KEGG   Felis catus (domestic cat): 101101194Help
Entry
101101194         CDS       T02385                                 

Gene name
DOT1L
Definition
(RefSeq) DOT1 like histone lysine methyltransferase
  KO
K11427  
histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
fca  Felis catus (domestic cat)
Pathway
Lysine degradation
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    101101194 (DOT1L)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    101101194 (DOT1L)
Enzymes [BR:fca01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     101101194 (DOT1L)
Chromosome [BR:fca03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     101101194 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Ensembl: 
Position
A2
AA seq 1567 aa AA seqDB search
MSLFWTFHKCGLTPRVASSFWFSPLALCDQGPSAGRRVWAPCSCLRSTDVRVHGGHAHLW
TCACTADPSYVLGSSVGQRVWAPRSCSRPRDVPLRGWTRSWDLGAPGGQRLLLGWQSSRL
PCLVGAPSSGPPGHWGPQSTACGAVWDRVCAGDKHHDAAHEIIETIRWVCEEIPDLKLAM
ENYVLIDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVY
NHSVTDPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAA
ATNCKHHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANT
SVIFVNNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVE
LSPLKGSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTT
PTKVPESKAAVAADTPVDSGAEEEKAGTTAIKKPSPSKARKKKLNKKGRKMAGRKRGRPK
KMSAANPERKPRKSQTALDLLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRP
LLAATPPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGH
CQAQKEEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQ
SLQLLKARCEELKLDWSTLSLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQE
LLQLKSCVPPDDALSAHLRGKGALGREPEADPGRLHLDLDCSRFSLPHFSSASPELSMNG
HAAGYELCGALSRPPSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLS
PAKLVLRRHLSQDHAAGGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSP
VALQMTGERGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAE
KVRSTPSPVPQTRESLSTLEKQMGANAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADP
GTFDEVPSAGGLFASVGSCGSTPQHPPLLPQPRGSGAASPAHPLCASPRLGGAAQGPLPD
ANKGDLPPEAGFSDPEGEAKRRIVFTVSAGGGSTKQSPPSKPSPLPTGGRGDGSQGHGQD
SRKRGRRKRAAAGTPGLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITA
ISSPESLKSSPVPYQDSDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERK
IATISLESRSPPKTLENGGGLAGRKPTPAGEPANSSKWKSTFSPISDLGLAKCADSPLQA
GSALSQNSLFAFRPPLEEPGSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGL
AADLSLHSFSDGASLSHKVPEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDAHRPFLG
TFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATRLTNSHAMGSFPSGVA
GGAVGGN
NT seq 4704 nt NT seq  +upstreamnt  +downstreamnt
atgagcctgttctggacgtttcacaaatgtggactcacaccccgcgtggcctctagtttc
tggttctctcccttagcgttgtgtgatcagggtccgtccgcggggcggcgggtgtgggcg
ccttgttcctgcttgcggtcgacggacgtgcgcgtgcacggcgggcacgctcatctgtgg
acgtgcgcgtgcacagcggacccgtcgtatgttctgggttcgtctgtcgggcagcgggtg
tgggctcctcgctcctgctcgcggccgagggacgttcccctacgtggatggaccaggtca
tgggatcttggggcaccaggtggccagcggctgctgctgggatggcagagctctagactc
ccctgccttgtgggggctccttcctccggaccccctggtcactggggtccgcagagcacg
gcgtgcggggctgtatgggaccgagtttgcgcaggggacaaacaccacgatgctgctcac
gaaatcatcgagaccatccggtgggtctgcgaagagatcccggacctcaagctcgctatg
gagaactacgttttaatcgactacgacaccaaaagcttcgagagcatgcagaggctctgt
gataagtacaaccgcgccatcgacagcatccaccagctgtggaaggggaccactcagccc
atgaaactgaacacccggccgtccaacgggctcctgcgccacatcctgcagcaggtgtat
aaccactcggtgacggaccccgagaagctcaacaactacgagcccttctccccggaggtg
tacggggagacctcctttgacctggtcgcgcagatgatcgacgagatcaagatgaccgag
gacgacctgtttgtggacctgggcagcggagtgggccaggtcgtgctccaggtggccgcg
gccaccaactgcaaacatcactacggcgtggagaaagccgacatcccagccaagtacgcg
gagaccatggaccgagagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaa
tacacactggaaagaggcgacttcctctcggaggagtggagagagcggattgccaacaca
agtgttatatttgtgaataactttgcctttggtcctgaggtggatcaccagctgaaggag
