KEGG   PATHWAY: gga05132Help
Entry
gga05132                    Pathway                                

Name
Salmonella infection - Gallus gallus (chicken)
Description
Salmonella infection usually presents as a self-limiting gastroenteritis or the more severe typhoid fever and bacteremia. The common disease-causing Salmonella species in human is a single species, Salmonella enterica, which has numerous serovars.
Following intestinal colonization Salmonella inject effector proteins into the host cells using a type III secretion system (T3SS), T3SS1. Then a small group of effector proteins induce rearrangement of the actin cytoskeleton resulting in membrane ruffles and rapid internalization of the bacteria.The T3SS2 is responsible for translocating effector proteins that direct Salmonella-containing vacuole (SCV) maturation. The majority of the bacteria are known to survive and replicate in SCV.
Class
Human Diseases; Infectious diseases
BRITE hierarchy
Pathway map
Salmonella infection
gga05132

All organismsOrtholog table
Organism
Gallus gallus (chicken) [GN:gga]
Gene
417241  
TLR4; toll like receptor 4 [KO:K10160]
420420  
MYD88; myeloid differentiation primary response 88 [KO:K04729]
554217  
TLR5; toll like receptor 5 [KO:K10168]
395764  
CASP1; caspase 1 [KO:K01370] [EC:3.4.22.36]
395871  
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) [KO:K04392]
395917  
CDC42; cell division cycle 42 [KO:K04393]
422207  
RHOG; ras homolog family member G [KO:K07863]
rho-related GTP-binding protein RhoG-like [KO:K07863]
417739  
MAPK11; mitogen-activated protein kinase 11 [KO:K04441] [EC:2.7.11.24]
421183  
MAPK14; mitogen-activated protein kinase 14 [KO:K04441] [EC:2.7.11.24]
769763  
MAPK12; mitogen-activated protein kinase 12 [KO:K04441] [EC:2.7.11.24]
771145  
MAPK13; mitogen-activated protein kinase 13 [KO:K04441] [EC:2.7.11.24]
373953  
MAPK1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
423778  
MAPK8; mitogen-activated protein kinase 8 [KO:K04440] [EC:2.7.11.24]
395983  
MAPK9; mitogen-activated protein kinase 9 [KO:K04440] [EC:2.7.11.24]
422592  
MAPK10; mitogen-activated protein kinase 10 [KO:K04440] [EC:2.7.11.24]
396512  
FOS; Fos proto-oncogene, AP-1 transcription factor subunit [KO:K04379]
424673  
JUN; Jun proto-oncogene, AP-1 transcription factor subunit [KO:K04448]
396033  
NFKB1; nuclear factor kappa B subunit 1 [KO:K02580]
396027  
RELA; RELA proto-oncogene, NF-kB subunit [KO:K04735]
395312  
IL18; interleukin 18 [KO:K05482]
395196  
IL1B; interleukin 1, beta [KO:K04519]
395337  
IL6; interleukin 6 [KO:K05405]
396495  
IL8L2; interleukin 8-like 2 [KO:K10030]
395872  
IL8L1; interleukin 8-like 1 [KO:K10030]
395551  
CCL4; chemokine (C-C motif) ligand 4 [KO:K12964]
416325  
CSF2; colony stimulating factor 2 [KO:K05427]
421761  
WASF1; WAS protein family member 1 [KO:K05753]
426359  
WASF2; WAS protein family member 2 [KO:K05748]
417750  
WASL; Wiskott-Aldrich syndrome like [KO:K05747]
429075  
ARPC5; actin related protein 2/3 complex subunit 5 [KO:K05754]
ARPC5L; actin related protein 2/3 complex subunit 5 like [KO:K05754]
416051  
ARPC4; actin related protein 2/3 complex subunit 4 [KO:K05755]
416837  
ARPC3; actin related protein 2/3 complex subunit 3 [KO:K05756]
416490  
ARPC1B; actin related protein 2/3 complex subunit 1B [KO:K05757]
770269  
ARPC1A; actin related protein 2/3 complex subunit 1A [KO:K05757]
429041  
ARPC2; actin related protein 2/3 complex subunit 2 [KO:K05758]
415388  
TJP1; tight junction protein 1 [KO:K05701]
396526  
ACTB; actin, beta [KO:K05692]
415296  
ACTG1; Actin, gamma 1 [KO:K05692]
776816  
ACTG1; actin, cytoplasmic 2-like [KO:K05692]
424519  
