KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101143811Help
Entry
101143811         CDS       T02442                                 

Gene name
PIK3CA
Definition
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101143811 (PIK3CA)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101143811 (PIK3CA)
   04015 Rap1 signaling pathway
    101143811 (PIK3CA)
   04012 ErbB signaling pathway
    101143811 (PIK3CA)
   04370 VEGF signaling pathway
    101143811 (PIK3CA)
   04630 Jak-STAT signaling pathway
    101143811 (PIK3CA)
   04668 TNF signaling pathway
    101143811 (PIK3CA)
   04066 HIF-1 signaling pathway
    101143811 (PIK3CA)
   04068 FoxO signaling pathway
    101143811 (PIK3CA)
   04070 Phosphatidylinositol signaling system
    101143811 (PIK3CA)
   04022 cGMP - PKG signaling pathway
    101143811 (PIK3CA)
   04151 PI3K-Akt signaling pathway
    101143811 (PIK3CA)
   04152 AMPK signaling pathway
    101143811 (PIK3CA)
   04150 mTOR signaling pathway
    101143811 (PIK3CA)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101143811 (PIK3CA)
  Cell growth and death
   04210 Apoptosis
    101143811 (PIK3CA)
  Cell communication
   04510 Focal adhesion
    101143811 (PIK3CA)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101143811 (PIK3CA)
   04620 Toll-like receptor signaling pathway
    101143811 (PIK3CA)
   04650 Natural killer cell mediated cytotoxicity
    101143811 (PIK3CA)
   04660 T cell receptor signaling pathway
    101143811 (PIK3CA)
   04662 B cell receptor signaling pathway
    101143811 (PIK3CA)
   04664 Fc epsilon RI signaling pathway
    101143811 (PIK3CA)
   04666 Fc gamma R-mediated phagocytosis
    101143811 (PIK3CA)
   04670 Leukocyte transendothelial migration
    101143811 (PIK3CA)
   04062 Chemokine signaling pathway
    101143811 (PIK3CA)
  Endocrine system
   04910 Insulin signaling pathway
    101143811 (PIK3CA)
   04915 Estrogen signaling pathway
    101143811 (PIK3CA)
   04914 Progesterone-mediated oocyte maturation
    101143811 (PIK3CA)
   04917 Prolactin signaling pathway
    101143811 (PIK3CA)
   04921 Oxytocin signaling pathway
    101143811 (PIK3CA)
   04919 Thyroid hormone signaling pathway
    101143811 (PIK3CA)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101143811 (PIK3CA)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101143811 (PIK3CA)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101143811 (PIK3CA)
  Nervous system
   04725 Cholinergic synapse
    101143811 (PIK3CA)
   04722 Neurotrophin signaling pathway
    101143811 (PIK3CA)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101143811 (PIK3CA)
  Development
   04380 Osteoclast differentiation
    101143811 (PIK3CA)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101143811 (PIK3CA)
   05205 Proteoglycans in cancer
    101143811 (PIK3CA)
   05203 Viral carcinogenesis
    101143811 (PIK3CA)
   05210 Colorectal cancer
    101143811 (PIK3CA)
   05212 Pancreatic cancer
    101143811 (PIK3CA)
   05214 Glioma
    101143811 (PIK3CA)
   05221 Acute myeloid leukemia
    101143811 (PIK3CA)
   05220 Chronic myeloid leukemia
    101143811 (PIK3CA)
   05218 Melanoma
    101143811 (PIK3CA)
   05211 Renal cell carcinoma
    101143811 (PIK3CA)
   05215 Prostate cancer
    101143811 (PIK3CA)
   05213 Endometrial cancer
    101143811 (PIK3CA)
   05222 Small cell lung cancer
    101143811 (PIK3CA)
   05223 Non-small cell lung cancer
    101143811 (PIK3CA)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101143811 (PIK3CA)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101143811 (PIK3CA)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101143811 (PIK3CA)
   05166 HTLV-I infection
    101143811 (PIK3CA)
   05162 Measles
    101143811 (PIK3CA)
   05164 Influenza A
    101143811 (PIK3CA)
   05161 Hepatitis B
    101143811 (PIK3CA)
   05160 Hepatitis C
    101143811 (PIK3CA)
   05169 Epstein-Barr virus infection
    101143811 (PIK3CA)
   05146 Amoebiasis
    101143811 (PIK3CA)
   05145 Toxoplasmosis
    101143811 (PIK3CA)
   05142 Chagas disease (American trypanosomiasis)
    101143811 (PIK3CA)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101143811 (PIK3CA)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
3
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacgagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacgcaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctgcagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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