC1)
BTA: 
513504(MCCC1) 783065
SSC: 
100518224 100624482(MCCC1)
ECB: 
100058574(MCCC1) 100073301
MDO: 
100011617 100016006(MCCC1) 100030370
SHR: 
100919153(MCCC1) 100934782
OAA: 
100073515(MCCC1)
GGA: 
424962(MCCC1) 427395(MCCC2) 429115
MGP: 
100539364
TGU: 
100221068(MCCC1) 100222774 100224632(MCCC2)
ACS: 
100552644 100555942 100560570(mccc1)
XLA: 
100037195(mccc2) 444497(mccc1)
XTR: 
100491878 100497391 448313(mccc1) 595048(mccc2)
DRE: 
100004018(im:7143041) 405863(mccc2) 777632(mccc1)
TRU: 
101062508 101066846 101076781
OLA: 
101161876 101162686 101163479
BFO: 
BRAFLDRAFT_124863 BRAFLDRAFT_266349
CIN: 
100178704(mccc1) 100181141
SPU: 
579180 579410
DME: 
Dmel_CG2118 Dmel_CG3267
DPO: 
Dpse_GA15253 Dpse_GA17055
DAN: 
Dana_GF11069 Dana_GF23246
DER: 
Dere_GG11849 Dere_GG23221
DPE: 
Dper_GL11118 Dper_GL24188
DSE: 
Dsec_GM16413 Dsec_GM20897
DSI: 
Dsim_GD10422 Dsim_GD16261
DWI: 
Dwil_GK14105 Dwil_GK22140
DYA: 
Dyak_GE19074 Dyak_GE23296
DGR: 
Dgri_GH14119 Dgri_GH21754
DMO: 
Dmoj_GI10647 Dmoj_GI19300
DVI: 
Dvir_GJ22177 Dvir_GJ23005
AGA: 
AgaP_AGAP002761 AgaP_AGAP010228
AAG: 
AaeL_AAEL010288 AaeL_AAEL010296 AaeL_AAEL013967
CQU: 
CpipJ_CPIJ003841 CpipJ_CPIJ009999
AME: 
410554 413233
NVI: 
100117061(NV18346) 100121033(NV16940)
TCA: 
657963 659023
API: 
100165961 100168720
PHU: 
Phum_PHUM076420 Phum_PHUM225970
ISC: 
IscW_ISCW016937
CEL: 
CELE_F32B6.2(F32B6.2)
CBR: 
CBG03464 CBG06810
NVE: 
NEMVE_v1g162924 NEMVE_v1g204823
TAD: 
TRIADDRAFT_18834 TRIADDRAFT_37004
AQU: 
100638943(Mccc1) 100640077
ATH: 
AT1G03090(MCCA) AT4G34030(MCCB)
ALY: 
ARALYDRAFT_328341 ARALYDRAFT_470289(MCCA)
GMX: 
100777651 100791763 100804850 548094(MCCA)
MTR: 
MTR_1g071610 MTR_4g085890
CSV: 
101204438 101221786
RCU: 
RCOM_0646250 RCOM_0813260
POP: 
POPTR_557395 POPTR_559591
VVI: 
100253805 100853875
OSA: 
4345605 4352741
DOSA: 
Os08t0424200-01(Os08g0424200) Os12t0605800-01(Os12g0605800)
BDI: 
100826561 100828042
SBI: 
SORBI_07g020640(SORBIDRAFT_07g020640) SORBI_08g020810(SORBIDRAFT_08g020810)
ZMA: 
100280665 100281617(pco103496(377))
SMO: 
SELMODRAFT_171851 SELMODRAFT_182941
PPP: 
PHYPADRAFT_176782 PHYPADRAFT_208593
CRE: 
CHLREDRAFT_24506
VCN: 
VOLCADRAFT_108896
CME: 
CMT071C CMT073C
YLI: 
YALI0B14619g
NCR: 
NCU00591 NCU02127
SMP: 
SMAC_01282 SMAC_05026
PAN: 
PODANSg4006 PODANSg4508
TTT: 
THITE_2111926 THITE_2112771
MTM: 
MYCTH_2297338 MYCTH_2297847
MGR: 
MGG_02541 MGG_10320
FGR: 
FG08509.1 FG08688.1
NHE: 
