KEGG   Gorilla gorilla gorilla (western lowland gorilla): 101152123Help
Entry
101152123         CDS       T02442                                 

Gene name
PIK3CB
Definition
phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
ggo  Gorilla gorilla gorilla (western lowland gorilla)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ggo00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101152123 (PIK3CB)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101152123 (PIK3CB)
   04015 Rap1 signaling pathway
    101152123 (PIK3CB)
   04012 ErbB signaling pathway
    101152123 (PIK3CB)
   04370 VEGF signaling pathway
    101152123 (PIK3CB)
   04630 Jak-STAT signaling pathway
    101152123 (PIK3CB)
   04668 TNF signaling pathway
    101152123 (PIK3CB)
   04066 HIF-1 signaling pathway
    101152123 (PIK3CB)
   04068 FoxO signaling pathway
    101152123 (PIK3CB)
   04070 Phosphatidylinositol signaling system
    101152123 (PIK3CB)
   04022 cGMP - PKG signaling pathway
    101152123 (PIK3CB)
   04151 PI3K-Akt signaling pathway
    101152123 (PIK3CB)
   04152 AMPK signaling pathway
    101152123 (PIK3CB)
   04150 mTOR signaling pathway
    101152123 (PIK3CB)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101152123 (PIK3CB)
  Cell growth and death
   04210 Apoptosis
    101152123 (PIK3CB)
  Cell communication
   04510 Focal adhesion
    101152123 (PIK3CB)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101152123 (PIK3CB)
   04620 Toll-like receptor signaling pathway
    101152123 (PIK3CB)
   04650 Natural killer cell mediated cytotoxicity
    101152123 (PIK3CB)
   04660 T cell receptor signaling pathway
    101152123 (PIK3CB)
   04662 B cell receptor signaling pathway
    101152123 (PIK3CB)
   04664 Fc epsilon RI signaling pathway
    101152123 (PIK3CB)
   04666 Fc gamma R-mediated phagocytosis
    101152123 (PIK3CB)
   04670 Leukocyte transendothelial migration
    101152123 (PIK3CB)
   04062 Chemokine signaling pathway
    101152123 (PIK3CB)
  Endocrine system
   04910 Insulin signaling pathway
    101152123 (PIK3CB)
   04915 Estrogen signaling pathway
    101152123 (PIK3CB)
   04914 Progesterone-mediated oocyte maturation
    101152123 (PIK3CB)
   04917 Prolactin signaling pathway
    101152123 (PIK3CB)
   04921 Oxytocin signaling pathway
    101152123 (PIK3CB)
   04919 Thyroid hormone signaling pathway
    101152123 (PIK3CB)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101152123 (PIK3CB)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101152123 (PIK3CB)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101152123 (PIK3CB)
  Nervous system
   04725 Cholinergic synapse
    101152123 (PIK3CB)
   04722 Neurotrophin signaling pathway
    101152123 (PIK3CB)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101152123 (PIK3CB)
  Development
   04380 Osteoclast differentiation
    101152123 (PIK3CB)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101152123 (PIK3CB)
   05205 Proteoglycans in cancer
    101152123 (PIK3CB)
   05203 Viral carcinogenesis
    101152123 (PIK3CB)
   05210 Colorectal cancer
    101152123 (PIK3CB)
   05212 Pancreatic cancer
    101152123 (PIK3CB)
   05214 Glioma
    101152123 (PIK3CB)
   05221 Acute myeloid leukemia
    101152123 (PIK3CB)
   05220 Chronic myeloid leukemia
    101152123 (PIK3CB)
   05218 Melanoma
    101152123 (PIK3CB)
   05211 Renal cell carcinoma
    101152123 (PIK3CB)
   05215 Prostate cancer
    101152123 (PIK3CB)
   05213 Endometrial cancer
    101152123 (PIK3CB)
   05222 Small cell lung cancer
    101152123 (PIK3CB)
   05223 Non-small cell lung cancer
    101152123 (PIK3CB)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101152123 (PIK3CB)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101152123 (PIK3CB)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101152123 (PIK3CB)
   05166 HTLV-I infection
    101152123 (PIK3CB)
   05162 Measles
    101152123 (PIK3CB)
   05164 Influenza A
    101152123 (PIK3CB)
   05161 Hepatitis B
    101152123 (PIK3CB)
   05160 Hepatitis C
    101152123 (PIK3CB)
   05169 Epstein-Barr virus infection
    101152123 (PIK3CB)
   05146 Amoebiasis
    101152123 (PIK3CB)
   05145 Toxoplasmosis
    101152123 (PIK3CB)
   05142 Chagas disease (American trypanosomiasis)
    101152123 (PIK3CB)
Enzymes [BR:ggo01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101152123 (PIK3CB)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
