KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101140164Help
Entry
101140164         CDS       T02442                                 

Gene name
MAPK1
Definition
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  
mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
Platinum drug resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Cellular senescence
Adrenergic signaling in cardiomyocytes
Vascular smooth muscle contraction
TGF-beta signaling pathway
Axon guidance
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Adherens junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Circadian entrainment
Long-term potentiation
Neurotrophin signaling pathway
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Type II diabetes mellitus
AGE-RAGE signaling pathway in diabetic complications
Aldosterone-regulated sodium reabsorption
Alzheimer's disease
Prion diseases
Alcoholism
Salmonella infection
Pertussis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101140164 (MAPK1)
   04015 Rap1 signaling pathway
    101140164 (MAPK1)
   04010 MAPK signaling pathway
    101140164 (MAPK1)
   04012 ErbB signaling pathway
    101140164 (MAPK1)
   04350 TGF-beta signaling pathway
    101140164 (MAPK1)
   04370 VEGF signaling pathway
    101140164 (MAPK1)
   04371 Apelin signaling pathway
    101140164 (MAPK1)
   04668 TNF signaling pathway
    101140164 (MAPK1)
   04066 HIF-1 signaling pathway
    101140164 (MAPK1)
   04068 FoxO signaling pathway
    101140164 (MAPK1)
   04072 Phospholipase D signaling pathway
    101140164 (MAPK1)
   04071 Sphingolipid signaling pathway
    101140164 (MAPK1)
   04024 cAMP signaling pathway
    101140164 (MAPK1)
   04022 cGMP - PKG signaling pathway
    101140164 (MAPK1)
   04151 PI3K-Akt signaling pathway
    101140164 (MAPK1)
   04150 mTOR signaling pathway
    101140164 (MAPK1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    101140164 (MAPK1)
  Cell growth and death
   04114 Oocyte meiosis
    101140164 (MAPK1)
   04210 Apoptosis
    101140164 (MAPK1)
   04218 Cellular senescence
    101140164 (MAPK1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    101140164 (MAPK1)
   04520 Adherens junction
    101140164 (MAPK1)
   04540 Gap junction
    101140164 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    101140164 (MAPK1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    101140164 (MAPK1)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101140164 (MAPK1)
   04620 Toll-like receptor signaling pathway
    101140164 (MAPK1)
   04621 NOD-like receptor signaling pathway
    101140164 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    101140164 (MAPK1)
   04660 T cell receptor signaling pathway
    101140164 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    101140164 (MAPK1)
   04659 Th17 cell differentiation
    101140164 (MAPK1)
   04657 IL-17 signaling pathway
    101140164 (MAPK1)
   04662 B cell receptor signaling pathway
    101140164 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    101140164 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    101140164 (MAPK1)
   04062 Chemokine signaling pathway
    101140164 (MAPK1)
  Endocrine system
   04910 Insulin signaling pathway
    101140164 (MAPK1)
   04912 GnRH signaling pathway
    101140164 (MAPK1)
   04915 Estrogen signaling pathway
    101140164 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    101140164 (MAPK1)
   04917 Prolactin signaling pathway
    101140164 (MAPK1)
   04921 Oxytocin signaling pathway
    101140164 (MAPK1)
   04926 Relaxin signaling pathway
    101140164 (MAPK1)
   04919 Thyroid hormone signaling pathway
    101140164 (MAPK1)
   04916 Melanogenesis
    101140164 (MAPK1)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101140164 (MAPK1)
   04270 Vascular smooth muscle contraction
    101140164 (MAPK1)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101140164 (MAPK1)
  Nervous system
   04724 Glutamatergic synapse
    101140164 (MAPK1)
   04725 Cholinergic synapse
    101140164 (MAPK1)
   04726 Serotonergic synapse
    101140164 (MAPK1)
   04720 Long-term potentiation
    101140164 (MAPK1)
   04730 Long-term depression
    101140164 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    101140164 (MAPK1)
   04722 Neurotrophin signaling pathway
    101140164 (MAPK1)
