KEGG   Heterocephalus glaber (naked mole-rat): 101704598
Entry
101704598         CDS       T02812                                 
Name
(RefSeq) cholesterol side-chain cleavage enzyme, mitochondrial
  KO
K00498  cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Organism
hgl  Heterocephalus glaber (naked mole-rat)
Pathway
hgl00140  Steroid hormone biosynthesis
hgl01100  Metabolic pathways
hgl04913  Ovarian steroidogenesis
hgl04925  Aldosterone synthesis and secretion
hgl04927  Cortisol synthesis and secretion
hgl04934  Cushing syndrome
Module
hgl_M00107  Steroid hormone biosynthesis, cholesterol => pregnenolone => progesterone
Brite
KEGG Orthology (KO) [BR:hgl00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    101704598
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    101704598
   04925 Aldosterone synthesis and secretion
    101704598
   04927 Cortisol synthesis and secretion
    101704598
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    101704598
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hgl00199]
    101704598
Enzymes [BR:hgl01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     101704598
Cytochrome P450 [BR:hgl00199]
 Cytochrome P450, animal type
  CYP11 family
   101704598
SSDB
Motif
Pfam: p450
Other DBs
NCBI-GeneID: 101704598
NCBI-ProteinID: XP_004855530
UniProt: A0A0P6JD65
Position
Un
AA seq 522 aa
MLSKRLSLHSVLVKGCQAFLSISLQGLTNHPKMLPRGMAGTSARRPRPFQEIPSPGDNGW
LNLYHFWREKGTYHIHYRHVQNFQKYGPIYREKLGNIESVYIMDPEDAALLFKCEGPHPE
RYLIPPWVAYHQYYQRPVGVLLKKSEAWKKDRVVLNQEVMALESIRNFVPLLEPVSQDFV
SLLHRRIQQQNSGKFSGDISDDLFRFAFESITNVIFGERMGMLEEVVDAEAQRFINAIYQ
MFHTSVPMLNLPPGLFRLFRTKTWRDHAAAWDVIFNKADTYTKNFYWDLRQKKDFQDKYP
GILYSLLGSNKLPFQNIQANITEMLAGGVDTTSMTLQWHLYEIACNLKVQAMLREEVQAA
RRQAQGDMIKMLQLVPLLKASIKETLRLHPISVTLQRYVSSDLVLRDYLIPAKTLVQVAN
YAMGREPSYFSKPVIFDPTRWLDKDKNTTHFRYLGFGWGVRQCLGRRIAELEMTIFLIYV
LENFRIQLQQLTDVGTKFNLILTPEKPIYFTFLPFKEDTAQV
NT seq 1569 nt   +upstreamnt  +downstreamnt
atgctgtccaagaggctttccctgcactcagtgctggtcaaaggctgccaggctttcctg
agcatcagccttcagggcctaacaaatcatcccaagatgctccctagaggcatggctggc
acctctgcccgccgtcctcgccccttccaggagatcccttccccaggtgacaatggttgg
ctaaacctgtaccatttctggagggagaaagggacttaccatatccactaccgccatgtc
cagaatttccagaagtacggccccatttacagggagaagcttggcaacatagagtcggtt
tatatcatggaccctgaggacgcggctttgctcttcaaatgcgagggcccgcaccctgag
cgatacctcattccaccctgggtggcttatcaccagtactaccagaggcccgttggtgtc
ctgctcaagaagtcggaagcctggaagaaagaccgtgtggtcctgaaccaggaggtgatg
gcactggagtccattaggaactttgtgcccctgctggagccagtatcccaggactttgtc
agtctcctacacaggcgcatccagcagcagaactccgggaagttctcaggggatatcagt
gatgacctgttccgctttgcctttgagtccatcaccaacgtcatatttggggagcggatg
ggaatgctggaggaggttgtggatgccgaggcccagcggttcatcaacgccatctaccag
atgtttcacaccagcgtgcccatgctcaacctgcccccaggcctcttccggctcttcagg
accaagacctggagggaccatgcggctgcctgggatgtgattttcaataaagccgacaca
tacaccaagaacttttactgggacttgagacagaagaaagactttcaggacaagtacccc
ggcatcctctatagcctcctgggaagtaacaagctgcccttccagaacattcaggccaac
atcaccgagatgttggcaggaggtgtggacacgacatccatgaccctccagtggcactta
tacgagatagcttgcaacctcaaggtgcaggccatgctgcgggaggaggtgcaggctgct
cggcgccaggcccagggggacatgatcaagatgctgcagctggtgccgctgctcaaggcc
agcatcaaggagacactgagactgcaccccatctctgtgaccctgcagagatatgtttcg
agtgacttggttctccgtgattacttgattccagccaagacattggtgcaggtggccaac
tatgccatgggccgggaacccagctacttctccaagcccgtcatttttgacccaacccgg
tggctagacaaggacaagaacactacccacttccggtatctgggcttcggctggggtgta
cggcagtgtctgggtcggcggatcgcagagctggaaatgaccatcttcctcatctatgtg
ctggagaacttcaggattcaattgcagcagttgacagatgtgggtaccaagttcaacctc
atcctcactccagagaagcccatctacttcaccttcctgcccttcaaagaggacactgcc
caggtgtga

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