KEGG   Homo sapiens (human): 1109Help
Entry
1109              CDS       H.sapiens                              
Gene name AKR1C4
Definition aldo-keto reductase family 1, member C4 (chlordecone reductase;
3-alpha hydroxysteroid dehydrogenase, type I; dihydrodiol
dehydrogenase 4) (EC:1.1.1.225 1.1.1.50)
Orthology K00037  3-alpha-hydroxysteroid dehydrogenase [EC:1.1.1.50]
K00089  3alpha-hydroxysteroid dehydrogenase (A-specific)
        [EC:1.1.1.213]
K00092  chlordecone reductase [EC:1.1.1.225]
K00212  trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
        [EC:1.3.1.20]
Pathway hsa00120  Primary bile acid biosynthesis
hsa00140  Steroid hormone biosynthesis
hsa00980  Metabolism of xenobiotics by cytochrome P450
hsa01100  Metabolic pathways
Class Metabolism; Lipid Metabolism; Primary bile acid biosynthesis
[PATH:hsa00120]
Metabolism; Lipid Metabolism; Steroid hormone biosynthesis
[PATH:hsa00140]
Metabolism; Xenobiotics Biodegradation and Metabolism; Metabolism of
xenobiotics by cytochrome P450 [PATH:hsa00980]
BRITE hierarchy
SSDB OrthologParalogGene clusterGFIT
Motif Pfam: Aldo_ket_red
PROSITE: ALDOKETO_REDUCTASE_2 ALDOKETO_REDUCTASE_1
         ALDOKETO_REDUCTASE_3
Motif
Other DBs NCBI-GI: 24497585
NCBI-GeneID: 1109
OMIM: 600451
HGNC: 387
HPRD: 07040
Ensembl: ENSG00000198610
UniProt: P17516
Structure
PDB: 2FVL
     Thumbnails

Jmol
Position 10p15-p14
AA seq 323 aa AA seqDB search
MDPKYQRVELNDGHFMPVLGFGTYAPPEVPRNRAVEVTKLAIEAGFRHIDSAYLYNNEEQ
VGLAIRSKIADGSVKREDIFYTSKLWCTFFQPQMVQPALESSLKKLQLDYVDLYLLHFPM
ALKPGETPLPKDENGKVIFDTVDLSATWEVMEKCKDAGLAKSIGVSNFNCRQLEMILNKP
GLKYKPVCNQVECHPYLNQSKLLDFCKSKDIVLVAHSALGTQRHKLWVDPNSPVLLEDPV
LCALAKKHKQTPALIALRYQLQRGVVVLAKSYNEQRIRENIQVFEFQLTSEDMKVLDGLN
RNYRYVVMDFLMDHPDYPFSDEY
NT seq 972 nt NT seq  +upstreamnt  +downstreamnt
atggatcccaaatatcagcgtgtagagctaaatgatggtcacttcatgcccgtattggga
tttggcacctatgcacctccagaggttccgaggaacagagctgtagaggtcaccaaatta
gcaatagaagctggcttccgccatattgattctgcttatttatacaataatgaggagcag
gttggactggccatccgaagcaagattgcagatggcagtgtgaagagagaagacatattc
tacacttcaaagctttggtgcactttctttcaaccacagatggtccaaccagccttggaa
agctcactgaaaaaacttcaactggactatgttgacctctatcttcttcatttcccaatg
gctctcaagccaggtgagacgccactaccaaaagatgaaaatggaaaagtaatattcgac
acagtggatctctctgccacatgggaggtcatggagaagtgtaaggatgcaggattggcc
aagtccatcggggtgtcaaacttcaactgcaggcagctggagatgatcctcaacaagcca
ggactcaagtacaagcctgtctgcaaccaggtagaatgtcatccttacctcaaccagagc
aaactgctggatttctgcaagtcaaaagacattgttctggttgcccacagtgctctggga
acccaacgacataaactatgggtggacccaaactccccagttcttttggaggacccagtt
ctttgtgccttagcaaagaaacacaaacaaaccccagccctgattgccctgcgctaccag
ctgcagcgtggggttgtggtcctggccaagagctacaatgagcagcggatcagagagaac
atccaggtttttgaattccagttgacatcagaggatatgaaagttctagatggtctaaac
agaaattatcgatatgttgtcatggattttcttatggaccatcctgattatccattttca
gatgaatattag
DBGET integrated database retrieval system