KEGG   Heterocephalus glaber (naked mole rat): 101715249Help
Entry
101715249         CDS       T02812                                 

Gene name
Pik3cb
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Orthology
K00922  
phosphatidylinositol-4,5-bisphosphate 3-kinase [EC:2.7.1.153]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
Inositol phosphate metabolism
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phosphatidylinositol signaling system
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Apoptosis
Adrenergic signaling in cardiomyocytes
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Signaling pathways regulating pluripotency of stem cells
Platelet activation
Toll-like receptor signaling pathway
Jak-STAT signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Leukocyte transendothelial migration
Neurotrophin signaling pathway
Cholinergic synapse
Inflammatory mediator regulation of TRP channels
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Carbohydrate digestion and absorption
Bacterial invasion of epithelial cells
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Amoebiasis
Hepatitis C
Hepatitis B
Measles
Influenza A
HTLV-I infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:hgl00001]
 Metabolism
  Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    101715249 (Pik3cb)
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101715249 (Pik3cb)
   04015 Rap1 signaling pathway
    101715249 (Pik3cb)
   04012 ErbB signaling pathway
    101715249 (Pik3cb)
   04370 VEGF signaling pathway
    101715249 (Pik3cb)
   04630 Jak-STAT signaling pathway
    101715249 (Pik3cb)
   04668 TNF signaling pathway
    101715249 (Pik3cb)
   04066 HIF-1 signaling pathway
    101715249 (Pik3cb)
   04068 FoxO signaling pathway
    101715249 (Pik3cb)
   04070 Phosphatidylinositol signaling system
    101715249 (Pik3cb)
   04024 cAMP signaling pathway
    101715249 (Pik3cb)
   04022 cGMP - PKG signaling pathway
    101715249 (Pik3cb)
   04151 PI3K-Akt signaling pathway
    101715249 (Pik3cb)
   04152 AMPK signaling pathway
    101715249 (Pik3cb)
   04150 mTOR signaling pathway
    101715249 (Pik3cb)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    101715249 (Pik3cb)
  Cell growth and death
   04210 Apoptosis
    101715249 (Pik3cb)
  Cellular commiunity
   04510 Focal adhesion
    101715249 (Pik3cb)
   04550 Signaling pathways regulating pluripotency of stem cells
    101715249 (Pik3cb)
 Organismal Systems
  Immune system
   04611 Platelet activation
    101715249 (Pik3cb)
   04620 Toll-like receptor signaling pathway
    101715249 (Pik3cb)
   04650 Natural killer cell mediated cytotoxicity
    101715249 (Pik3cb)
   04660 T cell receptor signaling pathway
    101715249 (Pik3cb)
   04662 B cell receptor signaling pathway
    101715249 (Pik3cb)
   04664 Fc epsilon RI signaling pathway
    101715249 (Pik3cb)
   04666 Fc gamma R-mediated phagocytosis
    101715249 (Pik3cb)
   04670 Leukocyte transendothelial migration
    101715249 (Pik3cb)
   04062 Chemokine signaling pathway
    101715249 (Pik3cb)
  Endocrine system
   04910 Insulin signaling pathway
    101715249 (Pik3cb)
   04915 Estrogen signaling pathway
    101715249 (Pik3cb)
   04914 Progesterone-mediated oocyte maturation
    101715249 (Pik3cb)
   04917 Prolactin signaling pathway
    101715249 (Pik3cb)
   04921 Oxytocin signaling pathway