cggtttgcgaacatgaaggaaggcggcagaattgtgtcctcgaagccctttgcgcctctg
aacttcagaataaacagcagaaacttgagcgacatcggcaccatcatgcgcgtcgtggag
ctctcgcccctgaagggctctgtgtcctggacggggaagccggtctcctactacctgcac
accatcgaccgcaccatacttgaaaactatttttctagtctgaaaaacccaaaactcagg
gaggagcaggaggcggctcggcgccggcagcagcgggagaacaagagcaacacgaccact
cccaccaaggtgcccgagagcaaggccgccgtggccgcggacacccccgtggattccggt
gccgaggaagagaaggctgggacgaccgccatcaaaaagccgtccccctccaaagcccgg
aagaagaagctgaacaagaaggggcggaaaatggccggcaggaagcgcgggcgccccaag
aagatgagcgctgccaaccccgagcgcaagccccggaagagccaaactgcactggacctc
ctgcacgccccggcctcgtcgcagacggcggcgccctcgccacaggatgcgtacaggtca
cctcacagccccttctatcagctacctccctgcgtgcagcggcacgcccccgaccggccg
ctgctggcagccaccccgcccgcactgcagaagctgctagaatccttcaagattcagtac
ttgcagttcttggcctacaccaagaccgcccagtacaaggccagccttcagcagctgctg
gaccaggagaaggagaagaacgcccggctgctgggggccgcacagcagctgttcggccac
tgccaggcccagaaagaggagatcaagaggctcttccagcagaaactggatgagctgggg
gtgaaggcgctgacctacaacgacctgattcaggcgcagaaggagatctcggcccataac
cagcagctgagggagcagacggagcagctgcaggaggacaacagggagctgaggagccag
agcctgcagctgctcaaggctcggtgtgaggagttgaagctggactggtccacgctgtcg
ctggagaacctgctgaaggagaagcaggccctgaggagccagatctccgagaagcagagg
cactgcctggagctgcagatcagcatcgtggagctggagaagagccagcggcagcaggag
ctcctgcagctcaagtcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgcggg
aaaggcgccctgggccgggagccggaggcggaccccggccggctgcacctcgacctggac
tgctctcggttctccctgccgcacttcagcagcgccagcccggaactctccatgaacggc
cacgcggccggctacgagctctgcggtgcgctgagccggcccccgtccaagcagaacacc
ccccagtacctggcctccccgctggaccaggaggtggtgccctgcacccccagccacggc
agccggccaaggctcgagaaggtgtctggcctggccttgccggactacaccaggctttcc
ccggccaagctggtgctgaggcggcacctcagccaggaccacgcggccggcggcaagacg
gcggccggggagctgcacccgcgagccgagcacgccaaggagaacggccttccgtaccag
agcccgggcatcgccaacggcatcaagctgagccctcaggacccccggccctcatccccc
gtggccttacagatgacaggggagaggggcagcgagaagggtttgaaggagcgtgcctac
gccagcagcggggaggccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcag
cccagcaagctgcccgtcagcatccctctggccagcgtggtgctgcccagccgtgccgag
aaagtgagaagcacccccagccccgtgccgcagacccgagagtccttgtccacacttgaa
aagcagatgggcgctaatgcacacagcgccggaagcaaaagtctcgccccagcccctgca
ggcttctacgcgggctcggtggccgtcagcccagcccccctcgcttccggagcagatccc
ggcacctttgacgaggtccccagcgcaggcggtctgtttgccagcgtggggtcctgtggc
tccaccccgcagcacccgcccctgctgccgcagccccgcggctctggcgcagcctcgccc
gcccacccgctctgcgccagcccccgcctgggcggcgccgcccagggtccgctccctgac
gccaacaaaggggaccttcctcccgaggccggcttctcggaccccgagggcgaagccaag
cggaggatcgtcttcaccgtctcggccggcgggggcagcaccaagcagtcgcctcccagc
aagcccagccctctgcccacgggcggccgtggggacggcagccagggccacgggcaggac
agccgcaagcggggcagaaggaagcgggcggcggcagggacccccggcctgagctcaggc
gtgtcgcccaagcgccgggccctgccgtccgtggccggcctcttcacgcagtcttcaggg
tcccccctgaacctcaactccatggttagcaacattaaccagcctttggaaatcacggcc
atttcgtcccctgagagcctgaagagctcccctgtcccctaccaggacagcgaccagccg
cccgtcctcaagaaggagaagcccctgagccagaccaacggggcccactactccccactg
acctcggacgaggagcagggctccgaggatgagccgggcagcaccagaattgagagaaaa
attgcgacaatctccttagaaagcagatctcccccgaaaaccttggaaaacggtggtggc
ctggcggggaggaagccgacccctgccggcgagcccgccaacagcagcaagtggaagtct
accttttcgcccatctccgacctcggcctggccaagtgcgccgacagcccgctgcaggcc
ggctccgccctgagccagaactccctgttcgctttccggccccccctggaggagcccggc
tcggccgacgccaagctggccgcccaccccaggaaaagttttcccggtgccctgtcgggg
gcaggcgggctgagcccaagcagcaaccctcccaacggcttcgccttcagcgggggcctg
gccgccgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggtcccc
gaggcggcaggcctgggcgcccccctgagctttcccgccccccggggcaaggacagcgct
gcggagcccgggccctttgtgaacaagaggcagctggacgcgcaccgccccttcctgggc
acgtttgcccccggcccgcagttcgccctgggccccatgtcgctgcaggccaacctgggc
tcgtctgtgctgcagtccctgtttggctccgtgccggccgctggcctggtgcacgtctcg
tccgccgcaaccagactgaccaactcgcacgccatgggcagctttccctccggggtggca
ggcggcgcagttggaggtaactag

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