KEGG H.sapiens: 10020

Homo sapiens (human): 10020

Entry

10020 CDS H.sapiens

Gene name GNE

Definition glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
(EC:5.1.3.14 2.7.1.60)

Orthology K12409 bifunctional UDP-N-acetylglucosamine
2-epimerase/N-acetylmannosamine kinase [EC:5.1.3.14
2.7.1.60]

Pathway hsa00520 Amino sugar and nucleotide sugar metabolism
hsa01100 Metabolic pathways

Disease H00147 Sialuria

Class Metabolism; Carbohydrate Metabolism; Amino sugar and nucleotide
sugar metabolism [PATH:hsa00520]

SSDB

Motif Pfam: Epimerase_2 ROK BcrAD_BadFG FGGY_N Hexokinase_1 DRTGG
Glucokinase

Other DBs NCBI-GI: 190014632
NCBI-GeneID: 10020
OMIM: 603824
HGNC: 23657
HPRD: 04825
Ensembl: ENSG00000159921
UniProt: A6PZH2 Q9Y223

Structure

PDB: 3EO3

Position 9p13.3

AA seq 753 aa
METYGYLQRESCFQGPHELYFKNLSKRNKQIMEKNGNNRKLRVCVATCNRADYSKLAPIM
FGIKTEPEFFELDVVVLGSHLIDDYGNTYRMIEQDDFDINTRLHTIVRGEDEAAMVESVG
LALVKLPDVLNRLKPDIMIVHGDRFDALALATSAALMNIRILHIEGGEVSGTIDDSIRHA
ITKLAHYHVCCTRSAEQHLISMCEDHDRILLAGCPSYDKLLSAKNKDYMSIIRMWLGDDV
KSKDYIVALQHPVTTDIKHSIKMFELTLDALISFNKRTLVLFPNIDAGSKEMVRVMRKKG
IEHHPNFRAVKHVPFDQFIQLVAHAGCMIGNSSCGVREVGAFGTPVINLGTRQIGRETGE
NVLHVRDADTQDKILQALHLQFGKQYPCSKIYGDGNAVPRILKFLKSIDLQEPLQKKFCF
PPVKENISQDIDHILETLSALAVDLGGTNLRVAIVSMKGEIVKKYTQFNPKTYEERINLI
LQMCVEAAAEAVKLNCRILGVGISTGGRVNPREGIVLHSTKLIQEWNSVDLRTPLSDTLH
LPVWVDNDGNCAALAERKFGQGKGLENFVTLITGTGIGGGIIHQHELIHGSSFCAAELGH
LVVSLDGPDCSCGSHGCIEAYASGMALQREAKKLHDEDLLLVEGMSVPKDEAVGALHLIQ
AAKLGNAKAQSILRTAGTALGLGVVNILHTMNPSLVILSGVLASHYIHIVKDVIRQQALS
SVQDVDVVVSDLVDPALLGAASMVLDYTTRRIY

NT seq 2262 nt +upstreamnt +downstreamnt
atggaaacctatggttatctgcagagggagtcatgctttcaaggacctcatgaactctat
tttaagaacctctcaaaacgaaacaagcaaatcatggagaagaatggaaataaccgaaag
ctgcgggtttgtgttgctacttgtaaccgtgcagattattctaaacttgccccgatcatg
tttggcattaaaaccgaacctgagttctttgaacttgatgttgtggtacttggctctcac
ctgatagatgactatggaaatacatatcgaatgattgaacaagatgactttgacattaac
accaggctacacacaattgtgaggggagaagatgaggcagccatggtggagtcagtaggc
ctggccctagtgaagctgccagatgtccttaatcgcctgaagcctgatatcatgattgtt
catggagacaggtttgatgccctggctctggccacatctgctgccttgatgaacatccga
atccttcacattgaaggtggggaagtcagtgggaccattgatgactctatcagacatgcc
ataacaaaactggctcattatcatgtgtgctgcacccgcagtgcagagcagcacctgata
tccatgtgtgaggaccatgatcgcatccttttggcaggctgcccttcctatgacaaactt
ctctcagccaagaacaaagactacatgagcatcattcgcatgtggctaggtgatgatgta
aaatctaaagattacattgttgcactacagcaccctgtgaccactgacattaagcattcc
ataaaaatgtttgaattaacattggatgcacttatctcatttaacaagcggaccctagtc
ctgtttccaaatattgacgcagggagcaaagagatggttcgagtgatgcggaagaagggc
attgagcatcatcccaactttcgtgcagttaaacacgtcccatttgaccagtttatacag
ttggttgcccatgctggctgtatgattgggaacagcagctgtggggttcgagaagttgga
gcttttggaacacctgtgatcaacctgggaacacgtcagattggaagagaaacaggggag
aatgttcttcatgtccgggatgctgacacccaagacaaaatattgcaagcactgcacctt
cagtttggtaaacagtacccttgttcaaagatatatggggatggaaatgctgttccaagg
attttgaagtttctcaaatctatcgatcttcaagagccactgcaaaagaaattctgcttt
cctcctgtgaaggagaatatctctcaagatattgaccatattcttgaaactctaagtgcc
ttggccgttgatcttggcgggacgaacctccgagttgcaatagtcagcatgaagggtgaa
atagttaagaagtatactcagttcaatcctaaaacctatgaagagaggattaatttaatc
ctacagatgtgtgtggaagctgcagcagaagctgtaaaactgaactgcagaattttggga
gtaggcatttccacaggtggccgtgtaaatcctcgggaaggaattgtgctgcattcaacc
aaactgatccaagagtggaactctgtggaccttaggacccccctttctgacactttgcat
ctccctgtgtgggtagacaatgatggcaactgtgctgccctggcggaaaggaaatttggc
caaggaaagggactggaaaactttgttacacttatcacaggcacaggaatcggtggtgga
attatccatcagcatgaattgatccacggaagctccttctgtgctgcagaactgggccac
cttgttgtgtctctggatgggcctgattgttcctgtggaagccatgggtgcattgaagca
tacgcctctggaatggccttgcagagggaggcaaaaaagctccatgatgaggacctgctc
ttggtggaagggatgtcagtgccaaaagatgaggctgtgggtgcgctccatctcatccaa
gctgcgaaacttggcaatgcgaaggcccagagcatcctaagaacagctggaacagctttg
ggtcttggggttgtgaacatcctccataccatgaatccctcccttgtgatcctctccgga
gtcctggccagtcactatatccacattgtcaaagacgtcattcgccagcaggccttgtcc
tccgtgcaggacgtggatgtggtggtttcggatttggttgaccccgccctgctgggtgct
gccagcatggttctggactacacaacacgcaggatctactag

All links

Pathway (2)   
   KEGG PATHWAY (2)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (2)   
   KEGG ENZYME (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (6)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (7)   
   UniProt (2)   
   RefSeq(pep) (2)   
   IPI (3)   
DNA sequence (8)   
   RefSeq(nuc) (2)   
   GenBank (3)   
   EMBL (3)   
3D Structure (1)   
   PDB (1)   
Protein domain (7)   
   Pfam (7)   
All databases (42)

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