KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101135988Help
Entry
101135988         CDS       T02442                                 

Gene name
MAPK3
Definition
(RefSeq) mitogen-activated protein kinase 3
  KO
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
Dorso-ventral axis formation
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101135988 (MAPK3)
   04015 Rap1 signaling pathway
    101135988 (MAPK3)
   04010 MAPK signaling pathway
    101135988 (MAPK3)
   04012 ErbB signaling pathway
    101135988 (MAPK3)
   04350 TGF-beta signaling pathway
    101135988 (MAPK3)
   04370 VEGF signaling pathway
    101135988 (MAPK3)
   04371 Apelin signaling pathway
    101135988 (MAPK3)
   04668 TNF signaling pathway
    101135988 (MAPK3)
   04066 HIF-1 signaling pathway
    101135988 (MAPK3)
   04068 FoxO signaling pathway
    101135988 (MAPK3)
   04072 Phospholipase D signaling pathway
    101135988 (MAPK3)
   04071 Sphingolipid signaling pathway
    101135988 (MAPK3)
   04024 cAMP signaling pathway
    101135988 (MAPK3)
   04022 cGMP - PKG signaling pathway
    101135988 (MAPK3)
   04151 PI3K-Akt signaling pathway
    101135988 (MAPK3)
   04150 mTOR signaling pathway
    101135988 (MAPK3)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    101135988 (MAPK3)
  Cell growth and death
   04114 Oocyte meiosis
    101135988 (MAPK3)
   04210 Apoptosis
    101135988 (MAPK3)
  Cellular community - eukaryotes
   04510 Focal adhesion
    101135988 (MAPK3)
   04520 Adherens junction
    101135988 (MAPK3)
   04540 Gap junction
    101135988 (MAPK3)
   04550 Signaling pathways regulating pluripotency of stem cells
    101135988 (MAPK3)
  Cell motility
   04810 Regulation of actin cytoskeleton
    101135988 (MAPK3)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101135988 (MAPK3)
   04620 Toll-like receptor signaling pathway
    101135988 (MAPK3)
   04621 NOD-like receptor signaling pathway
    101135988 (MAPK3)
   04650 Natural killer cell mediated cytotoxicity
    101135988 (MAPK3)
   04660 T cell receptor signaling pathway
    101135988 (MAPK3)
   04658 Th1 and Th2 cell differentiation
    101135988 (MAPK3)
   04659 Th17 cell differentiation
    101135988 (MAPK3)
   04657 IL-17 signaling pathway
    101135988 (MAPK3)
   04662 B cell receptor signaling pathway
    101135988 (MAPK3)
   04664 Fc epsilon RI signaling pathway
    101135988 (MAPK3)
   04666 Fc gamma R-mediated phagocytosis
    101135988 (MAPK3)
   04062 Chemokine signaling pathway
    101135988 (MAPK3)
  Endocrine system
   04910 Insulin signaling pathway
    101135988 (MAPK3)
   04912 GnRH signaling pathway
    101135988 (MAPK3)
   04915 Estrogen signaling pathway
    101135988 (MAPK3)
   04914 Progesterone-mediated oocyte maturation
    101135988 (MAPK3)
   04917 Prolactin signaling pathway
    101135988 (MAPK3)
   04921 Oxytocin signaling pathway
    101135988 (MAPK3)
   04919 Thyroid hormone signaling pathway
    101135988 (MAPK3)
   04916 Melanogenesis
    101135988 (MAPK3)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101135988 (MAPK3)
   04270 Vascular smooth muscle contraction
    101135988 (MAPK3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101135988 (MAPK3)
  Nervous system
   04724 Glutamatergic synapse
    101135988 (MAPK3)
   04725 Cholinergic synapse
    101135988 (MAPK3)
   04726 Serotonergic synapse
    101135988 (MAPK3)
   04720 Long-term potentiation
    101135988 (MAPK3)
   04730 Long-term depression
    101135988 (MAPK3)
   04723 Retrograde endocannabinoid signaling
    101135988 (MAPK3)
   04722 Neurotrophin signaling pathway
    101135988 (MAPK3)
  Development
   04320 Dorso-ventral axis formation
    101135988 (MAPK3)
