KEGG   Heterocephalus glaber (naked mole rat): 101707055Help
Entry
101707055         CDS       T02812                                 

Gene name
Pik3cg
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101707055 (Pik3cg)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101707055 (Pik3cg)
   04015 Rap1 signaling pathway
    101707055 (Pik3cg)
   04012 ErbB signaling pathway
    101707055 (Pik3cg)
   04370 VEGF signaling pathway
    101707055 (Pik3cg)
   04630 Jak-STAT signaling pathway
    101707055 (Pik3cg)
   04668 TNF signaling pathway
    101707055 (Pik3cg)
   04066 HIF-1 signaling pathway
    101707055 (Pik3cg)
   04068 FoxO signaling pathway
    101707055 (Pik3cg)
   04070 Phosphatidylinositol signaling system
    101707055 (Pik3cg)
   04022 cGMP - PKG signaling pathway
    101707055 (Pik3cg)
   04151 PI3K-Akt signaling pathway
    101707055 (Pik3cg)
   04152 AMPK signaling pathway
    101707055 (Pik3cg)
   04150 mTOR signaling pathway
    101707055 (Pik3cg)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101707055 (Pik3cg)
  Cell growth and death
   04210 Apoptosis
    101707055 (Pik3cg)
  Cell communication
   04510 Focal adhesion
    101707055 (Pik3cg)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101707055 (Pik3cg)
   04620 Toll-like receptor signaling pathway
    101707055 (Pik3cg)
   04650 Natural killer cell mediated cytotoxicity
    101707055 (Pik3cg)
   04660 T cell receptor signaling pathway
    101707055 (Pik3cg)
   04662 B cell receptor signaling pathway
    101707055 (Pik3cg)
   04664 Fc epsilon RI signaling pathway
    101707055 (Pik3cg)
   04666 Fc gamma R-mediated phagocytosis
    101707055 (Pik3cg)
   04670 Leukocyte transendothelial migration
    101707055 (Pik3cg)
   04062 Chemokine signaling pathway
    101707055 (Pik3cg)
  Endocrine system
   04910 Insulin signaling pathway
    101707055 (Pik3cg)
   04915 Estrogen signaling pathway
    101707055 (Pik3cg)
   04914 Progesterone-mediated oocyte maturation
    101707055 (Pik3cg)
   04917 Prolactin signaling pathway
    101707055 (Pik3cg)
   04921 Oxytocin signaling pathway
    101707055 (Pik3cg)
   04919 Thyroid hormone signaling pathway
    101707055 (Pik3cg)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101707055 (Pik3cg)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101707055 (Pik3cg)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101707055 (Pik3cg)
  Nervous system
   04725 Cholinergic synapse
    101707055 (Pik3cg)
   04722 Neurotrophin signaling pathway
    101707055 (Pik3cg)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101707055 (Pik3cg)
  Development
   04380 Osteoclast differentiation
    101707055 (Pik3cg)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101707055 (Pik3cg)
   05205 Proteoglycans in cancer
    101707055 (Pik3cg)
   05203 Viral carcinogenesis
    101707055 (Pik3cg)
   05210 Colorectal cancer
    101707055 (Pik3cg)
   05212 Pancreatic cancer
