KEGG T01001: 120227

Homo sapiens (human): 120227

Entry

120227 CDS T01001

Gene name

CYP2R1

Definition

cytochrome P450, family 2, subfamily R, polypeptide 1 (EC:1.14.13.159)

Orthology

K07419

cytochrome P450, family 2, subfamily R, polypeptide 1 (vitamin D 25-hydroxylase) [EC:1.14.13.159]

Organism

hsa Homo sapiens (human)

Pathway

hsa00100	Steroid biosynthesis
hsa01100	Metabolic pathways

Module

hsa_M00103

Cholecalciferol biosynthesis

Disease

H01143

Vitamin D-dependent rickets

Class

Metabolism; Lipid metabolism; Steroid biosynthesis [PATH:hsa00100]

SSDB

Motif

Pfam:

p450 DNA_primase_S

Other DBs

NCBI-GI:

NCBI-GeneID:

OMIM:

HGNC:

HPRD:

Ensembl:

Vega:

UniProt:

Structure

PDB:

3CZH 3DL9 3C6G

Position

11p15.2

AA seq 501 aa
MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSE
LPHVYMRKQSQVYGEIFSLDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTK
MGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEETKFFNDAIETYKGRPFDFK
QLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFPWIGILPF
GKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENL
IFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGKPSWDDKCKMPY
TEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVF
HPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPD
LKPRLGMTLQPQPYLICAERR

NT seq 1506 nt +upstreamnt +downstreamnt
atgtggaagctttggagagctgaagagggcgcggcggcgctcggcggcgcgctcttcctg
ctgctcttcgcgctaggggtccgccagctgctgaagcagaggcggccgatgggcttcccc
ccggggccgccggggctgccatttatcggcaacatctattccctggcagcctcatccgag
cttccccatgtctacatgagaaagcagagccaggtgtacggagagatcttcagtttagat
cttggaggcatatcaactgtggttctaaatggctatgatgtagtaaaggaatgccttgtt
catcaaagcgaaatttttgcagacagaccatgccttcctttattcatgaagatgacaaaa
atgggaggcttactcaattccagatatggccgaggatgggttgatcacagacgattagct
gtaaacagttttcgatattttggatatggccaaaagtcttttgaatctaaaatcttggaa
gaaaccaaatttttcaatgatgctattgaaacatacaaaggtagaccttttgactttaaa
cagttaataacgaatgctgtttcaaacataaccaatctgatcatttttggagaacgattc
acttatgaagacaccgattttcagcacatgattgagttatttagtgaaaatgtggaacta
gctgccagtgcctcagtcttcttgtataatgcctttccatggattggcatcctgcctttt
ggaaaacatcaacagctgtttagaaatgcagctgtagtctatgattttctctccagactc
attgaaaaagcttcagtcaacagaaagcctcagctacctcagcattttgttgatgcttat
ttagatgagatggatcaaggtaaaaatgacccatcatctactttctccaaagaaaaccta
attttctcagtgggtgaactcatcattgctggaactgaaactacaaccaatgtgctacgg
tgggcgattcttttcatggccctttatcctaatattcaaggacaagttcagaaagagatt
gatttaattatgggccctaatgggaagccttcttgggacgacaaatgcaaaatgccttat
actgaggcagttttgcatgaagttttaagattctgtaatatagttccattagggattttc
catgcaacctctgaagatgcagttgtacgtggttattccattcctaaaggcacaacagta
attacaaatctttattctgtacactttgatgaaaagtactggagagacccagaagtgttc
catcctgagcgatttctggacagcagtggatattttgccaagaaggaagctttggttcct
ttttccctaggaagaagacattgtcttggagaacacttggctcggatggaaatgttcttg
ttttttacagcattgcttcagaggtttcatttgcattttccacatgaactagttccagat
ctgaagcccaggttaggcatgacattgcagccccaaccctacctcatctgtgctgaaaga
cgctga

All links

Ontology (1)   
   KEGG BRITE (1)   
Pathway (3)   
   KEGG PATHWAY (2)   
   KEGG MODULE (1)   
Disease (3)   
   KEGG DISEASE (1)   
   OMIM (2)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (2)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
   OC (1)   
   VEGA (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (15)   
   RefSeq(nuc) (1)   
   GenBank (7)   
   EMBL (7)   
3D Structure (3)   
   PDB (3)   
Protein domain (2)   
   Pfam (2)   
All databases (51)   

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