KEGG   Felis catus (domestic cat): 101098152Help
Entry
101098152         CDS       T02385                                 

Gene name
MTOR
Definition
mechanistic target of rapamycin (serine/threonine kinase)
Orthology
K07203  
FKBP12-rapamycin complex-associated protein
Organism
fca  Felis catus (domestic cat)
Pathway
ErbB signaling pathway
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Acute myeloid leukemia
Central carbon metabolism in cancer
Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    101098152 (MTOR)
   04066 HIF-1 signaling pathway
    101098152 (MTOR)
   04151 PI3K-Akt signaling pathway
    101098152 (MTOR)
   04152 AMPK signaling pathway
    101098152 (MTOR)
   04150 mTOR signaling pathway
    101098152 (MTOR)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    101098152 (MTOR)
   04920 Adipocytokine signaling pathway
    101098152 (MTOR)
   04919 Thyroid hormone signaling pathway
    101098152 (MTOR)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101098152 (MTOR)
   05230 Central carbon metabolism in cancer
    101098152 (MTOR)
   05231 Choline metabolism in cancer
    101098152 (MTOR)
   05206 MicroRNAs in cancer
    101098152 (MTOR)
   05205 Proteoglycans in cancer
    101098152 (MTOR)
   05214 Glioma
    101098152 (MTOR)
   05221 Acute myeloid leukemia
    101098152 (MTOR)
   05215 Prostate cancer
    101098152 (MTOR)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101098152 (MTOR)
Protein kinases [BR:fca01001]
 Serine/threonine protein kinases: Atypical group
  PIKK family [OT]
   101098152 (MTOR)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Ensembl: 
Position
C1
AA seq 2550 aa AA seqDB search
MLGTGPATATTATTTSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEES
TRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNATRIGRFANYLRNLLPSNDP
VVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVP
TFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEE
AEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYC
KDLMGFGTKPRHITPFTSFQAGQPPQSNALVGLLGYSSHQGLMGFGASPSPAKSTLVESR
CCRDLMEEKFDQVCQWVLKCRNSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHV
LSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKAMQVDA
TVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLL
KMLSLVLMHKPLRHPGMPKGLAHQLASPGLTALPEASDVGSITLALRTLGSFEFEGHSLT
QFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSVHLISGHAHVVSQTAVQVVADVLSKLL
VVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSS
MNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALI
LKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVA
LWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHK
VNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFR
DQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLV
SFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLR
VFMHDNSPGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVD
RLTESLDFTDYASRIIHPIVRTLDQSPELRPTAMDTLSSLVFQLGKKYQIFIPMVNKVLV
RHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSGQGDALASGPVETGPMKKLHV
STINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNA
AFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGI
VLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAAAGVLEYAMKHF
GELEIQATWYEKLHEWEDALVAYDKKMDTNKDDPELMLGRMRCLEALGEWGQLHQQCCEK
WTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLA
QQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWW
ERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVD
PSRQLDHPLPTVHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIASEDQQHK
QELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRGWYKAWHAWAVMNFEA
VLHYKHQNQARDEKKKLRHASGANVTSTTTAATTAATATATATSTEGSNSESEAESTENS
PTPSPLQKKVTEDLSKTLLMYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDV
NEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVA
SKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYF
GERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQ
AWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPHQPIIRIQSIAPS
LQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKN
LSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLT
LMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDR
HPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRIT
CHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILD
GVELGEPAHKKTGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDETL
DVPTQVELLIKQATSHENLCQCYIGWCPFW
NT seq 7653 nt NT seq  +upstreamnt  +downstreamnt
atgctgggaaccggacctgccaccgccaccacagccaccaccacgtccagcaacgtgagc
gtcctgcagcagtttgccagcggcctgaagagccggaatgaggagaccagggccaaagct
gccaaggagctccagcactatgtcaccatggagcttcgagagatgagtcaagaggagtct
actcgcttctatgatcagctgaaccatcacatttttgaactggtttccagctcggatgcc
aatgaaaggaaaggtggcatcttggccatagccagcctcataggagtggaaggcgggaat
gccacccgtatcggcagatttgctaactatcttcggaacctcctcccctctaatgaccca
gttgtcatggagatggcatccaaggccattggccgccttgccatggcaggcgacactttt
acagctgagtatgtggagttcgaggtgaagcgagccttggagtggctgggcgctgaccgc
aacgagggccggagacacgcagccgttctggttctccgcgagctggctatcagcgtcccc
accttcttcttccagcaagtgcagcccttctttgacaacatttttgtggccgtgtgggac
cccaaacaggccatccgggagggagctgtggccgcccttcgtgcctgtttgattctcacc
acccagcgtgagccgaaggagatgcagaagcctcagtggtacaggcacacgtttgaagaa
gccgagaaggggtttgatgagacgttggccaaggagaagggcatgaatcgggatgatcgc
atccatggagccttgctgatcctcaacgagttggtccgaatcagcagcatggagggagag
cgcctgagagaagaaatggaagaaatcacgcagcagcagctggtccatgacaagtactgc
aaagacctcatgggcttcgggacgaaacctcgtcacatcacccccttcaccagcttccag
gctggccagcccccgcagtccaacgccttggtgggactgctggggtacagctctcaccaa
ggcctcatgggtttcggggcttcccccagcccagcgaagtccacgctggtggagagccgg
tgttgcagagacctgatggaggagaaattcgatcaggtgtgccagtgggtgctgaaatgc
aggaatagcaagaactcgctgatccaaatgacaatccttaatttgttgccccgcttggct
gcatttcgaccttctgccttcacagatacccagtacctccaagataccatgaaccacgtc
ttgagctgtgtcaagaaggagaaggagcggacagcagccttccaagccctggggctcctt
tctgtggctgtgagatctgagttcaaggtctatttgcctcgtgtgctggacatcatccga
gcagccttacccccaaaggactttgcccataagagacagaaggcaatgcaggtggatgcc
acagtgttcacctgcatcagcatgctggcccgggcaatggggccaggcatccagcaggat
atcaaggagctgctggagcccatgctggcagtgggactgagccctgccctcactgctgtg
ctgtacgacctgagccgtcagattccacagctgaagaaggacatccaggatgggctactg
aagatgctgtccctggtccttatgcacaaacccctccggcacccgggcatgcccaagggc
