KEGG   Heterocephalus glaber (naked mole rat): 101712941Help
Entry
101712941         CDS       T02812                                 

Gene name
Pik3cd
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101712941 (Pik3cd)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101712941 (Pik3cd)
   04015 Rap1 signaling pathway
    101712941 (Pik3cd)
   04012 ErbB signaling pathway
    101712941 (Pik3cd)
   04370 VEGF signaling pathway
    101712941 (Pik3cd)
   04630 Jak-STAT signaling pathway
    101712941 (Pik3cd)
   04668 TNF signaling pathway
    101712941 (Pik3cd)
   04066 HIF-1 signaling pathway
    101712941 (Pik3cd)
   04068 FoxO signaling pathway
    101712941 (Pik3cd)
   04070 Phosphatidylinositol signaling system
    101712941 (Pik3cd)
   04024 cAMP signaling pathway
    101712941 (Pik3cd)
   04022 cGMP - PKG signaling pathway
    101712941 (Pik3cd)
   04151 PI3K-Akt signaling pathway
    101712941 (Pik3cd)
   04152 AMPK signaling pathway
    101712941 (Pik3cd)
   04150 mTOR signaling pathway
    101712941 (Pik3cd)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101712941 (Pik3cd)
  Cell growth and death
   04210 Apoptosis
    101712941 (Pik3cd)
  Cellular commiunity
   04510 Focal adhesion
    101712941 (Pik3cd)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101712941 (Pik3cd)
   04620 Toll-like receptor signaling pathway
    101712941 (Pik3cd)
   04650 Natural killer cell mediated cytotoxicity
    101712941 (Pik3cd)
   04660 T cell receptor signaling pathway
    101712941 (Pik3cd)
   04662 B cell receptor signaling pathway
    101712941 (Pik3cd)
   04664 Fc epsilon RI signaling pathway
    101712941 (Pik3cd)
   04666 Fc gamma R-mediated phagocytosis
    101712941 (Pik3cd)
   04670 Leukocyte transendothelial migration
    101712941 (Pik3cd)
   04062 Chemokine signaling pathway
    101712941 (Pik3cd)
  Endocrine system
   04910 Insulin signaling pathway
    101712941 (Pik3cd)
   04915 Estrogen signaling pathway
    101712941 (Pik3cd)
   04914 Progesterone-mediated oocyte maturation
    101712941 (Pik3cd)
   04917 Prolactin signaling pathway
    101712941 (Pik3cd)
   04921 Oxytocin signaling pathway
    101712941 (Pik3cd)
   04919 Thyroid hormone signaling pathway
    101712941 (Pik3cd)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101712941 (Pik3cd)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101712941 (Pik3cd)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101712941 (Pik3cd)
  Nervous system
   04725 Cholinergic synapse
    101712941 (Pik3cd)
   04722 Neurotrophin signaling pathway
    101712941 (Pik3cd)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101712941 (Pik3cd)
  Development
   04380 Osteoclast differentiation
    101712941 (Pik3cd)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101712941 (Pik3cd)
   05205 Proteoglycans in cancer
    101712941 (Pik3cd)
   05203 Viral carcinogenesis
    101712941 (Pik3cd)
