KEGG   Felis catus (domestic cat): 100127108Help
Entry
100127108         CDS       T02385                                 

Gene name
INSR
Definition
(RefSeq) insulin receptor isoform X1
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
fca  Felis catus (domestic cat)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:fca00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    100127108 (INSR)
   04015 Rap1 signaling pathway
    100127108 (INSR)
   04010 MAPK signaling pathway
    100127108 (INSR)
   04066 HIF-1 signaling pathway
    100127108 (INSR)
   04068 FoxO signaling pathway
    100127108 (INSR)
   04072 Phospholipase D signaling pathway
    100127108 (INSR)
   04022 cGMP - PKG signaling pathway
    100127108 (INSR)
   04151 PI3K-Akt signaling pathway
    100127108 (INSR)
   04152 AMPK signaling pathway
    100127108 (INSR)
   04150 mTOR signaling pathway
    100127108 (INSR)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    100127108 (INSR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    100127108 (INSR)
   04923 Regulation of lipolysis in adipocyte
    100127108 (INSR)
   04913 Ovarian Steroidogenesis
    100127108 (INSR)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    100127108 (INSR)
  Aging
   04211 Longevity regulating pathway - mammal
    100127108 (INSR)
   04213 Longevity regulating pathway - multiple species
    100127108 (INSR)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    100127108 (INSR)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    100127108 (INSR)
   04931 Insulin resistance
    100127108 (INSR)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     100127108 (INSR)
Protein kinases [BR:fca01001]
 Tyrosine protein kinases
  InsR family [OT]
   100127108 (INSR)
Enzyme-linked receptors [BR:fca01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   100127108 (INSR)
Cytokine receptors [BR:fca04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   100127108 (INSR)
CD molecules [BR:fca04090]
 Proteins
  100127108 (INSR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
Position
A2
AA seq 1381 aa AA seqDB search
MGAGAGRGAATAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL
QILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VVFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTAKGKTNCPATVINGQFVERCWTHGHCQKVCPTVCKSHGCTADGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCRDLHNKCKNSRRQG
CHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE
RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKRNQSEYEESAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRKSFSSPGAEDSRPSRKRRALADAGNVTAAVPTVPGF
PNTSSSVPTSPEEHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVS
ARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVS
RRHFALERGCRLRGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGP
LIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE
KITLLRELGQGSFGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGF
TCHHVVRLLGVVSKGQPTLVVMELMVHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAA
EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR
WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC
PERVTDLMHMCWQFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF
EDMESVPLDRASHSQREEAGGRDGVSSLGLKRNYEDHIPYTHMNGGKKNGRILTLPRSNP
S
NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt
atgggcgccggggctgggcggggggcggccaccgcgccgctgctggtggcggtggccgcg
ctgctgctgggcgccgcgggccacctgtaccccggagaggtctgccctggcatggatatc
cggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaaggtcatttg
cagatactgctcatgttcaaaacgaggcccgaggacttccgagacctcagtttccccaaa
ctcgtcatgatcactgattacctgctgctcttccgggtgtacgggctggagagcctgaag
gacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcgctg
gtcgtcttcgagatggtgcacttgaaggagcttggcctctacagcttgatgaacattacc
cggggctccgtccgcatcgagaagaataatgagctgtgctacctggccaccatcgactgg
