KEGG   Felis catus (domestic cat): 101091310Help
Entry
101091310         CDS       T02385                                 

Gene name
MAPK8
Definition
(RefSeq) mitogen-activated protein kinase 8 isoform X1
  KO
K04440  mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
Organism
fca  Felis catus (domestic cat)
Pathway
fca01522  Endocrine resistance
fca04010  MAPK signaling pathway
fca04012  ErbB signaling pathway
fca04014  Ras signaling pathway
fca04024  cAMP signaling pathway
fca04068  FoxO signaling pathway
fca04071  Sphingolipid signaling pathway
fca04137  Mitophagy - animal
fca04140  Autophagy - animal
fca04141  Protein processing in endoplasmic reticulum
fca04210  Apoptosis
fca04215  Apoptosis - multiple species
fca04217  Necroptosis
fca04310  Wnt signaling pathway
fca04380  Osteoclast differentiation
fca04510  Focal adhesion
fca04530  Tight junction
fca04620  Toll-like receptor signaling pathway
fca04621  NOD-like receptor signaling pathway
fca04622  RIG-I-like receptor signaling pathway
fca04625  C-type lectin receptor signaling pathway
fca04657  IL-17 signaling pathway
fca04658  Th1 and Th2 cell differentiation
fca04659  Th17 cell differentiation
fca04664  Fc epsilon RI signaling pathway
fca04668  TNF signaling pathway
fca04722  Neurotrophin signaling pathway
fca04723  Retrograde endocannabinoid signaling
fca04728  Dopaminergic synapse
fca04750  Inflammatory mediator regulation of TRP channels
fca04910  Insulin signaling pathway
fca04912  GnRH signaling pathway
fca04914  Progesterone-mediated oocyte maturation
fca04917  Prolactin signaling pathway
fca04920  Adipocytokine signaling pathway
fca04926  Relaxin signaling pathway
fca04930  Type II diabetes mellitus
fca04931  Insulin resistance
fca04932  Non-alcoholic fatty liver disease (NAFLD)
fca04933  AGE-RAGE signaling pathway in diabetic complications
fca05132  Salmonella infection
fca05133  Pertussis
fca05142  Chagas disease (American trypanosomiasis)
fca05145  Toxoplasmosis
fca05152  Tuberculosis
fca05160  Hepatitis C
fca05161  Hepatitis B
fca05164  Influenza A
fca05167  Kaposi's sarcoma-associated herpesvirus infection
fca05168  Herpes simplex infection
fca05169  Epstein-Barr virus infection
fca05200  Pathways in cancer
fca05210  Colorectal cancer
fca05212  Pancreatic cancer
fca05231  Choline metabolism in cancer
fca05418  Fluid shear stress and atherosclerosis
Module
fca_M00688  MAPK (JNK) signaling
Brite
KEGG Orthology (KO) [BR:fca00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    101091310 (MAPK8)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101091310 (MAPK8)
   04010 MAPK signaling pathway
    101091310 (MAPK8)
   04012 ErbB signaling pathway
    101091310 (MAPK8)
   04310 Wnt signaling pathway
    101091310 (MAPK8)
   04668 TNF signaling pathway
    101091310 (MAPK8)
   04068 FoxO signaling pathway
    101091310 (MAPK8)
   04071 Sphingolipid signaling pathway
    101091310 (MAPK8)
   04024 cAMP signaling pathway
    101091310 (MAPK8)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    101091310 (MAPK8)
   04137 Mitophagy - animal
    101091310 (MAPK8)
  Cell growth and death
   04210 Apoptosis
    101091310 (MAPK8)
   04215 Apoptosis - multiple species
    101091310 (MAPK8)
   04217 Necroptosis
    101091310 (MAPK8)
  Cellular community - eukaryotes
   04510 Focal adhesion
    101091310 (MAPK8)
   04530 Tight junction
    101091310 (MAPK8)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    101091310 (MAPK8)
   04621 NOD-like receptor signaling pathway
    101091310 (MAPK8)
   04622 RIG-I-like receptor signaling pathway
    101091310 (MAPK8)
   04625 C-type lectin receptor signaling pathway
    101091310 (MAPK8)
   04658 Th1 and Th2 cell differentiation
    101091310 (MAPK8)
   04659 Th17 cell differentiation
    101091310 (MAPK8)
   04657 IL-17 signaling pathway
    101091310 (MAPK8)
   04664 Fc epsilon RI signaling pathway
    101091310 (MAPK8)
  Endocrine system
   04910 Insulin signaling pathway
    101091310 (MAPK8)
   04920 Adipocytokine signaling pathway
    101091310 (MAPK8)
