KEGG   Heterocephalus glaber (naked mole rat): 101722168Help
Entry
101722168         CDS       T02812                                 

Gene name
Insr
Definition
(RefSeq) insulin receptor
  KO
K04527  
insulin receptor [EC:2.7.10.1]
Organism
hgl  Heterocephalus glaber (naked mole rat)
Pathway
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Longevity regulating pathway - multiple species
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Regulation of lipolysis in adipocytes
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorption
Module
PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:hgl00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    101722168 (Insr)
   04015 Rap1 signaling pathway
    101722168 (Insr)
   04010 MAPK signaling pathway
    101722168 (Insr)
   04066 HIF-1 signaling pathway
    101722168 (Insr)
   04068 FoxO signaling pathway
    101722168 (Insr)
   04072 Phospholipase D signaling pathway
    101722168 (Insr)
   04022 cGMP - PKG signaling pathway
    101722168 (Insr)
   04151 PI3K-Akt signaling pathway
    101722168 (Insr)
   04152 AMPK signaling pathway
    101722168 (Insr)
   04150 mTOR signaling pathway
    101722168 (Insr)
 Cellular Processes
  Cellular community - eukaryotes
   04520 Adherens junction
    101722168 (Insr)
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    101722168 (Insr)
   04923 Regulation of lipolysis in adipocyte
    101722168 (Insr)
   04913 Ovarian Steroidogenesis
    101722168 (Insr)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    101722168 (Insr)
  Aging
   04211 Longevity regulating pathway - mammal
    101722168 (Insr)
   04213 Longevity regulating pathway - multiple species
    101722168 (Insr)
 Human Diseases
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    101722168 (Insr)
   04932 Non-alcoholic fatty liver disease (NAFLD)
    101722168 (Insr)
   04931 Insulin resistance
    101722168 (Insr)
Enzymes [BR:hgl01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     101722168 (Insr)
Protein kinases [BR:hgl01001]
 Tyrosine protein kinases
  InsR family [OT]
   101722168 (Insr)
Enzyme-linked receptors [BR:hgl01020]
 Receptor tyrosine kinases
  RTK class II (Insulin receptor family)
   101722168 (Insr)
Cytokine receptors [BR:hgl04050]
 Receptor tyrosine kinase
  RTK class II (Insulin receptor family)
   101722168 (Insr)
CD molecules [BR:hgl04090]
 Proteins
  101722168 (Insr)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
Position
Un
AA seq 1381 aa AA seqDB search
MGAWGARGAATAPLLVAAAALLVGVTGHLYPGEVCPGMDIRNNLTRLHRLENCSIIEGHL
QILLMFKTKPEDFRDLSFPKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL
VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE
ECGDICPGTTKGKTNCPATVINGQFIERCWTHSHCQKVCPTMCKSHGCTTEGLCCHSECL
GNCSEPDDPTKCVACRNFYLDGRCVASCPPPYYHFQDWRCVNFSFCQELHNKCKNSRRQG
CHQYVIHNDRCIPECPSGYTMNSSNLMCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGC
TVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL
EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE
RNDIALKTNGDQASCENELLKFSSIRTSSDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQ
NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKLQNHPGWLMRGLKPWTQYAIFVKTLVTFS
DERRTYGAKSDILYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVYWQ
RQEEDSELYELDYCLKGLKLPSRAWSPPFESEDAQKHNQSEYEESAGECCSCPKTDSQIL
KELEESSFRKTFEDYLHNVVFVPRNPSAGSGAQDPRPSRKRRSLGEVNVTTAVPLVPGFP
TLSSVSVPTNAEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVS
ARTMPEAKADDIVGPVTHEIFDNNAVHLMWQEPKEPNGLIVLYEVSYRRYGEEELHLCVS
RKHYALEKGCRLRGLQPGNYSVRIRATSLAGNGSWTEATYFYVTNYSDVSSNIAKMIIGP
LIFVFLFSIVIGSIYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPCSVYVPDEWEVPRE
KITLLRELGQGSFGMVYEGNAKDIVKGEAETRVAVKTVNEAASLRERIEFLNEASVMKGF
TCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPESENNPGRPPPTLQEMIQMAA
EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVR
WMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNC
PERVTDLMRMCWQFNPKMRPTFLEIVSLLKDDLHPSFPEVSFFHSEENKAPESEELEMEF
EDMENVPLDRSSHCQREEAGGREGGSSLGIKRNYEEHIPYTHMNGGKKNGRILPLPRSSP
S
NT seq 4146 nt NT seq  +upstreamnt  +downstreamnt
atgggcgcctggggcgcgcggggggcggcgaccgcgccgctgctggtggccgcggccgcg
ctgctggtgggcgtcacgggccacctgtacccgggagaggtgtgtccgggcatggacatc
