KEGG   Felis catus (domestic cat): 101092262Help
Entry
101092262         CDS       T02385                                 

Gene name
PLCB1
Definition
(RefSeq) phospholipase C, beta 1 (phosphoinositide-specific)
  KO
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
fca  Felis catus (domestic cat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Sphingolipid signaling pathway
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Glucagon signaling pathway
Renin secretion
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Pathways in cancer
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101092262 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    101092262 (PLCB1)
   04310 Wnt signaling pathway
    101092262 (PLCB1)
   04020 Calcium signaling pathway
    101092262 (PLCB1)
   04070 Phosphatidylinositol signaling system
    101092262 (PLCB1)
   04071 Sphingolipid signaling pathway
    101092262 (PLCB1)
   04022 cGMP - PKG signaling pathway
    101092262 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    101092262 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101092262 (PLCB1)
   04062 Chemokine signaling pathway
    101092262 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    101092262 (PLCB1)
   04922 Glucagon signaling pathway
    101092262 (PLCB1)
   04912 GnRH signaling pathway
    101092262 (PLCB1)
   04915 Estrogen signaling pathway
    101092262 (PLCB1)
   04921 Oxytocin signaling pathway
    101092262 (PLCB1)
   04918 Thyroid hormone synthesis
    101092262 (PLCB1)
   04919 Thyroid hormone signaling pathway
    101092262 (PLCB1)
   04916 Melanogenesis
    101092262 (PLCB1)
   04924 Renin secretion
    101092262 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101092262 (PLCB1)
   04270 Vascular smooth muscle contraction
    101092262 (PLCB1)
  Digestive system
   04970 Salivary secretion
    101092262 (PLCB1)
   04971 Gastric acid secretion
    101092262 (PLCB1)
   04972 Pancreatic secretion
    101092262 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101092262 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    101092262 (PLCB1)
   04725 Cholinergic synapse
    101092262 (PLCB1)
   04728 Dopaminergic synapse
    101092262 (PLCB1)
   04726 Serotonergic synapse
    101092262 (PLCB1)
   04720 Long-term potentiation
    101092262 (PLCB1)
   04730 Long-term depression
    101092262 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    101092262 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101092262 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    101092262 (PLCB1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101092262 (PLCB1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101092262 (PLCB1)
   05016 Huntington's disease
    101092262 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    101092262 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    101092262 (PLCB1)
   05143 African trypanosomiasis
    101092262 (PLCB1)
Enzymes [BR:fca01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101092262 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
A3
AA seq 1072 aa AA seqDB search
MITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKL
QVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP
RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN
DSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA
GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK
TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK
ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGAGEADTESDDDDDDDDCK
KSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNRSFEMSSFVETKGLEQLTK
SPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVALNFQTVDLAMQINMGMYE
YNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDM
FGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLACLRIAVYEEGGKFIGHRI
LPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLME
