KEGG   Felis catus (domestic cat): 101091892Help
Entry
101091892         CDS       T02385                                 

Gene name
PIK3CB
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
fca  Felis catus (domestic cat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101091892 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101091892 (PIK3CB)
   04015 Rap1 signaling pathway
    101091892 (PIK3CB)
   04012 ErbB signaling pathway
    101091892 (PIK3CB)
   04370 VEGF signaling pathway
    101091892 (PIK3CB)
   04630 Jak-STAT signaling pathway
    101091892 (PIK3CB)
   04668 TNF signaling pathway
    101091892 (PIK3CB)
   04066 HIF-1 signaling pathway
    101091892 (PIK3CB)
   04068 FoxO signaling pathway
    101091892 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    101091892 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    101091892 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    101091892 (PIK3CB)
   04152 AMPK signaling pathway
    101091892 (PIK3CB)
   04150 mTOR signaling pathway
    101091892 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101091892 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    101091892 (PIK3CB)
  Cell communication
   04510 Focal adhesion
    101091892 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101091892 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    101091892 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    101091892 (PIK3CB)
   04660 T cell receptor signaling pathway
    101091892 (PIK3CB)
   04662 B cell receptor signaling pathway
    101091892 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    101091892 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    101091892 (PIK3CB)
   04670 Leukocyte transendothelial migration
    101091892 (PIK3CB)
   04062 Chemokine signaling pathway
    101091892 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    101091892 (PIK3CB)
   04915 Estrogen signaling pathway
    101091892 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    101091892 (PIK3CB)
   04917 Prolactin signaling pathway
    101091892 (PIK3CB)
   04921 Oxytocin signaling pathway
    101091892 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    101091892 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101091892 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101091892 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101091892 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    101091892 (PIK3CB)
   04722 Neurotrophin signaling pathway
    101091892 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101091892 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    101091892 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101091892 (PIK3CB)
   05205 Proteoglycans in cancer
    101091892 (PIK3CB)
   05203 Viral carcinogenesis
    101091892 (PIK3CB)
   05210 Colorectal cancer
    101091892 (PIK3CB)
   05212 Pancreatic cancer
    101091892 (PIK3CB)
   05214 Glioma
    101091892 (PIK3CB)
   05221 Acute myeloid leukemia
    101091892 (PIK3CB)
   05220 Chronic myeloid leukemia
    101091892 (PIK3CB)
   05218 Melanoma
    101091892 (PIK3CB)
   05211 Renal cell carcinoma
    101091892 (PIK3CB)
   05215 Prostate cancer
    101091892 (PIK3CB)
   05213 Endometrial cancer
    101091892 (PIK3CB)
   05222 Small cell lung cancer
    101091892 (PIK3CB)
   05223 Non-small cell lung cancer
    101091892 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101091892 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101091892 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101091892 (PIK3CB)
   05166 HTLV-I infection
    101091892 (PIK3CB)
   05162 Measles
    101091892 (PIK3CB)
   05164 Influenza A
    101091892 (PIK3CB)
   05161 Hepatitis B
    101091892 (PIK3CB)
   05160 Hepatitis C
    101091892 (PIK3CB)
   05169 Epstein-Barr virus infection
    101091892 (PIK3CB)
   05146 Amoebiasis
    101091892 (PIK3CB)
   05145 Toxoplasmosis
    101091892 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    101091892 (PIK3CB)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101091892 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