NECHADRAFT_91797 NECHADRAFT_92030
VAL: 
VDBG_01631 VDBG_02306
SSL: 
SS1G_11418
BFU: 
BC1G_08864 BC1G_08870
ANI: 
AN4687.2 AN4690.2
NFI: 
NFIA_078370 NFIA_078400
AFM: 
AFUA_5G08910 AFUA_5G08940
AOR: 
AOR_1_858084(AO090020000492) AOR_1_864084(AO090020000495)
ANG: 
ANI_1_530064(An07g04270) ANI_1_536064(An07g04300)
AFV: 
AFLA_099250 AFLA_099280
ACT: 
ACLA_011610 ACLA_011640
PCS: 
Pc21g01060 Pc21g01110
CIM: 
CIMG_06723 CIMG_06726
CPW: 
CPC735_031660 CPC735_031690
PBL: 
PAAG_04099 PAAG_04103
URE: 
UREG_03732 UREG_03735
ABE: 
ARB_00735 ARB_06921
TVE: 
TRV_08012 TRV_08015
AJE: 
HCAG_00676 HCAG_00678
PNO: 
SNOG_02844 SNOG_09555
PTE: 
PTT_11603
ZTR: 
MYCGRDRAFT_70525 MYCGRDRAFT_99460
TML: 
GSTUM_00000074001
CNE: 
CNC01910
CNB: 
CNBC5340
CGI: 
CGB_C2740C
LBC: 
LACBIDRAFT_243007(MCCA) LACBIDRAFT_311566
MPR: 
MPER_09273
CCI: 
CC1G_14677
SCM: 
SCHCODRAFT_72259 SCHCODRAFT_72682
UMA: 
UM02822.1
PGR: 
PGTG_16677
MBR: 
MONBRDRAFT_21541 MONBRDRAFT_34022
NGR: 
NAEGRDRAFT_36506 NAEGRDRAFT_79559
DDI: 
DDB_G0271960(mccB) DDB_G0287377(mccA)
DPP: 
DICPUDRAFT_55908 DICPUDRAFT_78308
TGO: 
TGME49_069680
TET: 
TTHERM_00502240
PTM: 
GSPATT00001876001
TBR: 
Tb11.02.4480
TCR: 
504835.20 506773.40 508799.170
LMA: 
LMJF_11_0590 LMJF_31_3130
LIF: 
LINJ_11_0600 LINJ_31_3260
LDO: 
LDBPK_110600 LDBPK_313260
LMI: 
LMXM_11_0590 LMXM_30_3130
LBZ: 
LBRM_11_0370 LBRM_31_3570
PTI: 
PHATR_843
TPS: 
THAPSDRAFT_269328(PCB1)
PIF: 
PITG_04658 PITG_07975
XCC: 
XCC0244(accC) XCC0245(accD)
XCB: 
XC_0254 XC_0255
XCA: 
xccb100_0266(mccA) xccb100_0267(mccB)
XCV: 
XCV0271(accC) XCV0272(accD)
XCP: 
XCR_4268 XCR_4270
XAC: 
XAC0263(accC) XAC0264(accD)
XAX: 
XACM_0249(accC) XACM_0250(accD)
XAO: 
XAC29_01345 XAC29_01350
XOO: 
XOO4377(accC) XOO4378(accD)
XOM: 
XOO_4121 XOO_4122
XOP: 
PXO_03803 PXO_03804
XOR: 
XOC_4589 XOC_4590
XAL: 
XALc_0149(accC) XALc_0150(accD)
XCI: 
XCAW_00663(accC) XCAW_00664(accD)
SML: 
Smlt0237 Smlt0238
SMT: 
Smal_0196 Smal_0197
BUJ: 
BurJV3_0190 BurJV3_0191
SMZ: 
SMD_0205 SMD_0206
PSU: 
Psesu_1640 Psesu_1647
PSD: 
DSC_02185 DSC_02195
RHD: 
R2APBS1_1230 R2APBS1_2565
VVU: 
VV2_0497
VVY: 
VVA1047
VVM: 
VVMO6_03962
VPA: 
VPA0617 VPA1126 VPA1128
VPB: 
VPBB_A0563 VPBB_A1029 VPBB_A1031
VHA: 
VIBHAR_05479
VEX: 
VEA_000378 VEA_000380 VEA_001542
VEJ: 
VEJY3_18526 VEJY3_18536 VEJY3_20631
VFU: 
vfu_B01425
PPR: 
PBPRB1115 PBPRB1116
PAE: 
PA2012(liuD) PA2014(liuB)
PAU: 
PA14_38460(gnyB) PA14_38480(gnyA)
PAP: 