    101715249 (Pik3cb)
   04919 Thyroid hormone signaling pathway
    101715249 (Pik3cb)
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    101715249 (Pik3cb)
  Digestive system
   04973 Carbohydrate digestion and absorption
    101715249 (Pik3cb)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101715249 (Pik3cb)
  Nervous system
   04725 Cholinergic synapse
    101715249 (Pik3cb)
   04722 Neurotrophin signaling pathway
    101715249 (Pik3cb)
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    101715249 (Pik3cb)
  Development
   04380 Osteoclast differentiation
    101715249 (Pik3cb)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    101715249 (Pik3cb)
   05205 Proteoglycans in cancer
    101715249 (Pik3cb)
   05203 Viral carcinogenesis
    101715249 (Pik3cb)
   05210 Colorectal cancer
    101715249 (Pik3cb)
   05212 Pancreatic cancer
    101715249 (Pik3cb)
   05214 Glioma
    101715249 (Pik3cb)
   05221 Acute myeloid leukemia
    101715249 (Pik3cb)
   05220 Chronic myeloid leukemia
    101715249 (Pik3cb)
   05218 Melanoma
    101715249 (Pik3cb)
   05211 Renal cell carcinoma
    101715249 (Pik3cb)
   05215 Prostate cancer
    101715249 (Pik3cb)
   05213 Endometrial cancer
    101715249 (Pik3cb)
   05222 Small cell lung cancer
    101715249 (Pik3cb)
   05223 Non-small cell lung cancer
    101715249 (Pik3cb)
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101715249 (Pik3cb)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101715249 (Pik3cb)
  Infectious diseases
   05100 Bacterial invasion of epithelial cells
    101715249 (Pik3cb)
   05166 HTLV-I infection
    101715249 (Pik3cb)
   05162 Measles
    101715249 (Pik3cb)
   05164 Influenza A
    101715249 (Pik3cb)
   05161 Hepatitis B
    101715249 (Pik3cb)
   05160 Hepatitis C
    101715249 (Pik3cb)
   05169 Epstein-Barr virus infection
    101715249 (Pik3cb)
   05146 Amoebiasis
    101715249 (Pik3cb)
   05145 Toxoplasmosis
    101715249 (Pik3cb)
   05142 Chagas disease (American trypanosomiasis)
    101715249 (Pik3cb)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     101715249 (Pik3cb)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
UniProt: 
Position
Un
AA seq 1070 aa AA seqDB search
MCFSFIMPPAMADILDIWAVDSQIASDGSIAVDFLLPTGIYIQLEVPREATISYIKQMLW
KQVHSYPMFNLLMDIDSYMFACVNQTAVYEELEDETRRLCDVRPFLPVLKLVTRSCDPGE
KLDSKIGVLIGKGLHEFDALKDPEVNEFRRKMRKFSEEKIQSLVGLSWIDWLKQTYPPEH
DPSILENLEDKLYGGKLIVAVHFENSQDVFSFHVSPNVNPIKINELAIQKRLTIHGKEDE
ASPGDYVLQVIGRVEYVFGDHPLIQFQYVRNCVVNRALPHFVLVECYKIKKMYEQEMIAI
EAAINRNSSNFPLPLPPKKTRIISHVWDNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHG
TELLCKTIVSSEISGKNDHIWNETLEFDINTCDLPRMARLCFAVYAVLDKVKTKKSTKTI
NPSKYQTIRKAGKVHYPVAWVNTMVFDFKGQLRSGDIILHSWSSFPDELEEMLNPMGTVQ
TNPYTENATALHIKFPENKKQPYHYPPFDKIIEKAAEIASSDSANVSSRGGKKFLAVLKE
ILDRDPLSQLCENEMDLIWTLRQDCRENFPQSLPKLLLSIKWNKLEDVAQLQALLQIWPK
LPPREALELLDFNYPDQYVREYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFL
LERALANRRIGQFLFWHLRSEVHIPAISVQFGVILEAYCRGSVGHMKVLSKQVEALNKLK
TLNSLIKLNAVKLNRAKGKEAMHTCLKQNAYREALSDLQSPLNPCIILSELYIEKCKYMD
SKMKPLWLVYTNKVFGEDSVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYG
CLATGDRSGLIEVVSTSETIADIQLNSSNVAAAAAFNKDALLNWLKEYNSGDDLDRAIEE
FTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNFKSKFGIKRERVPFIL
TYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLTAGLPELTSVKD
IQYLKDSLALGKSDEEALKQFKQKFDEALRESWTTKVNWMAHTVRKDYRS
