KEGG H.sapiens: 1491

Homo sapiens (human): 1491

Entry

1491 CDS H.sapiens

Gene name CTH

Definition cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1)

Orthology K01758 cystathionine gamma-lyase [EC:4.4.1.1]

Pathway hsa00260 Glycine, serine and threonine metabolism
hsa00270 Cysteine and methionine metabolism
hsa00450 Selenoamino acid metabolism
hsa00910 Nitrogen metabolism
hsa01100 Metabolic pathways

Disease H00182 Cystathioninuria

Class Metabolism; Energy Metabolism; Nitrogen metabolism [PATH:hsa00910]
Metabolism; Amino Acid Metabolism; Glycine, serine and threonine
metabolism [PATH:hsa00260]
Metabolism; Amino Acid Metabolism; Cysteine and methionine
metabolism [PATH:hsa00270]
Metabolism; Metabolism of Other Amino Acids; Selenoamino acid
metabolism [PATH:hsa00450]

SSDB

Motif Pfam: Cys_Met_Meta_PP Aminotran_1_2 Aminotran_5 DegT_DnrJ_EryC1
GDC-P
PROSITE: CYS_MET_METAB_PP

Other DBs NCBI-GI: 21361334
NCBI-GeneID: 1491
OMIM: 607657
HGNC: 2501
HPRD: 09633
Ensembl: ENSG00000116761
UniProt: P32929

Structure

PDB: 3COG 3ELP 2NMP

Position 1p31.1

AA seq 405 aa
MQEKDASSQGFLPHFQHFATQAIHVGQDPEQWTSRAVVPPISLSTTFKQGAPGQHSGFEY
SRSGNPTRNCLEKAVAALDGAKYCLAFASGLAATVTITHLLKAGDQIICMDDVYGGTNRY
FRQVASEFGLKISFVDCSKIKLLEAAITPETKLVWIETPTNPTQKVIDIEGCAHIVHKHG
DIILVVDNTFMSPYFQRPLALGADISMYSATKYMNGHSDVVMGLVSVNCESLHNRLRFLQ
NSLGAVPSPIDCYLCNRGLKTLHVRMEKHFKNGMAVAQFLESNPWVEKVIYPGLPSHPQH
ELVKRQCTGCTGMVTFYIKGTLQHAEIFLKNLKLFTLAESLGGFESLAELPAIMTHASVL
KNDRDVLGISDTLIRLSVGLEDEEDLLEDLDQALKAAHPPSGSHS

NT seq 1218 nt +upstreamnt +downstreamnt
atgcaggaaaaagacgcctcctcacaaggtttcctgccacacttccaacatttcgccacg
caggcgatccatgtgggccaggatccagagcaatggacctccagggctgtagtgcccccc
atctcactgtccaccacgttcaagcaaggggcgcctggccagcactcgggttttgaatat
agccgttctggaaatcccactaggaattgccttgaaaaagcagtggcagcactggatggg
gctaagtactgtttggcctttgcttcaggtttagcagccactgtaactattacccatctt
ttaaaagcaggagaccaaattatttgtatggatgatgtgtatggaggtacaaacaggtac
ttcaggcaagtggcatctgaatttggattaaagatttcttttgttgattgttccaaaatc
aaattactagaggcagcaattacaccagaaaccaagcttgtttggatcgaaacccccaca
aaccccacccagaaggtgattgacattgaaggctgtgcacatattgtccataagcatgga
gacattattttggtcgtggataacacttttatgtcaccatatttccagcgccctttggct
ctgggagctgatatttctatgtattctgcaacaaaatacatgaatggccacagtgatgtt
gtaatgggcctggtgtctgttaattgtgaaagccttcataatagacttcgtttcttgcaa
aactctcttggagcagttccatctcctattgattgttacctctgcaatcgaggtctgaag
actctacatgtccgaatggaaaagcatttcaaaaacggaatggcagttgcccagttcctg
gaatctaatccttgggtagaaaaggttatttatcctgggctgccctctcatccacagcat
gagttggtgaagcgtcagtgtacaggttgtacagggatggtcaccttttatattaagggc
actcttcagcatgctgagattttcctcaagaacctaaagctatttactctggccgagagc
ttgggaggattcgaaagccttgctgagcttccggcaatcatgactcatgcatcagttctt
aagaatgacagagatgtccttggaattagtgacacactgattcgactttctgtgggctta
gaggatgaggaagacctactggaagatctagatcaagctttgaaggcagcacaccctcca
agtggaagtcacagctag

All links

Pathway (5)   
   KEGG PATHWAY (5)   
Disease (2)   
   KEGG DISEASE (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (11)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (5)   
   UNIGENE (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (6)   
   UniProt (1)   
   RefSeq(pep) (2)   
   IPI (3)   
DNA sequence (6)   
   RefSeq(nuc) (2)   
   GenBank (2)   
   EMBL (2)   
3D Structure (3)   
   PDB (3)   
Protein domain (6)   
   Pfam (5)   
   PROSITE (1)   
All databases (41)

DBGET integrated database retrieval system