PSPA7_3275 PSPA7_3277
PAG: 
PLES_33091(liuB) PLES_33111(liuD)
PAF: 
PAM18_3031(liuB) PAM18_3033(liuD)
PNC: 
NCGM2_2986(gnyA) NCGM2_2988(gnyB)
PDK: 
PADK2_15580 PADK2_15590
PSG: 
G655_15035 G655_15045
PPU: 
PP_4065 PP_4067
PPF: 
Pput_1774 Pput_1776
PPG: 
PputGB1_3663 PputGB1_3665
PPW: 
PputW619_1809 PputW619_1811
PPT: 
PPS_3469 PPS_3471
PPB: 
PPUBIRD1_1757 PPUBIRD1_1759
PPI: 
YSA_08663 YSA_08667
PPX: 
T1E_3323(mccc2) T1E_3325(mccc1)
PPUH: 
B479_17245 B479_17255
PPUU: 
PputUW4_01762 PputUW4_01764
PST: 
PSPTO_2736 PSPTO_2738
PSB: 
Psyr_2467 Psyr_2469
PSP: 
PSPPH_2627
PFL: 
PFL_3937(liuB) PFL_3939(liuD)
PFO: 
Pfl01_3657 Pfl01_3659
PFS: 
PFLU3890 PFLU3892
PFE: 
PSF113_3884(liuB) PSF113_3886
PFC: 
PflA506_3262(liuB) PflA506_3265(liuD)
PPZ: 
H045_11575 H045_11585
PEN: 
PSEEN3387(mccB) PSEEN3389
PMY: 
Pmen_2030 Pmen_2032
PMK: 
MDS_2689 MDS_2691
PSA: 
PST_3214 PST_3216
PSZ: 
PSTAB_3253 PSTAB_3255
PSR: 
PSTAA_3371 PSTAA_3373
PSC: 
A458_04595 A458_04605
PSJ: 
PSJM300_09955 PSJM300_09965
PSH: 
Psest_1080 Psest_1083
PBA: 
PSEBR_a1842 PSEBR_a1844
PFV: 
Psefu_1713 Psefu_1715
PDR: 
H681_11425 H681_11435
AVN: 
Avin_49520(accC) Avin_49550
AVL: 
AvCA_49520(accC) AvCA_49550
AVD: 
AvCA6_49520(accC) AvCA6_49550
PAR: 
Psyc_0309 Psyc_0311
PCR: 
Pcryo_0340 Pcryo_0342
PRW: 
PsycPRwf_2064 PsycPRwf_2067
ACD: 
AOLE_11850 AOLE_11860
ACB: 
A1S_1373 A1S_1375
ABY: 
ABAYE2289 ABAYE2291
ABC: 
ACICU_01408 ACICU_01410
ABN: 
AB57_1598 AB57_1600
ABB: 
ABBFA_002119 ABBFA_002121
ABX: 
ABK1_1855 ABK1_1857
ABZ: 
ABZJ_01568 ABZJ_01570
ABR: 
ABTJ_02302 ABTJ_02304
ABD: 
ABTW07_1573 ABTW07_1575
ABH: 
M3Q_1764 M3Q_1766
ABAD: 
ABD1_13700 ABD1_13720
ACC: 
BDGL_000748(accC2) BDGL_000750(mccC2)
SON: 
SO_1894(liuD) SO_1896(liuB)
SDN: 
Sden_2246 Sden_2248
SFR: 
Sfri_2728 Sfri_2730
SAZ: 
Sama_1359 Sama_1361
SBL: 
Sbal_2829 Sbal_2831
SBM: 
Shew185_2847 Shew185_2849
SBN: 
Sbal195_2974 Sbal195_2976
SBP: 
Sbal223_1527 Sbal223_1529
SBT: 
Sbal678_2984 Sbal678_2986
SBS: 
Sbal117_2969 Sbal117_2971
SBB: 
Sbal175_1520 Sbal175_1522
SLO: 
Shew_2571 Shew_2573
SPC: 
Sputcn32_1716 Sputcn32_1718
SHP: 
Sput200_1740 Sput200_1742
SSE: 
Ssed_1455 Ssed_1457
SPL: 
Spea_2798 Spea_2800
SHE: 
Shewmr4_2323 Shewmr4_2325
SHM: 
Shewmr7_2395 Shewmr7_2397
SHN: 
Shewana3_1669 Shewana3_1671
SHW: 
Sputw3181_2307 Sputw3181_2309
SHL: 
Shal_2903 Shal_2905
SWD: 
Swoo_3224 Swoo_3226
SWP: 
swp_3443 swp_3445
SVO: 
SVI_1280 SVI_1282(pccB)
ILO: 
IL0875 IL0877
CPS: 
