KEGG   Felis catus (domestic cat): 101088847Help
Entry
101088847         CDS       T02385                                 

Gene name
SOS2
Definition
(RefSeq) SOS Ras/Rho guanine nucleotide exchange factor 2
  KO
K03099  
son of sevenless
Organism
fca  Felis catus (domestic cat)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Focal adhesion
Gap junction
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Neurotrophin signaling pathway
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Estrogen signaling pathway
Prolactin signaling pathway
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Endometrial cancer
Glioma
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101088847 (SOS2)
   04010 MAPK signaling pathway
    101088847 (SOS2)
   04012 ErbB signaling pathway
    101088847 (SOS2)
   04630 Jak-STAT signaling pathway
    101088847 (SOS2)
   04068 FoxO signaling pathway
    101088847 (SOS2)
   04072 Phospholipase D signaling pathway
    101088847 (SOS2)
   04151 PI3K-Akt signaling pathway
    101088847 (SOS2)
   04150 mTOR signaling pathway
    101088847 (SOS2)
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    101088847 (SOS2)
   04540 Gap junction
    101088847 (SOS2)
  Cell motility
   04810 Regulation of actin cytoskeleton
    101088847 (SOS2)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    101088847 (SOS2)
   04660 T cell receptor signaling pathway
    101088847 (SOS2)
   04662 B cell receptor signaling pathway
    101088847 (SOS2)
   04664 Fc epsilon RI signaling pathway
    101088847 (SOS2)
   04062 Chemokine signaling pathway
    101088847 (SOS2)
  Endocrine system
   04910 Insulin signaling pathway
    101088847 (SOS2)
   04912 GnRH signaling pathway
    101088847 (SOS2)
   04915 Estrogen signaling pathway
    101088847 (SOS2)
   04917 Prolactin signaling pathway
    101088847 (SOS2)
  Nervous system
   04722 Neurotrophin signaling pathway
    101088847 (SOS2)
  Development
   04320 Dorso-ventral axis formation
    101088847 (SOS2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101088847 (SOS2)
   05231 Choline metabolism in cancer
    101088847 (SOS2)
   05206 MicroRNAs in cancer
    101088847 (SOS2)
   05205 Proteoglycans in cancer
    101088847 (SOS2)
   05214 Glioma
    101088847 (SOS2)
   05221 Acute myeloid leukemia
    101088847 (SOS2)
   05220 Chronic myeloid leukemia
    101088847 (SOS2)
   05211 Renal cell carcinoma
    101088847 (SOS2)
   05215 Prostate cancer
    101088847 (SOS2)
   05213 Endometrial cancer
    101088847 (SOS2)
   05224 Breast cancer
    101088847 (SOS2)
   05223 Non-small cell lung cancer
    101088847 (SOS2)
  Substance dependence
   05034 Alcoholism
    101088847 (SOS2)
  Infectious diseases
   05160 Hepatitis C
