KEGG   Felis catus (domestic cat): 101101194Help
Entry
101101194         CDS       T02385                                 

Gene name
DOT1L
Definition
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
  KO
K11427  histone-lysine N-methyltransferase, H3 lysine-79 specific [EC:2.1.1.43]
Organism
fca  Felis catus (domestic cat)
Pathway
fca00310  Lysine degradation
fca05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:fca00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    101101194 (DOT1L)
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    101101194 (DOT1L)
Enzymes [BR:fca01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     101101194 (DOT1L)
Chromosome and associated proteins [BR:fca03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     101101194 (DOT1L)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: DOT1 HALZ
Motif
Other DBs
NCBI-GeneID: 101101194
NCBI-ProteinID: XP_023099117
Ensembl: ENSFCAG00000008606
Position
A2
AA seq 1692 aa AA seqDB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVAADTPVDSGAEEEKAGTTAIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKPRKSQTALDLLHAPASSQTAAPSPQDAYRSPHSPFYQLPPCVQRHAPDRPLLAAT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQEDNRELRSQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSAHLRGKGALGREPEADPGRLHLDLDCSRFSLPHFSSASPELSMNGHAAGY
ELCGALSRPPSKQNTPQYLASPLDQEVVPCTPSHGSRPRLEKVSGLALPDYTRLSPAKLV
LRRHLSQDHAAGGKTAAGELHPRAEHAKENGLPYQSPGIANGIKLSPQDPRPSSPVALQM
TGERGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQTRESLSTLEKQMGANAHSAGSKSLAPAPAGFYAGSVAVSPAPLASGADPGTFDE
VPSAGGLFASVGSCGSTPQHPPLLPQPRGSGAASPAHPLCASPRLGGAAQGPLPDANKGD
LPPEAGFSDPEGEAKRRIVFTVSAGGGSTKQSPPSKPSPLPTGGRGDGSQGHGQDSRKRG
RRKRAAAGTPGLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAISSPE
SLKSSPVPYQDSDQPPVLKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSTRIERKIATIS
LESRSPPKTLENGGGLAGRKPTPAGEPANSSKWKSTFSPISDLGLAKCADSPLQAGSALS
QNSLFAFRPPLEEPGSADAKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFSGGLAADLS
LHSFSDGASLSHKVPEAAGLGAPLSFPAPRGKDSAAEPGPFVNKRQLDGAGGPKGREAGE
PGPPACGPPDKASLAHGKPGKGRDREPDLKNGHNLFIAAASVPPGGLLSGPGLATAASSV
VSAAPSAQAHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFGSVPAAGLVHVSSAATR
LTNSHAMGSFPSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSLTPLQAVAG
APPPPPPGQPALPAPPPPNAALPPAPALLPANSEPALLQNLASLPANQAFLPASSAASLQ
PANASLSIKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQASSTGPSAVWVSLGMPP
PYAARLAGVKPR
NT seq 5079 nt NT seq  +upstreamnt  +downstreamnt
atgggggagaagctggagctgaggctcaagtcgcccgtaggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcacgaaatcatcgagacc
atccggtgggtctgcgaagagatcccggacctcaagctcgctatggagaactacgtttta
atcgactacgacaccaaaagcttcgagagcatgcagaggctctgtgataagtacaaccgc
gccatcgacagcatccaccagctgtggaaggggaccactcagcccatgaaactgaacacc
cggccgtccaacgggctcctgcgccacatcctgcagcaggtgtataaccactcggtgacg
gaccccgagaagctcaacaactacgagcccttctccccggaggtgtacggggagacctcc
tttgacctggtcgcgcagatgatcgacgagatcaagatgaccgaggacgacctgtttgtg
gacctgggcagcggagtgggccaggtcgtgctccaggtggccgcggccaccaactgcaaa
catcactacggcgtggagaaagccgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcggaggagtggagagagcggattgccaacacaagtgttatatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggcggcagaattgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agcagaaacttgagcgacatcggcaccatcatgcgcgtcgtggagctctcgcccctgaag
ggctctgtgtcctggacggggaagccggtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggagcaggaggcg
gctcggcgccggcagcagcgggagaacaagagcaacacgaccactcccaccaaggtgccc
gagagcaaggccgccgtggccgcggacacccccgtggattccggtgccgaggaagagaag
gctgggacgaccgccatcaaaaagccgtccccctccaaagcccggaagaagaagctgaac
aagaaggggcggaaaatggccggcaggaagcgcgggcgccccaagaagatgagcgctgcc
aaccccgagcgcaagccccggaagagccaaactgcactggacctcctgcacgccccggcc
tcgtcgcagacggcggcgccctcgccacaggatgcgtacaggtcacctcacagccccttc