CPS_1600(mccA) CPS_1602(mccB)
PHA: 
PSHAa1449 PSHAa1451
PAT: 
Patl_2926 Patl_2928
PSM: 
PSM_A1494 PSM_A1496
MAQ: 
Maqu_2123 Maqu_2125
MHC: 
MARHY1163(mccA) MARHY1165(mccB)
MAD: 
HP15_1002 HP15_1004 HP15_4179
MBS: 
MRBBS_2579 MRBBS_2581
AMC: 
MADE_1008430 MADE_1008440
AMAC: 
MASE_07620 MASE_07630
AMB: 
AMBAS45_08205 AMBAS45_08215
AMG: 
AMEC673_07670 AMEC673_07680
AMK: 
AMBLS11_07635 AMBLS11_07645
AMAA: 
amad1_08465 amad1_08475
ALT: 
ambt_10285 ambt_10295
GAG: 
Glaag_1398 Glaag_1400
GNI: 
GNIT_1696 GNIT_1698
GPS: 
C427_4028 C427_4030(mccA)
FBL: 
Fbal_0991 Fbal_0993
CBU: 
CBU_0975 CBU_0977
CBS: 
COXBURSA331_A0962 COXBURSA331_A0964
CBD: 
CBUD_1070 CBUD_1072
CBG: 
CbuG_1028 CbuG_1030
CBC: 
CbuK_0862 CbuK_0864
LPN: 
lpg1827 lpg1829
LPU: 
LPE509_01358 LPE509_01360
LPF: 
lpl1791 lpl1793
LPP: 
lpp1790 lpp1792
LPC: 
LPC_1271(mccB) LPC_1273(mccA)
LPA: 
lpa_02640 lpa_02642
LPE: 
lp12_1766 lp12_1768
LLO: 
LLO_1074(mccA) LLO_1076
CYQ: 
Q91_1234 Q91_1235
NOC: 
Noc_1890
NHL: 
Nhal_2499
HCH: 
HCH_03944 HCH_03946
HEL: 
HELO_2932(mccB) HELO_2934(accA)
ABO: 
ABO_1237(fabG) ABO_1239
ADI: 
B5T_02440 B5T_02442(fabG)
KKO: 
Kkor_1056 Kkor_1058
MME: 
Marme_2209 Marme_2211
MPC: 
Mar181_2379 Mar181_2381
AHA: 
AHA_2075 AHA_2077
ASA: 
ASA_1909(mccA) ASA_1911(mccB)
AVR: 
B565_2185 B565_2187
OCE: 
GU3_15210 GU3_15220
SAGA: 
M5M_10065 M5M_10075
GPB: 
HDN1F_19790(purK) HDN1F_34230 HDN1F_34240
CVI: 
CV_1762 CV_1764
LHK: 
LHK_02056
PSE: 
NH8B_2940 NH8B_2942
RSO: 
RSc0265 RSc0269
RSC: 
RCFBP_21224 RCFBP_21228
RSL: 
RPSI07_3145 RPSI07_3149
RSN: 
RSPO_c03137 RSPO_c03141
RPI: 
Rpic_0116 Rpic_0120
RPF: 
Rpic12D_0123 Rpic12D_0128
REU: 
Reut_A0145 Reut_A0151 Reut_A1463 Reut_A1465
REH: 
H16_A0177(h16_A0177) H16_A0184(accC1) H16_A1973(h16_A1973) H16_A1974(h16_A1974)
RME: 
Rmet_0608(accC) Rmet_0609(accB)
CTI: 
RALTA_A0120 RALTA_A0127 RALTA_A1549 RALTA_A1550
CNC: 
CNE_1c01680 CNE_1c01750(accA1) CNE_1c19430 CNE_1c19440(accA3)
BMA: 
BMAA0803 BMAA0805
BMV: 
BMASAVP1_0539 BMASAVP1_0541
BML: 
BMA10229_0651 BMA10229_0653
BMN: 
BMA10247_A1605 BMA10247_A1607
BPS: 
BPSS1445 BPSS1447
BPM: 
BURPS1710b_A0468(accA) BURPS1710b_A0470(accB)
BPL: 
BURPS1106A_A1956 BURPS1106A_A1958(accB)
BPD: 
BURPS668_A2053 BURPS668_A2055(accB)
BPZ: 
BP1026B_II1534 BP1026B_II1536
BPQ: 
BPC006_II1939 BPC006_II1941
BTE: 
BTH_II0948 BTH_II0950
BTD: 
BTI_3937 BTI_3939
BVI: 
Bcep1808_3492 Bcep1808_3494
BUR: 
Bcep18194_B0424 Bcep18194_B0426
BCN: 
Bcen_3128 Bcen_3130