PKN2; protein kinase N2 [KO:K06071] [EC:2.7.11.13]
417209  
PKN3; protein kinase N3 [KO:K06071] [EC:2.7.11.13]
373970  
ROCK1; Rho-associated, coiled-coil containing protein kinase 1 [KO:K04514] [EC:2.7.11.1]
374182  
ROCK2; Rho associated coiled-coil containing protein kinase 2 [KO:K17388] [EC:2.7.11.1]
419457  
PLEKHM2; pleckstrin homology and RUN domain containing M2 [KO:K15348]
423484  
KLC1; kinesin light chain 1 [KO:K10407]
769965  
KLC2; kinesin light chain 2 [KO:K10407]
416016  
RAB7A; RAB7A, member RAS oncogene family [KO:K07897]
771782  
RAB7B; RAB7B, member RAS oncogene family [KO:K07898]
417558  
RILP; Rab interacting lysosomal protein [KO:K13883]
423461  
DYNC1H1; dynein cytoplasmic 1 heavy chain 1 [KO:K10413]
418979  
DYNC2H1; dynein cytoplasmic 2 heavy chain 1 [KO:K10414]
420571  
DYNC1I1; dynein cytoplasmic 1 intermediate chain 1 [KO:K10415]
424151  
DYNC1I2; dynein cytoplasmic 1 intermediate chain 2 [KO:K10415]
415793  
DYNC1LI2; dynein cytoplasmic 1 light intermediate chain 2 [KO:K10416]
420668  
DYNC1LI1; dynein cytoplasmic 1 light intermediate chain 1 [KO:K10416]
776720  
cytoplasmic dynein 1 light intermediate chain 2-like [KO:K10416]
428564  
PFN3; profilin 3 [KO:K05759]
771904  
PFN2; profilin 2 [KO:K05759]
PFN4; profilin family member 4 [KO:K05759]
395261  
FLNA; filamin A [KO:K04437]
378913  
FLNB; filamin B [KO:K04437]
395260  
FLNC; filamin C [KO:K04437]
396054  
IFNG; interferon gamma [KO:K04687]
421685  
IFNGR1; interferon gamma receptor 1 [KO:K05132]
418502  
IFNGR2; interferon gamma receptor 2 (interferon gamma transducer 1) [KO:K05133]
395807  
NOS2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
Compound
C00062  
L-Arginine
C00338  
Lipopolysaccharide
C00533  
Nitric oxide
C04637  
1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate
Reference
  Authors
Trebichavsky I, Splichal I, Splichalova A
  Title
Innate immune response in the gut against Salmonella - review.
  Journal
Folia Microbiol (Praha) 55:295-300 (2010)
DOI:10.1007/s12223-010-0044-3
Reference
  Authors
Talbot S, Totemeyer S, Yamamoto M, Akira S, Hughes K, Gray D, Barr T, Mastroeni P, Maskell DJ, Bryant CE
  Title
Toll-like receptor 4 signalling through MyD88 is essential to control Salmonella enterica serovar typhimurium infection, but not for the initiation of bacterial clearance.
  Journal
Immunology 128:472-83 (2009)
DOI:10.1111/j.1365-2567.2009.03146.x
Reference
  Authors
Ibarra JA, Steele-Mortimer O
  Title
Salmonella--the ultimate insider. Salmonella virulence factors that modulate intracellular survival.
  Journal
Cell Microbiol 11:1579-86 (2009)
DOI:10.1111/j.1462-5822.2009.01368.x
Reference
  Authors
Gewirtz AT, Navas TA, Lyons S, Godowski PJ, Madara JL
  Title
Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression.
  Journal
J Immunol 167:1882-5 (2001)
DOI:10.4049/jimmunol.167.4.1882
Reference
  Authors
Vijay-Kumar M, Wu H, Jones R, Grant G, Babbin B, King TP, Kelly D, Gewirtz AT, Neish AS
  Title
Flagellin suppresses epithelial apoptosis and limits disease during enteric infection.
  Journal
Am J Pathol 169:1686-700 (2006)
DOI:10.2353/ajpath.2006.060345
Reference
  Authors
Miao EA, Andersen-Nissen E, Warren SE, Aderem A
  Title
TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
  Journal
Semin Immunopathol 29:275-88 (2007)
DOI:10.1007/s00281-007-0078-z
Reference
  Authors
Bueno SM, Riedel CA, Carreno LJ, Kalergis AM
  Title
Virulence mechanisms displayed by Salmonella to impair dendritic cell function.
  Journal
Curr Med Chem 17:1156-66 (2010)
DOI:10.2174/092986710790827825
Reference
  Authors
Haraga A, Ohlson MB, Miller SI
  Title
Salmonellae interplay with host cells.