ctggcccatcagctggcttcccctggcctcacagccctccctgaggccagcgacgtgggc
agcattactcttgccctgcgaactctcggcagctttgagtttgaaggccactctctgacc
cagtttgtccgccactgtgcggatcatttcctaaacagcgagcacaaggagatccgcatg
gaagccgcccgcacctgctcccgcctgctcacgccctccgtccacctcatcagcggccac
gcgcacgtcgttagccagactgcggtgcaagtggtggcagacgtgctcagcaaactgctg
gtggtcgggatcacagatcctgaccccgacatccgctactgcgtcttggcatctctggat
gagcgctttgatgcacacctggcccaggcagagaacttgcaggccctgtttgtggccctg
aacgaccaggtgtttgagatccgggagttggccatctgcacggtgggccggctcagtagc
atgaacccggccttcgtcatgcccttcctgcgcaagatgctcatccagattttgacagag
ctggagcacagcggcatcgggagaatcaaagaacagagtgcccgcatgctgggccacttg
gtctccaatgccccccggctcatccgcccctacatggagcccattctgaaggctttaata
ttgaaactgaaagatccagaccctgatccaaacccaggtgtgatcaataatgtcttggcc
acaataggagagttggctcaggtcagtggcctagaaatgaggaaatgggttgatgaactc
tttattatcatcatggacatgctccaggactcctccctgttggccaaaaggcaggtggct
ctgtggaccctgggacagttggtggccagcactggctatgtggtggagccctacaggaag
taccccactttgcttgaggtcctgctgaattttctgaagactgagcagaaccagggtaca
cggagagaggctatccgtgtgttagggcttttgggggccctggatccctacaagcacaaa
gtgaacattggcatgattgaccagtcccgcgacgcttctgctgttagcctgtcagaatcc
aagtcaagtcaggattcctctgactacagcaccagcgagatgctggtcaacatgggcaac
ctgcccctggatgagttctaccccgccgtgtccatggtggcgctgatgcggatcttccgg
gaccagtccctctcgcaccatcacaccatggtagtccaggccatcaccttcatcttcaag
tccctgggcctcaagtgtgtgcagttcctgccccaggtcatgcccacgttcctcaacgtc
attcgagtctgtgacggggccatccgggagtttctgttccagcagctggggatgctggtg
tcctttgtgaagagccacatcagaccttacatggatgaaatagtcaccctcatgagagaa
ttctgggtcatgaacacctcgatccagagcacgatcattcttctcattgagcaaatcgtg
gtagctcttgggggcgaatttaagctctatctgcctcagctgatcccacacatgctacgt
gtcttcatgcatgacaacagcccaggccgcatcgtctccatcaagctgctggctgccatc
cagctgttcggcgccaacctggacgactatttgcacttgctgttgcctcctatcgtgaag
ctgtttgatgcccctgaagtccccctgccgtcccgcaaggcagcgttagagacagtagac
cgcctcacagagtccttggacttcactgactacgcctcccggatcattcacccgatcgtt
cgaaccctggaccagagcccggaactgcgtcccacggccatggacacgttgtcttcgctt
gtctttcagctggggaagaagtaccagattttcattccaatggtgaataaagtcctggta
cgacaccgaatcaaccatcagcgctatgacgtcctcatctgcagaatcgtcaagggatac
acccttgctgatgaagaagaggaccctttgatttaccagcatcgaatgctgaggagtggc
caaggagatgcgttggccagtgggccggtagaaacaggacccatgaagaaactgcatgtc
agcaccatcaaccttcaaaaggcctggggagctgccagaagggtctccaaagatgactgg
ctagaatggctgaggcggctgagtctggagctcctgaaggactcgtcttcaccttccctg
cgctcgtgctgggccctggctcaggcctacaacccgatggccagggatcttttcaacgcc
gcgtttgtgtcctgctggtctgaactgaacgaagaccagcaggatgaactcatcaggagc
atcgagctggccctcacctcgcaggacatcgccgaagtcacgcaaactctcttaaacttg
gctgaattcatggaacacagtgacaagggccccctgccactgagagacgacaacggcatc
gtcctgctgggcgagagggccgccaagtgccgagcatatgccaaagcactacactacaaa
gagctggagttccagaaaggtcccacccctgccatcctagagtctctcatcagcattaat
aataagctacaacagccagaggcagctgccggggtattagaatatgccatgaaacacttc
ggagagctggagatccaggccacctggtacgagaagctgcacgagtgggaagatgcgctc
gtggcctacgacaagaagatggacaccaacaaggatgacccagagctcatgctgggtcgc
atgcgctgcctcgaggccttgggggaatgggggcagctccaccagcagtgctgtgagaag
tggaccctggttaacgatgagacccaagccaagatggcccggatggccgctgcagctgcc
tggggcttaggtcagtgggacagcatggaggaatatacgtgtatgatccctcgggacacc
cacgatggggcattttatagagccgtgctggcactgcatcaggacctcttctccttggcg
