KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101140164Help
Entry
101140164         CDS       T02442                                 

Gene name
MAPK1
Definition
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo01521  EGFR tyrosine kinase inhibitor resistance
ggo01522  Endocrine resistance
ggo01524  Platinum drug resistance
ggo04010  MAPK signaling pathway
ggo04012  ErbB signaling pathway
ggo04014  Ras signaling pathway
ggo04015  Rap1 signaling pathway
ggo04022  cGMP-PKG signaling pathway
ggo04024  cAMP signaling pathway
ggo04062  Chemokine signaling pathway
ggo04066  HIF-1 signaling pathway
ggo04068  FoxO signaling pathway
ggo04071  Sphingolipid signaling pathway
ggo04072  Phospholipase D signaling pathway
ggo04114  Oocyte meiosis
ggo04140  Autophagy - animal
ggo04150  mTOR signaling pathway
ggo04151  PI3K-Akt signaling pathway
ggo04210  Apoptosis
ggo04218  Cellular senescence
ggo04261  Adrenergic signaling in cardiomyocytes
ggo04270  Vascular smooth muscle contraction
ggo04350  TGF-beta signaling pathway
ggo04360  Axon guidance
ggo04370  VEGF signaling pathway
ggo04371  Apelin signaling pathway
ggo04380  Osteoclast differentiation
ggo04510  Focal adhesion
ggo04520  Adherens junction
ggo04540  Gap junction
ggo04550  Signaling pathways regulating pluripotency of stem cells
ggo04611  Platelet activation
ggo04620  Toll-like receptor signaling pathway
ggo04621  NOD-like receptor signaling pathway
ggo04625  C-type lectin receptor signaling pathway
ggo04650  Natural killer cell mediated cytotoxicity
ggo04657  IL-17 signaling pathway
ggo04658  Th1 and Th2 cell differentiation
ggo04659  Th17 cell differentiation
ggo04660  T cell receptor signaling pathway
ggo04662  B cell receptor signaling pathway
ggo04664  Fc epsilon RI signaling pathway
ggo04666  Fc gamma R-mediated phagocytosis
ggo04668  TNF signaling pathway
ggo04713  Circadian entrainment
ggo04720  Long-term potentiation
ggo04722  Neurotrophin signaling pathway
ggo04723  Retrograde endocannabinoid signaling
ggo04724  Glutamatergic synapse
ggo04725  Cholinergic synapse
ggo04726  Serotonergic synapse
ggo04730  Long-term depression
ggo04810  Regulation of actin cytoskeleton
ggo04910  Insulin signaling pathway
ggo04912  GnRH signaling pathway
ggo04914  Progesterone-mediated oocyte maturation
ggo04915  Estrogen signaling pathway
ggo04916  Melanogenesis
ggo04917  Prolactin signaling pathway
ggo04919  Thyroid hormone signaling pathway
ggo04921  Oxytocin signaling pathway
ggo04926  Relaxin signaling pathway
ggo04928  Parathyroid hormone synthesis, secretion and action
ggo04930  Type II diabetes mellitus
ggo04933  AGE-RAGE signaling pathway in diabetic complications
ggo04934  Cushing's syndrome
ggo04960  Aldosterone-regulated sodium reabsorption
ggo05010  Alzheimer's disease
ggo05020  Prion diseases
ggo05034  Alcoholism
ggo05132  Salmonella infection
ggo05133  Pertussis
ggo05140  Leishmaniasis
ggo05142  Chagas disease (American trypanosomiasis)
ggo05145  Toxoplasmosis
ggo05152  Tuberculosis
ggo05160  Hepatitis C
ggo05161  Hepatitis B
ggo05164  Influenza A
ggo05165  Human papillomavirus infection
ggo05167  Kaposi's sarcoma-associated herpesvirus infection
ggo05200  Pathways in cancer
ggo05203  Viral carcinogenesis
ggo05205  Proteoglycans in cancer
ggo05210  Colorectal cancer
ggo05211  Renal cell carcinoma
ggo05212  Pancreatic cancer
ggo05213  Endometrial cancer
ggo05214  Glioma
ggo05215  Prostate cancer
ggo05216  Thyroid cancer
ggo05218  Melanoma
ggo05219  Bladder cancer
ggo05220  Chronic myeloid leukemia
ggo05221  Acute myeloid leukemia
ggo05223  Non-small cell lung cancer
ggo05224  Breast cancer
ggo05225  Hepatocellular carcinoma
ggo05226  Gastric cancer
ggo05230  Central carbon metabolism in cancer
ggo05231  Choline metabolism in cancer
Module
ggo_M00687  MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101140164 (MAPK1)
   04015 Rap1 signaling pathway
    101140164 (MAPK1)
