KEGG   Heterocephalus glaber (naked mole rat): 101711934Help
Entry
101711934         CDS       T02812                                 

Gene name
Pik3ca
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101711934 (Pik3ca)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101711934 (Pik3ca)
   04015 Rap1 signaling pathway
    101711934 (Pik3ca)
   04012 ErbB signaling pathway
    101711934 (Pik3ca)
   04370 VEGF signaling pathway
    101711934 (Pik3ca)
   04630 Jak-STAT signaling pathway
    101711934 (Pik3ca)
   04668 TNF signaling pathway
    101711934 (Pik3ca)
   04066 HIF-1 signaling pathway
    101711934 (Pik3ca)
   04068 FoxO signaling pathway
    101711934 (Pik3ca)
   04070 Phosphatidylinositol signaling system
    101711934 (Pik3ca)
   04024 cAMP signaling pathway
    101711934 (Pik3ca)
   04022 cGMP - PKG signaling pathway
    101711934 (Pik3ca)
   04151 PI3K-Akt signaling pathway
    101711934 (Pik3ca)
   04152 AMPK signaling pathway
    101711934 (Pik3ca)
   04150 mTOR signaling pathway
    101711934 (Pik3ca)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101711934 (Pik3ca)
  Cell growth and death
   04210 Apoptosis
    101711934 (Pik3ca)
  Cellular commiunity
   04510 Focal adhesion
    101711934 (Pik3ca)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101711934 (Pik3ca)
   04620 Toll-like receptor signaling pathway
    101711934 (Pik3ca)
   04650 Natural killer cell mediated cytotoxicity
    101711934 (Pik3ca)
   04660 T cell receptor signaling pathway
    101711934 (Pik3ca)
   04662 B cell receptor signaling pathway
    101711934 (Pik3ca)
   04664 Fc epsilon RI signaling pathway
    101711934 (Pik3ca)
   04666 Fc gamma R-mediated phagocytosis
    101711934 (Pik3ca)
   04670 Leukocyte transendothelial migration
    101711934 (Pik3ca)
   04062 Chemokine signaling pathway
    101711934 (Pik3ca)
  Endocrine system
   04910 Insulin signaling pathway
    101711934 (Pik3ca)
   04915 Estrogen signaling pathway
    101711934 (Pik3ca)
   04914 Progesterone-mediated oocyte maturation
    101711934 (Pik3ca)
   04917 Prolactin signaling pathway
    101711934 (Pik3ca)
   04921 Oxytocin signaling pathway
    101711934 (Pik3ca)
   04919 Thyroid hormone signaling pathway
    101711934 (Pik3ca)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101711934 (Pik3ca)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101711934 (Pik3ca)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101711934 (Pik3ca)
  Nervous system
   04725 Cholinergic synapse
    101711934 (Pik3ca)
   04722 Neurotrophin signaling pathway
    101711934 (Pik3ca)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101711934 (Pik3ca)
  Development
   04380 Osteoclast differentiation
    101711934 (Pik3ca)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101711934 (Pik3ca)
   05205 Proteoglycans in cancer
    101711934 (Pik3ca)
   05203 Viral carcinogenesis
    101711934 (Pik3ca)
