KEGG   Felis catus (domestic cat): 101087257Help
Entry
101087257         CDS       T02385                                 

Gene name
IRS1
Definition
insulin receptor substrate 1
Orthology
K16172  
insulin receptor substrate 1
Organism
fca  Felis catus (domestic cat)
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    101087257 (IRS1)
   04022 cGMP - PKG signaling pathway
    101087257 (IRS1)
   04151 PI3K-Akt signaling pathway
    101087257 (IRS1)
   04152 AMPK signaling pathway
    101087257 (IRS1)
   04150 mTOR signaling pathway
    101087257 (IRS1)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    101087257 (IRS1)
   04920 Adipocytokine signaling pathway
    101087257 (IRS1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101087257 (IRS1)
  Nervous system
   04722 Neurotrophin signaling pathway
    101087257 (IRS1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    101087257 (IRS1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101087257 (IRS1)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101087257 (IRS1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
C1
AA seq 1234 aa AA seqDB search
MASPPETEGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKSH
HDGAAAPGAGGGGGSCSGSSGLGEAGEDLSYGDVPPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPISVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GSSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGSSTLTAPN
GHYILPRGGNGHRYVAGAGLGTSPALAGDEGASAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTHSYPEEGLEVHRGHHRPDTSS
LHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIINPIRRHPQRVDPNGYMMM
SPSGSCSPDIGGGPSSSGSGAAPSGSSYGKLWTNGVGGHHPHALPHPKLPVESGGGKLLS
CTGDYINMSPVGDSNTSSPSDCYYGQEDPQHKPVLSYYSLPRSFKHTQRPGELEESARHQ
HLRLSSSSGRLLYATTAEDSSSSTSSDSLGGGYCGVRPDSGLPHIHHQVLQPHLPRKVDT
AAQTNSRLARPTRLSLGDPKASTLPRVREQQPQPPLLHPPEPKSPGEYVNIEFGGDQPGY
LSGPVASRGSPSVRCPSQLQPAPREEETGTEEYMNMDLGPGRRATWQEGAGGQPGRVGPT
PPGAASVCRPTRAVPSSRGHYMTMQMGCPGQSYVDTSPVAPISYADMRTGLVAEEASLPG
TTAAAPSSSSAASASPTAPQKAGELVARSSLLGGPQGPGGMSAFTRVNLSPNRNQSAKVI
RADPQGCRRRHSSETFSSTPSATRAGNTVPFGGGAAGGGSGGGNGSAEEVKRHSSASFEN
VWLRPGELGGAPKELAQVCGAAGGLENGLNYIDLDLVKDFKQRPQERPPQPQPPPPPPPH
QPLGSSEGSSTRRSSEDLSAYASISFQKQPEDLQ
NT seq 3705 nt NT seq  +upstreamnt  +downstreamnt
atggcgagccctccggagaccgaaggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctggagagctgcttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcggacagcgag
gcggagcaggacagctggtaccaggccctcctgcagctgcacaaccgggccaagagccac
cacgacggggccgcggcccccggggcaggaggcggcgggggcagctgcagtggcagctcg
ggcctcggcgaggctggggaggacttgagctacggggatgtgcccccaggacctgcgttc
aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggcatctaccgtctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcggag
gcggcggccgtggtgctgcagctgatgaacatcagacgctgcggccactccgagaacttc
ttcttcatcgaagtgggccgttccgcggtgacgggacctggggagttctggatgcaggtg
gatgactctgtggtggcccagaacatgcacgagacaatcctggaggccatgcgggccatg
agcgacgagttccgtcctcgaagtaagagccagtcctcttccaactgctccaaccccatc
