KEGG   Felis catus (domestic cat): 101097413Help
Entry
101097413         CDS       T02385                                 

Gene name
PIK3CA
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
fca  Felis catus (domestic cat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101097413 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101097413 (PIK3CA)
   04015 Rap1 signaling pathway
    101097413 (PIK3CA)
   04012 ErbB signaling pathway
    101097413 (PIK3CA)
   04370 VEGF signaling pathway
    101097413 (PIK3CA)
   04630 Jak-STAT signaling pathway
    101097413 (PIK3CA)
   04668 TNF signaling pathway
    101097413 (PIK3CA)
   04066 HIF-1 signaling pathway
    101097413 (PIK3CA)
   04068 FoxO signaling pathway
    101097413 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    101097413 (PIK3CA)
   04024 cAMP signaling pathway
    101097413 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    101097413 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    101097413 (PIK3CA)
   04152 AMPK signaling pathway
    101097413 (PIK3CA)
   04150 mTOR signaling pathway
    101097413 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101097413 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    101097413 (PIK3CA)
  Cellular commiunity
   04510 Focal adhesion
    101097413 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101097413 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    101097413 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    101097413 (PIK3CA)
   04660 T cell receptor signaling pathway
    101097413 (PIK3CA)
   04662 B cell receptor signaling pathway
    101097413 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    101097413 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    101097413 (PIK3CA)
   04670 Leukocyte transendothelial migration
    101097413 (PIK3CA)
   04062 Chemokine signaling pathway
    101097413 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    101097413 (PIK3CA)
   04915 Estrogen signaling pathway
    101097413 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    101097413 (PIK3CA)
   04917 Prolactin signaling pathway
    101097413 (PIK3CA)
   04921 Oxytocin signaling pathway
    101097413 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    101097413 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101097413 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101097413 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101097413 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    101097413 (PIK3CA)
   04722 Neurotrophin signaling pathway
    101097413 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101097413 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    101097413 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101097413 (PIK3CA)
   05205 Proteoglycans in cancer
    101097413 (PIK3CA)
   05203 Viral carcinogenesis
    101097413 (PIK3CA)
   05210 Colorectal cancer
    101097413 (PIK3CA)
   05212 Pancreatic cancer
    101097413 (PIK3CA)
   05214 Glioma
    101097413 (PIK3CA)
   05221 Acute myeloid leukemia
    101097413 (PIK3CA)
   05220 Chronic myeloid leukemia
    101097413 (PIK3CA)
   05218 Melanoma
    101097413 (PIK3CA)
   05211 Renal cell carcinoma
    101097413 (PIK3CA)
   05215 Prostate cancer
    101097413 (PIK3CA)
   05213 Endometrial cancer
    101097413 (PIK3CA)
   05222 Small cell lung cancer
    101097413 (PIK3CA)
   05223 Non-small cell lung cancer
    101097413 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101097413 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101097413 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101097413 (PIK3CA)
   05166 HTLV-I infection
    101097413 (PIK3CA)
   05162 Measles
    101097413 (PIK3CA)
   05164 Influenza A
    101097413 (PIK3CA)
   05161 Hepatitis B
    101097413 (PIK3CA)
   05160 Hepatitis C
    101097413 (PIK3CA)
   05169 Epstein-Barr virus infection
    101097413 (PIK3CA)
   05146 Amoebiasis
    101097413 (PIK3CA)
   05145 Toxoplasmosis
    101097413 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    101097413 (PIK3CA)
Enzymes [BR:fca01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101097413 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
UniProt: 
Position
C2
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccaagaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgacgttagaatgcctccgtgaggct
acattaataactataaagcatgaattatttaaagaagcaagaaaatatcctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggaa
gaattttttgatgaaacaagacgactttgtgacctgcggctttttcaaccctttttaaaa
gtaattgagccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
attggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttcgggatcttaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatataataaactagataaagggcaaataatagtggtgatttgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcatctgaacaactaaaa
ctctgtgttttagaataccagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttccttgaaaaatatcctctaagtcagtataagtacataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactcccaactgccaatggac
tgtttcacaatgccatcttattccagacgcatctccacagctacaccatatatgaatgga
gaaacatctacaaagtccctttgggttataaatagtgcactcagaataaaaatcctttgt
gcaacctatgtgaatgtaaatattcgagacatcgacaagatctatgttcgaacaggtatc
tatcatggaggagaacccttatgtgataatgtgaacactcaaagagtaccttgttctaat
cccaggtggaatgaatggctaaactacgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgttctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcctggggaaatataaacttgtttgattacacagatactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactgggtcaaatccaaataaagaaaccccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaactggtctgtg
tctcgagaagcaggatttagttattcccatgcaggactgagtaacagactagctagagac
aacgaattaagagaaaatgataaagaacagctccgagcaatttgtacccgagatcctcta
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacccaaactgcttctgtctgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcctccaatcaaacctgaacaggcaatggag
cttctggattgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatatttaacagatgacaagctttctcagtacttaattcagctagtacaggtcctaaaa
tatgaacagtatttggataacctgcttgtgagatttttactcaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agtcagaggtttggcctgcttttggagtcgtattgtcgtgcatgtgggatgtatttgaag
cacctaaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaaa
caagaaaagaaggatgaaacacaaaaggtacagatgaagtttttagttgagcaaatgcgg
agaccagatttcatggatgctctacagggttttctgtctcctctaaatcctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactctttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgttaacactgcagatcattcgcattatg
gaaaatatctggcaaaatcaaggccttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggttagaaattctcacactattatgcagatt
caatgcaaaggtggcctgaaaggcgcactgcagttcaacagccacactctacaccagtgg
ctcaaagacaagaacaaaggcgaaatatacgatgcagccattgacctgttcacacgttca
tgtgctggatattgtgttgctaccttcatactgggaatcggagatcgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcat
aagaagaaaaaatttggttataaacgggaacgtgtgccgtttgttttgacacaagatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaattcgaaaggttt
caggagatgtgttacaaggcttatctagctattcggcagcatgccaatctcttcataaat
ctcttctcaatgatgcttggctctggaatgccagaactgcaatcttttgatgatattgca
tacattcgaaagaccctagctttagataaaactgaacaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgctttgaactga

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