   05210 Colorectal cancer
    101711934 (Pik3ca)
   05212 Pancreatic cancer
    101711934 (Pik3ca)
   05214 Glioma
    101711934 (Pik3ca)
   05221 Acute myeloid leukemia
    101711934 (Pik3ca)
   05220 Chronic myeloid leukemia
    101711934 (Pik3ca)
   05218 Melanoma
    101711934 (Pik3ca)
   05211 Renal cell carcinoma
    101711934 (Pik3ca)
   05215 Prostate cancer
    101711934 (Pik3ca)
   05213 Endometrial cancer
    101711934 (Pik3ca)
   05222 Small cell lung cancer
    101711934 (Pik3ca)
   05223 Non-small cell lung cancer
    101711934 (Pik3ca)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101711934 (Pik3ca)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101711934 (Pik3ca)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101711934 (Pik3ca)
   05166 HTLV-I infection
    101711934 (Pik3ca)
   05162 Measles
    101711934 (Pik3ca)
   05164 Influenza A
    101711934 (Pik3ca)
   05161 Hepatitis B
    101711934 (Pik3ca)
   05160 Hepatitis C
    101711934 (Pik3ca)
   05169 Epstein-Barr virus infection
    101711934 (Pik3ca)
   05146 Amoebiasis
    101711934 (Pik3ca)
   05145 Toxoplasmosis
    101711934 (Pik3ca)
   05142 Chagas disease (American trypanosomiasis)
    101711934 (Pik3ca)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101711934 (Pik3ca)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1068 aa AA seqDB search
MPPRPSSGELWGIHLMPPRILVECLLPNGMIVTLECLREATLITIKHELFKEARKYPLHQ
LLQDESSYIFVSVTQEAEREEFFDETRRLCDLRLFQPFLKVIEPVGNREEKILNREIGFV
IGMPVCEFDMVKDPEVQDFRRNILNVCKEAVDLRDLNSPHSRAMYVYPPNVESSPELPKH
IYNKLDKGQIIVVIWVIVSPNNDKQKYTLKINHDCVPEQVIAEAIRKKTRSMLLSSEQLK
LCVLEYQGKYILKVCGCDEYFLEKYPLSQYKYIRSCIMLGRMPNLMLMAKESLYSQLPMD
CFTMPSYSRRISTATPYMNGETSTKSLWVINSALRIKILCATYVNVNIRDIDKIYVRTGI
CHGGEPLCDNVNTQRVPCSNPRWNEWLNYDMYIPDLPRAARLCLSICSVKGRKGAKEEHC
PLAWGNINLFDYTDTLVSGKMALNLWPVPHGLEDLLNPIGVTGSNPNKETPCLELEFDWF
SSVVKFPDMSVIEEHANWSVSREAGFSYSHAGLSNRLARDNELRENDKEQLRAICTRDPL
SEITEQEKDFLWSHRHYCVTIPEILPKLLLSVKWNSRDEVAQMYCLVKDWPPIKPEQAME
LLDCNYPDPMVRGFAVRCLEKYLTDDKLSQYLIQLVQVLKYEQYLDNLLVRFLLKKALTN
QRIGHFFFWHLKSEMHNKTVSQRFGLLLESYCRACGMYLKHLNRQVEAMEKLINLTDILK
QEKKDETQKVQMKFLVEQMRQPDFMDALQGFLSPLNPAHQLGNLRLEECRIMSSAKRPLW
LNWENPDIMSELLFQNNEIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLS
IGDCVGLIEVVRNSHTIMQIQCKGGLKGALQFNSHTLHQWLKDKNKGEIYDAAIDLFTRS
CAGYCVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDF
LIVISKGAQECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDDIA
YIRKTLALDKTEQEALEYFMKQMNDAHHGGWTTKMDWIFHTIKQHALN
NT seq 3207 nt NT seq  +upstreamnt  +downstreamnt
atgcctccacgaccatcatcaggtgaactgtggggcatccacttgatgcccccaagaatc
ctagtagaatgtttattaccaaatggaatgatcgtgactttagaatgcctccgtgaggct
acattaataaccataaagcatgaactatttaaggaagcaagaaaataccctctccatcaa
cttcttcaagatgaatcttcttacattttcgtaagtgttacccaagaagcagaaagggag
gaattttttgatgaaacaagacgactttgtgaccttcgcctttttcaaccctttttaaaa
gtaattgaaccagtaggcaaccgtgaggaaaagatcctcaatcgagaaattggttttgtt
