KEGG H.sapiens: 10157

Homo sapiens (human): 10157

Entry

10157 CDS H.sapiens

Gene name AASS

Definition aminoadipate-semialdehyde synthase (EC:1.5.1.8 1.5.1.9)

Orthology K00290 saccharopine dehydrogenase (NAD+, L-lysine forming)
[EC:1.5.1.7]
K00291 saccharopine dehydrogenase (NADP+, L-lysine forming)
[EC:1.5.1.8]
K00292 saccharopine dehydrogenase (NAD+, L-glutamate forming)
[EC:1.5.1.9]

Pathway hsa00300 Lysine biosynthesis
hsa00310 Lysine degradation
hsa01100 Metabolic pathways

Disease H00188 Hyperlysinemia

Class Metabolism; Amino Acid Metabolism; Lysine biosynthesis
[PATH:hsa00300]
Metabolism; Amino Acid Metabolism; Lysine degradation
[PATH:hsa00310]

SSDB

Motif Pfam: Saccharop_dh AlaDh_PNT_C AlaDh_PNT_N DUF2325 TatD_DNase ThiF

Other DBs NCBI-GI: 13027640
NCBI-GeneID: 10157
OMIM: 605113
HGNC: 17366
HPRD: 05489
Ensembl: ENSG00000008311
UniProt: A4D0W4 Q9UDR5

Position 7q31.3

AA seq 926 aa
MLQVHRTGLGRLGVSLSKGLHHKAVLAVRREDVNAWERRAPLAPKHIKGITNLGYKVLIQ
PSNRRAIHDKDYVKAGGILQEDISEACLILGVKRPPEEKLMSRKTYAFFSHTIKAQEANM
GLLDEILKQEIRLIDYEKMVDHRGVRVVAFGQWAGVAGMINILHGMGLRLLALGHHTPFM
HIGMAHNYRNSSQAVQAVRDAGYEISLGLMPKSIGPLTFVFTGTGNVSKGAQAIFNELPC
EYVEPHELKEVSQTGDLRKVYGTVLSRHHHLVRKTDAVYDPAEYDKHPERYISRFNTDIA
PYTTCLINGIYWEQNTPRLLTRQDAQSLLAPGKFSPAGVEGCPALPHKLVAICDISADTG
GSIEFMTECTTIEHPFCMYDADQHIIHDSVEGSGILMCSIDNLPAQLPIEATECFGDMLY
PYVEEMILSDATQPLESQNFSPVVRDAVITSNGTLPDKYKYIQTLRESRERAQSLSMGTR
RKVLVLGSGYISEPVLEYLSRDGNIEITVGSDMKNQIEQLGKKYNINPVSMDICKQEEKL
GFLVAKQDLVISLLPYVLHPLVAKACITNKVNMVTASYITPALKELEKSVEDAGITIIGE
LGLDPGLDHMLAMETIDKAKEVGATIESYISYCGGLPAPEHSNNPLRYKFSWSPVGVLMN
VMQSATYLLDGKVVNVAGGISFLDAVTSMDFFPGLNLEGYPNRDSTKYAEIYGISSAHTL
LRGTLRYKGYMKALNGFVKLGLINREALPAFRPEANPLTWKQLLCDLVGISPSSEHDVLK
EAVLKKLGGDNTQLEAAEWLGLLGDEQVPQAESILDALSKHLVMKLSYGPEEKDMIVMRD
SFGIRHPSGHLEHKTIDLVAYGDINGFSAMAKTVGLPTAMAAKMLLDGEIGAKGLMGPFS
KEIYGPILERIKAEGIIYTTQSTIKP