    101707055 (Pik3cg)
   05214 Glioma
    101707055 (Pik3cg)
   05221 Acute myeloid leukemia
    101707055 (Pik3cg)
   05220 Chronic myeloid leukemia
    101707055 (Pik3cg)
   05218 Melanoma
    101707055 (Pik3cg)
   05211 Renal cell carcinoma
    101707055 (Pik3cg)
   05215 Prostate cancer
    101707055 (Pik3cg)
   05213 Endometrial cancer
    101707055 (Pik3cg)
   05222 Small cell lung cancer
    101707055 (Pik3cg)
   05223 Non-small cell lung cancer
    101707055 (Pik3cg)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101707055 (Pik3cg)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101707055 (Pik3cg)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101707055 (Pik3cg)
   05166 HTLV-I infection
    101707055 (Pik3cg)
   05162 Measles
    101707055 (Pik3cg)
   05164 Influenza A
    101707055 (Pik3cg)
   05161 Hepatitis B
    101707055 (Pik3cg)
   05160 Hepatitis C
    101707055 (Pik3cg)
   05169 Epstein-Barr virus infection
    101707055 (Pik3cg)
   05146 Amoebiasis
    101707055 (Pik3cg)
   05145 Toxoplasmosis
    101707055 (Pik3cg)
   05142 Chagas disease (American trypanosomiasis)
    101707055 (Pik3cg)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101707055 (Pik3cg)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1102 aa AA seqDB search
MELENSEPPVILREDNLRRRRRMKPRSAASSLSSTELVPIEFVLPTSQRHSKTPETVLLH
VAGHGNVEQMKAQVWFRALETSAAADFYHRLGPDHFLLLYQKKGQWYEIYDKYQVVQTLD
CLQYWKVLHQSPGQIHLVQRHAPSEETLAFQRQLTALIGYDVTDVSNVHDDELESARRRL
VTPRMAEVASRDARLYSMHPWVTSKPLPEYLSKKITNNCIFIVIHRSTTSQTIKVSADDT
PASILQSFFAKMARKKSLMDIPESQSEQDFVLRVCGRDEYLVGDTPIKNFQWLRHCLKNG
EEIHLVLDTPPDPALDEVRKEEWPLVDDCTGVTGYHEQLTIHGKDHESVFTVSLWDCDRN
FRVKIRGIDIPVLPRNADLTVFVEANIQHGQQVLCQRRTSAKPFTEEVLWNVWLEFSIKI
KDLPKGALLNLEIYCGKAPGQSGKSPAETPGSESRGKAQLLYYVNLLLIDHRFLLRHGEY
VLHMWQIPGKGEDQGSFNADKLTSATNPDKENSMSISILLDNYCHPIALPKHQPTPDPEG
DRVRAEMPNQLRKQLEEIIATDPLNPLTAEDKELLWHFRYESLKHPKAYPKLFSSVKWGE
QETVAKTYQLLARREIWDQSALDVGLTMQLLDCNFSDENVRAIAVQKLESLEDDDVLHYL
LQLVQAVKFEPYHDSALARFLLKRGLRNKRIGHFLFWFLRSEIAQSRHYQQRFAVILEAY
LRGCGTAMLQDLAQQVHVIEMLQRVTIDIKSLSAEKYDVSAQVISQLKQKLENLQNSNLP
KSFRVPYDPGLKAGTLVIEKCKVMASKKKPLWLEFKCADPTALSNETIGIIFKHGDDLRQ
DMLILQILRIMESIWETESLDLCLLPYGCISTGDKIGMIEIVKDATTIAKIQQSTVGNTG
AFKDEVLNHWLKEKCPIEEKFQAAVERFVYSCAGYCVATFVLGIGDRHNDNIMISETGNL
FHIDFGHILGNYKSFLGINKERVPFVLTPDFLFVMGTSGKKTSLHFQKFQDVCVKAYLAL
RHHTNLLIILFSMMLMTGMPQLTSKEDIEYIRDALTVGKSEEDSKKYFLDQIEVCRDKGW
TVQFNWFLHLVLGIKQGEKHSA
NT seq 3309 nt NT seq  +upstreamnt  +downstreamnt
atggagctggagaactctgagcctcctgtgatcctgagggaggacaacctccgccggcgt
cggaggatgaagccgcgcagcgcggcctccagcctgtcctccacagagctcgtacccatt
gagttcgtgctgcccaccagccagcgccacagcaagacccctgaaaccgtgctgctgcac
gtggcgggccacggcaacgtggagcagatgaaagcccaggtgtggtttcgcgcgctggag
accagcgcagcagccgacttctaccaccgcctgggcccggaccacttcctcctgctgtac
cagaagaagggccagtggtatgagatctacgataagtaccaggtggtgcagaccttggac
tgcctgcaatattggaaggtgctgcaccagagccccgggcagatccacctggtgcagcgg
cacgccccctcggaggagacgctggccttccagcggcagctcacggcgctcattggctac
