KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101143811Help
Entry
101143811         CDS       T02442                                 

Gene name
PIK3CA
Definition
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Class
Metabolism; Carbohydrate metabolism; Inositol phosphate metabolism [PATH:ggo00562]
Environmental Information Processing; Signal transduction; Ras signaling pathway [PATH:ggo04014]
Environmental Information Processing; Signal transduction; Rap1 signaling pathway [PATH:ggo04015]
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:ggo04012]
Environmental Information Processing; Signal transduction; VEGF signaling pathway [PATH:ggo04370]
Environmental Information Processing; Signal transduction; Jak-STAT signaling pathway [PATH:ggo04630]
Environmental Information Processing; Signal transduction; TNF signaling pathway [PATH:ggo04668]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:ggo04066]
Environmental Information Processing; Signal transduction; FoxO signaling pathway [PATH:ggo04068]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:ggo04070]
Environmental Information Processing; Signal transduction; PI3K-Akt signaling pathway [PATH:ggo04151]
Environmental Information Processing; Signal transduction; mTOR signaling pathway [PATH:ggo04150]
Cellular Processes; Cell motility; Regulation of actin cytoskeleton [PATH:ggo04810]
Cellular Processes; Cell growth and death; Apoptosis [PATH:ggo04210]
Cellular Processes; Cell communication; Focal adhesion [PATH:ggo04510]
Organismal Systems; Immune system; Toll-like receptor signaling pathway [PATH:ggo04620]
Organismal Systems; Immune system; Natural killer cell mediated cytotoxicity [PATH:ggo04650]
Organismal Systems; Immune system; T cell receptor signaling pathway [PATH:ggo04660]
Organismal Systems; Immune system; B cell receptor signaling pathway [PATH:ggo04662]
Organismal Systems; Immune system; Fc epsilon RI signaling pathway [PATH:ggo04664]
Organismal Systems; Immune system; Fc gamma R-mediated phagocytosis [PATH:ggo04666]
Organismal Systems; Immune system; Leukocyte transendothelial migration [PATH:ggo04670]
Organismal Systems; Immune system; Chemokine signaling pathway [PATH:ggo04062]
Organismal Systems; Endocrine system; Insulin signaling pathway [PATH:ggo04910]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:ggo04915]
Organismal Systems; Endocrine system; Progesterone-mediated oocyte maturation [PATH:ggo04914]
Organismal Systems; Endocrine system; Prolactin signaling pathway [PATH:ggo04917]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:ggo04921]
Organismal Systems; Endocrine system; Thyroid hormone signaling pathway [PATH:ggo04919]
Organismal Systems; Circulatory system; Adrenergic signaling in cardiomyocytes [PATH:ggo04261]
Organismal Systems; Digestive system; Carbohydrate digestion and absorption [PATH:ggo04973]
Organismal Systems; Excretory system; Aldosterone-regulated sodium reabsorption [PATH:ggo04960]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:ggo04725]
Organismal Systems; Nervous system; Neurotrophin signaling pathway [PATH:ggo04722]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:ggo04750]
Organismal Systems; Development; Osteoclast differentiation [PATH:ggo04380]
Human Diseases; Cancers; Pathways in cancer [PATH:ggo05200]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:ggo05205]
Human Diseases; Cancers; Viral carcinogenesis [PATH:ggo05203]
Human Diseases; Cancers; Colorectal cancer [PATH:ggo05210]
Human Diseases; Cancers; Pancreatic cancer [PATH:ggo05212]
Human Diseases; Cancers; Glioma [PATH:ggo05214]
Human Diseases; Cancers; Acute myeloid leukemia [PATH:ggo05221]
Human Diseases; Cancers; Chronic myeloid leukemia [PATH:ggo05220]
Human Diseases; Cancers; Melanoma [PATH:ggo05218]
Human Diseases; Cancers; Renal cell carcinoma [PATH:ggo05211]
Human Diseases; Cancers; Prostate cancer [PATH:ggo05215]
Human Diseases; Cancers; Endometrial cancer [PATH:ggo05213]
Human Diseases; Cancers; Small cell lung cancer [PATH:ggo05222]
Human Diseases; Cancers; Non-small cell lung cancer [PATH:ggo05223]
Human Diseases; Endocrine and metabolic diseases; Type II diabetes mellitus [PATH:ggo04930]
Human Diseases; Endocrine and metabolic diseases; Non-alcoholic fatty liver disease (NAFLD) [PATH:ggo04932]