BCH: 
Bcen2424_5237 Bcen2424_5239
BCM: 
Bcenmc03_5033 Bcenmc03_5035
BCJ: 
BCAM2430 BCAM2432
BAM: 
Bamb_4585 Bamb_4587
BAC: 
BamMC406_5118 BamMC406_5120
BMU: 
Bmul_3467 Bmul_3469
BMJ: 
BMULJ_05047 BMULJ_05049(pccB)
BCT: 
GEM_3257 GEM_3259
BXE: 
Bxe_A2760 Bxe_B0961 Bxe_B0963
BPH: 
Bphy_3559 Bphy_3561
BPY: 
Bphyt_4687 Bphyt_4689
BGL: 
bglu_2g11270 bglu_2g11290
BUG: 
BC1001_3992 BC1001_3994
BGE: 
BC1002_4300 BC1002_4302
BGF: 
BC1003_5410 BC1003_5412
BRH: 
RBRH_02770 RBRH_02772
BGD: 
bgla_2g15400 bgla_2g15420
BYI: 
BYI23_B009490 BYI23_B009500
BUK: 
MYA_3117 MYA_3119
BPX: 
BUPH_00574 BUPH_00576
BPE: 
BP0448(accB) BP0449(accA)
BPC: 
BPTD_0484(accA) BPTD_0485(accB)
BPER: 
BN118_0420(accB) BN118_0421(accA)
BPA: 
BPP4362(accB) BPP4363(accA)
BPAR: 
BN117_4495(accB)
BBR: 
BB4948(accB) BB4949(accA)
BBM: 
BN115_4605(accB) BN115_4606(accA)
BBH: 
BN112_3476(accA) BN112_3477(accB)
BPT: 
Bpet0055(accA1) Bpet0056(accB1)
BAV: 
BAV3371 BAV3372
AXY: 
AXYL_00111 AXYL_00112
PUT: 
PT7_3025 PT7_3026
AKA: 
TKWG_02150
RFR: 
Rfer_3830 Rfer_3832
POL: 
Bpro_4157 Bpro_4160 Bpro_5266
PNA: 
Pnap_0471 Pnap_0475
AAV: 
Aave_4351 Aave_4354
AJS: 
Ajs_3759 Ajs_3763
DIA: 
Dtpsy_3040 Dtpsy_3044
AAA: 
Acav_4251 Acav_4254
ACK: 
C380_20525 C380_20545
VEI: 
Veis_0847 Veis_4244
DAC: 
Daci_5970 Daci_5973
DEL: 
DelCs14_0619 DelCs14_0622
VAP: 
Vapar_4719 Vapar_4722
VPE: 
Varpa_5355 Varpa_5358
CTT: 
CtCNB1_0503 CtCNB1_0507 CtCNB1_1721
ADN: 
Alide_3797 Alide_3800
ADK: 
Alide2_1872 Alide2_1873 Alide2_4143 Alide2_4146
RTA: 
Rta_06610 Rta_06650
MPT: 
Mpe_A3356 Mpe_A3359
HSE: 
Hsero_4690 Hsero_4691(accC)
CFU: 
CFU_4251(mccC1) CFU_4261(mccB)
LCH: 
Lcho_2116 Lcho_2118
TIN: 
Tint_2719 Tint_2726
THI: 
THI_3267(accA1) THI_3274(mccB)
RGE: 
RGE_43410(mccA) RGE_43450
EBA: 
ebA4657 ebA4659
AZO: 
azo3068(accC2) azo3070
AZA: 
AZKH_3283 AZKH_3284
DAR: 
Daro_0089 Daro_0092
TMZ: 
Tmz1t_0749 Tmz1t_0751
DSU: 
Dsui_0980 Dsui_0982
APP: 
CAP2UW1_4326 CAP2UW1_4328
GME: 
Gmet_3290(mccB) Gmet_3292(mccA)
BBA: 
Bd3580(mccB)
BBAT: 
Bdt_3481 Bdt_3483(mccB)
BEX: 
A11Q_2274
BMX: 
BMS_1995(accB)
DAL: 
Dalk_3793
DAT: 
HRM2_09980(mmc)
SCL: 
sce4836(accC2)
HOH: 
Hoch_1857
DBR: 
Deba_3253
MLO: 
mll6011 mll6012 mll7727 mll7731
MCI: 
Mesci_4846 Mesci_4850
MOP: 
Mesop_5348 Mesop_5350
MAM: 
Mesau_04907 Mesau_04910
MES: 
Meso_0918 Meso_0930
PLA: 
Plav_2786 Plav_2788
SME: 
SM_b21122(mccA) SM_b21124(mccB)
SMK: 
Sinme_4997 Sinme_4999
SMQ: 
SinmeB_3956 SinmeB_3958
