| Entry |
|
|---|
| Gene name |
HADHA
|
|---|
| Definition |
hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
|
|---|
| Orthology |
| enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC: 4.2.1.17 1.1.1.211] |
|
|---|
| Organism |
fca Felis catus (domestic cat)
|
|---|
| Pathway |
| Fatty acid elongation | | Fatty acid degradation | | Valine, leucine and isoleucine degradation | | Lysine degradation | | Tryptophan metabolism | | beta-Alanine metabolism | | Propanoate metabolism | | Butanoate metabolism | | Biosynthesis of unsaturated fatty acids | | Metabolic pathways | | Carbon metabolism | | Fatty acid metabolism |
|
|---|
| Module |
| Malonate semialdehyde pathway, propanoyl-CoA => Acetyl-CoA | | Lysine degradation, lysine => saccharopine => acetoacetyl-CoA | | Fatty acid biosynthesis, elongation, mitochondria | | beta-Oxidation |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:fca00001]
Metabolism
Overview
01200 Carbon metabolism
101084701 (HADHA)
01212 Fatty acid metabolism
101084701 (HADHA)
Carbohydrate metabolism
00640 Propanoate metabolism
101084701 (HADHA)
00650 Butanoate metabolism
101084701 (HADHA)
Lipid metabolism
00062 Fatty acid elongation
101084701 (HADHA)
00071 Fatty acid degradation
101084701 (HADHA)
01040 Biosynthesis of unsaturated fatty acids
101084701 (HADHA)
Amino acid metabolism
00280 Valine, leucine and isoleucine degradation
101084701 (HADHA)
00310 Lysine degradation
101084701 (HADHA)
00380 Tryptophan metabolism
101084701 (HADHA)
Metabolism of other amino acids
00410 beta-Alanine metabolism
101084701 (HADHA)
Enzymes [BR:fca01000]
1. Oxidoreductases
1.1 Acting on the CH-OH group of donors
1.1.1 With NAD+ or NADP+ as acceptor
1.1.1.211 long-chain-3-hydroxyacyl-CoA dehydrogenase
101084701 (HADHA)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.17 enoyl-CoA hydratase
101084701 (HADHA)
 |
|---|
| SSDB |
   |
|---|
| Motif |
 |
|---|
| Other DBs |
NCBI-GI: NCBI-GeneID: Ensembl: |
|---|
| Position |
A3
|
|---|
| AA seq |
763 aa  
MVASRAIGSLRRFTASRTLRCPGYTCRNFSASSALLTRTHINYGVKGDVAVVRINSPNSK
VNTLSRELQSEFVEVMNEIWANDQIRSAVLISSKPGCFIAGADINMLASCKSAEEVTQVS
QEGQRMFEKLEKSTKPIVAAISGSCLGGGLELAISCQYRIATKDRKTVLGSPEVLLGILP
GAGGTQRLPKMVGVPAAFDMMLTGRNIRADRAKKMGLVDQLVEPLGPGLKPSEERTIEYL
EEVAVTFAKELSDKKISLKRDKGLVEKLTSYAMSIPFVRQQIYKKVEEKVRKQTKGLYPA
PLKIIDAVKTGIEQGNDAGYVSESQKFGELAMTKESKALMGLYHGQVLCKKNKFGTPQKD
VKHLAILGAGLMGXGIAQVSVDKGIKTILKDATLAGLDRGQQQVFKGLNDKVKKKALTSF
ERDSIFSNLTGQLDYQGFEKADMVIEAVFEDLNVKHRVLKEVEAVVPDHCVFASNTSALP
IRQIASVSKRPEKVIGMHYFSPVDKMQLLEIITTEKTSKDTTASVVAVGLKQGKVIVVVK
DGPGFYTTRCLAPMMSEVLRILQEGVDPKKLDSLTTSFGFPVGAATLVDEVGVDVAKHVA