Human Diseases; Infectious diseases; Bacterial invasion of epithelial cells [PATH:ggo05100]
Human Diseases; Infectious diseases; HTLV-I infection [PATH:ggo05166]
Human Diseases; Infectious diseases; Measles [PATH:ggo05162]
Human Diseases; Infectious diseases; Influenza A [PATH:ggo05164]
Human Diseases; Infectious diseases; Hepatitis B [PATH:ggo05161]
Human Diseases; Infectious diseases; Hepatitis C [PATH:ggo05160]
Human Diseases; Infectious diseases; Epstein-Barr virus infection [PATH:ggo05169]
Human Diseases; Infectious diseases; Amoebiasis [PATH:ggo05146]
Human Diseases; Infectious diseases; Toxoplasmosis [PATH:ggo05145]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:ggo05142]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
3
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFA
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
YHGGEPLCDNVNTQRVPCSNPRWNEWLNYDIYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLKAISTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRRPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttactaccaaatggaatgatagtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaagaagcaagaaaataccccctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttactcaagaagcagaaagggaa
gaattttttgatgaaacgagacgactttgtgaccttcggctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaagaaaagatcctcaatcgagaaattggttttgct
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtacaggacttccga
agaaatattctgaacgtttgtaaagaagctgtggatcttagggacctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaattgccaaagcac
atatataataaattagataaagggcaaataatagtggtgatctgggtaatagtttctcca
aataatgacaagcagaagtatactctgaaaatcaaccatgactgtgtaccagaacaagta
attgctgaagcaatcaggaaaaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtgtgtggatgtgatgaatac
ttcctagaaaaatatcctctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgttgatggctaaagaaagcctttattctcaactgccaatggac
tgttttacaatgccatcttattccagacgcatttccacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacctacgtgaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
taccatggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cccaggtggaatgaatggctgaattatgatatatacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggaacactgt
ccattggcatggggaaatataaacttgtttgattacacagacactctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagatttgctgaaccctattggt
gttactggatcaaatccaaataaagaaactccatgcttagagttggagtttgactggttc
agcagtgtggtaaagttcccagatatgtcagtgattgaagagcatgccaattggtctgta
tcccgagaagcaggatttagctattcccacgcaggactgagtaacagactagctagagac
aatgaattaagggaaaatgacaaagaacagctcaaagcaatttctacacgagatcctctc
tctgaaatcactgagcaggagaaagattttctatggagccacagacactattgtgtaact
atccccgaaattctacccaaattgcttctgtctgttaaatggaattctagagatgaagta
gcccagatgtattgcttggtaaaagattggcctccaatcaaacctgaacaggctatggaa
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcggtgcttggaa
aaatatttaacagatgacaaactttctcagtatttaattcagctagtacaggtcctaaaa
tatgaacaatatttggataacttgcttgtgagatttttactgaagaaagcattgactaat
caaaggattgggcactttttcttttggcatttaaaatctgagatgcacaataaaacagtt
agccagaggtttggcctgcttttggagtcctattgtcgtgcatgtgggatgtatttgaag
cacctgaataggcaagtcgaggcaatggaaaagctcattaacttaactgacattctcaaa
caggagaagaaggatgaaacgcaaaaggtacagatgaagtttttagttgagcaaatgagg
cgaccagatttcatggatgctctgcagggctttctgtctcctctaaaccctgctcatcaa
ctaggaaacctcaggcttgaagagtgtcgaattatgtcctctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacggcaagatatgctaacacttcaaattattcgtattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgttaccttatggttgtctgtca
atcggtgactgtgtgggacttattgaggtggtgcgaaattctcacactattatgcaaatt
cagtgcaaaggcggcttgaaaggtgcactgcagttcaacagccacacactacatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctgtttacacgttca
tgtgctggatactgtgtagctaccttcattttgggaattggagatcgtcacaatagtaac
atcatggtgaaagacgatggacaactgtttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtgccatttgttttgacacaggatttc
ttaatagtgattagtaaaggagcccaagaatgcacaaagacaagagaatttgagaggttt
caggagatgtgttacaaggcttatctagctattcgacagcatgccaatctcttcataaat
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tacattcgaaagaccctagccttagataaaactgagcaagaggctttggagtatttcatg
aaacaaatgaatgatgcacatcatggtggctggacaacaaaaatggattggatcttccac
acaattaaacagcatgcattgaactga

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