atcggcatgccagtgtgtgaatttgatatggttaaagatccagaagtgcaggacttccga
agaaatattctgaatgtttgtaaagaagctgtggatcttagggatctcaattcacctcat
agtagagcaatgtatgtctatcctccaaatgtagaatcttcaccagaactgccaaagcac
atatacaataaattagataaaggacaaataattgtggtgatttgggtaatagtttctcca
aataatgacaagcagaaatatactttgaaaatcaaccatgactgtgtgccagaacaagta
attgctgaagcaatcaggaagaaaactcgaagtatgttgctatcctctgaacaactaaaa
ctctgtgttttagaatatcagggcaagtatattttaaaagtatgtggatgtgatgaatac
ttcctagaaaaatatcccctgagtcagtataagtatataagaagctgtataatgcttggg
aggatgcccaatttgatgctgatggctaaagaaagcctttactctcaactaccaatggac
tgttttacaatgccatcctattccagacgcatctctacagctacaccatatatgaatgga
gaaacatctacaaaatccctttgggttataaatagtgcactcagaataaaaattctttgt
gcaacttatgtaaatgtaaatattcgagacattgataagatctatgttcgaacaggtatc
tgccacggaggagaacccttatgtgacaatgtgaacactcaaagagtaccttgttccaat
cctaggtggaatgaatggctgaattatgatatgtacattcctgatcttcctcgtgctgct
cgactttgcctttccatttgctctgttaaaggccgaaagggtgctaaagaggagcactgt
ccattggcctggggaaatataaacttgtttgattatacagacaccctagtatctggaaaa
atggctttgaatctttggccagtacctcatggattagaagacttgctaaaccctattggt
gttaccgggtcaaatccaaacaaagaaactccatgcctagagttggagtttgattggttc
agcagtgtggtaaagtttccagatatgtcagtgattgaagagcatgcaaattggtctgta
tcccgagaagcaggatttagttattcacatgcaggactgagtaacagactagctagagac
aatgaattaagagaaaatgacaaagaacagctccgagcaatttgtacacgagaccctctg
tctgaaatcactgagcaagagaaagattttctgtggagccacagacactattgtgtaact
atccctgaaattctacctaaattgcttctgtccgttaaatggaattctagagatgaagta
gctcagatgtactgcttagtaaaagattggcccccaatcaaacctgagcaggcaatggag
cttctggactgtaattacccagatcctatggttcgaggttttgctgttcgatgcttggaa
aaatatttgacagatgacaagctttctcagtacctaattcagctagtacaggtcctaaaa
tatgaacaatatttggataatctgcttgtgagatttttactcaagaaagcactaacaaat
caaaggattggacactttttcttttggcatttaaaatctgagatgcataataaaacagtt
agtcaaagattcggtctgcttttggaatcctattgtcgtgcctgtgggatgtatctgaag
cacctgaataggcaagttgaagctatggaaaagctcattaacttaactgacattctcaag
caggaaaagaaggatgagacacaaaaggtacagatgaagtttttagttgagcagatgagg
caaccagatttcatggatgctctacagggctttctatctcctctaaaccctgctcatcaa
ctaggaaatctcaggcttgaagagtgtcgaattatgtcttctgcaaaaaggccactgtgg
ttgaattgggagaacccagacatcatgtcagagttactgtttcagaacaatgagatcatc
tttaaaaatggggatgatttacgccaagatatgctaacgcttcaaattattcgcattatg
gaaaatatctggcaaaatcaaggtcttgatcttcgaatgctgccttacggttgtctctca
attggtgactgcgtgggacttattgaggtggtgagaaattctcacactatcatgcagatt
cagtgcaaagggggcctgaaaggtgcactgcagttcaatagccacacactgcatcagtgg
ctcaaagacaagaacaaaggagaaatatatgatgcagccattgacctctttacacgttca
tgtgctggatattgcgtggctaccttcattttgggaattggagaccgtcacaatagtaac
atcatggttaaagatgatggacaactatttcatatagattttggacactttttggatcac
aagaagaaaaaatttggttataaacgagaacgtgtcccatttgttttgacacaagatttc
ttaatagtgataagtaaaggggcccaagaatgtacaaagacgagagaatttgaaaggttt
caggagatgtgttacaaggcatatctagctattcggcagcatgccaatctcttcataaac
cttttctcaatgatgcttggctctggaatgccagaactacaatcttttgatgacattgca
tatattcgaaagaccctagccttagataaaactgagcaagaggctttggaatatttcatg
aaacaaatgaatgatgcacatcatggaggctggacaacaaaaatggattggatcttccac
acaattaagcagcatgcattgaactga

DBGET integrated database retrieval system