   04010 MAPK signaling pathway
    101140164 (MAPK1)
   04012 ErbB signaling pathway
    101140164 (MAPK1)
   04350 TGF-beta signaling pathway
    101140164 (MAPK1)
   04370 VEGF signaling pathway
    101140164 (MAPK1)
   04371 Apelin signaling pathway
    101140164 (MAPK1)
   04668 TNF signaling pathway
    101140164 (MAPK1)
   04066 HIF-1 signaling pathway
    101140164 (MAPK1)
   04068 FoxO signaling pathway
    101140164 (MAPK1)
   04072 Phospholipase D signaling pathway
    101140164 (MAPK1)
   04071 Sphingolipid signaling pathway
    101140164 (MAPK1)
   04024 cAMP signaling pathway
    101140164 (MAPK1)
   04022 cGMP - PKG signaling pathway
    101140164 (MAPK1)
   04151 PI3K-Akt signaling pathway
    101140164 (MAPK1)
   04150 mTOR signaling pathway
    101140164 (MAPK1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    101140164 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    101140164 (MAPK1)
   04210 Apoptosis
    101140164 (MAPK1)
   04218 Cellular senescence
    101140164 (MAPK1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    101140164 (MAPK1)
   04520 Adherens junction
    101140164 (MAPK1)
   04540 Gap junction
    101140164 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101140164 (MAPK1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    101140164 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101140164 (MAPK1)
   04620 Toll-like receptor signaling pathway
    101140164 (MAPK1)
   04621 NOD-like receptor signaling pathway
    101140164 (MAPK1)
   04625 C-type lectin receptor signaling pathway
    101140164 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    101140164 (MAPK1)
   04660 T cell receptor signaling pathway
    101140164 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    101140164 (MAPK1)
   04659 Th17 cell differentiation
    101140164 (MAPK1)
   04657 IL-17 signaling pathway
    101140164 (MAPK1)
   04662 B cell receptor signaling pathway
    101140164 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    101140164 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    101140164 (MAPK1)
   04062 Chemokine signaling pathway
    101140164 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    101140164 (MAPK1)
   04912 GnRH signaling pathway
    101140164 (MAPK1)
   04915 Estrogen signaling pathway
    101140164 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    101140164 (MAPK1)
   04917 Prolactin signaling pathway
    101140164 (MAPK1)
   04921 Oxytocin signaling pathway
    101140164 (MAPK1)
   04926 Relaxin signaling pathway
    101140164 (MAPK1)
   04919 Thyroid hormone signaling pathway
    101140164 (MAPK1)
   04928 Parathyroid hormone synthesis, secretion and action
    101140164 (MAPK1)
   04916 Melanogenesis
    101140164 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101140164 (MAPK1)
   04270 Vascular smooth muscle contraction
    101140164 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101140164 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    101140164 (MAPK1)
   04725 Cholinergic synapse
    101140164 (MAPK1)
   04726 Serotonergic synapse
    101140164 (MAPK1)
   04720 Long-term potentiation
    101140164 (MAPK1)
   04730 Long-term depression
    101140164 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    101140164 (MAPK1)
   04722 Neurotrophin signaling pathway
    101140164 (MAPK1)
  Development
   04360 Axon guidance
    101140164 (MAPK1)
   04380 Osteoclast differentiation
    101140164 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    101140164 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101140164 (MAPK1)
   05230 Central carbon metabolism in cancer
    101140164 (MAPK1)
   05231 Choline metabolism in cancer
    101140164 (MAPK1)
   05205 Proteoglycans in cancer
    101140164 (MAPK1)
   05203 Viral carcinogenesis
    101140164 (MAPK1)
   05210 Colorectal cancer
    101140164 (MAPK1)