SMX: 
SM11_pD0889(mccB) SM11_pD0891(mccA)
SMI: 
BN406_05949(MCCC1) BN406_05951(Mccc2)
SMEG: 
C770_GR4pD0873 C770_GR4pD0875
SMEL: 
SM2011_b21122(mccA) SM2011_b21124(mccB)
SMD: 
Smed_4533 Smed_4535
RHI: 
NGR_b11610(mccA) NGR_b11630(mccB)
SFH: 
SFHH103_05992(mccA) SFHH103_05994(mccB)
SFD: 
USDA257_c31610(yngE) USDA257_c31630(accA12)
ATU: 
Atu3478(mccB) Atu3479(mccA)
ARA: 
Arad_1374(mccA) Arad_1376
AVI: 
Avi_7689(mccB) Avi_7691(accC)
AGR: 
AGROH133_11614 AGROH133_11615
RET: 
RHE_PC00062(mccB) RHE_PC00063(mccA)
RLE: 
pRL100294(mccc1) pRL100295(mccc2)
RLT: 
Rleg2_4376 Rleg2_4377
RLG: 
Rleg_6511 Rleg_6512
RTR: 
RTCIAT899_CH05045 RTCIAT899_CH05055
BME: 
BMEI1924 BMEI1925
BMI: 
BMEA_A0018 BMEA_A0019
BMZ: 
BM28_A0017 BM28_A0018
BMG: 
BM590_A0017 BM590_A0018
BMW: 
BMNI_I0017 BMNI_I0018
BMF: 
BAB1_0018 BAB1_0019
BMB: 
BruAb1_0018 BruAb1_0019
BMC: 
BAbS19_I00150 BAbS19_I00160
BAA: 
BAA13334_I00447 BAA13334_I00450
BMS: 
BR0018 BR0019
BSI: 
BS1330_I0018 BS1330_I0019
BMT: 
BSUIS_A0019 BSUIS_A0020
BSV: 
BSVBI22_A0018 BSVBI22_A0019
BOV: 
BOV_0015 BOV_0016
BCS: 
BCAN_A0018 BCAN_A0019
BSK: 
BCA52141_I1670 BCA52141_I1674
BMR: 
BMI_I18 BMI_I19
BPP: 
BPI_I18 BPI_I19
OAN: 
Oant_0038 Oant_0039
BJA: 
blr4420(mccB) blr4421(mccA)
BJU: 
BJ6T_53660 BJ6T_53670
BRA: 
BRADO3679 BRADO3680
BBT: 
BBta_4047 BBta_4048
BRS: 
S23_37700(mccA) S23_37710(mccB)
RPA: 
RPA2538 RPA2539
RPB: 
RPB_2933 RPB_2934
RPC: 
RPC_2781 RPC_2782
RPD: 
RPD_2534 RPD_2535
RPE: 
RPE_2911 RPE_2912
RPT: 
Rpal_2808 Rpal_2809
RPX: 
Rpdx1_2926 Rpdx1_2927
NWI: 
Nwi_1604 Nwi_1605
NHA: 
Nham_2124 Nham_2125
AOL: 
S58_37810 S58_37820
XAU: 
Xaut_1855 Xaut_1857
AZC: 
AZC_4591 AZC_4593
MET: 
M446_2316 M446_2317
MNO: 
Mnod_0290 Mnod_0291
MSL: 
Msil_3433 Msil_3434
RVA: 
Rvan_0701 Rvan_0702
PHL: 
KKY_1082 KKY_1083
MSC: 
BN69_1004 BN69_1006
CCR: 
CC_2170
CCS: 
CCNA_02250 CCNA_02252
CAK: 
Caul_1876 Caul_3151 Caul_3154
CSE: 
Cseg_2817 Cseg_2820
PZU: 
PHZ_c3024 PHZ_c3025(bccA)
BSB: 
Bresu_1580 Bresu_1583
AEX: 
Astex_2028 Astex_2030
SIL: 
SPO2789(mccA) SPO2790(mccB)
SIT: 
TM1040_0737 TM1040_0738
RSP: 
RSP_2508(mccB) RSP_2509(mccA)
RSH: 
Rsph17029_1170 Rsph17029_1171
RSQ: 
Rsph17025_2010 Rsph17025_2011
RSK: 
RSKD131_0823 RSKD131_0824
RCP: 
RCAP_rcc01512(mccB) RCAP_rcc01513(mccA)
JAN: 
Jann_1145 Jann_1147
RDE: 
RD1_3297(mccA) RD1_3298(mccB)
RLI: 
RLO149_c025140(mccA) RLO149_c025150(mccB)
PDE: 
Pden_3637
DSH: 
Dshi_1300(mccB) Dshi_1301(mccA)