   05210 Colorectal cancer
    101712941 (Pik3cd)
   05212 Pancreatic cancer
    101712941 (Pik3cd)
   05214 Glioma
    101712941 (Pik3cd)
   05221 Acute myeloid leukemia
    101712941 (Pik3cd)
   05220 Chronic myeloid leukemia
    101712941 (Pik3cd)
   05218 Melanoma
    101712941 (Pik3cd)
   05211 Renal cell carcinoma
    101712941 (Pik3cd)
   05215 Prostate cancer
    101712941 (Pik3cd)
   05213 Endometrial cancer
    101712941 (Pik3cd)
   05222 Small cell lung cancer
    101712941 (Pik3cd)
   05223 Non-small cell lung cancer
    101712941 (Pik3cd)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101712941 (Pik3cd)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101712941 (Pik3cd)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101712941 (Pik3cd)
   05166 HTLV-I infection
    101712941 (Pik3cd)
   05162 Measles
    101712941 (Pik3cd)
   05164 Influenza A
    101712941 (Pik3cd)
   05161 Hepatitis B
    101712941 (Pik3cd)
   05160 Hepatitis C
    101712941 (Pik3cd)
   05169 Epstein-Barr virus infection
    101712941 (Pik3cd)
   05146 Amoebiasis
    101712941 (Pik3cd)
   05145 Toxoplasmosis
    101712941 (Pik3cd)
   05142 Chagas disease (American trypanosomiasis)
    101712941 (Pik3cd)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101712941 (Pik3cd)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
Position
Un
AA seq 1045 aa AA seqDB search
MPPGVDCPMEFWTKEENQNVVVDFLLPTGIYLNFPVSLNANLRTIKQVLWYRAQYEPLFH
MLSGPEAYVFTCVNQTAEQQELEDEQRRLCDIRPFLPVLRVVAREGDRVKKLINSQISLL
IGKGLHEFDSLGDPEVNDFRAKMRQFCEEAAARRQQLGWEDWLQYSFPLQLEPSAGSWGP
STLRLPNRALLVNVKFEGSEESFTFQVSTKDMPLALMACALRKKATVFRQPLVEQPEDYV
LQVNGRLEYLYGSYPLCQFQYVCSCLHSGLTPHLTMVHSSSILAMRDGQGNPDPQVQKPH
PKPPPVPTKKPSSVSLWSLEQLFCIELIQGSKVNADERMKLVVQAGLFHGHEMLCKTVSS
SEVSVCSEPVWKQRLEFDISICDLPRMARLCFALYAVVEKAKKARSTKKKSKKADCPIAW
ANIMLFDYRDQLKTGERRLYMWPSVPDEKGELLNPAGSVHGNPNTESAAALVIFLPEVAP
HPVYYPALEKILELGRHGEQRGQGTEEEQLQLREILERRGSGELYEHEKDLVWKMRHEVQ
EHFPDALARLLLVTKWHKHEDVAQMLYLLCSWPELPILSALELLDFSFPDCHVGSFAIRS
LRKLTDDELFQYLLQLVQVLKYESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPS
VALRFGLIMEAYCRGSTHHMKVLMKQGEALNKLKALNDFVKVSSQKTTKPQTKELMHLCM
RQETYLEALSHLQSPLDPSTLLEEVCVEQCTFMDSKMKPLWIMYSSKEAGTTGSVGIIFK
NGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCLPTGDRTGLIEVVLHSDTIANIQL
NKSNMAATAAFNKDALLNWLKSKNPGEALERAIEEFTLSCAGYCVATYVLGIGDRHSDNI
MIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGKTNNSEKFERFRGY
CERAYTILRRHGLLFLHLFALMRAAGLPELSCSKDIQYLKDSLALGKTEEEALKHFRVKF
NEALRESWKTKVNWLAHNVSKDNRQ
NT seq 3138 nt NT seq  +upstreamnt  +downstreamnt
atgccccccggggtcgactgccccatggagttctggaccaaggaggaaaatcagaacgtg
gtggtggacttcctgctccccacggggatctacctcaacttccctgtgtccctcaatgcc
aacctcaggaccatcaagcaggtgctgtggtatcgggcacagtatgagccgctcttccac
atgctcagcggtcctgaggcctacgtgttcacctgcgtcaaccagacagcagagcagcag
gagctggaggacgagcagcggcggctgtgcgacattcggcccttcctgccggtgctgcgc
gtggtggcccgggagggcgatcgagtcaagaagctcatcaactcccagatcagcctcctc