  Journal
Nat Rev Microbiol 6:53-66 (2008)
DOI:10.1038/nrmicro1788
Reference
  Authors
Kimbrough TG, Miller SI
  Title
Assembly of the type III secretion needle complex of Salmonella typhimurium.
  Journal
Microbes Infect 4:75-82 (2002)
DOI:10.1016/S1286-4579(01)01512-X
Reference
  Authors
Patel JC, Galan JE
  Title
Differential activation and function of Rho GTPases during Salmonella-host cell interactions.
  Journal
J Cell Biol 175:453-63 (2006)
DOI:10.1083/jcb.200605144
Reference
  Authors
Bulgin R, Raymond B, Garnett JA, Frankel G, Crepin VF, Berger CN, Arbeloa A
  Title
Bacterial guanine nucleotide exchange factors SopE-like and WxxxE effectors.
  Journal
Infect Immun 78:1417-25 (2010)
DOI:10.1128/IAI.01250-09
Reference
  Authors
Bakowski MA, Braun V, Brumell JH
  Title
Salmonella-containing vacuoles: directing traffic and nesting to grow.
  Journal
Traffic 9:2022-31 (2008)
DOI:10.1111/j.1600-0854.2008.00827.x
Reference
  Authors
Wasylnka JA, Bakowski MA, Szeto J, Ohlson MB, Trimble WS, Miller SI, Brumell JH
  Title
Role for myosin II in regulating positioning of Salmonella-containing vacuoles and intracellular replication.
  Journal
Infect Immun 76:2722-35 (2008)
DOI:10.1128/IAI.00152-08
Reference
  Authors
Nikolaus T, Deiwick J, Rappl C, Freeman JA, Schroder W, Miller SI, Hensel M
  Title
SseBCD proteins are secreted by the type III secretion system of Salmonella pathogenicity island 2 and function as a translocon.
  Journal
J Bacteriol 183:6036-45 (2001)
DOI:10.1128/JB.183.20.6036-6045.2001
Reference
  Authors
Eckmann L, Kagnoff MF
  Title
Cytokines in host defense against Salmonella.
  Journal
Microbes Infect 3:1191-200 (2001)
DOI:10.1016/S1286-4579(01)01479-4
Reference
  Authors
Fu Y, Galan JE
  Title
A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion.
  Journal
Nature 401:293-7 (1999)
DOI:10.1038/45829
Reference
  Authors
Du F, Galan JE
  Title
Selective inhibition of type III secretion activated signaling by the Salmonella effector AvrA.
  Journal
PLoS Pathog 5:e1000595 (2009)
DOI:10.1371/journal.ppat.1000595
Reference
  Authors
Jones RM, Wu H, Wentworth C, Luo L, Collier-Hyams L, Neish AS
  Title
Salmonella AvrA Coordinates Suppression of Host Immune and Apoptotic Defenses via JNK Pathway Blockade.
  Journal
Cell Host Microbe 3:233-44 (2008)
DOI:10.1016/j.chom.2008.02.016
Reference
  Authors
Haraga A, Miller SI
  Title
A Salmonella type III secretion effector interacts with the mammalian serine/threonine protein kinase PKN1.
  Journal
Cell Microbiol 8:837-46 (2006)
DOI:10.1111/j.1462-5822.2005.00670.x
Reference
  Authors
Abrahams GL, Muller P, Hensel M
  Title
Functional dissection of SseF, a type III effector protein involved in positioning the salmonella-containing vacuole.
  Journal
Traffic 7:950-65 (2006)
DOI:10.1111/j.1600-0854.2006.00454.x
Reference
  Authors
Henry T, Couillault C, Rockenfeller P, Boucrot E, Dumont A, Schroeder N, Hermant A, Knodler LA, Lecine P, Steele-Mortimer O, Borg JP, Gorvel JP, Meresse S
  Title
The Salmonella effector protein PipB2 is a linker for kinesin-1.
  Journal
Proc Natl Acad Sci U S A 103:13497-502 (2006)
DOI:10.1073/pnas.0605443103
Reference
  Authors
Miao EA, Brittnacher M, Haraga A, Jeng RL, Welch MD, Miller SI
  Title
Salmonella effectors translocated across the vacuolar membrane interact with the actin cytoskeleton.
  Journal
Mol Microbiol 48:401-15 (2003)
DOI:10.1046/j.1365-2958.2003.t01-1-03456.x
Reference
  Authors
Prior K, Hautefort I, Hinton JC, Richardson DJ, Rowley G
  Title
All stressed out. Salmonella pathogenesis and reactive nitrogen species.
  Journal
Adv Microb Physiol 56:1-28 (2009)
DOI:10.1016/S0065-2911(09)05601-X
KO pathway
 

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