3
AA seq 1020 aa AA seqDB search
MCFSFIMPPAMADILDIWAVDSQIASDGSIPVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHNYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDSLKDPEVNEFRRKMRKFSEEKILSLVGLSWMDWLKQTYPPEH
EPSIPENLEDKLYGGKLIVAVHFENCQDVFSFQVSPNMNPIKVNELAIQKRLTIHGKEDE
VSPYDYVLQVSGRVEYVFGDHPLIQFQHRIFISFIKIICIYFILLQHVWENNNPFQIVLV
KGNKLNTEETVKVHVRAGLFHGTELLCKTIVSSEVSGKNDHIWNEPLEFDINICDLPRMA
RLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRTGDII
LHSWSSFPDELEEMLNPMGTVQTNPYTENATALHVKFPENKKQPYYYPPFDKIIEKAAEI
ASSDSANVSSRGGKKFLPVLKEILDRDPLSQLCENEMDLIWTLRQDCREIFPQSLPKLLL
SIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQY
LLQLVQVLKYEPFLDCALSRFLLERALGNRRIGQFLFWHLRSEVHIPAVSVQFGVILEAY
CRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLNRAKGKEAMHTCLKQSAYREALSDL
QSPLNPCVILSELYVEKCKYMDSKMKPLWLVYNNKVFGEDSVGVIFKNGDVKVAVSKEFA
IQLGRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNS
GDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFG
IKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTA
GLPELTSVKDIQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3063 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcggtg
gattcacagatagcatctgatggctccatacctgtggatttccttttgcccactgggatt
tatatccagttggaggtacctcgggaagctaccatttcttatattaagcagatgttatgg
aagcaagttcacaattacccaatgttcaacctccttatggatattgactcctatatgttt
gcatgtgtgaatcagactgctgtatatgaggagcttgaagatgaaacacgaagactctgt
gatgtcagaccttttcttccagttctcaaattagtgacaagaagttgtgacccaggggaa
aaattagactcaaaaattggagtccttataggaaaaggtctgcatgaatttgattccttg
aaggatcctgaagtaaatgaatttcgaagaaaaatgcgcaaattcagtgaggaaaaaatc
ctgtcacttgtgggattgtcttggatggactggctaaaacaaacatatccaccagagcat
gaaccatccatcccggaaaacttagaagataaactttatgggggaaagctcatcgtagct
gttcattttgaaaactgccaggacgtgtttagctttcaagtgtctcctaatatgaatcct
atcaaagtaaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gttagcccctatgattatgtgttgcaagtcagcgggagagtagaatatgtttttggtgat
catccactaattcagttccagcatagaatattcatttctttcattaaaataatttgtatt
tattttattcttttacagcatgtttgggaaaataacaaccctttccaaattgtcttggtt
aagggaaataaacttaacacagaggaaactgtaaaagttcatgtcagggctggtcttttt
catggtactgagctcctgtgtaaaaccatcgtaagctcagaggtgtcagggaaaaatgat
catatttggaatgaaccactggaatttgatattaatatttgtgacttaccaagaatggct
cgattatgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaacgaaa
actattaatccctctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgta
gcgtgggtaaatacgatggtttttgactttaaaggacaattgagaactggagacataata
ttacacagctggtcttcatttcctgatgaactcgaagaaatgttgaatccaatgggaact
gttcaaacaaatccatatactgaaaatgcaacagctttgcatgttaaatttccagagaat
aaaaaacaaccttattattaccctcccttcgataagattattgaaaaggcagctgagatt
gcaagcagtgatagtgctaatgtgtcaagtcgaggtggaaaaaagtttcttcctgtattg
aaagaaatcttggacagggatcccttgtctcaactgtgtgaaaatgaaatggatcttatt
tggactttgcgacaagactgccgagagattttcccacaatcactgccaaaattactgctg
tccatcaagtggaataaacttgaggatgttgctcagcttcaggcgctgcttcagatttgg
cctaaactgcccccccgggaggccctagagcttctggatttcaactatccagaccagtac
gttcgagaatatgctgtaggctgcctgcgacagatgagtgatgaagaactttctcaatat
cttttacaactggtgcaagtgttaaaatatgagccttttcttgattgtgccctctctaga
ttcctattagaaagagcacttggtaatcggaggatagggcagtttctattttggcatctt
aggtcagaagtgcacattcctgctgtctcagtacaatttggtgtcatccttgaagcatac
tgccggggaagtgtggggcacatgaaagtgctttctaagcaggttgaagcactcaataag
ttaaaaactttaaatagtttaatcaaactgaatgccgtgaagttaaacagagccaaaggg
aaggaggccatgcatacctgtttaaaacagagtgcttaccgggaagccctctctgacctg
cagtcacccctgaacccatgtgttatcctctcagaactctatgttgaaaagtgcaaatac
atggattccaaaatgaagcctttgtggctggtatacaataacaaggtatttggtgaggat
tcagttggagtgatttttaaaaatggtgatgttaaagttgctgtctccaaggagtttgca
atccaattggggaggatgttgccttatggctgtttagcaacaggagatcgctctggcctc
attgaagttgtgagcacctctgaaacaattgctgacattcagctgaacagtagcaatgtg
gctgctgcagcagccttcaacaaagatgcccttctgaactggcttaaagaatacaattct
ggggatgacctggaccgagccattgaggaatttacactgtcctgtgctggctactgtgta
gcttcttatgtccttgggattggtgacagacatagtgacaacatcatggtcaaaaaaact
ggccagctcttccacattgactttggacatattcttggaaatttcaaatctaagtttggc
attaaaagggagcgagtgccttttattcttacctatgatttcatccatgtcattcaacaa
ggaaaaacaggaaatacagaaaagtttggccggttccgccagtgttgtgaggatgcatat
ctgattttacgacggcatgggaatctcttcatcactctctttgcgctgatgttgactgca
gggcttcctgaactcacatcagtcaaagatatacagtatcttaaggactctcttgcatta
gggaagagtgaagaagaagcactcaaacagtttaagcaaaaatttgatgaggcgctcagg
gaaagctggactactaaagtgaactggatggcccacacggttcggaaagactacagatct
taa

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