tatcagctacctccctgcgtgcagcggcacgcccccgaccggccgctgctggcagccacc
ccgcccgcactgcagaagctgctagaatccttcaagattcagtacttgcagttcttggcc
tacaccaagaccgcccagtacaaggccagccttcagcagctgctggaccaggagaaggag
aagaacgcccggctgctgggggccgcacagcagctgttcggccactgccaggcccagaaa
gaggagatcaagaggctcttccagcagaaactggatgagctgggggtgaaggcgctgacc
tacaacgacctgattcaggcgcagaaggagatctcggcccataaccagcagctgagggag
cagacggagcagctgcaggaggacaacagggagctgaggagccagagcctgcagctgctc
aaggctcggtgtgaggagttgaagctggactggtccacgctgtcgctggagaacctgctg
aaggagaagcaggccctgaggagccagatctccgagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaag
tcctgcgtgccgcccgacgacgccctgtcggcgcacctgcgcgggaaaggcgccctgggc
cgggagccggaggcggaccccggccggctgcacctcgacctggactgctctcggttctcc
ctgccgcacttcagcagcgccagcccggaactctccatgaacggccacgcggccggctac
gagctctgcggtgcgctgagccggcccccgtccaagcagaacaccccccagtacctggcc
tccccgctggaccaggaggtggtgccctgcacccccagccacggcagccggccaaggctc
gagaaggtgtctggcctggccttgccggactacaccaggctttccccggccaagctggtg
ctgaggcggcacctcagccaggaccacgcggccggcggcaagacggcggccggggagctg
cacccgcgagccgagcacgccaaggagaacggccttccgtaccagagcccgggcatcgcc
aacggcatcaagctgagccctcaggacccccggccctcatcccccgtggccttacagatg
acaggggagaggggcagcgagaagggtttgaaggagcgtgcctacgccagcagcggggag
gccatcaccagcctgcccgtcagcatcccgctcagcaccgtgcagcccagcaagctgccc
gtcagcatccctctggccagcgtggtgctgcccagccgtgccgagaaagtgagaagcacc
cccagccccgtgccgcagacccgagagtccttgtccacacttgaaaagcagatgggcgct
aatgcacacagcgccggaagcaaaagtctcgccccagcccctgcaggcttctacgcgggc
tcggtggccgtcagcccagcccccctcgcttccggagcagatcccggcacctttgacgag
gtccccagcgcaggcggtctgtttgccagcgtggggtcctgtggctccaccccgcagcac
ccgcccctgctgccgcagccccgcggctctggcgcagcctcgcccgcccacccgctctgc
gccagcccccgcctgggcggcgccgcccagggtccgctccctgacgccaacaaaggggac
cttcctcccgaggccggcttctcggaccccgagggcgaagccaagcggaggatcgtcttc
accgtctcggccggcgggggcagcaccaagcagtcgcctcccagcaagcccagccctctg
cccacgggcggccgtggggacggcagccagggccacgggcaggacagccgcaagcggggc
agaaggaagcgggcggcggcagggacccccggcctgagctcaggcgtgtcgcccaagcgc
cgggccctgccgtccgtggccggcctcttcacgcagtcttcagggtcccccctgaacctc
aactccatggttagcaacattaaccagcctttggaaatcacggccatttcgtcccctgag
agcctgaagagctcccctgtcccctaccaggacagcgaccagccgcccgtcctcaagaag
gagaagcccctgagccagaccaacggggcccactactccccactgacctcggacgaggag
cagggctccgaggatgagccgggcagcaccagaattgagagaaaaattgcgacaatctcc
ttagaaagcagatctcccccgaaaaccttggaaaacggtggtggcctggcggggaggaag
ccgacccctgccggcgagcccgccaacagcagcaagtggaagtctaccttttcgcccatc
tccgacctcggcctggccaagtgcgccgacagcccgctgcaggccggctccgccctgagc
cagaactccctgttcgctttccggccccccctggaggagcccggctcggccgacgccaag
ctggccgcccaccccaggaaaagttttcccggtgccctgtcgggggcaggcgggctgagc
ccaagcagcaaccctcccaacggcttcgccttcagcgggggcctggccgccgacctcagt
ttacacagcttcagtgatggtgcttctctctcccacaaggtccccgaggcggcaggcctg
ggcgcccccctgagctttcccgccccccggggcaaggacagcgctgcggagcccgggccc
tttgtgaacaagaggcagctggacggcgcgggcggccccaagggcagggaggcaggcgag
ccgggccccccggcgtgcggccccccggacaaggcctcgctggcgcacggcaagccgggc
aagggccgggaccgtgagcccgacctgaagaacggccacaacctcttcattgcggccgcc
agcgtgccccccgggggcctcctcagtggcccgggcctcgccacggcggcgtcctcggtg
gtcagcgcggccccctccgcccaggcgcaccgccccttcctgggcacgtttgcccccggc
ccgcagttcgccctgggccccatgtcgctgcaggccaacctgggctcgtctgtgctgcag
tccctgtttggctccgtgccggccgctggcctggtgcacgtctcgtccgccgcaaccaga
ctgaccaactcgcacgccatgggcagctttccctccggggtggcaggcggcgcagttgga
ggtgtctttaaccacgcggtgccttccgcctccgctcatccgtttggagccagtttcggc
agcggggctgcgtgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccggc
gccccgcccccgcccccaccggggcagcctgccctccccgcgccccctccccctaacgcc
gccttgcctcccgcccccgcgctgctcccggctaactctgagcccgcgcttctgcagaac
ctcgcgtccctcccggctaaccaggctttcttacccgcctcctctgccgcctctctgcag
cctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggccccccgcccc
tccttcacggtgcaccaccagcccctgcccgggctggccctggcccaggccgcgcccgtg
atcccacaggccagctccacggggccgtccgccgtgtgggtttcccttggcatgccgcct
ccgtatgccgcgcgccttgcgggggttaagccaagataa

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