KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101133643Help
Entry
101133643         CDS       T02442                                 

Gene name
PLCG2
Definition
(RefSeq) phospholipase C gamma 2
  KO
K05859  
phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
Inositol phosphate metabolism
Metabolic pathways
EGFR tyrosine kinase inhibitor resistance
ErbB signaling pathway
Ras signaling pathway
Calcium signaling pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phosphatidylinositol signaling system
Phospholipase D signaling pathway
Axon guidance
VEGF signaling pathway
Osteoclast differentiation
Platelet activation
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Inflammatory mediator regulation of TRP channels
Thyroid hormone signaling pathway
AGE-RAGE signaling pathway in diabetic complications
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Non-small cell lung cancer
Hepatocellular carcinoma
Module
Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101133643 (PLCG2)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101133643 (PLCG2)
   04012 ErbB signaling pathway
    101133643 (PLCG2)
   04370 VEGF signaling pathway
    101133643 (PLCG2)
   04064 NF-kappa B signaling pathway
    101133643 (PLCG2)
   04066 HIF-1 signaling pathway
    101133643 (PLCG2)
   04020 Calcium signaling pathway
    101133643 (PLCG2)
   04070 Phosphatidylinositol signaling system
    101133643 (PLCG2)
   04072 Phospholipase D signaling pathway
    101133643 (PLCG2)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101133643 (PLCG2)
   04650 Natural killer cell mediated cytotoxicity
    101133643 (PLCG2)
   04662 B cell receptor signaling pathway
    101133643 (PLCG2)
   04664 Fc epsilon RI signaling pathway
    101133643 (PLCG2)
   04666 Fc gamma R-mediated phagocytosis
    101133643 (PLCG2)
   04670 Leukocyte transendothelial migration
    101133643 (PLCG2)
  Endocrine system
   04919 Thyroid hormone signaling pathway
    101133643 (PLCG2)
  Nervous system
   04722 Neurotrophin signaling pathway
    101133643 (PLCG2)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101133643 (PLCG2)
  Development
   04360 Axon guidance
    101133643 (PLCG2)
   04380 Osteoclast differentiation
    101133643 (PLCG2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101133643 (PLCG2)
   05206 MicroRNAs in cancer
    101133643 (PLCG2)
   05205 Proteoglycans in cancer
    101133643 (PLCG2)
   05225 Hepatocellular carcinoma
    101133643 (PLCG2)
   05214 Glioma
    101133643 (PLCG2)
   05223 Non-small cell lung cancer
    101133643 (PLCG2)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    101133643 (PLCG2)
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    101133643 (PLCG2)
   05169 Epstein-Barr virus infection
    101133643 (PLCG2)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    101133643 (PLCG2)
Enzymes [BR:ggo01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     101133643 (PLCG2)
Membrane trafficking [BR:ggo04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    101133643 (PLCG2)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    101133643 (PLCG2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Ensembl: 
Position
16
AA seq 1265 aa AA seqDB search
MSTTVNVDSLAEYEKSQIKRALELGTVMTVFSFRKSTPERRTVQVIMETRQVAWSKTADK
IEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAV
NWLSGLKILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSA
KFLKDKFVEIGAHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASA
VYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENS
IWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDC
WDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKA
FKEVFGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLGPRGDVDVNMEDKKDEHKQQGE
LYMWDSIDQKWTRHYCAIADAKLSFSDDIEQTVEEEVPQDIPATELHFGEKWFHKKVEKR
TSAEKLLQEYCMETGGKDGTFLVRESETFPNDYTLSFWRSGRVQHCRIRSTMEGGTLKYY
LTDNLTFSSIYALIQHYRETHLRCAEFELRLTDPVPNPNPHESKPWYYDSLSRGEAEDML
MRIPRDGAFLIRKREGSDSYAITFRARGKVKHCRINRDGRHFVLGTSAYFESLVELVSYY
EKHSLYRKMRLRYPVTPELLERYNMERDINSLYDVSRMYVDPSEINPSMPQRTVKALYDY
KAKRSDELSFCRGALIHNVSKEPGGWWKGDYGTRIQQYFPSNYVEDISTADFEELEKQII
EDNPLGSLCRGILDLNTYNVVKAPQGKNQKSFVFILEPKKQGDPPVEFATDRVEELFEWF
QSIREITWKIDTKENNMKYWEKNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVE
TKADSIIRQKPVDLLKYNQKGLTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKY
MQMNHALFSLNGRTGYVLQPESMRTEKYDPMPPESQRKILMTLTVKVLGARHLPKLGRSI
ACPFVEVEICGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEED
MFSDPNFLAHATYPIKAIKSGFRSVPLKNGYSEDIELASLLVFCEMRPVLESEEELYSSC
RQLRRRQEELNNQLFLYDTHQNLRNANRDALVKEFSVNENQLQLYQEKCNKRLREKRVSN
SKFYS
NT seq 3798 nt NT seq  +upstreamnt  +downstreamnt
atgtccaccacggtcaatgtagattcccttgcggaatatgagaagagccagatcaagaga
gccctggagctggggacggtgatgaccgtgttcagcttccgcaagtccacccctgagcgg
aggaccgtccaggtgatcatggagacgcggcaggtggcctggagcaagaccgctgacaag
atcgagggcttcttggatatcatggaaataaaagaaatccgcccagggaagaactccaaa
gatttcgagcgagcaaaagcagttcgccagaaagaagactgctgcttcaccatcctgtat
ggcactcagtttgtcctcagcacgctcagcttggcagctgactctaaagaggatgcagtt
aactggctctctggcttgaaaatcttacaccaagaagcgatgaatgcgtccacgcccacc
attatcgagagttggctgagaaagcagatatattctgtggatcaaaccagaagaaacagc
atcagtctccgagagttgaagaccatcttgcccctgatcaactttaaagtgagcagtgcc
aagttccttaaagataagtttgtggaaataggagcacacaaagatgagctcagctttgaa
cagttccatctcttctataaaaaacttatgtttgaacagcaaaaatcgattctcgatgaa
ttcaaaaaggattcgtccgtgttcatcctggggaacactgacaggccggatgcctctgct
gtttacctgcatgacttccagaggtttctcatacatgaacagcaggagcattgggctcag
gatctgaacaaagtccgtgagcggatgacaaagttcattgatgacaccatgcgtgaaact
gctgagcctttcttgtttgtggatgagttcctcacgtacctgttttcacgagaaaacagc
atctgggatgagaagtatgacgcggtggacatgcaggacatgaacaaccccctgtctcat
tactggatctcctcgtcacataacacgtaccttacaggtgaccagctgcggagcgagtcg
tccccggaagcttacatccgctgcctgcgcatgggctgtcgctgcattgaactggactgc
tgggatgggcccgatgggaagccggtcatctaccatggctggacgcggactaccaagatc
aagtttgacgacgtcgtgcaggccatcaaagaccacgcctttgttacctcgagcttccca
gtgatcctgtccatcgaggagcactgcagcgtggagcaacagcgtcacatggccaaggcc
ttcaaggaagtgtttggcgacctgctgttgacaaagcccacggaggccagcgctgaccag
ctgccctcacccagccagctgcgggagaagatcatcatcaagcataagaagctgggcccc
cgaggcgatgtggatgtcaacatggaggacaagaaggacgaacacaagcaacagggagag
ctgtacatgtgggattccattgaccagaaatggactcggcactactgcgccatcgccgat
gccaagctgtccttcagtgatgacattgaacagactgtggaggaggaagtgccccaggat
atacccgctacagaactacattttggggagaaatggttccacaagaaggtggagaagagg
acgagtgccgagaagttgctgcaggaatactgcatggagacggggggcaaggatggcacc
ttcctggttcgggagagcgagaccttccccaatgactacaccctgtccttctggcggtca
ggccgggtccagcactgccggatccgctccaccatggagggcgggaccctgaaatactac
ttgactgacaacctcaccttcagcagcatctatgccctcatccagcactaccgcgagacg
cacctgcgctgcgccgagttcgagctgcggctcacggaccctgtgcccaaccccaacccc
cacgagtccaagccgtggtactatgacagcctgagccgcggagaggcagaggacatgctg
atgaggattccccgggacggggccttcctgatccggaagagagaggggagcgactcctat
gccatcaccttcagggctaggggcaaggtgaagcattgtcgcatcaaccgggacggccgg
cactttgtgctggggacctccgcctattttgagagtctggtggagctcgtcagttactac
gagaagcattccctttaccgaaagatgagactgcgctaccccgtgacccccgagctcctg
gagcgctacaatatggaaagagatataaactccctctacgacgtcagcagaatgtatgtg
gatcccagtgaaatcaatccgtccatgcctcagagaaccgtgaaagctctgtatgactac
aaagccaagcgaagcgatgagctgagcttctgccgtggtgccctcatccacaatgtctcc
aaggagcccgggggctggtggaaaggagactatggaaccaggatccagcagtacttccca
tccaactacgtcgaggacatctcaactgcagacttcgaggagctagaaaagcagattatt
gaagacaatcccttagggtctctttgcagaggaatattggacctcaatacctataacgtc
gtgaaagcccctcagggaaaaaaccagaagtcctttgtcttcatcctggagcccaagaag
cagggcgatcctccggtggagtttgccacagacagggtggaggagctctttgagtggttt
cagagcatccgagagatcacctggaagattgacaccaaggagaacaacatgaagtactgg
gagaagaaccagtccatcgccatcgagctctctgacctggttgtctactgcaaaccaacc
agcaaaaccaaggacaacttagaaaatcctgacttccgagaaatccgctcctttgtggag
acgaaggctgacagcatcatcagacagaagcccgtcgacctcctgaagtacaatcaaaag
ggcctgacccgcgtctacccaaagggacaaagagttgactcttcaaactacgaccccttc
cgcctctggctgtgcggttctcagatggtggcactcaatttccagacagcagataagtac
atgcagatgaatcacgcgttgttttctctcaatgggcgcacgggctacgttctgcagcct
gagagcatgaggacagagaaatatgacccgatgccacccgagtcccagaggaagatcctg
atgacgctgacagtcaaggttctcggtgctcgccatctccccaaacttggacgaagtatt
gcctgtccctttgtagaagtggagatctgtggagctgagtatgacaacaacaagttcaag
acgacggttgtgaatgataatggcctcagccctatctgggctccaacacaggagaaggtg
acatttgaaatttatgacccaaacctggcatttctgcgctttgtggtttatgaagaagat
atgttcagcgatcccaactttcttgctcatgccacttaccccattaaagcaatcaaatca
ggattcagatccgttcctctgaagaatgggtacagcgaggacatagagctggcttccctc
ctggtcttctgtgagatgcggccagtcctggagagcgaagaggaactttactcctcctgt
cgccagctgaggaggcggcaagaagaactgaacaaccagctctttctgtatgacacacac
cagaacttgcgcaatgccaaccgggatgccctggttaaagagttcagtgttaatgagaac
cagctccaactgtaccaggaaaaatgcaacaagaggttaagagagaagagagtcagcaac
agcaagttttactcatag

DBGET integrated database retrieval system