PSF: 
PSE_4993 PSE_4994(mccA)
PGA: 
PGA1_c10320 PGA1_c10330
PGL: 
PGA2_c10170 PGA2_c10180
OAT: 
OAN307_c20900(mccB) OAN307_c20920(mccA)
OAR: 
OA238_c28780(mccA) OA238_c28800(mccB)
MMR: 
Mmar10_1734
HNE: 
HNE_1277
HBA: 
Hbal_1602 Hbal_1603
NAR: 
Saro_1642 Saro_1643
NPP: 
PP1Y_AT4367 PP1Y_AT4385
SAL: 
Sala_1532
SWI: 
Swit_2162 Swit_2163
SPHM: 
G432_06255 G432_06265
SJP: 
SJA_C1-23860 SJA_C1-23870(pccB)
SCH: 
Sphch_1300 Sphch_1301
SSY: 
SLG_09720 SLG_09730
ELI: 
ELI_09900 ELI_11765
ACR: 
Acry_1514 Acry_1516
AMV: 
ACMV_15590 ACMV_15610
RRU: 
Rru_A1941 Rru_A1943
RRF: 
F11_09975 F11_09985
RCE: 
RC1_0381(mccA) RC1_0390(mccB)
RPM: 
RSPPHO_00163 RSPPHO_00165
MAG: 
amb0674 amb0676
AZL: 
AZL_a02260 AZL_a02280
ALI: 
AZOLI_p10025 AZOLI_p10027
ABS: 
AZOBR_p210006 AZOBR_p210008
TMO: 
TMO_2575
PGV: 
SL003B_0384 SL003B_0385(mccA) SL003B_1069(purK)
MAI: 
MICA_885 MICA_888
MAN: 
A11S_801 A11S_804
MTU: 
Rv2502c(accD1)
MTV: 
RVBD_2502c
MTC: 
MT2577(pccB-3)
MRA: 
MRA_2528(accD1)
MTF: 
TBFG_12524
MTB: 
TBMG_01469
MTK: 
TBSG_01480
MTZ: 
TBXG_001456
MTG: 
MRGA327_15430
MTI: 
MRGA423_15650
MTE: 
CCDC5079_2306
MTL: 
CCDC5180_2278
MTO: 
MTCTRI2_2548(accD1)
MTD: 
UDA_2502c(accD1)
MTN: 
ERDMAN_2752(accD1)
MTJ: 
J112_13420
MTUB: 
MT7199_2533
MBO: 
Mb2530c(accD1)
MBB: 
BCG_2522c(accD1)
MBT: 
JTY_2516(accD1)
MBM: 
BCGMEX_2514c(accD1)
MBK: 
K60_026000
MAF: 
MAF_25170(accD1)
MCE: 
MCAN_25411(accD1)
MCQ: 
BN44_50494(accD)
MCV: 
BN43_40169(accD)
MCX: 
BN42_40459(accD)
MCZ: 
BN45_50887(accD)
MPA: 
MAP2314c(accD1)
MAV: 
MAV_1670
MIT: 
OCO_17390
MIR: 
OCQ_15030
MIA: 
OCU_17580
MID: 
MIP_02449
MSM: 
MSMEG_4717
MSG: 
MSMEI_4600
MSA: 
Mycsm_04394
MVA: 
Mvan_4091
MGI: 
Mflv_2552
MSP: 
Mspyr1_19810
MAB: 
MAB_4540c
MMV: 
MYCMA_2512(yngE)
MMC: 
Mmcs_3631
MKM: 
Mkms_3704
MJL: 
Mjls_3636
MJD: 
JDM601_1403(accD1)
MMI: 
MMAR_3849(accD1)
MRH: 
MycrhN_4088
MMM: 
W7S_07360
MCB: 
Mycch_3534
MLI: 
MULP_04095(accD1)
ASD: 
AS9A_4361
CRD: 
CRES_1680(accD1)
CVA: 
CVAR_2092
NFA: 
nfa50370
NCY: 
NOCYR_4820
NBR: 
O3I_037965
RHA: 
RHA1_ro06095
RER: 
RER_18300(accD)
ROP: 
ROP_61520(accD)
REQ: 
REQ_36040
GBR: 
Gbro_1357
GPO: 
GPOL_c11960
GOR: 
KTR9_1271
TPR: 
Tpau_3321
SCO: 
SCO2776(accD1)
SMA: 
SAV_5278(accD1)
SGR: 
SGR_4759
SCB: 
SCAB_58031(accD1)
SSX: 
SACTE_2269
SVL: 
Strvi_8094
SCT: 
SCAT_1854(Mccc)
SCY: 
SCATT_18490
SFA: 
Sfla_4113
SBH: 
SBI_06922
SHY: 
SHJG_4277
SHO: 
SHJGH_4041
SVE: 
SVEN_2565
SDV: 
BN159_5502
SALB: 
XNR_4212