   04360 Axon guidance
    101135988 (MAPK3)
   04380 Osteoclast differentiation
    101135988 (MAPK3)
  Environmental adaptation
   04713 Circadian entrainment
    101135988 (MAPK3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101135988 (MAPK3)
   05230 Central carbon metabolism in cancer
    101135988 (MAPK3)
   05231 Choline metabolism in cancer
    101135988 (MAPK3)
   05205 Proteoglycans in cancer
    101135988 (MAPK3)
   05203 Viral carcinogenesis
    101135988 (MAPK3)
   05210 Colorectal cancer
    101135988 (MAPK3)
   05212 Pancreatic cancer
    101135988 (MAPK3)
   05214 Glioma
    101135988 (MAPK3)
   05216 Thyroid cancer
    101135988 (MAPK3)
   05221 Acute myeloid leukemia
    101135988 (MAPK3)
   05220 Chronic myeloid leukemia
    101135988 (MAPK3)
   05218 Melanoma
    101135988 (MAPK3)
   05211 Renal cell carcinoma
    101135988 (MAPK3)
   05219 Bladder cancer
    101135988 (MAPK3)
   05215 Prostate cancer
    101135988 (MAPK3)
   05213 Endometrial cancer
    101135988 (MAPK3)
   05224 Breast cancer
    101135988 (MAPK3)
   05223 Non-small cell lung cancer
    101135988 (MAPK3)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101135988 (MAPK3)
   05020 Prion diseases
    101135988 (MAPK3)
  Substance dependence
   05034 Alcoholism
    101135988 (MAPK3)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101135988 (MAPK3)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101135988 (MAPK3)
  Infectious diseases
   05132 Salmonella infection
    101135988 (MAPK3)
   05133 Pertussis
    101135988 (MAPK3)
   05152 Tuberculosis
    101135988 (MAPK3)
   05164 Influenza A
    101135988 (MAPK3)
   05161 Hepatitis B
    101135988 (MAPK3)
   05160 Hepatitis C
    101135988 (MAPK3)
   05145 Toxoplasmosis
    101135988 (MAPK3)
   05140 Leishmaniasis
    101135988 (MAPK3)
   05142 Chagas disease (American trypanosomiasis)
    101135988 (MAPK3)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    101135988 (MAPK3)
   01522 Endocrine resistance
    101135988 (MAPK3)
   01524 Platinum drug resistance
    101135988 (MAPK3)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101135988 (MAPK3)
Protein kinases [BR:ggo01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   101135988 (MAPK3)
Chromosome [BR:ggo03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     101135988 (MAPK3)
Exosome [BR:ggo04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   101135988 (MAPK3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
Position
16
AA seq 265 aa AA seqDB search
MRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLI
NTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCI
LAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAK
LFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDD
LPKERLKELIFQETARFQPGVLEAP
NT seq 798 nt NT seq  +upstreamnt  +downstreamnt
atgagggatgtctacattgtgcaggacctgatggagactgacctgtacaagttgctgaaa
agccagcagctgagcaatgaccatatctgctacttcctctaccagatcctgcggggcctc
aagtacatccactccgccaacgtgctccaccgagatctaaagccctccaacctgctcatc
aacaccacctgcgaccttaagatttgtgatttcggcctggcccggattgccgatcctgag
catgaccacactggcttcctgacggagtatgtggctacgcgctggtaccgggccccagag
atcatgctgaactccaagggctataccaagtccatcgacatctggtctgtgggctgcatt
ctggctgagatgctctctaaccggcccatcttccctggcaagcactacctggatcagctc
aaccacattctgggcatcctgggctccccatcccaggaggacctgaattgtatcatcaac
atgaaggcccgaaactacctacagtctctgccctccaagaccaaggtggcttgggccaag
cttttccccaagtcagactccaaagcccttgacctgctggaccggatgttaacctttaac
cccaataaacggatcacagtggaggaagcgctggctcacccctacctggagcagtactat
gacccgacggatgagccagtggccgaggagcccttcaccttcgccatggagctggatgac
ctacctaaggagcggctgaaggagctcatcttccaggagacagcacgcttccagcccgga
gtgctggaggccccctag

DBGET integrated database retrieval system