agcgtcccgctgcgcaggcaccacctcaacaacccgccacccagccaggtggggctgacc
cgccgctctcgcaccgagagcatcaccgccacctctccggccagcatggtgggcgggaag
cagggctccttccgcgtgcgcgcgtccagcgacggcgagggcaccatgtcccgcccggcc
tcggtggacggcagccccgtgagtcctagcaccaacaggacgcacgcgcaccggcatcgc
ggcagctcccggctgcacccgcctctcaaccacagccgctccatccccatgccttcgtcc
cgctgctcgccttctgccaccagcccggtcagtctgtcgtccagcagcaccagtggccac
ggctccacctcggactgcctcttcccccggcgctctagtgcttctgtgtccggttccccc
agcgatggcggtttcatctcctcggacgagtacggctccagtccttgcgatttccgaagt
tccttccgcagtgtcaccccggattccctgggccacaccccaccggcccgcggggaggag
gagctgagcaactacatctgcatgggaggcaaaggatcctccaccctcaccgcccccaat
ggtcactacattttgcctcggggtggcaatggtcaccgctacgtcgccggggccggcctg
ggcaccagcccagccctggccggggatgaaggagctagtgcagccgatctggataatcgg
ttccgaaagcggactcactcggccggcacgtcccctaccatttcccaccagaagacccca
tcgcagtcctcggtggcttccattgaggagtacacggagatgatgcctgcctacccgcca
ggaggtggcagcggaggccgcctgcccggctaccggcactccgccttcgtgcccacccac
tcctaccccgaggagggtctggaggtgcaccggggccaccaccgcccagacacctcctct
ctccacactgatgatggctacatgcccatgtccccaggagtggccccagtgcccagcagc
cgcaagggcagcggggactacatgcccatgagccccaagagcgtgtctgcgccacagcag
atcatcaaccccatcaggcgccatccccagagggtggatcccaatggctacatgatgatg
tcccctagcggcagctgctctcctgacatcggaggtgggcccagcagcagcggcagcggc
gccgccccctctgggagcagctacgggaagctgtggaccaacggggtcgggggccaccac
cctcacgctctgccacatcccaaactccccgtagagagtggtggcggcaagctcttgtct
tgtactggtgactacataaatatgtcgccggtgggggactccaataccagcagcccctcc
gactgctactatggccaggaggacccccagcacaagccagtcctctcctactactcgttg
ccaaggtcctttaagcacacccagcgccccggggagctggaggagagtgcccggcaccag
cacctccgcctttcctccagctctggtcgccttctctatgccaccaccgcagaagattcc
tcctcctctaccagcagcgacagcctgggcggcgggtactgtggggtcaggcccgattct
ggcctcccgcacatccaccatcaggtcctgcagccccatctgcctcgaaaggtggacaca
gctgcccagaccaacagccgcctggctcggcccacgaggctgtccctgggggatcccaag
gccagcaccttacctcgggtccgagagcagcagccacagcccccgctgctgcaccctccg
gagcccaagagcccaggggaatatgtgaatattgagtttgggggggatcagccgggctac
ttatctggtcccgtggcttcccgcggctcgccttctgtcaggtgcccatcccagctccag
ccagcccccagggaggaagagactggcactgaagagtacatgaacatggacctggggcca
ggcaggagggccacctggcaggagggtgccggcggccagccaggcagagtgggccccaca
cctcctggggcggccagcgtgtgcaggcccacccgggccgtgcccagcagccgcggtcac
tacatgaccatgcagatgggctgtcccggtcagagctatgtggacacctcaccagttgcc
cccatcagctatgctgacatgcggacaggcctcgttgcggaggaggcgagccttccgggg
accacggccgccgctccctcctcatcctcggcagcctcggcttcccccactgcgcctcaa
aaagcaggggagctggtggcccgctcttccctgctggggggcccgcagggacccggaggc
atgagcgccttcaccagggtgaacctcagccccaaccggaaccagagtgccaaagtgatc
cgtgcggacccgcaagggtgccggaggcggcacagctctgagaccttctcctcgacaccc
agtgccacccgggcgggcaacacggtgcccttcggagggggcgctgcaggagggggcagc
ggtggtggcaacggcagcgccgaggaggtgaaacgccacagttctgcttccttcgagaac
gtgtggctgaggcctggggagctcgggggagcccccaaggagctggcccaagtgtgcggg
gccgccgggggtttggagaacgggcttaactacatagacctggatttggtcaaggacttc
aaacagcgccctcaggagcgcccccctcaaccacagccgccccctcccccgccccctcat
cagcctctgggcagcagcgagggcagctccacccgccgctccagcgaggatttaagcgcc
tatgccagcatcagtttccagaagcagccagaggacctccagtag

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