    101088847 (SOS2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    101088847 (SOS2)
   01522 Endocrine resistance
    101088847 (SOS2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
B3
AA seq 1272 aa AA seqDB search
MAQPRTVQDVEERVQKTFPHPIDKWAIADAQSAIEKRKRRNPLLLPVDKIHPSLKEVLGY
KVDYHVSLYIVAVLEYISADILKLAGNYVFNIRHYEISQQDIKVSMCADKVLMDMFDQDD
IGLVSLCEDEPSSSGELNYYDLVRTEIAEERQYLRELNMIIKVFREAFLSDRKLFKPCDI
ERIFSNISDIHELTVKLLGLIEDTVEMTDESSPHPLAGSCFEDLAEEQAFDPYETLSQDI
LSPKFNEHFSKLMARPAVALHFQSIADGFKEAVRYVLPRLMLVPVYHCWHYFELLKQLKA
CSEEQEDRECLNQAITALMNLQGSMDRIYKQYSPRRRPGDPICPFYNRHLRSKHLAIKKM
NEIQKNIDGWEGKDIGQCCNEFIMEGPLTRIGAKHERHIFLFDGLMISCKPNHSQSRLPG
YSSAEYRLKEKFVMRKIQICDKEDTCECKHAFEIVSKDENSIIFAAKSAEEKNNWMAALI
SLHYRSTLDRMLDSVLLKEENEQPLRLPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIK
GGTVVKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLLIERFEIPEPEPTEADKLA
VEKGEQPISADLKRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFISSVR
GKAMKKWVESIAKIIKRKKQAQANGISHNITFESPPPPIEWHISRPGQFETFDLMTLHPI
EIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEA
ENFEERVAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRRILD
EAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRR
KVAEITGEIQQYQNQPYCLRIEPEMRRFFENLNPMGSASEKEFTDYLFNKSLEIEPRNCK
QPPRFPRKSTFSLKSPGIRPNTGRHGSTSGTLRGHPTPLEREPYKISFSRIAETDLESTV
SAPTSPNTPSTPPVSASSDLSVFLDVDLNSSCGSNSIFAPVLLPHSKSFFSSCGSLHKLN
EEPLIPPPLPPRKKFDHDASNSKGNTKSDDDPPAIPPRQPPPPKVKPRVPAPTGAFDGPL
HSPPPPPPRDPLPDTPPPVPLRPPEHFINCPFNLQPPPLGHLHRDPEWLRDVSTCPNSPN
TPPSTPSPRVPRRCYALSSSHNNLAHPQAPPVPPRQNSSPHLPKLPPKTYKRELSHPPSY
RLPLLENAETPQ
NT seq 3819 nt NT seq  +upstreamnt  +downstreamnt
atggctcagccaaggactgttcaagatgtggaggaacgtgttcagaagacctttcctcat
ccaattgacaagtgggctattgctgatgcacaatctgccatagaaaaacgaaaacgaaga
aatcctctcttactgcctgtggacaaaatccatccttcattgaaggaggttttagggtac
aaagtggactatcatgtatccctgtatattgtggctgtactagagtatatctcagctgat
attttgaagttggctggtaattatgtttttaatatccgacattatgaaatatctcagcag
gacattaaagtgtcaatgtgtgcagataaggttttgatggacatgtttgatcaggatgac
ataggtttggtttctctctgtgaagatgaaccaagttcttcaggtgaattaaactattat
gaccttgtcagaactgaaattgcagaagaaaggcagtatctacgggaattaaatatgatt
ataaaagtgtttcgagaagctttcctttctgacaggaagctatttaaaccttgtgatatt
gaaaggattttcagtaacatttcagatatacatgaattgaccgtgaaacttctaggtctt
attgaagacacagttgaaatgactgatgaaagcagccctcatccattagctggcagctgt
tttgaagatttggcagaagagcaagcatttgatccttatgaaacattatcacaggatatt
ctgtctccaaaatttaatgaacatttcagtaagttgatggccagacctgcagtggctcta
cactttcagtccattgctgatggttttaaagaggcagttcgttatgtccttccacgcctt
atgctggtgcctgtatatcattgttggcactattttgaattattaaagcaattgaaagca
tgtagtgaagagcaggaagacagagaatgtttgaaccaagctattactgctcttatgaat
ctccaaggtagtatggaccgaatttacaagcagtattcacctagacgccgacctggggat
cctatttgccctttttataatcgtcacttaagaagcaagcatctggctattaaaaaaatg
aatgaaattcagaaaaacatagatggatgggaaggcaaagatattggacagtgttgtaat