STRP: 
F750_2603
SFI: 
SFUL_2367
KSK: 
KSE_26820(accB)
MTS: 
MTES_1633
ART: 
Arth_1385
AAU: 
AAur_1528
ACH: 
Achl_1403
AAI: 
AARI_32530
APN: 
Asphe3_13760
ARR: 
ARUE_c14410(mccb)
RSA: 
RSal33209_0550
KRH: 
KRH_22770(accD)
MLU: 
Mlut_06850
BCV: 
Bcav_3852
BFA: 
Bfae_00440
XCE: 
Xcel_2100
IVA: 
Isova_0519
CFI: 
Celf_2559
MPH: 
MLP_10120 MLP_10130
NCA: 
Noca_0147
TFU: 
Tfu_0948
NDA: 
Ndas_3264
NAL: 
B005_0219
TCU: 
Tcur_1977
SRO: 
Sros_6413
FRA: 
Francci3_1527
FRE: 
Franean1_4047
FRI: 
FraEuI1c_1634
FAL: 
FRAAL2343(accD) FRAAL3158(accD)
NML: 
Namu_1728 Namu_1729
GOB: 
Gobs_1470
BSD: 
BLASA_1276
MMAR: 
MODMU_1448
SEN: 
SACE_7039(accD1)
SVI: 
Svir_30520
TBI: 
Tbis_2154
AMD: 
AMED_7922
AMN: 
RAM_40720
AMM: 
AMES_7804
PDX: 
Psed_6157
AMI: 
Amir_6230
SESP: 
BN6_74960(mccC)
CAI: 
Caci_0164 Caci_3760 Caci_3761
RXY: 
Rxyl_1702 Rxyl_1703
CWO: 
Cwoe_0235
LIL: 
LA_2736
LIE: 
LIF_A2234 LIF_A3045
LIC: 
LIC11277(accC)
LBI: 
LEPBI_I0520
LBF: 
LBF_0501 LBF_0538
TPX: 
Turpa_2721
CTM: 
Cabther_A2118
RRS: 
RoseRS_0434
RCA: 
Rcas_0979
CAU: 
Caur_2832
CAG: 
Cagg_1133
CHL: 
Chy400_3068
HAU: 
Haur_2628
STI: 
Sthe_2513
CAP: 
CLDAP_21360(accC) CLDAP_38240(accB)
NDE: 
NIDE3121(pccB)
 » show all
Taxonomy
Reference
1  [PMID:14457200]
  Authors
KNAPPE J, SCHLEGEL HG, LYNEN F.
  Title
[On the biochemical function of biotin. I. The participation of beta-methyl-crotonyl-carboxylase in the formation of beta-hydroxy-beta-methyl-glutaryl-CoA from beta-hydroxy-isovaleryl-CoA.]
  Journal
Biochem. Z. 335 (1961) 101-22.
Reference
2  [PMID:14467590]
  Authors
LYNEN F, KNAPPE J, LORCH E, JUETTING G, RINGELMANN E, LACHANCE JP.
  Title
[On the biochemical function of biotin. II. Purification and mode of action of beta-methyl-crotonyl-carboxylase.]
  Journal
Biochem. Z. 335 (1961) 123-67.
Reference
3  [PMID:13741692]
  Authors
RILLING HC, COON MJ.
  Title
The enzymatic isomerization of alpha-methylvinylacetyl coenzyme A and the specificity of a bacterial alpha-methylcrotonyl coenzyme A carboxylase.
  Journal
J. Biol. Chem. 235 (1960) 3087-92.
  Organism
Bos taurus [GN:bta]
Reference
4
  Authors
Vagelos, P.
  Title
Regulation of fatty acid biosynthesis.
  Journal
Curr. Top. Cell. Regul. 4 (1971) 119-166.
Other DBs
ExplorEnz - The Enzyme Database: 
IUBMB Enzyme Nomenclature: 
ExPASy - ENZYME nomenclature database: 
BRENDA, the Enzyme Database: 
CAS: 
9023-95-4
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