KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101129357Help
Entry
101129357         CDS       T02442                                 

Gene name
PLCB3
Definition
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3
Orthology
K05858  
phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
Inositol phosphate metabolism
Metabolic pathways
Rap1 signaling pathway
Calcium signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
Phosphatidylinositol signaling system
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Wnt signaling pathway
Gap junction
Platelet activation
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
Insulin secretion
GnRH signaling pathway
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Endocrine and other factor-regulated calcium reabsorption
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Chagas disease (American trypanosomiasis)
African trypanosomiasis
Amoebiasis
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101129357 (PLCB3)
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    101129357 (PLCB3)
   04310 Wnt signaling pathway
    101129357 (PLCB3)
   04020 Calcium signaling pathway
    101129357 (PLCB3)
   04070 Phosphatidylinositol signaling system
    101129357 (PLCB3)
   04022 cGMP - PKG signaling pathway
    101129357 (PLCB3)
 Cellular Processes
  Cellular commiunity
   04540 Gap junction
    101129357 (PLCB3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101129357 (PLCB3)
   04062 Chemokine signaling pathway
    101129357 (PLCB3)
  Endocrine system
   04911 Insulin secretion
    101129357 (PLCB3)
   04912 GnRH signaling pathway
    101129357 (PLCB3)
   04915 Estrogen signaling pathway
    101129357 (PLCB3)
   04921 Oxytocin signaling pathway
    101129357 (PLCB3)
   04918 Thyroid hormone synthesis
    101129357 (PLCB3)
   04919 Thyroid hormone signaling pathway
    101129357 (PLCB3)
   04916 Melanogenesis
    101129357 (PLCB3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101129357 (PLCB3)
   04270 Vascular smooth muscle contraction
    101129357 (PLCB3)
  Digestive system
   04970 Salivary secretion
    101129357 (PLCB3)
   04971 Gastric acid secretion
    101129357 (PLCB3)
   04972 Pancreatic secretion
    101129357 (PLCB3)
  Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    101129357 (PLCB3)
  Nervous system
   04724 Glutamatergic synapse
    101129357 (PLCB3)
   04725 Cholinergic synapse
    101129357 (PLCB3)
   04728 Dopaminergic synapse
    101129357 (PLCB3)
   04726 Serotonergic synapse
    101129357 (PLCB3)
   04720 Long-term potentiation
    101129357 (PLCB3)
   04730 Long-term depression
    101129357 (PLCB3)
   04723 Retrograde endocannabinoid signaling
    101129357 (PLCB3)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101129357 (PLCB3)
  Environmental adaptation
   04713 Circadian entrainment
    101129357 (PLCB3)
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101129357 (PLCB3)
   05016 Huntington's disease
    101129357 (PLCB3)
  Infectious diseases
   05146 Amoebiasis
    101129357 (PLCB3)
   05142 Chagas disease (American trypanosomiasis)
    101129357 (PLCB3)
   05143 African trypanosomiasis
    101129357 (PLCB3)
Enzymes [BR:ggo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101129357 (PLCB3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
11
AA seq 1350 aa AA seqDB search
MRLPRSHLWNADFRAPAVGQALQSPSSTLLSGDIDKASDPSGQTTASPPRFPAKRLTAPP
RPRPARAPPRLWSVRDRLAGGRALTPRGRSGPRGGSSGAVGPRQGSVGPRPAPGRAMAGA
QPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNMEVDTL
DISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNFMAVQ
DDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFSADKK
RVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLE
QLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEE
NGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELD
VWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAK
MAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDSSGRK
RPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGDEGLN
RGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPVKFKS
FEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYMPQLF
WNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIVDGIV
ANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFP
KVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLIYTEA
SDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQLGSQP
SSNPTPSPLDASPRRHPTTLSSSSSQGLCSSGQRDDLIASILSEVAPTPLDELRGHKALV
KLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVEDTKEG
EDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQFKRLK
EMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLEEAQK
QRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLGDGPL
VACASNGHAPGSSGHLSGADSESQEENTQL
NT seq 4053 nt NT seq  +upstreamnt  +downstreamnt
atgcgccttccccgctcccatctctggaacgcagatttcagggcacctgctgtgggccag
gcactgcagagcccctcctcaaccctcctgtctggggacatcgacaaagcttctgacccc
tccgggcagacaacagcgtcccccccgcggttcccagccaagaggctcacagccccgccc
cgtccccgccccgcccgggccccgccgaggctctggtcggtccgggacagactggcgggc
gggcgggcactgacgccgcggggccggagcgggccgcgcggtgggagcagcggcgccgtc
ggtccccgtcagggctccgtgggtccccgacccgcccctggccgggccatggcgggcgcc
cagcccggcgtccacgcgctgcagctggagccgcccaccgtggtggagaccctgcggcgc
gggagtaagttcatcaaatgggacgaggagacctccagtcggaacctggtgactctgcgt
gtggaccccaatggcttcttcttgtactggacgggccccaacatggaggtggacacactg
gacatcagttccatcagggacacacggacaggccggtacgcccgcctgcccaaggacccc
aagatccgggaagttctgggctttgggggtcccgatgcccggctggaggagaagctgatg
acggtggtgtctgggccagacccggtgaacacagtgttcttgaacttcatggccgtgcag
gatgacacagccaaggtctggtctgaggagctattcaagctggctatgaacatcctggct
cagaacgcctctcggaacaccttcctgcgcaaagcatacacgaagctgaagctgcaggtg
aaccaggatggtcggatccccgtcaagaacatcctgaagatgttctcagcagacaagaag
cgggtggagactgcgctggaatcctgtggcctcaaattcaaccggagtgagtccatccgg
cccgatgagttttccttggaaatctttgagcggttcctgaacaagctgtgtctgcggccg
gacattgacaagatcctgctggagataggcgccaagggcaagccatacctgacgctggag
cagctcatggacttcatcaaccagaagcaacgtgacccgagactcaacgaagtgctgtac
ccgcccctgcggccctcccaggcccggctgctcatcgaaaagtatgagcccaaccagcag
tttctggagcgagaccagatgtccatggagggctttagccgctacctgggaggcgaggag
aatggcatcctgcccctggaagccctggatctgagcacggacatgacccagccactgagt
gcctacttcatcaactcctcgcataacacctatctcactgcggggcagctggctgggacc
tcgtcggtggagatgtaccgccaggcactgctatggggctgccgctgcgtggagctggat
gtgtggaagggacggccgcccgaggaggaacccttcattacccatggcttcaccatgacc
acagaggtgcctctgcgcgacgtgctggaggccattgccgagactgccttcaagacctcg
ccctaccccgtcatcctctccttcgagaaccatgtggactcggcaaagcaacaggcaaag
atggctgagtactgccgctccatctttggagacgcgctactcatcgagcctctggacaag
tacccgctggccccaggcgttcccctgcccagcccccaggacctgatgggccgtatcctg
gtgaagaacaagaagcggcaccgacccagcgcaggtggcccagacagctccgggcgcaag
cggcccctggagcagagcaattctgccctgagtgagagctccgcggccactgagccctcc
tccccgcagcttgggtctcccagctctgacagctgcccaggcctgagcaacggggaggag
gtagggcttgagaagcccagcctggagcctcagaagtctctgggcgacgagggcctgaac
cggggcccctatgttcttggacctgctgaccgtgaggatgaggaggaagatgaagaagag
gaggaacagacagaccccaaaaagccaactacagatgagggcacagccagcagcgaggtg
aatgccactgaggagatgtccacgcttgtcaactacatcgagcctgtcaagttcaagtcc
tttgaggctgctcgaaagaggaacaaatgcttcgagatgtcgtccttcgtggagaccaag
gccatggagcaactgaccaagagccccatggagtttgtggaatacaacaagcagcagctc
agccgcatctaccccaagggcacccgcgtggactcctccaactatatgccccagctcttc
tggaacgtagggtgccagcttgttgcgctcaacttccagaccctcgatgtggcgatgcag
ctcaacgcgggcgtttttgagtacaacgggcgcagcgggtacctgctcaagccggagttc
atgcggcggccggacaagtccttcgaccccttcactgaggtcatcgtggatggcatcgtg
gccaatgccttgcgggtcaaggtgatctcagggcagttcctgtccgacaggaaggtgggc
atctacgtggaggtggacatgtttggcctccctgttgacacgcggcgcaagtaccgcacc
cggacctctcaggggaactcgttcaaccccgtgtgggacgaagagcccttcgacttcccc
aaggtggtgctgcccacgctggcttcacttcgcatcgcagcctttgaggaggggggtaaa
ttcgtagggcaccggatcctgcctgtctctgccatccgctccggataccactacgtctgc
ctgcggaacgaggccaaccaaccgctgtgcctgccggccctgctcatctacaccgaagcc
tcggactacattcctgacgaccaccaggactacgcggaggccctgatcaaccccattaag
cacgtcagcctgatggaccagagggcccggcagctggccgccctcattggagagagtgag
gctcaggctggccaagagacgtgccaggacacccagtctcagcagctggggtctcagccg
tcctcaaaccccacccctagcccactggatgcctccccccggaggcaccccaccaccctg
tcctccagctcctcacagggcctctgctcctcagggcagcgcgacgatctcatcgccagc
atcctctcagaggtggcccccaccccgctggatgagctccgaggtcacaaggctttggtc
aagctccggagccggcaagagcgagacctgcgggagctgcgcaagaagcatcagcggaag
gcagtcaccctcacccgccgcctgctggacggcctggctcaggcacaggctgagggcagg
tgccggctgcggccaggtgccctaggtggggccgctgatgtggaggacacgaaggagggg
gaggacgaggcaaagcggtatcaggagttccagaacagacaggtgcagagcctgctggag
ctgcgggaggcccaggtggacgcagaggcccagcggaggctggaacacctgagacaggct
ctgcagcggctcagggaggtcgtccttgatgcaaacacaactcagttcaagaggctgaaa
gagatgaacgagagggagaagaaggagctgcagaagatcctggacagaaagcgccataac
agcatctcggaggccaagatgagggacaagcataagaaggaggcggaactgacggagatt
aaccgtcggcacatcactgagtcagtcaactccatccgtcggctggaggaggcccagaag
cagcggcatgaccgtcttgtggctgggcagcagcaggtcctgcaacagctggcagaagag
gagcccaagctgctggcccagctggcccaggagtgtcaggagcagcgggcgaggctcccc
caggagatccgccggagcctgctgggcgagatgccggaggggctgggggacgggcctctg
gtggcctgtgccagcaacggtcatgcacccgggagcagcgggcacctgtcgggcgctgac
tcggagagccaggaggagaacacgcagctctga

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