   04912 GnRH signaling pathway
    101091310 (MAPK8)
   04914 Progesterone-mediated oocyte maturation
    101091310 (MAPK8)
   04917 Prolactin signaling pathway
    101091310 (MAPK8)
   04926 Relaxin signaling pathway
    101091310 (MAPK8)
  Nervous system
   04728 Dopaminergic synapse
    101091310 (MAPK8)
   04723 Retrograde endocannabinoid signaling
    101091310 (MAPK8)
   04722 Neurotrophin signaling pathway
    101091310 (MAPK8)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101091310 (MAPK8)
  Development
   04380 Osteoclast differentiation
    101091310 (MAPK8)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101091310 (MAPK8)
   05231 Choline metabolism in cancer
    101091310 (MAPK8)
   05210 Colorectal cancer
    101091310 (MAPK8)
   05212 Pancreatic cancer
    101091310 (MAPK8)
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    101091310 (MAPK8)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101091310 (MAPK8)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101091310 (MAPK8)
   04931 Insulin resistance
    101091310 (MAPK8)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101091310 (MAPK8)
  Infectious diseases
   05132 Salmonella infection
    101091310 (MAPK8)
   05133 Pertussis
    101091310 (MAPK8)
   05152 Tuberculosis
    101091310 (MAPK8)
   05164 Influenza A
    101091310 (MAPK8)
   05161 Hepatitis B
    101091310 (MAPK8)
   05160 Hepatitis C
    101091310 (MAPK8)
   05168 Herpes simplex infection
    101091310 (MAPK8)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    101091310 (MAPK8)
   05169 Epstein-Barr virus infection
    101091310 (MAPK8)
   05145 Toxoplasmosis
    101091310 (MAPK8)
   05142 Chagas disease (American trypanosomiasis)
    101091310 (MAPK8)
  Drug resistance
   01522 Endocrine resistance
    101091310 (MAPK8)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101091310 (MAPK8)
Protein kinases [BR:fca01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101091310 (MAPK8)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr Kdo Kinase-like RIO1 APH FTA2 DUF530
Motif
Other DBs
NCBI-GeneID: 101091310
NCBI-ProteinID: XP_003994204
Ensembl: ENSFCAG00000003342
UniProt: A0A2I2V255
Position
D2
AA seq 427 aa AA seqDB search
MSRSKRDSNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP
FQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ
MELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSF
MMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQ
LGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSK
MLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEV
MDLEERTKNGVIRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEASA
GPLGCCR
NT seq 1284 nt NT seq  +upstreamnt  +downstreamnt
atgagcagaagcaagcgtgacagcaatttttatagtgtagagattggagattctacattt
acagttttgaaacgatatcagaatttaaaacctataggctcaggagctcaaggaatagta
tgtgcagcttatgatgccattctggaaagaaatgttgcaatcaagaagctgagccggccg
tttcagaatcagactcatgctaaacgggcttacagagagctagttctaatgaaatgtgtt
aatcacaaaaatataattggccttttgaatgttttcacaccacagaaatccctagaagaa
tttcaagatgtttacatagtcatggagctcatggatgcaaatctttgccaagtgattcag
atggaactagatcatgaaagaatgtcctaccttctctatcagatgctgtgtggaatcaag
caccttcactctgctggaattattcatcgggacttaaagcccagtaatatagtggtaaaa
tcagactgcactttgaagattcttgactttggactggccaggactgcaggaactagtttt
atgatgacgccttacgtagtgactcgctactacagagcacctgaggtcatcctagggatg
ggctacaaagaaaacgttgacatttggtcagttgggtgcatcatgggagaaatgatcaaa
ggtggtgttttgttcccaggtacagatcatattgatcagtggaataaagttatcgaacag
cttggaacaccatgccctgaattcatgaagaaactacaaccaacagtaaggacttatgtt
gaaaacagacctaaatatgctggatatagctttgagaaactcttccccgatgtacttttc
ccagctgactcggaacacaacaaacttaaagccagtcaggcaagggacttgttatccaaa
atgctggtaattgatgcatctaaaaggatctctgtagatgaagccctccagcatccatat
atcaatgtctggtatgatccttctgaagcagaagctccaccacccaagatacctgacaag
caattagatgaaagggaacatacaatagaagagtggaaagagttgatatacaaagaagtt
atggacttggaggagagaaccaagaatggagttatacgggggcagccctctcctttaggt
gcagcagtgatcaatggctctcagcatccatcgtcatcatcgtctgtcaatgatgtgtct
tcaatgtcaacagatccgactttggcctcagatacagatagcagtctggaagcatcagct
ggacctctgggctgttgtagatga

DBGET integrated database retrieval system