EDLGKAFGERFEGGSVELLKQMVSRGFLGRKSGKGFYIYQEGVKNKSLNSDMDGILASLK
VPPKSDVCSDEDLQYRLVTRFVNEAIMCLQEGILATPAEGDIGAVFGLGFPPCLGGPFRY
VDLYGAQKIVDRLRKYEAAYGKPFTPCQLLIDHANSPSKKFYQ |
|---|
| NT seq |
2292 nt  +upstreamnt +downstreamnt
atggtggcctcccgggcgataggcagtctccgccgcttcactgcctccaggacgcttcgc
tgcccaggttatacctgccgcaacttttcagcatcctctgctttgctaaccagaacccat
attaactatggagtcaaaggggatgtggctgttgttcgaattaactcacccaattcaaag
gtaaatacactgagcagagaactgcaatcagagttcgtagaagtaatgaatgaaatctgg
gctaatgatcaaatcagaagtgccgtccttatctcatcaaagccaggctgctttattgca
ggtgctgacatcaacatgttagcctcttgtaagagcgcggaagaggtaacgcaggtatcg
caggaaggccagagaatgtttgagaaacttgagaagtccacaaagcctattgtggctgcc
atcagtggatcctgcttaggaggaggacttgagcttgccatttcctgccaatacagaata
gccacaaaagataggaaaacagtattaggtagccctgaagtcttgctggggatcttacca
ggagcaggaggcacacaaaggctgcccaaaatggtgggtgtgcctgctgcttttgacatg
atgttgactggtagaaacattcgtgcagacagagcaaagaaaatggggctagttgaccaa
ttggtggaacccctgggaccaggactaaaaccttcagaggaacggacaattgaatatcta
gaagaagttgcagttacttttgccaaagaactatctgataagaaaatctctctaaagaga
gacaaaggattagtagaaaaattgacatcatatgccatgagcattccatttgtcaggcaa
cagatttataaaaaggtggaagaaaaagtacgaaaacagaccaaaggcctttatcctgca
cctctgaaaataattgatgcggtaaagactggaattgagcaagggaatgatgctggctat
gtctctgaatctcagaaatttggagagcttgcaatgaccaaagaatcaaaggccttgatg
ggactttatcatggtcaggtcctgtgtaagaagaataaatttggaactccgcagaaggac
gtgaagcacctagccattcttggtgcggggctgatggggnccggcatcgcccaggtgtct
gtggataagggcataaagaccatccttaaagatgctacactagccggactggaccgagga
cagcaacaagtgttcaaaggattgaatgataaagtgaagaagaaagctctaacatcattt
gaaagggactccattttcagcaacttgactggacagctcgattaccagggttttgaaaag
gccgacatggtgattgaagctgtttttgaggatcttaatgttaaacacagagtgttaaag
gaagtagaagcggtggttccggatcactgtgtctttgccagtaacacgtctgctctcccc
atccgtcaaattgcctctgtcagcaaaagacctgagaaggtgatcggcatgcactacttc
tctccggtggacaagatgcagctgctggagattatcacaaccgagaaaacttctaaggac
acaactgcctccgtcgtggcagtcgggctcaagcaggggaaggtcatcgttgtggtgaag
gacggacctggcttctataccacccggtgtctcgcacccatgatgtctgaagtcctccga
atcctccaggaaggagttgaccctaagaagctggattcccttaccacaagctttggcttt
cccgtgggtgctgccacactggtcgatgaagttggcgtggacgtggcaaaacacgtggca
gaagatctaggcaaagcctttggggagcggtttgaaggtggaagcgtagaactgctgaag
cagatggtgtccaggggcttcctaggtcgcaagtctgggaagggcttttacatctaccag
gagggcgtgaagaataagagtttgaattctgacatggatggtattttggcaagtctgaag
gtgcctcctaagtctgacgtctgctctgatgaagacctccagtaccgcctggtgacaaga
tttgtgaatgaggccatcatgtgcctgcaggaagggatcctggccacgcccgcagaggga
gacatcggagccgtcttcgggcttggctttcccccgtgccttggagggcccttccgctat
gtggatctgtatggcgcccagaagatagtggacaggctcaggaagtacgaggctgcctac
ggaaaaccgttcaccccgtgccagctgctcatcgaccacgctaacagccccagcaagaag
ttctaccagtga |
|---|