NT seq 3213 nt NT seq  +upstreamnt  +downstreamnt
atgtgcttcagtttcataatgcctcctgctatggcagacatccttgacatctgggcagta
gattcacaaatagcttcggatggctccatagctgtggatttccttttacccactgggatt
tatatccagttggaggtaccacgggaagctaccatttcctatattaagcagatgttatgg
aagcaagtgcacagttacccaatgtttaacctgcttatggacattgactcctatatgttt
gcatgtgtgaatcaaactgctgtatatgaggaacttgaagatgaaacacgaagactttgc
gatgttagaccttttcttccagttctcaagttagtgacaagaagttgtgatccaggggaa
aaattggactcaaaaattggagtccttataggaaaaggtctgcatgaatttgatgcctta
aaggatcctgaagtgaatgaatttcgacgaaaaatgcgcaaattcagtgaggaaaagatt
cagtcacttgtgggattatcgtggattgactggctaaagcaaacctacccaccagaacat
gatccatccatccttgaaaacttggaagacaagctttatggaggaaagctcattgtagct
gttcattttgaaaatagtcaggatgtgtttagctttcatgtatctcctaatgtgaatcct
ataaagataaatgaattggcaatccaaaaacgtttgactattcatgggaaggaagatgaa
gccagccctggtgactatgtgttacaagtcattgggagagtagaatatgtatttggtgat
cacccactcattcagttccagtacgtccggaactgtgttgtgaacagggccctgccccat
tttgtgcttgtggaatgctacaagatcaagaagatgtatgagcaagaaatgattgccata
gaggctgccataaaccggaattcatctaactttcctcttcccttaccaccaaagaaaaca
cgaattatttctcatgtttgggacaataacaaccctttccaaattgttttggttaaggga
aataaacttaacactgaagaaactgtaaaagttcatgtcagggctggtctttttcatggt
actgagcttctgtgtaaaaccatcgtaagctcagagatatcagggaaaaatgatcacatt
tggaatgaaacactggaatttgatattaatacttgtgacttgccaagaatggctcgatta
tgttttgctgtttatgcagttttggataaagtaaaaacgaagaaatcaaccaaaactatt
aatccttctaaatatcagaccatcaggaaagctggaaaagtgcattatcctgtagcatgg
gtaaataccatggtttttgactttaaaggacagttgaggtctggagacataatattgcac
agctggtcttcatttcctgatgaacttgaagaaatgttgaatccaatgggaactgttcaa
acaaatccatatactgaaaatgcaacagctctgcacattaaatttccagagaataaaaaa
caaccttatcattaccctcccttcgataagattattgaaaaggcagctgaaattgcaagc
agcgatagtgctaatgtatcaagtcgaggtggaaaaaagtttcttgctgtactgaaagaa
atcttggacagggatcccttgtctcagctgtgtgagaatgaaatggatcttatttggact
ttgcgacaagactgcagagagaatttcccacagtcactgccaaaattactcctgtcaatc
aagtggaataaacttgaagatgttgctcagctccaggcactgcttcagatttggcctaaa
ctgcccccgagggaggccctggagcttctggatttcaactatccagatcagtatgtacgg
gaatatgcagtgggctgcctgcgtcagatgagtgatgaagaactctctcaatatctttta
caactggtccaagttttaaaatatgagccttttcttgattgtgcactttctagatttcta
ttagaaagagcacttgctaatcggagaatagggcagtttctattttggcatctcaggtca
gaggtgcacattcctgccatctcagtacagtttggcgtcatccttgaagcgtactgtcga
ggaagtgtagggcacatgaaagtgctttccaagcaggttgaagcactcaataaattaaaa
actttaaatagtttaatcaaactgaatgcagtgaagttaaacagagctaaagggaaggag
gccatgcacacttgtttaaaacagaatgcttaccgggaagccctctctgatttgcagtca
cctctgaatccatgtatcatcctctcagagctctatattgaaaagtgcaaatacatggat
tccaaaatgaagcctttgtggctcgtatataccaataaggtatttggtgaggattcagtt
ggagtgatttttaaaaatggtgatgatttacgacaggatatgttgactctccaaatgctg
cgcttgatggatttactctggaaagaagctggtctggaccttcggatgctgccttatggc
tgtttagcaacaggagatcgctctggcctcattgaagttgtgagcacctctgaaacaatt
gctgacattcagctgaacagtagcaatgtggctgctgcagcggccttcaataaagatgcc
cttctgaactggcttaaagaatacaattctggggatgacctggaccgagccattgaagag
tttaccctatcctgtgctggctactgtgtagcttcttatgtcctcgggattggtgacaga
catagtgacaacataatggtcaaaaaaactggccagctcttccacattgactttggacat
attcttggaaatttcaaatctaaatttggcattaaaagagaacgagtgccttttattctt
acttatgatttcattcatgtcattcaacaaggaaaaacaggaaacacggaaaagtttggc
cgatttcgccagtgttgtgaagatgcatatttgattttacgaagacatggaaatctcttc
atcactctctttgcactgatgttgactgcagggcttcctgaacttacatcagtcaaggat
atacagtatcttaaggactctcttgccttaggaaagagtgatgaagaagcactcaaacaa
tttaagcaaaaatttgatgaggcactcagggaaagctggactactaaagtgaactggatg
gctcacactgttcggaaagactacagatcttaa

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