  Development
   04360 Axon guidance
    101140164 (MAPK1)
   04380 Osteoclast differentiation
    101140164 (MAPK1)
  Environmental adaptation
   04713 Circadian entrainment
    101140164 (MAPK1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101140164 (MAPK1)
   05230 Central carbon metabolism in cancer
    101140164 (MAPK1)
   05231 Choline metabolism in cancer
    101140164 (MAPK1)
   05205 Proteoglycans in cancer
    101140164 (MAPK1)
   05203 Viral carcinogenesis
    101140164 (MAPK1)
   05210 Colorectal cancer
    101140164 (MAPK1)
   05212 Pancreatic cancer
    101140164 (MAPK1)
   05225 Hepatocellular carcinoma
    101140164 (MAPK1)
   05226 Gastric cancer
    101140164 (MAPK1)
   05214 Glioma
    101140164 (MAPK1)
   05216 Thyroid cancer
    101140164 (MAPK1)
   05221 Acute myeloid leukemia
    101140164 (MAPK1)
   05220 Chronic myeloid leukemia
    101140164 (MAPK1)
   05218 Melanoma
    101140164 (MAPK1)
   05211 Renal cell carcinoma
    101140164 (MAPK1)
   05219 Bladder cancer
    101140164 (MAPK1)
   05215 Prostate cancer
    101140164 (MAPK1)
   05213 Endometrial cancer
    101140164 (MAPK1)
   05224 Breast cancer
    101140164 (MAPK1)
   05223 Non-small cell lung cancer
    101140164 (MAPK1)
  Neurodegenerative diseases
   05010 Alzheimer's disease
    101140164 (MAPK1)
   05020 Prion diseases
    101140164 (MAPK1)
  Substance dependence
   05034 Alcoholism
    101140164 (MAPK1)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101140164 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    101140164 (MAPK1)
  Infectious diseases
   05132 Salmonella infection
    101140164 (MAPK1)
   05133 Pertussis
    101140164 (MAPK1)
   05152 Tuberculosis
    101140164 (MAPK1)
   05164 Influenza A
    101140164 (MAPK1)
   05161 Hepatitis B
    101140164 (MAPK1)
   05160 Hepatitis C
    101140164 (MAPK1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    101140164 (MAPK1)
   05165 Human papillomavirus infection
    101140164 (MAPK1)
   05145 Toxoplasmosis
    101140164 (MAPK1)
   05140 Leishmaniasis
    101140164 (MAPK1)
   05142 Chagas disease (American trypanosomiasis)
    101140164 (MAPK1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    101140164 (MAPK1)
   01524 Platinum drug resistance
    101140164 (MAPK1)
   01522 Endocrine resistance
    101140164 (MAPK1)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     101140164 (MAPK1)
Protein kinases [BR:ggo01001]
 Serine/threonine protein kinases: CMGC group
  MAPK family [OT]
   101140164 (MAPK1)
Chromosome [BR:ggo03036]
 Eukaryotic Type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     101140164 (MAPK1)
Exosome [BR:ggo04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   101140164 (MAPK1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
22
AA seq 348 aa AA seqDB search
MVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREI
KILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQ
ILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRW
YRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL
NCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY
LEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1047 nt NT seq  +upstreamnt  +downstreamnt
atggtccgcgggcaggtgttcgacgtggggccgcgctacaccaacctctcgtacatcggc
gagggcgcctacggcatggtgtgctctgcttatgataatgtcaacaaagttcgagtagct
atcaagaaaatcagcccctttgagcaccagacctactgccagagaaccctgagggagata
aaaatcttactgcgcttcagacatgagaacatcattggaatcaatgacattattcgagca
ccaaccatcgagcaaatgaaagatgtatatatagtacaggacctcatggaaacagatctt
tacaagctcttgaagacacaacacctcagcaatgaccatatctgctattttctctaccag
atcctcagagggttaaaatatatccattcagctaacgttctgcaccgtgacctcaagcct
tccaacctgctgctcaacaccacctgtgatctcaagatctgtgactttggcctggcccgt
gttgcagatccagaccatgatcacacagggttcctgacagaatatgtggccacacgttgg
tacagggctccagaaattatgttgaattccaagggctacaccaagtccattgatatttgg
tctgtaggctgcattctggcagaaatgctttctaacaggcccatctttccagggaagcat
tatcttgaccagctgaaccacattctgggtattcttggatccccatcacaagaagacctg
aattgtataataaatttaaaagctaggaactatttgctttctcttccacacaaaaataag
gtgccatggaacaggctgttcccaaatgctgactccaaagctctggacttattggacaaa
atgttgacattcaacccacacaagaggattgaagtagaacaggctctggcccacccatat
ctggagcagtattatgacccgagtgacgagcccatcgccgaagcaccattcaagttcgac
atggaattggatgacttgcctaaggaaaagctgaaagaactaatttttgaagagactgct
agattccagccaggatacagatcttaa

DBGET integrated database retrieval system