KEGG   Felis catus (domestic cat): 100616070
Entry
100616070         CDS       T02385                                 
Symbol
HSD3B2
Name
(RefSeq) 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
  KO
K00070  3beta-hydroxy-Delta5-steroid dehydrogenase / steroid Delta-isomerase [EC:1.1.1.145 5.3.3.1]
Organism
fca  Felis catus (domestic cat)
Pathway
fca00140  Steroid hormone biosynthesis
fca01100  Metabolic pathways
fca04913  Ovarian steroidogenesis
fca04925  Aldosterone synthesis and secretion
fca04927  Cortisol synthesis and secretion
fca04934  Cushing syndrome
Module
fca_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
fca_M00110  C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
fca_M00976  C19-Steroid hormone biosynthesis, pregnenolone => testosterone => dihydrotestosterone
fca_M00977  C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone
Brite
KEGG Orthology (KO) [BR:fca00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    100616070 (HSD3B2)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    100616070 (HSD3B2)
   04925 Aldosterone synthesis and secretion
    100616070 (HSD3B2)
   04927 Cortisol synthesis and secretion
    100616070 (HSD3B2)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    100616070 (HSD3B2)
Enzymes [BR:fca01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.145  3beta-hydroxy-Delta5-steroid dehydrogenase
     100616070 (HSD3B2)
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.1  steroid Delta-isomerase
     100616070 (HSD3B2)
SSDB
Motif
Pfam: 3Beta_HSD Epimerase NAD_binding_4 GDP_Man_Dehyd Polysacc_synt_2 NAD_binding_10 RmlD_sub_bind NmrA Sacchrp_dh_NADP KR
Other DBs
NCBI-GeneID: 100616070
NCBI-ProteinID: NP_001233123
EnsemblRapid: ENSFCTG00005026446
UniProt: F5CSS4
Position
C1:102194337..102202193
AA seq 373 aa
MAGWICLVTGAGGFLGQRIVHLLVEEKDLQEIRALDKVFSPELREEFSKLQSKIKLTILE
GDILDEQCLKKACQDTSVIIHTACIIDFLDVVHRETIMNVNLKGTQLLLEACVQASVPIF
IYTSTIEVAGPNSYREIIQNGHEDEHLESTWSTSYPYSKKLAEKAVLAANGWVLKNGGTL
HTCALRPMYIYGEGSIFLYDHIYKALRNNGIIQQNSKFSIANPVYVGNVAWAHILASRAL
QDPKKAPRVGGQFYYISDDTPHQSYDNLNYSLSKEWGLSLESRMSLPLFLEYWLAFLLEI
VSFLLSPIYKYQPPFNRHTVTLLNSVFTFSYKKAQRDLGYEPLFSWEEAKQKTMEWIGSI
VKEHKKSLKTKTH
NT seq 1122 nt   +upstreamnt  +downstreamnt
atggctgggtggatctgccttgtgacaggggcaggagggtttctgggtcagagaatcgtg
catttgttggtggaggagaaggacctacaggagatccgggcactggacaaagtcttcagc
ccagaattgcgggaggaattttcgaagctccagagcaagatcaagctgaccattctggaa
ggagacattctggatgaacagtgcttgaagaaggcctgccaggacacctcagtcatcatc
cacaccgcctgtatcattgacttcttggatgtcgttcaccgagaaaccatcatgaatgtc
aatctgaagggtacccagctccttttggaagcctgtgtccaggcgagtgtgccaatcttc
atctataccagcaccatagaggtggctgggcccaactcctacagggagatcatccagaac
ggccacgaagacgaacatctcgaatccacatggtccacttcgtatccatacagcaaaaaa
cttgcggagaaagctgtgctggctgctaatgggtgggttcttaaaaatggtggcaccttg
cacacttgtgccttaaggcccatgtatatctatggggaaggaagcatattcctttatgac
catatatacaaggccctgaggaacaatgggatcatccaacagaacagcaaattctccata
gccaaccctgtctatgtaggcaacgtggcctgggctcacattctggcctcgagggcccta
caggaccccaagaaggcccccagagttggaggacagttctattatatctcagatgacaca
cctcaccaaagctatgataacctcaattacagtttgagcaaagaatggggcttatccctt
gagtccagaatgagccttcctctatttctggagtactggcttgccttcctgctggaaata
gtgagcttcctactcagtccaatttacaaataccaacccccctttaaccgccacacggtg
acattgttaaatagtgtgtttaccttctcctataagaaagctcagcgggacctggggtat
gagccactcttcagctgggaggaagcaaagcaaaagaccatggagtggattggctccata
gtgaaagagcacaagaagtccctaaaaacaaagactcactga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (10)   
   KEGG PATHWAY (6)   
   KEGG MODULE (4)   
Chemical substance (19)   
   KEGG COMPOUND (19)   
Chemical reaction (10)   
   KEGG ENZYME (2)   
   KEGG REACTION (8)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   RefGene (5)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   ENSEMBLRAPID (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (10)   
   Pfam (10)   
All databases (69)   

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