tcgcgcatcctggattcggtggaggataattacattgtgttgaacaaagacgacaacgag
gagtgtggggacatttgtccaggcactgcaaagggcaagaccaactgccctgccactgtc
atcaacgggcagtttgtggagcgttgttggacacacggccattgccagaaagtttgtccg
accgtctgcaagtcgcacggctgcacggccgacggcctctgctgccacagcgagtgtttg
ggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgcaacttctacctg
gacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagactggcgctgc
gtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccggagacagggt
tgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcggggtacacg
atgaattccagcaacctgatgtgtactccctgcctgggcccctgtcccaaggtctgccac
atcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctccgaggctgc
accgtcatcaacggaagcctaatcatcaacattcgagggggcaacaacctggcagctgag
ctggaggccaacctcggactcattgaagaaatttctgggtatctgaagatccgaagatcc
tatgctcttgtgtcactttcctttttccggaagttacggctgattcggggagagaccttg
gaaatcgggaactactctttctatgccttggacaaccagaacctgaggcagctatgggac
tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa
ctctgcttgtcggagattcacaagatggaggaggtttcaggaaccaaggggcgccaggag
cggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgaactactt
aaattttcttacattcggacgtcttacgacaagatcttgctgaaatgggaaccgtactgg
ccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggccccttaccag
aatgtgaccgagttcgacgggcaggacgcgtgtggctccaacagctggacggtggtggac
attgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccagggtggctgatg
cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttttct
gatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagaccgatgccacc
aacccttccgtccccctggatcctatctcggtttcgaattcctcctctcagatcattctg
aagtggaagcctccctcggaccccaatggcaacatcacgcactacctggtgttctgggag
aggcaggcggaggacagcgagctgtatgagttggattattgcctcaaagggttgaagctg
ccttcccggacctggtccccgccgtttgagtccgagggctcccagaagcgcaatcagagt
gagtacgaggagtccgctggcgaatgctgctcgtgtcccaaaaccgactctcagatcctg
aaggagctggaggagtcctctttcaggaagacgttcgaggattacctgcacaatgtggtt
ttcgtgcccagaaaatccttttcaagccctggtgctgaggacagtaggccgtcgcggaag
cgcagggccctcgccgacgctgggaacgtgacggccgccgtgcccacggtgcctggtttc
cccaacacttccagcagcgtgcccacgagcccggaagagcacaagcccttcgagaaggtg
gtgaacaaagagtcgctggtcatctccggcctgcgtcacttcaccggctaccgcatcgag
ctgcaggcttgcaaccaagatgcccccgaggagaggtgcagcgtggccgcctacgtcagc
gccaggaccatgcccgaagccaaggcagacgacattgttggccctgtgacccatgaaatc
ttcgagaacaacgtggttcacttgatgtggcaagagcctaaagaacccaatggattgatc
gtgctgtatgaagtgagttaccgacggtatggtgatgaggagctgcacctctgtgtctcc
cgtagacactttgctctggagcggggctgcaggctgcgagggctgccgccggggaattac
agtgtgcgagttcgggccacctccctggcgggcaacggctcctggacagaagccacttat
ttctatgtgacagactatttagatgtcccatcgaacattgcaaaaattatcatcgggcct
ctcatctttgtctttctcttcagtgttgtgattggaagtatttatctattcctgagaaag
aggcagccggatgggccgctggggccgctgtatgcttcttcaaaccctgagtacctcagt
gccagtgatgtgtttccctgctctgtgtatgtgccggacgagtgggaggtgcctcgggag
aagatcactctcctgcgcgagctggggcagggctccttcggcatggtatacgagggcaat
gccagggacatcgtcaagggcgaggcggagacccgcgtggcggtgaagacggtcaacgag
tccgccagtctgcgagagaggatcgagtttctcaacgaggcctcagtcatgaagggcttc
acctgtcatcacgtggtccgcctcctgggggtggtgtccaaaggccagccgacgctggtg
gtgatggagctgatggttcacggagacctcaagagctacctccgctccctgcggccggag
gctgagaataaccctggccgccctccccctactctgcaagagatgattcagatggcggcg
gagatcgccgacgggatggcgtacctgaatgccaagaagtttgtgcaccgggatctcgca
gctcgaaattgcatggtggcccacgacttcaccgtcaaaattggagacttcggaatgacc
agagacatctatgaaacggattactaccggaaaggaggcaagggtctgctccccgtgcgg
tggatggcaccggaatccctgaaggacggggtcttcaccacttcttctgacatgtggtcc
tttggtgtggtcctttgggaaatcaccagcttggcggaacaaccttaccaaggcctgtct
aatgaacaggtgttgaaatttgtcatggacggaggatatttggaccaacctgacaactgt
ccggagagagtcaccgacctgatgcacatgtgctggcagttcaatcccaagatgcggccc
accttcctggagatcgttgacctgctcaaggacgacctgcaccccagctttccagaagtt
tccttcttccacagcgaggagaacaaggcgcctgagagtgaggagttggaaatggagttt
gaggacatggagagtgtccccctggatcgggcctcacactcacagagggaagaggccggg
ggccgggatggagtgtcctcgctgggcctcaagcggaactacgaggaccacatcccctac
acccacatgaacgggggcaagaaaaacggacggattctgaccctgccgaggtcgaatcct
tcctaa

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