caacagtgtatcgacaaagccagggacctgctggatgcagagctaaccgctatggcagga
gagagctacagtcgggcatatggggccatggtttcttgccacatgctctccgagctggag
gaggttatccagtacaaactcgtccccgagcgacgggagatcatccgccagatctggtgg
gagagactgcagggctgccagcgcatcgtggaggactggcagaaaatcctgatggtgcgc
tccctcgtggtcagcccccacgaggacatgaggacctggctcaagtatgccagcctgtgt
ggcaagagtggcaggctggctcttgctcataagaccttggtgttgctcctgggagttgat
ccgtctcggcaacttgaccatcctctgccaacagttcaccctcaggtgacctacgcctac
atgaaaaacatgtggaagagtgctcgcaagatcgatgccttccagcacatgcagcacttc
gtgcagaccatgcagcagcaagcccagcacgccatcgccagcgaggaccagcaacacaag
caggagctgcacaagctcatggccaggtgtttcctgaaactcggggagtggcagctgaac
ctgcagggcatcaatgagagcaccatccccaaagtgctgcagtactacagcgccgccacg
gagcacgaccgcggctggtacaaggcctggcacgcgtgggcagtgatgaacttcgaagct
gtgctgcactacaaacatcagaaccaagcccgcgacgagaagaagaagctgcgtcacgcc
agcggggccaacgtcaccagcacgaccaccgccgccaccacagcggccaccgccaccgcc
acggccaccagcaccgagggcagcaacagcgagagtgaggccgagagcaccgagaacagc
cccaccccgtcccctctgcagaagaaggtcactgaggatttgtccaaaaccctcttgatg
tacaccgtccctgccgtccagggcttcttccgttctatctccttgtcgcgaggcaacaac
ctccaggacacgctgagggtcctcaccctgtggtttgattacggtcactggccggacgta
aacgaagccttggtggagggggtgaaggcgatccagattgacacgtggttacaggtcata
cctcagctcattgcaagaattgatacgcccaggcccctggtgggacgcctcatccaccag
cttctcaccgacattggccggtaccacccgcaggccctcatctatcccctgaccgtggcc
tccaagtccaccaccacggcccgccacaacgcagccaacaagattctgaagaacatgtgt
gagcacagtaacaccctggtccagcaggccatgatggtgagtgaggaactgatccgcgtg
gccatcctctggcacgagatgtggcacgaaggcctggaagaagcgtctcgtttatacttt
ggggagaggaacgtgaaaggcatgtttgaggtgttggagcccctgcatgctatgatggaa
cggggcccccagactctgaaggaaacgtcttttaatcaggcatatgggcgagacttaatg
gaggcccaagagtggtgcaggaagtacatgaaatcgggaaacgtgaaggacctcactcaa
gcctgggacctctactatcacgtgttcagacgaatctcaaagcagctgcctcagctcaca
tccttagaactgcagtatgtttcccccaaacttctgatgtgccgggaccttgaattggcc
gtgccgggaacatacgatccccaccagccgatcatccgcattcagtccatagcgccgtct
ctacaggtcatcacctccaagcagcggccccggaagttgaccctcatgggcagcaacggg
catgagtttgttttcctcctgaagggccacgaggacctgcggcaggacgagcgagtgatg
cagctcttcggcctggtgaacaccctcctggccaacgaccccacgtctcttcgcaagaac
ctcagcatccagagatacgccgtcatccccttatcaaccaactcgggcctcatcggctgg
gtcccccactgcgacacgctgcacgccctcatccgggactacagagagaaaaagaagatc
cttctcaacatcgagcatcgcatcatgttgcggatggctccggactacgaccatctgacg
ctgatgcagaaggtggaggtgttcgagcacgccgtcaataacacggccggggatgacctg
gccaagctgctatggctgaaaagccccagctccgaggtgtggtttgaccgaagaaccaac
tacacccgctctttagcggtcatgtccatggtcgggtatattttgggcctgggagataga
cacccatccaacttaatgctggaccggctgagcgggaagatcctgcacattgacttcggg
gactgctttgaggttgctatgaccagggagaaattcccagagaagattccatttagacta
accagaatgctgaccaatgctatggaggttactggtctggatggcaactatagaatcacg
tgccacacagtgatggaagtgcttcgggaacacaaggatagtgtcatggccgtgctggaa
gcctttgtctatgaccccttgctgaactggaggctgatggacacaaataccaaaggcaac
aagcggtcccgaacaaggacagattcctactctgctggccagtcagtagaaattttggac
ggtgtggagcttggggaacccgcgcataagaaaacagggaccacggtgccagagtccatt
cattccttcattggagacggtttggtgaaaccagaggccctaaataagaaagctattcag
attatcaaccgggttcgagacaagctcactggtcgggacttttctcatgacgaaaccctg
gatgtccccactcaagttgagctgctgatcaagcaagcaacatcccatgaaaacctgtgc
cagtgctacatcggctggtgtcctttttggtaa

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