cggaacaacctcaccaggctgcacaggctggagaactgctccatcatcgagggacatttg
cagatcctcttgatgttcaagacgaagccagaagacttccgagacctcagtttccccaaa
ctggtcatgatcaccgattacttgctgctcttccgggtatatggccttgagagcctgaag
gacctgttccccaacctcacggtcatccgtggctcccgcctcttcttcaactacgcgctg
gtcatcttcgagatggtccatctgaaggagctggggctctacagcctcatgaacatcacg
cggggctccgtgcgcatcgagaagaacaatgagctctgctacttggccaccatcgactgg
tcccgcatcctggattctgtggaggacaactacatcgtgctgaacaaagatgacaatgag
gagtgtggagacatctgcccaggcaccacgaagggcaagaccaactgtcccgccactgtc
atcaacgggcaattcatagagcggtgctggactcacagtcactgtcagaaagtctgcccg
accatgtgcaagtcccacggctgtaccaccgaaggcctctgctgtcacagcgaatgcttg
ggcaactgctccgagcctgatgaccccaccaagtgtgtggcttgccgaaacttctacctg
gatggcaggtgcgtggcgtcctgcccgcctccctactaccacttccaggactggcgctgt
gtgaacttcagcttctgccaggagctgcacaataaatgcaagaactctcgcaggcaaggt
tgccaccagtacgtcattcacaatgacaggtgcatccctgagtgtccctctgggtacacg
atgaattccagcaacttgatgtgcaccccgtgcctgggcccctgccccaaggtctgtcac
ctcctggaaggcgagaaaaccattgactccgtcacgtcggcgcaggagcttcgaggctgc
actgtgatcaacgggagcctcatcatcaacatccggggaggcaacaacctggcagcagaa
ctggaggctaacctcggcctcattgaggagatttcagggtatctaaaaatccgccgatcc
tatgctcttgtatcactttccttcttccggaagttacgcttgattcgaggggaaaccttg
gaaatcgggaactactctttctatgccttggacaaccagaacctaaggcagctgtgggac
tggagcaaacacaacctcaccatcactcaggggaaactcttcttccattataatcccaaa
ctctgcctgtcagaaatccacaagatggaagaagtttcgggaaccaaggggcgccaggag
aggaacgacattgccctgaagacgaacggggaccaggcatcttgtgaaaatgaattactt
aaattttcatccattcggacaagttctgacaagatcttgctgagatgggagccctactgg
ccccccgacttcagggacctcttaggattcatgctcttctacaaagaggccccttatcag
aacgtgaccgagtttgacgggcaggatgcgtgtggctccaacagctggaccgtggtggac
atcgacccgcccttgagatccaatgaccccaagttgcagaaccaccctgggtggctgatg
agaggtctcaagccctggacccagtacgccatctttgtcaagaccttggtcaccttttct
gacgagcgccggacgtatggggccaagagcgacatcctctacgtgcagacggatgccacc
aacccgtctgtcccgctggaccccatctccgtgtcgaattcttcatcccagataattttg
aagtggaagcctccctcggaccccaacggcaacatcacgcactacctggtttactggcag
aggcaggaggaagacagtgagctgtacgagttggattattgcctcaaagggctgaagctg
ccctcccgggcgtggtccccgcccttcgagtctgaggatgcccagaaacacaaccagagc
gagtacgaggagtcggcgggcgagtgctgctcctgccccaagaccgactctcagatcctc
aaggagctggaggagtcttcgttccggaagaccttcgaggattacctgcacaacgtggtc
ttcgtgcccagaaatccctctgcaggcagtggtgcccaggaccctaggccctcgcggaag
cgcaggtccctgggtgaggtgaatgtgaccacagcggtgcccttggtaccgggtttcccc
accctctcctccgtcagcgtgcccaccaacgcggaggagcacaggcccttcgagaaggtg
gtgaacaaggagtccctggtcatctctggcctgcgacacttcaccggctatcggattgag
ctgcaggcctgcaaccaggatgctccggaggagaggtgcagcgtggctgcctatgtcagc
gccaggaccatgcccgaagccaaggcggatgacatcgtcggccctgtgacgcacgaaatc
tttgataacaacgctgttcacttgatgtggcaagaaccaaaggaacccaatggcctgatc
gtgctgtatgaagtgagttatcggcggtacggggaagaggagctgcacctgtgtgtctcc
cggaagcactacgccctggagaaggggtgcagactgcgggggctgcagccaggcaactac
agcgtgcggatccgggccacctccctggcggggaacggctcctggacggaagccacctat
ttctacgtgacaaattattcagatgtctcatcaaacattgcaaagatgatcattggtccc
ctcattttcgtctttctcttcagtattgtgattgggagtatttatctattcctgaggaag
agacagccggatgggccaatgggaccgctgtacgcctcctcgaaccctgagtacctcagc
gccagtgacgtatttccctgttctgtgtatgtgccggacgagtgggaggtccctcgagag
aagatcaccctcctgagagagctggggcagggctcctttggcatggtatacgagggaaat
gccaaggacatcgtcaagggtgaggcagagactcgagtggcggtgaagacggtcaatgaa
gcagccagtctccgagagaggatcgaattcctcaacgaggcctccgtcatgaaaggcttc
acatgtcatcacgtggttcgcctcctgggagtggtgtccaagggccagccaacgctggtg
gtgatggagttgatggcccatggagacttgaagagctacctccgctccttgcggccagag
tctgagaataaccccggccgccctccccctactctacaagagatgattcagatggcggcg
gagattgccgatgggatggcgtacctgaatgccaagaagtttgtgcaccgagacctggca
gctcgaaactgcatggttgcccatgattttactgtcaaaatcggagactttggaatgacc
agggacatctacgaaacggattactaccggaaagggggcaaaggtctgctccctgtgcgg
tggatggcaccggagtccctgaaagatggggtcttcaccacttcctccgacatgtggtcc
tttggtgtagtcctttgggaaatcaccagcttggcagaacagccttaccaagggctgtct
aatgaacaggtgttgaaatttgtcatggatggagggtatctggaccagcctgacaattgt
ccagagagagtcactgacctgatgcgcatgtgctggcagttcaaccccaagatgcggccg
accttcttggagatcgtcagcctgctgaaggatgaccttcatcccagcttcccagaagtc
tccttcttccacagcgaggagaacaaggcccctgagagtgaggagttggagatggagttc
gaggacatggagaatgtccccttggatcggtcctcacactgtcagagggaggaggccggg
ggccgggagggagggtcctcgctgggcatcaagcggaactatgaagagcacatcccgtac
acccacatgaacgggggcaagaagaacgggcggatcctgcccctgccccggtccagccct
tcctaa

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