atcggcaaaggcctccacgagttcgactccctgggtgacccagaagtgaacgacttccgt
gccaagatgcgccagttctgcgaggaggcggctgcaaggcgccagcagctgggctgggag
gactggctgcagtatagcttccccctgcagctcgagccctcggccgggagctgggggccc
agcaccctgaggctccccaaccgggccctgctggtcaacgtcaaattcgagggcagcgag
gagagcttcaccttccaggtgtccaccaaggacatgccgctggcgctcatggcctgcgcc
ctgcgcaagaaggccacagtcttccggcagccgctggtggagcagccggaggactacgtg
ctgcaggtgaacgggcggctcgagtacctatacggcagctacccgctgtgccagttccag
tatgtctgcagctgcctgcacagtggactgaccccccacctcaccatggtgcactcctct
tctatcctggccatgcgggatgggcagggcaaccctgacccccaggtccagaagccccac
cccaagccgccccccgttcccaccaagaagccctcctccgtgtccctgtggtcgctggag
cagctgttctgcatcgagctcatccagggcagcaaggtgaatgcggatgagcgcatgaag
ctcgtggtgcaggccgggctcttccacggccatgagatgctatgcaagacagtgtccagc
tcagaggtcagcgtgtgctccgagcctgtgtggaagcagcggctggagtttgacatcagc
atctgcgacctgccgcgcatggcccggctctgcttcgcgctctatgccgtggtggagaaa
gccaagaaggcgcgctccaccaagaagaagtctaagaaggcggactgcccgatcgcctgg
gccaacatcatgctgttcgactaccgggaccagctgaagactggcgagcgccgcctgtac
atgtggccctcggtcccagatgagaaaggtgagctgctgaaccccgcggggagcgtgcac
ggaaaccccaacacagagagcgctgctgccctggtcatcttcctgcccgaggtggccccc
caccccgtgtactaccctgccctggagaagatcctggagctggggagacacggggagcag
cgcggacaaggcacggaggaggagcagctgcagctgagggagatcctggagcggcggggc
tcgggcgagctgtacgagcatgagaaggacctggtgtggaagatgcggcatgaggtccag
gagcacttcccagacgcgctggcccgcctgctgctggtcaccaagtggcacaagcacgag
gatgtggcccagatgctctacctcctgtgctcctggcccgagctgcccatcctgagtgcc
ctggagctgctggacttcagcttccctgactgtcacgtgggctcctttgccatcaggtcc
ctgcggaaactgacggatgatgagctcttccagtacctgctgcagctggtccaggtgctc
aagtatgagtcctacctggactgcgagctgaccaagttcttgctggaccgggcgctggcc
aaccgcaagatcggccacttcctcttctggcatctccgctctgagatgcacgtgccgtca
gtggccctgcgctttggcctcatcatggaggcctattgcaggggcagcacccaccacatg
aaggtgctgatgaagcagggggaagcactgaacaagctgaaggcgctgaatgacttcgtg
aaggtgagctcccagaagaccaccaagccccagaccaaggagctcatgcacctgtgcatg
cggcaggagacctatctggaggcactctcccacctgcagtccccactggacccaagcaca
ctgctggaggaagtgtgcgtggagcagtgcaccttcatggactccaagatgaagccgctg
tggatcatgtacagcagcaaggaggcgggcaccactggcagcgtgggcatcatcttcaag
aacggggatgacctccgccaggacatgctgaccctgcagatgatccagctcatggatgtg
ctatggaagcaggagggcctggacctgaggatgacgccctacggctgcctccccaccggg
gaccgcacgggcctcatcgaggtggtgctgcactcggacaccatcgccaacatccagctg
aacaagagcaacatggcagccacggccgccttcaacaaggacgccctgctcaactggctc
aagtccaagaaccctggggaggccctggagcgagccattgaagagttcaccctgtcctgt
gctggctactgtgtggccacctacgtgctgggcatcggtgaccggcacagcgacaacatc
atgatccgtgagagtgggcagctgttccacattgattttggccacttcctgggaaatttc
aagaccaagtttggaatcaaccgtgagcgggtcccgttcatcctcacctatgacttcgtc
cacgtgattcagcagggaaagacgaataacagcgagaaatttgaaaggttccggggctac
tgcgaacgagcctacaccatcctgcggcgccatggcctcctcttcctccacctctttgca
ctgatgcgggcagcgggcctgcctgagctcagctgctccaaagacatccagtacctcaag
gactccctggcgctggggaaaacagaggaggaggcgctgaagcacttccgggtgaagttc
aacgaagccctcagggagagctggaagaccaaagtgaactggctggcacacaacgtgtcc
aaagataacaggcagtag

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