C2
AA seq 1070 aa AA seqDB search
MCFNFIMPPAMADILDIWAVDSQLASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMEIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRIKMRKFSEEKIQSLVGLSWMDWLKQTYPPEH
EPSILENLEDKLYGGKLIVAVHFENCQDVFSFQISPNMNPIKINELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQYIRNCVMNRTLPHFMLVECCKIKKMYEQEMIAI
EAAINRNSSNLPLPLPPKKMRIISHVWENNNPFQIVLVKGNKLNTEESVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNEPLEFDINICDLPRMARLCFAIYAVLDKVKTKKSTKTI
NPSKYQTIRKSGKVHYPVAWVNTMVFDFKGQLRSGDITLHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYYYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAMKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCVILSELYVEKCKYMD
SKMKPLWLVYNNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcaatttcataatgcctcctgctatggcagacatccttgacatctgggcagtg
gattcacagttagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatattcagttggaggttcctcgggaagctaccatttcctatattaaacagatgttatgg
aagcaagttcacaattacccaatgtttaacctccttatggaaattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggagcttgaagatgaaacaagaaggctctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctacatgaatttgatgcactg
aaggatcctgaagtgaatgaattccgaataaaaatgcgcaaattcagtgaagaaaagatt
cagtcacttgtgggattgtcttggatggattggctaaaacagacgtatccaccagaacat
gaaccatccatccttgaaaacttagaagataaactttatggaggaaagctcattgtggct
gttcattttgaaaattgtcaggatgtgtttagctttcaaatatctcctaatatgaatcct
atcaaaataaatgaactggcaatccaaaaacgtttgactattcatgggaaagaagatgaa
gttagcccgtatgactatgtgttacaagtcagtgggcgagtagaatatgtgtttggtgat
cacccactaattcagttccagtatatccggaactgtgtaatgaataggaccttgcctcat
tttatgcttgtggaatgttgcaagatcaagaagatgtatgaacaggaaatgattgccata
gaagctgccataaatagaaattcatcaaaccttcctcttcctttaccaccaaagaaaatg
cgaattatttctcatgtttgggaaaataacaaccctttccaaattgtcttggttaaggga
aataaacttaacacagaagaaagtgtaaaagttcatgtcagggctggcctttttcatggt
accgaactcctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaccactggaatttgatataaatatttgtgacctgccacgaatggctcgatta
tgttttgctatttatgcagttttggataaagtgaaaacgaaaaaatcgactaaaactatt
aatccctctaaatatcagaccatccggaaatctgggaaagtgcattatcctgtagcatgg
gtaaatacaatggtttttgactttaaaggacagttgagatctggagacataacattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcag
acaaatccatatacggaaaatgcaacagctttgcatatcaaattcccagagaataaaaaa
caaccttattattatcctccctttgataagataatcgagaaggcagctgagattgcaagc
agtgacagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcaactgtgtgagaacgaaatggatcttatttggact
ttgcgacaagattgcagagagaatttcccacagtcactgccaaaattactgctgtcgatc
aagtggaataaacttgaagatgttgctcagcttcaagccctacttcagatttggcctaaa
ctgcccccccgggaggccttggagcttctagatttcaactatccagatcagtacgtgcga
gaatatgctgtgggctgcctgcgacagatgagtgatgaagaactctctcaatatctttta
caactggtgcaagttttgaaatacgagccttttcttgattgtgccctctctagattccta
ttagaaagagcacttgctaaccgcaggatagggcagtttctattttggcaccttaggtca
gaagtgcatattcctgctgtctcagtacagtttggtgtcatccttgaagcatactgccgg
ggaagtgtagggcatatgaaagtgctttctaagcaggttgaagcactcaataagttaaaa
actttaaatagtttaatcaaactgaatgcaatgaagctaaacagagccaaagggaaggag
gccatgcatacttgtttaaaacagaatgcttaccgggaagccctctctgacctgcagtca
cctctgaatccgtgtgtcatcctctcagaactctatgttgaaaaatgtaaatacatggat
tccaaaatgaagcctttgtggctcgtgtacaacaacaaagtttttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaagatatgttgacactccagatgttg
cgcttgatggatttactttggaaagaagctggtctggatcttcggatgctgccttatggc
tgtttagcaacaggagaccgctctggcctcatcgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgcagcagcggccttcaacaaagatgcc
cttctgaactggcttaaagaatacaactctggggatgacctagaccgagccattgaagag
tttaccttgtcctgtgccggctactgtgtagcttcttatgtccttgggattggtgataga
catagtgacaacatcatggtcaagaaaaccggccagctcttccacattgactttggacat
attcttggaaatttcaagtctaaatttggcattaaaagggaacgagtgccttttattctt
acctatgatttcattcatgtgattcaacaaggaaaaacaggaaacacagaaaaatttggc
cgtttccgccagtgttgtgaggatgcatatctgattttacgacgtcacgggaatctcttc
atcactctttttgcactgatgttgactgcagggcttcctgagctcacatcagtcaaggat
atacagtatcttaaggactctcttgccttaggaaagagtgaagaagaagcgcttaagcaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gcccacacagttcggaaagactacagatcttaa

DBGET integrated database retrieval system