   05212 Pancreatic cancer
    101140164 (MAPK1)
   05225 Hepatocellular carcinoma
    101140164 (MAPK1)
   05226 Gastric cancer
    101140164 (MAPK1)
   05214 Glioma
    101140164 (MAPK1)
   05216 Thyroid cancer
    101140164 (MAPK1)
   05221 Acute myeloid leukemia
    101140164 (MAPK1)
   05220 Chronic myeloid leukemia
    101140164 (MAPK1)
   05218 Melanoma
    101140164 (MAPK1)
   05211 Renal cell carcinoma
    101140164 (MAPK1)
   05219 Bladder cancer
    101140164 (MAPK1)
   05215 Prostate cancer
    101140164 (MAPK1)
   05213 Endometrial cancer
    101140164 (MAPK1)
   05224 Breast cancer
    101140164 (MAPK1)
   05223 Non-small cell lung cancer
    101140164 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101140164 (MAPK1)
   05020 Prion diseases
    101140164 (MAPK1)
  Substance dependence
   05034 Alcoholism
    101140164 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101140164 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101140164 (MAPK1)
   04934 Cushing's syndrome
    101140164 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    101140164 (MAPK1)
   05133 Pertussis
    101140164 (MAPK1)
   05152 Tuberculosis
    101140164 (MAPK1)
   05164 Influenza A
    101140164 (MAPK1)
   05161 Hepatitis B
    101140164 (MAPK1)
   05160 Hepatitis C
    101140164 (MAPK1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    101140164 (MAPK1)
   05165 Human papillomavirus infection
    101140164 (MAPK1)
   05145 Toxoplasmosis
    101140164 (MAPK1)
   05140 Leishmaniasis
    101140164 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    101140164 (MAPK1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    101140164 (MAPK1)
   01524 Platinum drug resistance
    101140164 (MAPK1)
   01522 Endocrine resistance
    101140164 (MAPK1)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101140164 (MAPK1)
Protein kinases [BR:ggo01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   101140164 (MAPK1)
Chromosome [BR:ggo03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     101140164 (MAPK1)
Exosome [BR:ggo04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   101140164 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: Pkinase Pkinase_Tyr APH Haspin_kinase Choline_kinase FTA2 Kinase-like Kdo
Motif
Other DBs
NCBI-GeneID: 101140164
NCBI-ProteinID: XP_004063154
UniProt: G3R7J0
Position
22
AA seq 348 aa AA seqDB search
MVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREI
KILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQ
ILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRW
YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL
NCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY
LEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1047 nt NT seq  +upstreamnt  +downstreamnt
atggtccgcgggcaggtgttcgacgtggggccgcgctacaccaacctctcgtacatcggc
gagggcgcctacggcatggtgtgctctgcttatgataatgtcaacaaagttcgagtagct
atcaagaaaatcagcccctttgagcaccagacctactgccagagaaccctgagggagata
aaaatcttactgcgcttcagacatgagaacatcattggaatcaatgacattattcgagca
ccaaccatcgagcaaatgaaagatgtatatatagtacaggacctcatggaaacagatctt
tacaagctcttgaagacacaacacctcagcaatgaccatatctgctattttctctaccag
atcctcagagggttaaaatatatccattcagctaacgttctgcaccgtgacctcaagcct
tccaacctgctgctcaacaccacctgtgatctcaagatctgtgactttggcctggcccgt
gttgcagatccagaccatgatcacacagggttcctgacagaatatgtggccacacgttgg
tacagggctccagaaattatgttgaattccaagggctacaccaagtccattgatatttgg
tctgtaggctgcattctggcagaaatgctttctaacaggcccatctttccagggaagcat
tatcttgaccagctgaaccacattctgggtattcttggatccccatcacaagaagacctg
aattgtataataaatttaaaagctaggaactatttgctttctcttccacacaaaaataag
gtgccatggaacaggctgttcccaaatgctgactccaaagctctggacttattggacaaa
atgttgacattcaacccacacaagaggattgaagtagaacaggctctggcccacccatat
ctggagcagtattatgacccgagtgacgagcccatcgccgaagcaccattcaagttcgac
atggaattggatgacttgcctaaggaaaagctgaaagaactaatttttgaagagactgct
agattccagccaggatacagatcttaa

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