KEGG   Felis catus (domestic cat): 101092262Help
Entry
101092262         CDS       T02385                                 

Gene name
PLCB1
Definition
phospholipase C, beta 1 (phosphoinositide-specific)
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
fca  Felis catus (domestic cat)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101092262 (PLCB1)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    101092262 (PLCB1)
   04310 Wnt signaling pathway
    101092262 (PLCB1)
   04020 Calcium signaling pathway
    101092262 (PLCB1)
   04070 Phosphatidylinositol signaling system
    101092262 (PLCB1)
   04022 cGMP - PKG signaling pathway
    101092262 (PLCB1)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    101092262 (PLCB1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101092262 (PLCB1)
   04062 Chemokine signaling pathway
    101092262 (PLCB1)
  Endocrine system
   04911 Insulin secretion
    101092262 (PLCB1)
   04912 GnRH signaling pathway
    101092262 (PLCB1)
   04915 Estrogen signaling pathway
    101092262 (PLCB1)
   04921 Oxytocin signaling pathway
    101092262 (PLCB1)
   04918 Thyroid hormone synthesis
    101092262 (PLCB1)
   04919 Thyroid hormone signaling pathway
    101092262 (PLCB1)
   04916 Melanogenesis
    101092262 (PLCB1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101092262 (PLCB1)
   04270 Vascular smooth muscle contraction
    101092262 (PLCB1)
  Digestive system
   04970 Salivary secretion
    101092262 (PLCB1)
   04971 Gastric acid secretion
    101092262 (PLCB1)
   04972 Pancreatic secretion
    101092262 (PLCB1)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101092262 (PLCB1)
  Nervous system
   04724 Glutamatergic synapse
    101092262 (PLCB1)
   04725 Cholinergic synapse
    101092262 (PLCB1)
   04728 Dopaminergic synapse
    101092262 (PLCB1)
   04726 Serotonergic synapse
    101092262 (PLCB1)
   04720 Long-term potentiation
    101092262 (PLCB1)
   04730 Long-term depression
    101092262 (PLCB1)
   04723 Retrograde endocannabinoid signaling
    101092262 (PLCB1)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101092262 (PLCB1)
  Environmental adaptation
   04713 Circadian entrainment
    101092262 (PLCB1)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101092262 (PLCB1)
   05016 Huntington's disease
    101092262 (PLCB1)
  Infectious diseases
   05146 Amoebiasis
    101092262 (PLCB1)
   05142 Chagas disease (American trypanosomiasis)
    101092262 (PLCB1)
   05143 African trypanosomiasis
    101092262 (PLCB1)
Enzymes [BR:fca01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101092262 (PLCB1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
A3
AA seq 1252 aa AA seqDB search
MALLWEPTRQRTQRSSRQVVADAKLQRLAPEWRRQKIIKNTSDVEIRSDARTVLERSPVR
HYLKKDSTIVTPIILRTDPQGFFFYWTDQNKETELLDLSLVKDARCGKHAKAPKDPKLRE
LLDVGNIGRLEHRMITVVYGPDLVNISHLNLVAFQEEVAKEWTNEVFSLATNLLAQNMSR
DAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSADRKRVETALEACSLPSSRNDSIPQEDFT
PEVYRVFLNNLCPRPXXXXXXXHFFSQFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYP
PLKQEQVQVLIEKYEPNDSLAKKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSH
YFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTT
EISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKY
PLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSVFEPSSPGA
GEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVKFESFETSKKRNRS
FEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQMVAL
NFQTVDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVKIIS
GQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEPIVFKKVVLPSLAC
LRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNERNQPLMLPAVFVYIEVKDYVPDTYA
DVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKKEADPGETPSEAPSETRTTPAENGV
NHTTSLAPKPPSQAPHSQPAPGSVKAPAKTEDLIQSVLTEVEAQTIEELKQQKPFVKLQK
KHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYLRRRAALEKTAKKDSKKKSEPSSPD
HGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLRQEQYYSEKYQKREHIKLLIQKLTD
VAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKITEAKSKDKSQMEEEKTEMIRSYIQ
EVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKPKLQMDLEQEYQDKFKRLPLEILEF
VQEAMKGKISEDSNHSSAPPSLASDPGKLNHRPPSSEELEGDNPGKEFDTPL
NT seq 3759 nt NT seq  +upstreamnt  +downstreamnt
atggcacttttatgggagcccacgcggcagaggacacagcggtccagccgacaggtggtc
gctgatgccaaacttcagcgcctggctccggagtggaggagacagaaaattatcaagaac
accagtgatgtagagattagaagtgatgcaaggacagtattggagaggtcaccagtcaga
cactacctgaagaaggactccactattgtcactccaattattttgaggactgaccctcag
ggatttttcttttactggacagatcaaaataaggagacggagctgttagatctcagcctt
gtcaaggatgccagatgtgggaaacatgccaaagctcccaaggaccccaaattacgtgaa
cttttggatgtggggaacatcggacgcttggagcatcgcatgataacggtggtgtacggg
cctgacttagttaacatctcccatttgaatctcgtggctttccaagaggaagtggccaag
gaatggacaaatgaggttttcagtttggcaacaaacctgctggcccaaaatatgtccaga
gacgcatttctggaaaaagcctatacgaagcttaagctgcaagtcactccagaagggcgc
attcctctcaaaaacatataccgcttgttctcagcagaccggaagcgagttgaaactgct
ttagaggcttgtagtcttccatcttcaaggaatgattcaatacctcaagaagatttcact
ccagaagtgtacagagttttcctgaacaacctttgccctcgacctgnnnnnnnnnnnnnn
nnnnnncactttttctcgcaatttggtgccaaaagcaaaccataccttacagttgatcag
atgatggattttatcaacctgaagcagcgagatcctcggctaaatgaaatactttaccca
cctttaaagcaagagcaagtccaagtactgattgagaagtatgagcccaacgatagcctt
gccaaaaaaggacagatatcagtggatggctttatgcgctatctgagtggagaagaaaat
ggagtcgtttcgcctgagaaactggatttgaatgaagatatgtctcagcccctttctcac
tatttcatcaattcctcacacaacacctacctcacagctggccagctggctggaaattcc
tctgttgagatgtatcgccaagtgctcctgtctggttgtcgctgtgtggagttggactgc
tggaaaggacggactgcagaagaggaaccagtcatcacccatgggttcaccatgacaact
gaaatatccttcaaggaagtgatagaagcaattgctgagtgtgcatttaagacgtcacct
tttccaattctgctttcatttgagaaccacgtagattccccaaagcagcaagccaagatg
gcagagtattgccgactgatctttggagatgctcttctcatggaaccactggaaaaatac
ccactggaatctggagttcctcttccaagccctatggatttaatgtacaaaattttggtg
aaaaataagaagaaatcgcataagtcatcagaaggaagtggcaaaaagaagctctcagaa
caagcctccaacacgtacagtgactcctccagcgtgtttgagccctcatctccaggagcc
ggggaagctgatactgagagtgacgacgatgacgatgatgacgactgtaaaaaatcttca
atggatgagggtactgctggcagtgaggccatggccacagaagagatgtctaacctggtg
aactatattcagccagtcaagtttgagtcctttgaaacttcaaaaaaaagaaatagaagt
tttgaaatgtcttccttcgtggaaaccaaaggactcgagcaactgacaaagtctccagtg
gaatttgtagaatataacaaaatgcagctcagcaggatatatccaaaaggaacccgtgtg
gattcatccaactacatgcctcagctcttctggaatgctggttgccaaatggttgcactt
aattttcaaactgtggacctggctatgcaaataaatatggggatgtatgaatacaatggg
aaaagtggctacagattaaagccagagttcatgaggagacccgacaagcactttgatcca
ttcaccgaaggcatcgtagatgggatagtggccaacactttatctgtgaagattatttca
ggtcagtttctttctgataagaaagttgggacctatgtggaagtggatatgtttggtttg
cctgtggacacaaggaggaaggcatttaagaccaaaacatcacaaggaaatgctgtaaat
cctgtctgggaagaagagcccattgtgttcaaaaaggtggttcttccttctctggcctgt
ttgaggatagcagtttatgaagaaggaggtaaatttatcggtcaccggatcttgcctgta
caggcaattcggccaggctatcactacatctgtctgcggaatgagaggaaccagcctctg
atgctcccagctgtctttgtctacatagaggtgaaagactatgtcccagatacatatgca
gatgtgattgaagctttgtcaaatccaatacgatatgtgaatctgatggagcagagagca
aagcaactggctgctctgacactggaagatgaagaagaagtaaagaaagaggctgatcct
ggggaaacaccatcagaagctccaagtgaaaccaggacaactccagcagaaaacggagtg
aatcacactacatccctggcacccaaaccaccctcccaggctccccacagccaaccagct
ccaggttctgtaaaggcacctgccaaaacagaagatcttattcagagtgttttaacagaa
gtggaagcacagactatcgaagagctaaagcaacagaaaccgtttgtgaaacttcaaaag
aagcactacaaagaaatgaaagacctggtgaaaagacaccacaagaaaaccactgacctt
atcaaagaacacactacaaaatataatgaaattcagaatgactacttgagaaggagggca
gctttggaaaagacagccaaaaaggatagtaagaaaaaatcagaacccagcagtcctgac
catggttcatcaacaattgagcaagatcttgctgccctagatgctgaaatgacccaaaag
ttaatagacttgaaggacaaacaacagcagcagctgcttaatcttcgacaagaacagtat
tacagtgagaaataccagaagcgagaacatattaaactgcttattcagaaattgacggat
gttgccgaagaatgtcagaacaatcagctgaagaagctcaaagaaatctgtgagaaggag
aagaaggaattaaagaagaaaatggataaaaaaaggcaggagaagatcacagaagctaaa
tccaaagacaaaagtcaaatggaagaggaaaagacagagatgatccggtcatacatccag
gaggtggtacagtacatcaagaggttagaagaggcacaaagtaaacggcaagaaaaactt
gtagagaaacacaaggagatccgtcagcagatcctggatgaaaagcccaagctgcagatg
gatctggagcaagagtaccaagacaagttcaaaagactgcccctggagatcttggagttc
gtgcaggaagccatgaaagggaagatcagtgaagacagcaatcacagttctgcccctccc
tccctggcctcagaccctggaaaactgaaccacaggcctccttccagtgaggagctagaa
ggggacaacccaggaaaagagtttgatactcctctgtga

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