KEGG   Homo sapiens (human): 10858
Entry
10858             CDS       T01001                                 
Symbol
CYP46A1, CP46, CYP46
Name
(RefSeq) cytochrome P450 family 46 subfamily A member 1
  KO
K07440  cholesterol 24-hydroxylase [EC:1.14.14.25]
Organism
hsa  Homo sapiens (human)
Pathway
hsa00120  Primary bile acid biosynthesis
Drug target
Soticlestat: D11590
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    10858 (CYP46A1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:hsa00199]
    10858 (CYP46A1)
Enzymes [BR:hsa01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.25  cholesterol 24-hydroxylase
     10858 (CYP46A1)
Cytochrome P450 [BR:hsa00199]
 Cytochrome P450, animal type
  CYP46 family
   10858 (CYP46A1)
SSDB
Motif
Pfam: p450 Peptidase_M1 WASH-7_mid
Other DBs
NCBI-GeneID: 10858
NCBI-ProteinID: NP_006659
OMIM: 604087
HGNC: 2641
Ensembl: ENSG00000036530
UniProt: Q9Y6A2
Structure
Position
14:99684298..99727301
AA seq 500 aa
MSPGLLLLGSAVLLAFGLCCTFVHRARSRYEHIPGPPRPSFLLGHLPCFWKKDEVGGRVL
QDVFLDWAKKYGPVVRVNVFHKTSVIVTSPESVKKFLMSTKYNKDSKMYRALQTVFGERL
FGQGLVSECNYERWHKQRRVIDLAFSRSSLVSLMETFNEKAEQLVEILEAKADGQTPVSM
QDMLTYTAMDILAKAAFGMETSMLLGAQKPLSQAVKLMLEGITASRNTLAKFLPGKRKQL
REVRESIRFLRQVGRDWVQRRREALKRGEEVPADILTQILKAEEGAQDDEGLLDNFVTFF
IAGHETSANHLAFTVMELSRQPEIVARLQAEVDEVIGSKRYLDFEDLGRLQYLSQVLKES
LRLYPPAWGTFRLLEEETLIDGVRVPGNTPLLFSTYVMGRMDTYFEDPLTFNPDRFGPGA
PKPRFTYFPFSLGHRSCIGQQFAQMEVKVVMAKLLQRLEFRLVPGQRFGLQEQATLKPLD
PVLCTLRPRGWQPAPPPPPC
NT seq 1503 nt   +upstreamnt  +downstreamnt
atgagccccgggctgctgctgctcggcagcgccgtcctgctcgccttcggcctctgctgc
accttcgtgcaccgcgctcgcagccgctacgagcacatccccgggccgccgcggcccagt
ttccttctaggacacctcccctgcttttggaaaaaggatgaggttggtggccgtgtgctc
caagatgtgtttttggattgggctaagaagtatggacctgttgtgcgggtcaacgtcttc
cacaaaacctcagtcatcgtcacgagtcctgagtcggttaagaagttcctgatgtcaacc
aagtacaacaaggactccaagatgtaccgtgcgctccagactgtgtttggtgagagactc
ttcggccaaggcttggtgtccgaatgcaactatgagcgctggcacaagcagcggagagtc
atagacctggccttcagccggagctccttggttagcttaatggaaacattcaacgagaag
gctgagcagctggtggagattctagaagccaaggcagatgggcagaccccagtgtccatg
caggacatgctgacctacaccgccatggacatcctggccaaggcagcttttgggatggag
accagtatgctgctgggtgcccagaagcctctgtcccaggcagtgaaacttatgttggag
ggaatcactgcgtcccgcaacactctggcaaagttcctgccagggaagaggaagcagctc
cgggaggtccgggagagcattcgcttcctgcgccaggtgggcagggactgggtccagcgc
cgccgggaagccctgaagaggggcgaggaggttcctgccgacatcctcacacagattctg
aaagctgaagagggagcccaggacgacgagggtctgctggacaacttcgtcaccttcttc
attgctggtcacgagacctctgccaaccacttggcgttcacagtgatggagctgtctcgc
cagccagagatcgtggcaaggctgcaggccgaggtggatgaggtcattggttctaagagg
tacctggatttcgaggacctggggagactgcagtacctgtcccaggtcctcaaagagtcg
ctgaggctgtacccaccagcatggggcacctttcgcctgctggaagaggagaccttgatt
gatggggtcagagtccccggcaacaccccgctcttgttcagcacctatgtcatggggcgg
atggacacatactttgaggacccgctgactttcaaccccgatcgcttcggccctggagca
cccaagccacggttcacctacttccccttctccctgggccaccgctcctgcatcgggcag
cagtttgctcagatggaggtgaaggtggtcatggcaaagctgctgcagaggctggagttc
cggctggtgcccgggcagcgcttcgggctgcaggagcaggccacactcaagccactggac
cccgtgctgtgcaccctgcggccccgcggctggcagcccgcacccccaccacccccctgc
tga

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