gaattcattatggaaggtccattgacacgaattggtgctaaacatgaacggcatattttt
ctctttgatggcttaatgattagctgtaagcccaatcatagccagtcacgccttccaggt
tacagtagtgcagaatacagattaaaagaaaaatttgtcatgaggaaaatacaaatatgt
gataaagaagatacctgtgaatgtaaacatgcttttgaaatagtatccaaagatgaaaac
agcataatatttgctgctaagtctgctgaagagaaaaataattggatggccgcacttatt
tctcttcactatcgtagtacgctagatcgaatgctagattcagtgttattgaaagaagaa
aatgagcagccactgagattaccaagtcctgaagtgtatcgttttgtggtaaaagactct
gaggaaaacattgtttttgaagacaacttgcaaagtagaagtggaattcccatcattaaa
ggaggaactgtggtgaaattaattgaaaggttaacatatcatatgtatgcagatcccaat
tttgtccgtacttttcttactacataccgttcattttgtaaaccacaggaattactaagc
ttactgattgaacgatttgaaattccagagccagaacctactgaagcagataaattggca
gtagagaaaggcgaacagccaatcagtgcagaccttaaaaggtttcgcaaggaatatgtc
caaccagtacaacttaggatcttaaatgtgtttcggcactgggttgaacatcatttttat
gactttgaaagagatttggagttgcttgagagactagaatccttcatttcaagtgtaaga
gggaaagctatgaagaagtgggtagagtcaattgctaagatcatcaagaggaagaaacaa
gctcaggcaaatggaataagccataatattacctttgagagtccacctccaccaattgaa
tggcatattagcagaccaggacagtttgaaacatttgatcttatgacacttcatccaata
gaaattgcacgtcagctgacacttttggaatctgatctctacaggaaagtccagccttct
gaacttgtagggagtgtgtggaccaaagaagataaagaaataaattctccaaatttatta
aaaatgattcgccataccacaaatctcaccctctggtttgaaaagtgcattgtggaagca
gaaaattttgaggaacgggtggcagtactaagtagaattatagaaattctgcaagttttt
caagatttgaataatttcaatggtgtattggagatagtcagtgcagtaaattcagtgtca
gtgtacagactagaccatacttttgaggcattgcaggaaagaaaaaggagaattttggat
gaagctgtggaattaagtcaagatcactttaaaaaatacctagtaaaacttaagtcaatc
aatccaccttgtgtgcctttttttggaatatatttaacaaatattctgaaaactgaagaa
gggaataatgattttttaaaaaagaaagggaaagatttaatcaatttcagtaagaggagg
aaagtagctgaaattactggagaaattcagcagtatcagaatcaaccttactgtttacgg
atagaaccagaaatgaggagattctttgaaaaccttaaccccatgggaagtgcttctgaa
aaggagtttacagattatttgttcaataagtcactagaaattgaaccccgaaactgcaaa
cagccacctcgatttcctaggaaatcaactttctctttaaaatctcctggaataaggcct
aatacaggccgacatggctctacctcaggcactttacgaggtcatccaacaccattagaa
agagaaccatataagataagctttagtcggattgctgaaactgatcttgaatcaactgtg
tcagcaccaacctctccaaatacgccatctactccaccagtatctgcttcttcagacctt
agtgtgtttttagatgtggatctcaacagttcctgtggcagcaatagcatctttgctcca
gtcctcttgccacattcaaagtctttcttcagttcatgtggtagtttacataaactaaat
gaagagccactgattcctcctccacttcctcctcgaaaaaagtttgatcatgatgcttca
aattccaagggaaatacgaaatctgatgatgacccccctgctattccaccaagacaacct
cctcctccaaaggtaaaacccagagttcctgctcctactggtgcatttgacgggcctctg
catagtccacctccaccaccgccgagagatcctcttcctgatacccctccaccagttccc
cttcggcctccagaacactttataaactgtccatttaatcttcagccacctccactagga
catcttcacagagatccagagtggctcagagacgttagtacctgtccaaattcaccaaat
actcctcctagcacaccctctccaagagtaccacgtcgatgctatgcgctcagttccagt
cacaataaccttgctcatcctcaagctccccctgttccaccaaggcagaattcaagccct
cacctaccaaaactgccaccaaagacttataaacgggagctttcacaccccccatcgtac
agactgcctttgctagaaaatgcagaaactcctcaatga

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