gacgtcacggacgtcagcaacgtgcacgacgacgagctggagtccgcgcgccgccggctg
gtgacgccgcgcatggccgaggtggccagccgcgacgccaggctctactctatgcacccc
tgggtgacatccaagcccctcccggagtacctgtccaagaagatcaccaacaactgtatc
ttcatcgtcatccaccgcagcactaccagccagaccatcaaggtctcggctgacgacacc
cccgccagcatcctccagagcttcttcgccaagatggccaggaagaagtcgctaatggac
atccccgagagccagagcgagcaggacttcgtgctgcgcgtctgcggccgggatgaatac
ctggtgggggacacccccatcaaaaacttccagtggttgaggcactgcctcaaaaatgga
gaagagatccacctggtgctggacacgcccccggacccagccttggacgaggtaaggaaa
gaggagtggcccctcgtggatgactgcacgggtgtcaccggctaccatgagcagctgacc
atccacggcaaggaccacgagagcgtgttcaccgtgtccttgtgggactgtgaccggaac
ttcagggtcaagatcagaggcatcgacatccccgtcctgccccggaacgcggacctcaca
gtttttgtggaagccaacatccagcatgggcagcaggtcctttgccaacggcgaaccagt
gccaaacccttcacagaggaggtgctctggaacgtgtggcttgagttcagcatcaaaatc
aaggacttgcccaagggggctctgctgaacctcgagatctactgcggcaaagctccgggg
cagtcgggcaagtcccctgcagaaacccccggctccgaatccaggggcaaagctcagctt
ctctactacgtgaacctgctgctgatagaccaccgcttcctcctgcgacacggggagtac
gtgctgcacatgtggcagatacccgggaagggagaagaccaagggagcttcaatgcggac
aagctcacctccgcaactaacccagacaaggagaactcaatgtccatctccatccttctg
gacaattactgtcacccaatagcactccctaagcatcagcccacccctgaccctgaaggg
gaccgagtgcgagccgaaatgcccaaccagcttcgaaagcaactggaagagatcatagct
actgatccactcaatcctctcacagcagaggacaaagaactgctctggcactttagatat
gaaagcctgaagcacccaaaagcatatcctaagctgttcagctcagtgaagtggggagag
caagaaacagtggccaaaacataccaactgttagccaggagggagatctgggatcagagt
gctttggatgttgggttaacgatgcaacttctggactgcaacttttcagatgaaaacgtc
agagccattgcagttcagaagctggagagcttggaggacgatgatgttttgcattacctt
ctgcagctggtgcaggctgtgaaatttgaaccctaccatgacagtgccctggccaggttt
ctgctgaagcgcggcttaagaaacaaaagaatcggtcacttcttgttttggttcttgaga
agtgagatagcacagtccagacactatcagcagaggtttgccgtcatcctggaagcctat
ctgaggggctgtggcaccgccatgctgcaggacttggcccagcaggtccacgtcattgag
atgctgcaaagggtcaccattgacatcaaatccctctctgctgagaagtacgacgtcagt
gcccaggttatttcacagcttaagcaaaagcttgaaaacctacagaattcgaatctccca
aagagctttagagttccatatgatcctggactgaaagcaggaactctggtgattgagaag
tgtaaagtgatggcctctaagaagaagcccctgtggctggaatttaaatgtgctgacccc
accgctctatccaatgagacaattggaattatctttaaacacggagatgatctgcgccaa
gacatgcttatcttacagattctacgaatcatggagtccatttgggagactgaatctttg
gatttgtgcctcctgccatatggttgcatttcaactggggacaaaataggaatgatagag
atcgtgaaagacgccaccaccattgccaaaattcagcaaagcaccgtgggcaacaccggc
gcattcaaagatgaagtcctgaatcactggctcaaagaaaaatgcccgattgaagaaaag
tttcaggcagcagtggagagatttgtttactcctgtgcaggctactgtgtggcaaccttt
gttcttggaataggcgacaggcacaacgacaatattatgatctcagagacaggtaaccta
ttccatattgactttgggcacattcttgggaattacaaaagtttcctgggcattaataaa
gagagagtgccatttgtgctgaccccagacttcttgtttgtgatgggaacttccgggaag
aaaacgagtctgcacttccagaaatttcaggatgtctgtgtgaaggcttatctggccctc
cgccatcacacaaacctcctgatcatcctgttctccatgatgctgatgacaggaatgccc
cagttaacaagtaaagaagatatcgaatatatccgggatgccctgacagttgggaaaagc
gaggaggattccaagaagtatttcctggatcagattgaagtttgtagagacaaaggatgg
acagtgcagttcaattggttcctacatcttgttcttggcatcaaacaaggagagaaacac
tcagcctaa

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