NT seq 2781 nt +upstreamnt +downstreamnt
atgctgcaagtacataggactggactgggcaggctgggggtcagcctctccaagggtctt
caccacaaagctgtgttggccgtccggagggaggatgtgaacgcctgggagagaagggcc
ccgctagctcccaagcacatcaaaggcatcaccaatctgggatacaaggtcttgatacag
ccttcgaatcggcgggccattcatgataaggactatgtcaaagctggtggcattcttcag
gaggatatttctgaagcttgtctaattttaggagttaaaagacctccagaggaaaaatta
atgtccaggaagacttatgcatttttctcccacacaataaaagctcaggaggccaatatg
ggcttgttggatgagattctaaaacaggaaattcgccttattgattatgagaaaatggtg
gatcatagaggagtacgggtagtggcatttggacagtgggctggtgtggcaggaatgatc
aacattttacatggaatgggtttaaggctccttgctttgggacatcacacaccttttatg
cacattggcatggctcataactacaggaatagcagtcaggctgtgcaagctgtccgtgat
gctggctatgaaatatctttgggtttgatgcctaagtcaataggacccttaacatttgtg
ttcacaggaactggtaatgtttctaagggagcccaagcaatctttaatgagctaccttgt
gaatatgtggagccccatgaattaaaagaagtttcccaaactggagacctcagaaaagtg
tatgggacggtgttaagtcgtcatcatcatcttgtcaggaaaacagatgctgtgtatgat
cctgcagagtatgacaaacatccggagcgctacataagtcgttttaatactgatattgca
ccctatacaacttgcttaattaatggaatctactgggaacaaaacactcctcgcctccta
acccgccaagatgctcagagtctcctggctccgggcaagttctcacctgctggtgtggaa
ggctgccctgcattaccacacaaactcgtggcaatatgtgacatttcagctgacacagga
gggtctatagagtttatgactgagtgtacaacaatagagcatcccttttgcatgtatgat
gcagaccagcatattattcatgacagtgttgaaggctcggggatcctgatgtgttccatt
gacaatttgccggcacagctcccaattgaagctacagaatgctttggagacatgctttac
ccttatgttgaagaaatgatattatcagacgcgacacagcctcttgaaagtcagaatttt
tctcctgtggtgagagatgcagtgattacatccaacggtacattacctgataaatataaa
tatatccagacactccgggagagcagggaacgtgctcagtcactttcaatgggcaccagg
agaaaggttttggttcttggatctggctacatatctgagcctgtattagaatatttatca
agagatggcaatatagaaataacagtaggatctgacatgaagaatcaaattgaacagtta
ggcaagaaatataatattaatcctgttagcatggacatttgtaaacaagaagagaagctg
ggcttcttggtggcaaaacaggatcttgtcatcagcttgttgccttatgtattgcaccct
cttgtggccaaggcctgcatcacaaacaaagttaacatggtcactgcaagctacatcaca
ccagcactaaaagaattggaaaagagtgtggaagatgctggcatcacaatcattggtgaa
ttgggattggaccctggtctggatcacatgttagcaatggaaacaatagataaagccaag
gaagtgggagccacgattgaatcatatatttcctactgtggtgggcttccagcccctgaa
cattcaaacaatccattgagatataaatttagctggagtccagtgggagttttgatgaat
gtaatgcagtctgccacctatctgctcgatggaaaggttgtgaatgttgcaggaggcatc
tcctttcttgatgccgttacgtccatggatttttttccaggattaaatttggaaggctat
cctaacagagacagtacgaaatatgctgagatttatggcatttcttctgctcacactttg
ttgcgggggacactgagatataagggatatatgaaagctttgaatggatttgtaaaatta
ggtcttataaacagagaagcgcttcctgcctttagacctgaggccaaccctctcacctgg
aaacaactcctctgtgacctagttgggatttcaccctcctctgagcatgatgtgttgaag
gaagctgttcttaagaaactaggaggagacaatacccagttggaggctgctgaatggttg
ggcttacttggggatgaacaagttcctcaggcagagtccattctggatgccctctccaag
catttggtcatgaagctttcctatggtcctgaagaaaaagatatgattgtgatgagagac
agctttggaatcagacatccttctggacatttagaacataaaacgattgatcttgtggct
tatggggacatcaatggcttttcagccatggctaaaaccgtggggttacccaccgccatg
gcagccaaaatgttgcttgatggtgaaattggagccaaaggcctaatggggcccttttca
aaggagatctatggaccaatattggagcgaattaaagcagaaggcattatatatactaca
cagagtacaattaaaccataa

All links

Pathway (3)   
   KEGG PATHWAY (3)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (3)   
   KEGG ENZYME (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (3)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (7)   
   UniProt (2)   
   RefSeq(pep) (1)   
   IPI (4)   
DNA sequence (7)   
   RefSeq(nuc) (1)   
   GenBank (3)   
   EMBL (3)   
Protein domain (6)   
   Pfam (6)   
All databases (42)

DBGET integrated database retrieval system