QRAKQLAALTLEDEEEVKKEADPGETPSEAPSETRTTPAENGVNHTTSLAPKPPSQAPHS
QPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKPFVKLQKKHYKEMKDLVKRHHKKT
TDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEM
TQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEIC
EKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQ
EKLVEKHKEIRQQILDEKPKGDGSSSFLSETCHEDPSVSPNFTPPNPQALKW
NT seq 3219 nt NT seq  +upstreamnt  +downstreamnt
atgataacggtggtgtacgggcctgacttagttaacatctcccatttgaatctcgtggct
ttccaagaggaagtggccaaggaatggacaaatgaggttttcagtttggcaacaaacctg
ctggcccaaaatatgtccagagacgcatttctggaaaaagcctatacgaagcttaagctg
caagtcactccagaagggcgcattcctctcaaaaacatataccgcttgttctcagcagac
cggaagcgagttgaaactgctttagaggcttgtagtcttccatcttcaaggaatgattca
atacctcaagaagatttcactccagaagtgtacagagttttcctgaacaacctttgccct
cgacctgaaattgataacatcttttctgaatttggtgccaaaagcaaaccataccttaca
gttgatcagatgatggattttatcaacctgaagcagcgagatcctcggctaaatgaaata
ctttacccacctttaaagcaagagcaagtccaagtactgattgagaagtatgagcccaac
gatagccttgccaaaaaaggacagatatcagtggatggctttatgcgctatctgagtgga
gaagaaaatggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcagccc
ctttctcactatttcatcaattcctcacacaacacctacctcacagctggccagctggct
ggaaattcctctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggag
ttggactgctggaaaggacggactgcagaagaggaaccagtcatcacccatgggttcacc
atgacaactgaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcatttaag
acgtcaccttttccaattctgctttcatttgagaaccacgtagattccccaaagcagcaa
gccaagatggcagagtattgccgactgatctttggagatgctcttctcatggaaccactg
gaaaaatacccactggaatctggagttcctcttccaagccctatggatttaatgtacaaa
attttggtgaaaaataagaagaaatcgcataagtcatcagaaggaagtggcaaaaagaag
ctctcagaacaagcctccaacacgtacagtgactcctccagcgtgtttgagccctcatct
ccaggagccggggaagctgatactgagagtgacgacgatgacgatgatgacgactgtaaa
aaatcttcaatggatgagggtactgctggcagtgaggccatggccacagaagagatgtct
aacctggtgaactatattcagccagtcaagtttgagtcctttgaaacttcaaaaaaaaga
aatagaagttttgaaatgtcttccttcgtggaaaccaaaggactcgagcaactgacaaag
tctccagtggaatttgtagaatataacaaaatgcagctcagcaggatatatccaaaagga
acccgtgtggattcatccaactacatgcctcagctcttctggaatgctggttgccaaatg
gttgcacttaattttcaaactgtggacctggctatgcaaataaatatggggatgtatgaa
tacaatgggaaaagtggctacagattaaagccagagttcatgaggagacccgacaagcac
tttgatccattcaccgaaggcatcgtagatgggatagtggccaacactttatctgtgaag
attatttcaggtcagtttctttctgataagaaagttgggacctatgtggaagtggatatg
tttggtttgcctgtggacacaaggaggaaggcatttaagaccaaaacatcacaaggaaat
gctgtaaatcctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttccttct
ctggcctgtttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccggatc
ttgcctgtacaggcaattcggccaggctatcactacatctgtctgcggaatgagaggaac
cagcctctgatgctcccagctgtctttgtctacatagaggtgaaagactatgtcccagat
acatatgcagatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggag
cagagagcaaagcaactggctgctctgacactggaagatgaagaagaagtaaagaaagag
gctgatcctggggaaacaccatcagaagctccaagtgaaaccaggacaactccagcagaa
aacggagtgaatcacactacatccctggcacccaaaccaccctcccaggctccccacagc
caaccagctccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgtt
ttaacagaagtggaagcacagactatcgaagagctaaagcaacagaaaccgtttgtgaaa
cttcaaaagaagcactacaaagaaatgaaagacctggtgaaaagacaccacaagaaaacc
actgaccttatcaaagaacacactacaaaatataatgaaattcagaatgactacttgaga
aggagggcagctttggaaaagacagccaaaaaggatagtaagaaaaaatcagaacccagc
agtcctgaccatggttcatcaacaattgagcaagatcttgctgccctagatgctgaaatg
acccaaaagttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgacaa
gaacagtattacagtgagaaataccagaagcgagaacatattaaactgcttattcagaaa
ttgacggatgttgccgaagaatgtcagaacaatcagctgaagaagctcaaagaaatctgt
gagaaggagaagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagatcaca
gaagctaaatccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccggtca
tacatccaggaggtggtacagtacatcaagaggttagaagaggcacaaagtaaacggcaa
gaaaaacttgtagagaaacacaaggagatccgtcagcagatcctggatgaaaagcccaag
ggggacggttcctcctcattcttgtcggaaacttgccatgaggatccctctgtttccccc
aactttactccccccaaccctcaagctctcaagtggtga

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